1. Synthesis of Quinone-Based N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity
- Author
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Wagner O. Valença, Fernanda G. Brito, Claus Jacob, Irishi N. N. Namboothiri, Maria Helena Araujo, Bruno C. Cavalcanti, Thekke V. Baiju, Cláudia Pessoa, Carlos A. de Simone, and Eufrânio N. da Silva Júnior
- Subjects
Anticancer Activity ,Stereochemistry ,Electrochemical Aspects ,C-H Iodination ,010402 general chemistry ,01 natural sciences ,Peripheral blood mononuclear cell ,Nor-Beta-Lapachone ,Substituted 1,4-Naphthoquinones ,Cytotoxic T cell ,2 Redox Centers ,Catalyzed Transannulation ,Cytotoxicity ,Naphthoquinone Derivatives ,Cancer ,Antitumor activity ,Sulfonyl ,chemistry.chemical_classification ,010405 organic chemistry ,Chemistry ,Quinones ,General Chemistry ,V79 cells ,Triazoles ,0104 chemical sciences ,Quinone ,Rhodium(Ii) Azavinyl Carbenes ,Antiallergic Activities ,Click chemistry ,Click Chemistry ,Proteasome Inhibitors - Abstract
Quinone-based N-sulfonyl-1,2,3-triazoles were synthesized by click chemistry and subsequently evaluated against eight types of cancer cell lines. Some of the compounds exhibited potent cytotoxicity with IC50 values < 1.0 mu M. Also, the cytotoxic potential of the quinones was evaluated against peripheral blood mononuclear (PBMC) and V79 cells. Additionally, the chemical reactivity of Rh(II) aza-vinyl carbenes generated in situ from these triazoles was studied. These compounds could provide promising new lead derivatives for more potent anticancer drug development.
- Published
- 2017
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