1. Maternal Amino Acid Profiles to Distinguish Constitutionally Small versus Growth-Restricted Fetuses Defined by Doppler Ultrasound: A Pilot Study
- Author
-
Kenneth N. Maclean, John C. Hobbins, Anne C. Porter, Sally P. Stabler, K. Joseph Hurt, Henry L. Galan, Diane L. Gumina, Michael Armstrong, Beth A. Bailey, and Nichole Reisdorph
- Subjects
Adult ,medicine.medical_specialty ,Percentile ,Pregnancy Trimester, Third ,Gestational Age ,Pilot Projects ,Gas Chromatography-Mass Spectrometry ,Ultrasonography, Prenatal ,Umbilical Arteries ,Cohort Studies ,Dimethylglycine ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Amino Acids ,030304 developmental biology ,0303 health sciences ,Fetus ,Fetal Growth Retardation ,030219 obstetrics & reproductive medicine ,Methionine ,business.industry ,Obstetrics ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Ultrasonography, Doppler ,Ornithine ,medicine.disease ,Uterine Artery ,chemistry ,Infant, Small for Gestational Age ,Pediatrics, Perinatology and Child Health ,Small for gestational age ,Female ,business ,Cohort study - Abstract
Objective Fetuses measuring below the 10th percentile for gestational age may be either constitutionally small for gestational age (SGA) or have pathologic fetal growth restriction (FGR). FGR is associated with adverse outcomes; however, identification of low-risk SGA cases is difficult. We performed a pilot study evaluating maternal markers of pathologic FGR, hypothesizing there are distinct amino acid signatures that might be used for diagnosis and development of new interventions. Study Design This was a cohort study of healthy women with sonographic fetal estimated fetal weight Results Among 14 women included, five had abnormal UmA, and three had abnormal UtA Doppler results. Those with abnormal UmA showed elevated ornithine. Those with abnormal UtA had lower dimethylglycine, isoleucine, methionine, phenylalanine, and 1-methylhistidine. Conclusion We found several amino acids that might identify pregnancies affected by pathologic FGR. These findings support the feasibility of future larger studies to identify maternal metabolic approaches to accurately stratify risk for small fetuses.
- Published
- 2020
- Full Text
- View/download PDF