1. Bone Marrow Mast Cell Density Correlates with Circulating Biomarkers of Bone Disease in Multiple Myeloma
- Author
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Maria Devetzoglou, Anastasia Papadopoulou, Constantina A. Pappa, George Tsirakis, Michael G. Alexandrakis, Samer Masud, Rodanthi Vyzoukaki, and Andreas N. Antonakis
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Environmental Engineering ,biology ,Bone disease ,business.industry ,medicine.disease ,Mast cell ,Industrial and Manufacturing Engineering ,Bone remodeling ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Osteoprotegerin ,030220 oncology & carcinogenesis ,medicine ,biology.protein ,Bone marrow ,Osteopontin ,Receptor ,business ,Multiple myeloma - Abstract
Aims: There is increased mast cell density (MCD) in multiple myeloma (MM) bone marrow (BM) that is correlated with advanced disease stage. Mast cells (MCs) produce various mediators promoting MM growth and bone metabolism. The aim of this study was to evaluate whether BM MCD correlates with markers of bone metabolism, such as circulating levels of osteoprotegerin (OPG), soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteopontin (OPN) and macrophage inflammatory protein-1 alpha (MIP-1 alpha). Original Research Article
- Published
- 2016
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