1. Modifications of 5,12-dihydroindolo[3,2-a]carbazole scaffold via its regioselective C2,9-formylation and C2,9-acetylation
- Author
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Gennady L. Rusinov, Ekaterina F. Zhilina, Nikita A. Kazin, Roman A. Irgashev, and Nadezhda S. Demina
- Subjects
010405 organic chemistry ,Carbazole ,Organic Chemistry ,Regioselectivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,0104 chemical sciences ,Formylation ,chemistry.chemical_compound ,chemistry ,Acetylation ,Acetyl chloride ,Dichloromethyl methyl ether ,Drug Discovery ,Knoevenagel condensation ,Malononitrile - Abstract
The effective approaches for regioselective double formylation and acetylation of 5,12-dialkyl-6,7-diaryl-substituted 5,12-dihydroindolo[3,2- a ]carbazoles by their treatment with dichloromethyl methyl ether in the presence of SnCl 4 or with acetyl chloride in the presence of AlCl 3 to afford the 2,9-diformyl or 2,9-diacetyl derivatives, respectively, were developed. Furthermore, new 2,9-bis(2,2-dicyanovinyl) derivatives were synthesized by the Knoevenagel condensation of diformyl-containing substrates with malononitrile, when new 2,9-bis(quinoxaline-2-yl)- and 2,9-bis(benzo[ g ]quinoxaline-2-yl) derivatives were formed via microwave-promoted oxidation of diacetyl-containing substrates with SeO 2 to the corresponding diglyoxals, followed by the reaction of these intermediates with o -phenylendiamine or 2,3-diaminonaphthalene, respectively. The basic optical and electrochemical properties of some 5,12-dihydroindolo[3,2- a ]carbazoles were investigated.
- Published
- 2019