1. In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane
- Author
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P. Sagitha, Nandita Mishra, C.R. Reshmi, Athiyanathil Sujith, Suja P. Sundaran, and Anupama Binoy
- Subjects
Blood Platelets ,Staphylococcus aureus ,Curcumin ,Polyurethanes ,Microbial Sensitivity Tests ,02 engineering and technology ,Matrix (biology) ,Biochemistry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Platelet Adhesiveness ,X-Ray Diffraction ,Structural Biology ,Spectroscopy, Fourier Transform Infrared ,Animals ,Humans ,Molecular Biology ,030304 developmental biology ,Polyurethane ,0303 health sciences ,Dextrans ,Serum Albumin, Bovine ,3T3 Cells ,General Medicine ,Fibroblasts ,Hydrogen-Ion Concentration ,Biodegradation ,021001 nanoscience & nanotechnology ,Anti-Bacterial Agents ,Drug Liberation ,Kinetics ,Steam ,Membrane ,Dextran ,chemistry ,Thermogravimetry ,Solvents ,Wettability ,Adsorption ,0210 nano-technology ,Wound healing ,Antibacterial activity ,Porosity ,Nuclear chemistry - Abstract
pH stimuli drug release nanofibrous membranes of polyurethane/dextran were developed for tailoring of antibacterial wound dressings. Incorporation of dextran in polyurethane (PU) showed increment in hydrophilicity, vapour transmission rate, percentage sorption values, and biodegradability. Dextran also acts as reinforcement filler in PU matrix. Dextran induces a high degree of platelet adhesion and hemostasis potential which is essential for promoting the wound healing process. Moreover, 20 wt% dextran loaded membranes (PU/20D) exhibited enhanced cell proliferation, attachment and viability against 3T3 fibroblasts. Curcumin loaded PU/20 dextran membrane exhibited pH-controlled drug release potency and synergistic antibacterial activity against gram-positive bacteria. It is confirmed that, PU/20D membranes could promote, pH-controlled drug release and synergistic antibacterial activity for a promising wound dressing material.
- Published
- 2019
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