1. Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system
- Author
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Tugba Bal, Seda Giray, Ayşe Meriç Kartal, Can Erkey, and Seda Kizilel
- Subjects
Materials science ,Chemistry, Pharmaceutical ,Composite number ,Biomedical Engineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Hydrogel, Polyethylene Glycol Dimethacrylate ,Polyethylene Glycols ,Diffusion ,Biomaterials ,Polymer chemistry ,PEG ratio ,Solubility ,Prepolymer ,Supercritical carbon dioxide ,technology, industry, and agriculture ,Metals and Alloys ,Aerogel ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Supercritical fluid ,0104 chemical sciences ,Chemical engineering ,Ketoprofen ,Delayed-Action Preparations ,Drug delivery ,Ceramics and Composites ,Eosine Yellowish-(YS) ,Adsorption ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions ,Porosity - Abstract
A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.
- Published
- 2012
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