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2 results on '"University of Missouri ( Saisissez le sigle en majuscules sans points )"'

1. Bisphenol A in Thermal Paper Receipts: Taylor et al. Respond

Author

George E. Rottinghaus, Patricia A. Hunt, Frederick S. vom Saal, Pierre-Louis Toutain, Céline M. Laffont, Bertram E. Drury, Wade V. Welshons, Julia A. Taylor, University of Missouri [Columbia] (Mizzou), University of Missouri System, School of Molecular Biosciences, Washington State University (WSU), Toxicologie Alimentaire (UTA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), University of Missouri ( Saisissez le sigle en majuscules sans points ), Washington State University ( WSU ), Toxicologie Alimentaire ( UTA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, ToxAlim ( ToxAlim ), Institut National Polytechnique [Toulouse] ( INP ) -Institut National de la Recherche Agronomique ( INRA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Ecole Nationale Vétérinaire de Toulouse, University of Missouri [Columbia], and Taylor, Julia A

Subjects
Bisphenol A, [ SDV ] Life Sciences [q-bio], Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, Thermal paper, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, 030225 pediatrics, Economics, Biochemical engineering, 0105 earth and related environmental sciences
Abstract

We agree with Schwartz and Landrigan that there is a need for change in the regulatory system for chemicals used in products in the United States. Bisphenol A (BPA) is one of thousands of chemicals of concern, but it provides a striking example of what happens when there is no requirement for premarket testing.

Published
2012
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2. Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure

Author

Pierre-Louis Toutain, Bertram E. Drury, George E. Rottinghaus, Patricia A. Hunt, Frederick S. vom Saal, Céline M. Laffont, Wade V. Welshons, Catherine A. VandeVoort, Julia A. Taylor, Div Biol Sci, University of Missouri [Columbia] (Mizzou), University of Missouri System-University of Missouri System, Toxicologie Alimentaire (UTA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Dept Biomed Sci, Vet Med Diagnost Lab, Sch Mol Biosci, Washington State University (WSU), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Calif Natl Primate Res Ctr, Dept Obstet & Gynecol, University of California [Davis] (UC Davis), University of California-University of California, California National Primate Research Center [RR00169], National Institute of Environmental Health Sciences [ES016770, ES018764], University of Missouri [Columbia], Taylor, Julia A., VOM SAAL, FREDERICK, Welshons, Wade V., Drury, Bertram, Rottinghaus, George, Hunt, Patricia A., Toutain, Pierre-Louis, Laffont, Céline M., VandeVoort, Catherine A., University of Missouri ( Saisissez le sigle en majuscules sans points ), Toxicologie Alimentaire ( UTA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Washington State University ( WSU ), Ecole Nationale Vétérinaire de Toulouse, ToxAlim ( ToxAlim ), Institut National Polytechnique [Toulouse] ( INP ) -Institut National de la Recherche Agronomique ( INRA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Ecole Nationale Vétérinaire de Toulouse, and University of California Davis

Subjects
medicine.medical_specialty, endocrine system, Ratón, Health, Toxicology and Mutagenesis, bisphenol A, [SDV]Life Sciences [q-bio], Review, 010501 environmental sciences, Biology, 01 natural sciences, biomonitoring, endocrine disruption, pharmacokinetics, xenobiotic metabolism, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Oral administration, Internal medicine, medicine, Benzhydryl compounds, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, [ SDV ] Life Sciences [q-bio], urogenital system, Public Health, Environmental and Occupational Health, Metabolism, Environmental exposure, Endocrinology, Endocrine disruptor, chemistry, Drug metabolism, hormones, hormone substitutes, and hormone antagonists
Abstract

OBJECTIVE: Daily adult human exposure to bisphenol A (BPA) has been estimated at < 1 mu g/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women.[br/] METHODS: Eleven adult female rhesus macaques were fed 400 mu g/kg deuterated BPA (dBPA) daily for 7 days. Levels of serum dBPA were analyzed by isotope-dilution liquid chromatography-mass spectrometry (0.2 ng/mL limit of quantitation) over 24 hr on day 1 and on day 7. The same dose of BPA was fed to adult female CD-1 mice; other female mice were administered (3)H-BPA at doses ranging from 2 to 100,000 mu g/kg.[br/] RESULTS: In monkeys, the maximum unconjugated serum dBPA concentration of 4 ng/mL was reached 1 hr after feeding and declined to low levels by 24 hr, with no significant bioaccumulation after seven daily doses. Mice and monkeys cleared unconjugated serum BPA at virtually identical rates. We observed a linear (proportional) relationship between administered dose and serum BPA in mice. [br/] CONCLUSIONS: BPA pharmacokinetics in women, female monkeys, and mice is very similar. By comparison with approximately 2 ng/mL unconjugated serum BPA reported in multiple human studies, the average 24-hr unconjugated serum BPA concentration of 0.5 ng/mL in both monkeys and mice after a 400 mu g/kg oral dose suggests that total daily human exposure is via multiple routes and is much higher than previously assumed.

Published
2011
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