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Your search keyword '"Zhiyong Lam"' showing total 3 results
Start Over Author "Zhiyong Lam" Topic 010402 general chemistry
3 results on '"Zhiyong Lam"'

1. High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic in vivo imaging

Author

Richard D. Webster, Kien Voon Kong, Bahareh Khezri, Douglas Goh, Malini Olivo, Weng Kee Leong, Bo Yang Chor, Zhiyong Lam, and Ghayathri Balasundaram

Subjects
indocyanine green, Biomedical Engineering, Analytical chemistry, chemistry.chemical_element, Nanoparticle, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, chemistry.chemical_compound, gas, Microscopy, Cluster (physics), Molecule, General Materials Science, Osmium, molecules, mechanisms, optoacoustic tomography, General Chemistry, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Ruthenium, monoxide, rats, chemistry, microscopy, nanoparticles, 0210 nano-technology, Indocyanine green, Preclinical imaging
Abstract

High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na-2[Os-10(mu(6)-C)(CO)(24)] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.

Published
2020

2. Ruthenacyclic carbamoyl mimics of the [Fe]-hydrogenase active site: Derivatisation at the 4-position of the pyridinyl ring

Author

Rakesh Ganguly, Zhiyong Lam, Jian Ming Kwan, Chandan Kr Barik, Si Yuan Wong, and Weng Kee Leong

Subjects
biology, 010405 organic chemistry, Active site, chemistry.chemical_element, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Medicinal chemistry, Cofactor, 0104 chemical sciences, Ruthenium, Inorganic Chemistry, Metal, chemistry.chemical_compound, (Fe) hydrogenase, chemistry, visual_art, Materials Chemistry, visual_art.visual_art_medium, biology.protein, Physical and Theoretical Chemistry, Derivative (chemistry), Phosphine
Abstract

The ruthenacyclic carbamoyl complexes [RuBr(2-NHC(O)C5H3N-4-R)(CO)2(MeCN)] in which the 4-position of the pyridinyl ring is derivatized, have been synthesized. These are ruthenium-based structural mimics of the natural [Fe]-hydrogenase metal cofactor. The derivative with R = H reacts with phosphine to form a disubstituted product [RuBr(2-NHC(O)C5H4N)(CO)(PPh2SPh)2].

Published
2021
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3. Vibrational spectroscopy of metal carbonyls for bio-imaging and -sensing

Author

Malini Olivo, Zhiyong Lam, Weng Kee Leong, Kien Voon Kong, and School of Physical and Mathematical Sciences

Subjects
Spectrophotometry, Infrared, Infrared spectroscopy, Metal carbonyl, 02 engineering and technology, Bio-imaging and -sensing, Biosensing Techniques, 010402 general chemistry, Photochemistry, Spectrum Analysis, Raman, 01 natural sciences, Biochemistry, Vibration, Analytical Chemistry, symbols.namesake, Bio imaging, Transition metal, Spectrophotometry, Electrochemistry, medicine, Organometallic Compounds, Environmental Chemistry, Animals, Humans, Spectroscopy, Group 2 organometallic chemistry, medicine.diagnostic_test, Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Molecular Imaging, Metal carbonyls, symbols, 0210 nano-technology, Raman spectroscopy, Plasmonic nanostructures
Abstract

Transition metal carbonyls exhibit strong CO absorptions in the 2200–1800 cm−1 region, which is free of interference from other functional groups. This feature has led to their applications in bio-imaging and -sensing, in particular through mid-IR, Raman and more recently, surface-enhanced Raman spectroscopy (SERS). Their use in mid-IR quantitative sensing based on vibrational intensities, and chemical sensing based on frequency shifts and vibrational lifetimes, is reviewed. Their development for Raman sensing following the breakthrough in SERS highlights the potential of coupling metal carbonyls to plasmonic nanostructures as novel optical materials for SERS-based bio-imaging and -sensing. ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version

Published
2016

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