1. TiO2 -SiO2 Catalyzed Eco-friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3-d ]pyrimidine Derivatives
- Author
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Shaik Ahammed Kabeer, Gajjala Raghavendra Reddy, Cirandur Suresh Reddy, P. Sreelakshmi, and Darla Mark Manidhar
- Subjects
Antioxidant ,Pyrimidine ,010405 organic chemistry ,Cost effectiveness ,medicine.medical_treatment ,Organic Chemistry ,010402 general chemistry ,Ring (chemistry) ,01 natural sciences ,Environmentally friendly ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,medicine ,Organic chemistry ,Malononitrile - Abstract
A cost-effective and eco-friendly synthesis of benzopyrano[2,3-d]pyrimidine derivatives has been developed via three component one-pot tandem approach by condensing different salicylaldehydes and secondary amines with malononitrile in the presence of TiO2–SiO2 catalyst at 80°C under solvent-free conditions. Mild experimental conditions, reusability of the catalyst, and cost effectiveness are the merits of this procedure. Compounds 4g, 4h, and 4i bearing 2-OMe group on the hydroxyphenyl group linked to the central carbon present in between the two nitrogen atoms of the pyrimidine ring were found to exhibit good antioxidant activity while other compounds have moderate antioxidant activity.
- Published
- 2017
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