1. pH-sensitive hydrogels based on (meth)acrylates and itaconic acid
- Author
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Jovana S. Vuković, Marija M. Babić, Neda B. Malešić, Jovanka M. Filipović, Katarina M. Antić, and Simonida Lj. Tomić
- Subjects
Materials science ,Polymers and Plastics ,General Chemical Engineering ,Chemical structure ,02 engineering and technology ,010402 general chemistry ,Methacrylate ,poly(alkylene glycol) (meth)acrylates ,01 natural sciences ,chemistry.chemical_compound ,pH-sensitive swelling ,morphology ,Polymer chemistry ,Materials Chemistry ,medicine ,Side chain ,mechanical and thermal properties ,Itaconic acid ,Organic Chemistry ,itaconic acid ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,controlled drug release ,chemistry ,Methacrylic acid ,2-hydroxyethyl methacrylate ,Self-healing hydrogels ,cytotoxicity ,Swelling ,medicine.symptom ,0210 nano-technology ,Ethylene glycol - Abstract
Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.
- Published
- 2014
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