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Your search keyword '"Zhi-Hao Shang"' showing total 2 results
Start Over Author "Zhi-Hao Shang" Topic 0104 chemical sciences
2 results on '"Zhi-Hao Shang"'

1. Convergent Domino Cyclization: Oxidative [3+1+1] Annulation for One‐Pot Synthesis of 2‐Quinoline‐4,5‐diaryl‐oxazoles from Methyl Azaarenes, Benzoins and NH 4 OAc

Author

Yuan-Yuan Sun, Cong Zhao, Ya‐Qing Yin, Fei‐Fei Liang, Hong‐Mei Kong, Kai-Xuan Liu, Yan-Ping Zhu, Zhi‐Hao Shang, and Jian‐Wen Yao

Subjects
Reaction conditions, Annulation, 010405 organic chemistry, Chemistry, Organic Chemistry, Quinoline, One-pot synthesis, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Domino, 0104 chemical sciences, chemistry.chemical_compound, Physical and Theoretical Chemistry
Abstract

A metal‐free oxidative [3+1+1] convergent domino annulation has been developed for the synthesis of 2,4,5‐trisubstituted oxazoles. Compared with existing methods, this method has the advantages of wide substrate scope, mild reaction conditions, and obtaining raw materials.

Published
2021
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2. Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

Author

Jiang-Shan Guo, Yan-Ping Zhu, Zhi‐Hao Shang, Zeng-Jing Li, Ji-Na Sun, Zhen-Xiao Zhang, Yuan-Yuan Sun, and Wei-Zhao Weng

Subjects
Annulation, 010405 organic chemistry, Organic Chemistry, Quinoline, chemistry.chemical_element, Substrate (chemistry), Oxidative phosphorylation, 010402 general chemistry, Iodine, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Functional group
Abstract

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

Published
2020
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