1. UVA-Triggered Drug Release and Photo-Protection of Skin
- Author
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Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew D. Lloyd, Charareh Pourzand, and Julia Li Zhong
- Subjects
Photo protection ,UVA Radiation ,genetic structures ,UVA-triggered drug release ,Nanotechnology ,02 engineering and technology ,Review ,010402 general chemistry ,01 natural sciences ,Cell and Developmental Biology ,Light source ,up-conversion nanoparticles ,lcsh:QH301-705.5 ,drug delivery systems (DDS) ,smart sunscreens ,Chemistry ,Cell Biology ,Ultraviolet a ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,lcsh:Biology (General) ,caged iron chelators ,Photoprotection ,Drug delivery ,skin photo-protection ,Drug release ,sense organs ,0210 nano-technology ,Developmental Biology - Abstract
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
- Published
- 2020