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Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy., Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.

Gas hydrates that occur in offshore sediments and onshore permafrost represent a vast source of natural gas. However, current gas production trials indicate that sand production, which refers to the migration of sand into boreholes is an obstacle for long-term safe and efficient gas production from gas hydrate reservoirs. Therefore, understanding sand production behaviors during hydrate mining is especially important. In this study, we conducted laboratory-scale tests to investigate the effect of hydrate saturation and overlying stress on the sand production behaviors of hydrate-bearing sediments with a sand screen before, during, and after hydrate dissociation by depressurization. The synthesized methane hydrate saturations and simulated overlying stresses were ~20%, ~30%, ~40%, ~50%, and ~60% and ~11, ~12, ~13, ~14, and ~15 MPa, respectively. The experimental results indicate that sand production before hydrate dissociation is relatively minor and primarily silty. The amount of sand produced increases and silt, fine sand, and medium sand were observed during and after hydrate dissociation. The mass of sand production increases as hydrate saturation increases under constant overlying stress; however, under constant hydrate saturation, it increases then decreases as overlying stress increases. Friction among particles may become the primary control factor once the overlying stress exceeds a critical value. We considered hydrate saturation and overlying stress to establish a sand production prediction model. Our findings help understand sand production behavior using sand screens during gas production from hydrate reservoirs and provide a reference for sand production control design in future hydrate mining.

Understanding of the stability of oil-dominated emulsion, such as the oil-based drilling fluids and crude oils, is of great importance to control the gas hydrate risk management when gas hydrates formation and dissociation occurs in the emulsion. Here, a high-pressure optical capillary cell with micro-Raman spectroscopy is utilized to investigate the effects of hydrate formation and dissociation on the stability of a simulated oil-water emulsion and the micro kinetics near the oil/water interface. Both the hydrate formation and dissociation processes are stimulated in water phase near the oil-water interface. The results show that the oil can enter the water phase from the oil phase with the oil-water interface failure when hydrates rapidly growth very close to the water-oil interface, even resulting in a series of oil droplets in the water phase (oil-droplet trajectory). The interesting phenomenon are mainly caused by the concentration gradient of methane and the Marangoni effect. Subsequently, the hydrate phase dissociates, a new stable water-oil interface presents when the system becomes rebalanced. The methane diffusion behavior induced by the chemical potential gradient in hydrate formation and dissociation processes could affect the stability of the emulsion. In addition, a more profound conceptual hydrate-induced destabilization model for different types of oil-water emulsions is proposed. This study can provide a theoretical and experimental basis for the safe implementation for deep-water oil and gas drilling, hydrate drilling in permafrost and multiphase mixing transportation in pipelines.