1. An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico
- Author
-
Iram Mondaca Fernández, María Mercedes Meza Montenegro, R. Clark Lantz, Jefferey L. Burgess, Leticia Yañez Estrada, Ana Gabriela Dévora Figueroa, Diana Meza Figueroa, José de Jesús Balderas Cortés, Leticia García Rico, Juan Francisco Maldonado Escalante, and Marco Antonio Martínez Cinco
- Subjects
021110 strategic, defence & security studies ,medicine.medical_specialty ,Health risk assessment ,business.industry ,Health, Toxicology and Mutagenesis ,Ecological Modeling ,Public health ,0211 other engineering and technologies ,chemistry.chemical_element ,02 engineering and technology ,Urine ,Pollution ,Comet assay ,chemistry ,Environmental health ,Relative risk ,Medicine ,business ,Cancer risk ,ARSENIC EXPOSURE ,Arsenic - Abstract
Exposure to inorganic arsenic (InAs) through drinking water, even at low to moderate concentrations, is a global public health problem. The objectives of this study were to estimate the risk ratio (HQ), cancer risk (R), and DNA damage (comet assay) of children from three indigenous Yaqui populations located in southern Sonora, Mexico, who were exposed to InAs through drinking water. A cross-sectional study was employed, and analysis of InAs in water and urine was performed via HPLC/ICP-MS. InAs levels in drinking water from Potam, Vicam, and Cocorit were 108.2, 36.0, and 6.2 μg/L−1 respectively. Children from Potam had arsenic concentrations in urine of 107.1 μg As L−1 compared with 40.3 μg As L−1 for the children of Cocorit. The HQ values for the children of Potam, Vicam, and Cocorit were 16.64, 6.02, and 0.94, while the R values were 9.4E-04, 3.5E-04, and 5.7E-05, respectively. Children with the highest arsenic exposure had significantly increased DNA damage (OTM = 14.4 vs. 4.3) [p < 0.0005] whi...
- Published
- 2018
- Full Text
- View/download PDF