1. Partial depolymerization of hydroxypropylmethyl cellulose for production of low molar mass polymer chains
- Author
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Eddy Petit, Marleny Caceres, André Deratani, Institut Européen des membranes (IEM), and Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)
- Subjects
animal structures ,Polymers and Plastics ,Dispersity ,02 engineering and technology ,Cellulase ,010402 general chemistry ,01 natural sciences ,Nanomaterials ,METHYLCELLULOSE ,POLYSACCHARIDES ,HPMC ,Hydroxypropylmethyl cellulose ,SUBSTITUENT DISTRIBUTION ,Materials Chemistry ,[CHIM]Chemical Sciences ,Endoglucanase ,chemistry.chemical_classification ,Molar mass ,biology ,Depolymerization ,Organic Chemistry ,Polymer ,DEGRADATION ,021001 nanoscience & nanotechnology ,Low molar mass polymer ,0104 chemical sciences ,BLOCK-COPOLYMERS ,PATTERN ,MOLECULAR-WEIGHT ,chemistry ,Chemical engineering ,Controlled polymer ,biology.protein ,HYDROLYZED METHYL CELLULOSE ,0210 nano-technology ,BEHAVIOR - Abstract
Low molar mass (LMM) biopolymers are highly required to design functional nanomaterials, which mainly find application in biomedical fields. However, the synthesis of LMM polymer is a challenging task. In this work, we report a partial enzymatic depolymerization process which allows to produce a series of LMM hydroxypropylmethyl cellulose (HPMC) polymer, with a weight average molar mass (M w) under and over 10,000 g mol −1 and low dispersity (Ɖ < 1.5). Variation of the starting HPMC grade, reaction time, and enzyme concentration were the key parameters to control the M w and yield of the target molecules. This approach provides a versatile way of producing LMM HPMCs with varying degrees of substitution, and having a single reactive aldehyde function at one chain extremity. LMM HPMC can find for instance application as building blocks for the development of new functional molecular architectures.
- Published
- 2020
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