1. Operationalizing mild cognitive impairment criteria in small vessel disease: The VMCI-Tuscany Study
- Author
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Antonio Giorgio, Stefano Magnolfi, Guido Gori, Laura Stromillo, Enza Zicari, Renato Galli, Patrizia Formichi, Emilia Salvadori, Francesca Cesari, Stefania Brotini, Roberto Marconi, Rossana Tassi, Alessandro Rossi, Luca Massacesi, Marco Vista, Serena Nannucci, Maria Boddi, Anna Maria Gori, Francesca Pescini, Veronica Caleri, Gloria Tognoni, Nicola De Stefano, Carlo Biagini, Renzo Cisbani, Sandro Marini, Stefania Boschi, Antonella Notarelli, Claudia Pozzi, Paola Vanni, Claudia Gambetti, Paolo Zolo, Carla Giorgi, Laura Bracco, Stefania Mugnai, Giovanni Pracucci, Tiziano Borgogni, Filippo Baldacci, Sandro Sorbi, Giuseppe Meucci, Domenico Inzitari, Giovanni Orlandi, Giovanna Bellini, Leonardo Pantoni, Ilaria Di Donato, Rosanna Abbate, Luciano Gabrielli, Laura Ciolli, Francesca Rossi, Francesco Pinto, Carlo Valente, Alberto Chiti, Ubaldo Bonuccelli, Cristina Frittelli, Gabriele Siciliano, Mario Mancuso, Massimo Cadelo, Antonio Federico, Gaetano Zaccara, Raffaella Valenti, Pasquale Palumbo, Stefano Bartolini, Paolo Cecchi, Stefano Diciotti, Andrea Ginestroni, Mario Mascalchi, Monica Mazzoni, Donatella Calvani, Luciano Gabbani, Anna Poggesi, Leonello Guidi, Maria Lombardi, Maristella Piccininni, Marco Paganini, Marco Pasi, Enrico Mossello, Alessandro Tiezzi, Mirco Cosottini, Mirella Coppo, Maria Teresa Dotti, E Bertini, Betti Giusti, Lorella Lambertucci, G Gambaccini, Cristina Pagni, Alessandra Del Bene, Salvadori, Emilia, Poggesi, Anna, Valenti, Raffaella, Pracucci, Giovanni, Pescini, Francesca, Pasi, Marco, Nannucci, Serena, Marini, Sandro, Del Bene, Alessandra, Ciolli, Laura, Ginestroni, Andrea, Diciotti, Stefano, Orlandi, Giovanni, Di Donato, Ilaria, De Stefano, Nicola, Cosottini, Mirco, Chiti, Alberto, Federico, Antonio, Dotti, Maria Teresa, Bonuccelli, Ubaldo, Inzitari, Domenico, and Pantoni, Leonardo
- Subjects
Male ,Epidemiology ,Cerebrovascular disease ,Cognitive aging ,Mild cognitive impairment ,Neuropsychology ,Vascular dementia ,Health Policy ,Developmental Neuroscience ,Geriatrics and Gerontology ,Neurology (clinical) ,Cellular and Molecular Neuroscience ,Psychiatry and Mental Health ,Neuropsychological Tests ,0302 clinical medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,medicine.diagnostic_test ,Magnetic Resonance Imaging ,White Matter ,Temporal Lobe ,medicine.anatomical_structure ,Italy ,Disease Progression ,Cardiology ,Female ,Psychology ,medicine.medical_specialty ,Prodromal Symptoms ,behavioral disciplines and activities ,Temporal lobe ,White matter ,03 medical and health sciences ,Atrophy ,Neuroimaging ,Internal medicine ,mental disorders ,medicine ,Humans ,Cognitive Dysfunction ,Psychiatry ,Aged ,Magnetic resonance imaging ,medicine.disease ,nervous system diseases ,Cerebrovascular Disorders ,human activities ,030217 neurology & neurosurgery - Abstract
Introduction Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.
- Published
- 2016