1. Insulin resistance and potential modulators of ovarian reserve in young reproductive-aged women with obesity and type 1 diabetes
- Author
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Annalisa De Silvestri, Chiara Mameli, Riccardo Albertini, Valeria Calcaterra, Elisavietta Tenuta, Mara De Amici, Federica Vinci, Rossella E. Nappi, Gloria Pelizzo, and Gian Vincenzo Zuccotti
- Subjects
Anti-Mullerian Hormone ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Body Mass Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Kisspeptin ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Obesity ,Ovarian Reserve ,Ovarian reserve ,Kisspeptins ,Type 1 diabetes ,030219 obstetrics & reproductive medicine ,Adiponectin ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,Diabetes Mellitus, Type 1 ,Female ,Insulin Resistance ,business ,Biomarkers - Abstract
Both obesity and diabetes play a significant role in reproductive disorders in women and insulin resistance (IR) is a confirmedWe recruited 32 female youths: 14 of them presented with T1D (14.6 ± 2.6 years) and 18 with obesity (15.1 ± 2.6 years). The control group included 20 age-matched normal weight females. Each patient underwent physical examination and hormonal assessment. AMH, kisspeptin and adiponectin levels were also measured. IR was calculated as the homeostasis model assessment for insulin resistance (HOMA-IR) and the glucose disposal rate (eGDR) in patients with obesity and with T1D, respectively.adiponectin and kisspeptin levels were significantly different into groups (IR displays a relationship with adiponectin and kisspeptin in young reproductive-aged women with obesity and T1D. Interventions to correct IR in adolescents could be part of an early approach to prevent reproductive disorders and to promote factors associated with longevity in adult women.
- Published
- 2021