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An efficient and facile synthesis of tri-indolylmethane derivatives in a deep eutectic solvent, starting from indoles and indole-3-carbaldehydes, is developed. This methodology offers several advantages, such as simple reaction procedures, use of an inexpensive and a recyclable solvent, and a high yield.

An efficient and facile synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved using deep eutectic solvent (DES) promoting a four-component reaction. The protocol avoids the use of costly and toxic catalysts and organic solvents which encounters many side effects on the environment and human beings. The simplicity and versatility of this eco-friendly green method is described. Deep eutectic solvent (DES) promoted eco-friendly synthesis of spirooxindole derivatives involving a four-component reaction is described in this article. This procedure is highly sustainable because of the involvement of readily available and biodegradable deep eutectic solvent as a reaction medium and promoter.