1. Metal-free C–H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source
- Author
-
Xiaoxia Liu, Yajun Liu, Yan Xiao, Xue Hongyu, and Bing Jing
- Subjects
Letter ,C–H functionalization ,1,3-propanedithiol ,mercaptalization ,010402 general chemistry ,01 natural sciences ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,1,3-Propanedithiol ,lcsh:Science ,chemistry.chemical_classification ,Potassium hydroxide ,010405 organic chemistry ,Organic Chemistry ,benzothiazole ,Benzoxazole ,Combinatorial chemistry ,0104 chemical sciences ,Chemistry ,benzoxazole ,Benzothiazole ,chemistry ,Metal free ,Thiol ,Surface modification ,lcsh:Q ,Reaction system - Abstract
A facile and effective C–H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C–H mercaptalization of heteroarenes and a simple reaction system.
- Published
- 2019