1. Four new diarylheptanoids from Rhizoma Zingiberis
- Author
-
Yan-Zhi Wang, Wan-Hua Cui, Weisheng Feng, Yan Guo, Gao Meiling, Ze-Zhi Li, and Yong-Xian Cheng
- Subjects
Pharmaceutical Science ,Ginger ,01 natural sciences ,Medicinal chemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Diarylheptanoids ,Drug Discovery ,Humans ,Cytotoxicity ,Pharmacology ,Heptane ,biology ,010405 organic chemistry ,Organic Chemistry ,General Medicine ,Hep G2 Cells ,biology.organism_classification ,Heptene ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Hepg2 cells ,Molecular Medicine ,Zingiberaceae ,Rhizome - Abstract
Four new diarylheptanoids, (1S, 3R, 5R, 6R)-1, 5-epoxy-3, 6 dihydroxy-1-(4-hydroxy-3, 5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptane (1), (1R, 3R, 5S)-1, 5-epoxy-3-acetoxy-1-(4, 5-dihydroxy-3-methoxyphenyl)-7-(3, 4- hydroxyphenyl) heptane (2), (3R, 5S, 6R, 7S)-3, 6-epoxy-7-hydroxyl-1-(4-hydroxyphenyl)-7-(3-methoxy-4-hydroxyphenyl) heptane (3), (E)-3-keto-1-(3-methoxy-4-hydroxyphenyl)-7-(4, 5-dihydroxy-3-methoxyphenyl)-4- heptene (4), were isolated from Rhizoma Zingiberis, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-NMR and 2D-NMR). Compounds 1-4 exhibited no cytotoxicity against HepG2 cell lines.
- Published
- 2018