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Start Over Author "Jiang-Shan Guo" Topic 010405 organic chemistry
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1. Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

Author

Jiang-Shan Guo, Yan-Ping Zhu, Zhi‐Hao Shang, Zeng-Jing Li, Ji-Na Sun, Zhen-Xiao Zhang, Yuan-Yuan Sun, and Wei-Zhao Weng

Subjects
Annulation, 010405 organic chemistry, Organic Chemistry, Quinoline, chemistry.chemical_element, Substrate (chemistry), Oxidative phosphorylation, 010402 general chemistry, Iodine, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Functional group
Abstract

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

Published
2020
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