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3 results on '"Falkerby J"'

1. Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms

Author

Capdevila, Jaume, Bodei, Lisa, Davies, Philippa, Gorbounova, Vera, Jensen, Robert T., Knigge, Ulrich P., Krejs, Guenter J., Krenning, Eric, O'Connor, Juan Manuel, Peeters, Marc, Rindi, Guido, Salazar, Ramon, Vullierme, Marie-Pierre, Pavel, Marianne E., Arnold, R., Bartsch, D., Baudin, E., Bodei, L., Borbath, I, Capdevila, J., Caplin, M., Chen, J., Costa, F., Couvelard, A., Cwikla, J. B., Davies, P., de Herder, W. W., Falconi, M., Falkerby, J., Fazio, N., Ferone, D., Frilling, A., Garcia-Carbonero, R., Glasberg, S., Gorbunova, V, Grossman, A., Hoersch, D., Jensen, R. T., Kaltsas, G., Kloeppel, G., Knigge, U. P., Kos-Kudla, B., Krejs, G. J., Krenning, E., Kulke, M., Lamberts, S. W. J., van Dijkum, Nieveen E., O'Connor, J. M., O'Toole, D., Pape, U. F., Partelli, S., Pavel, M. E., Ramage, J., Reed, N. Simon Beatson, Rindi, G., Rinke, A., Ruszniewski, P., Sorbye, H., Sundin, A., Scoazec, J. Y., Taal, B. G., Tiensuu, J. E., Toumpanakis, C., Valle, J., Vullierme, M. P., Welin, S., Wiedenmann, B., Capdevila, J, Bodei, L, Davies, P, Gorbounova, V, Jensen, Rt, Knigge, Up, Krejs, Gj, Krenning, E, O'Connor, Jm, Peeters, M, Rindi, G, Salazar, R, Vullierme, Mp, Pavel, Me, on behalf the ENETS 2016 Munich Advisory Board, Participant, Partelli, S, Falconi, M, Erasmus MC other, Internal Medicine, ENETS 2016 Munich Advisory Board, and Dr. Heinz-Horst Deichmann Stiftung

Subjects
Biomedical Research, Lung Neoplasms, Endocrinology, Diabetes and Metabolism, Metastasi, Lanreotide, Digestive System Neoplasms, Metastasis, 030218 nuclear medicine & medical imaging, Imaging, chemistry.chemical_compound, EVEROLIMUS, 0302 clinical medicine, Endocrinology, LANREOTIDE, Treatment options, TUMORS, Clinical Practice, Neuroendocrine Tumors, Unmet medical needs, SURVIVAL, ENETS 2016 Munich Advisory Board Participants, Life Sciences & Biomedicine, medicine.medical_specialty, 030209 endocrinology & metabolism, SUNITINIB, Endocrinology & Metabolism, 03 medical and health sciences, Cellular and Molecular Neuroscience, Drug Development, Internal medicine, medicine, Biomarkers, Tumor, Humans, Limited evidence, Intensive care medicine, Science & Technology, Endocrine and Autonomic Systems, business.industry, Neurosciences, 1103 Clinical Sciences, Biomarker, Neuroendocrine neoplasm, chemistry, Neuroendocrine neoplasms, Neurosciences & Neurology, Human medicine, Therapy, 1109 Neurosciences, business, Who classification, Biomarkers
Abstract

Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

Published
2019

2. ENETS Consensus Recommendations for the Standards of Care in Neuroendocrine Neoplasms: Follow-Up and Documentation

Author

Knigge, U, Capdevila, J, Bartsch, D K, Baudin, E, Falkerby, J, Kianmanesh, R, Kos-Kudla, B, Niederle, B, Nieveen van Dijkum, E, O'Toole, D, Pascher, A, Reed, N, Sundin, A, Vullierme, M-P, Ferone, D, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Other Research, and Surgery

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, MEDLINE, TNM staging, 030209 endocrinology & metabolism, 610 Medicine & health, 5-Hydroxyindoleacetic acid, Neuron specific enolase, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Documentation, Neuroendocrine tumor, Internal medicine, medicine, Neuroendocrine carcinoma, Neuroendocrine neoplasm, Follow up, Chromogranin A, NT-pro-brain natriuretic peptide, Functional imaging, Somatostatin receptor imaging, Endocrine and Autonomic Systems, business.industry, 030220 oncology & carcinogenesis, TNM Staging, 570 Life sciences, biology, business
Abstract

ENETS consensus recommendations for the standards of care in neuroendocrine neoplasms (NEN) concerning follow-up and documentation are considered in this review. The documentation of patients with NEN should include the most relevant data characterizing an individual patient from the first contact with his/her physician/hospital until his/her last presentation during follow-up. It is advocated that follow-up occurs in specialized NEN centers with regular NEN tumor boards with expert panels. The follow-up should be in accordance with the ENETS consensus guidelines from 2011 and 2016, the present and coming WHO classification and ENETS/UICC recommendations for TNM staging. The recommendations for follow-up in patients with thymic, bronchopulmonary and gastroenteropancreatic NEN are given in Table 1. However, it should be stressed that evidence-based studies for follow-up are largely missing. (C) 2017 S. Karger AG, Basel

Published
2017
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3. Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Author

Baudin, Eric, Hayes, Aimee R., Scoazec, Jean-Yves, Filosso, Pier Luigi, Lim, Eric, Kaltsas, Gregory, Frilling, Andrea, Chen, Jie, Kos-Kudla, Beata, Gorbunova, Vera, Wiedenmann, Bertram, van Dijkum, Els Nieveen, Cwikla, Jaroslaw B., Falkerby, Jenny, Valle, Juan W., Kulke, Matthew H., Caplin, Martyn E., Detlef, Bartsch, Rudolf, Arnold, Eric, Baudin, Lisa, Bodei, Ivan, Borbath, Jaume, Capdevila, Martyn, Caplin, Jie, Chen, Frederico, Costa, Anne, Couvelard, Jaroslaw, Cwikla B., Philippa, Davies, de Herder, Wouter W., Massimo, Falconi, Jenny, Falkerby, Nicola, Fazio, Diego, Ferone, Andrea, Frilling, Rocio, Garcia-Carbonero, Simona, Glasberg, Vera, Gorbunova, Ashley, Grossman, Dieter, Hoech, Robert, Jensen, Gregory, Kaltsas, Guenter, Kloeppel, Peter, Knigge Ulrich, Beata, Kos-Kudla, Guenter, Krejs J., Eric, Krenning, Matthew, Kulke, Steven, Lamberts W. J., van Elisabeth, Nieveen Dijkum, Juan Manuel, O'Connor, Dermot, O'Toole, Ulrich-Frank, Pape, Stefano, Partelli, Ellen, Pavel Marianne, Peeters, Marc, John, Ramage, Simon, Reed Nicholas, Guido, Rindi, Anja, Rinke, Philippe, Ruszniewski, Halfdan, Sorbye, Anders, Sundin, Jean-Yves, Scoazec, Babs, Taal G., Eva, Tiensuu Janson, Christos, Toumpanakis, Juan, Valle, Marie-Pierre, Vullierme, Staffan, Welin, Bertram, Wiedenmann, ENETS 2016 Munich Advisory Board, Internal Medicine, Baudin, E, Hayes, A R, Scoazec, J-Y, Filosso, Pl, Lim, E, Kaltsas, G, Frilling, A, Chen, J, Kos-Kudla, B, Gorbunova, V, Wiedenmann, B, Nieveen, Van Dijkum E, Cwikla, J B, Falkerby, J, Valle, J W, Kulke, M H, Caplin, M E, on behalf The ENETS 2016 Munich Advisory Board, Participant, Partelli, S, Falconi, M, and Dr. Heinz-Horst Deichmann Stiftung

Subjects
Oncology, Biomedical Research, Lung Neoplasms, SOMATOSTATIN RECEPTORS, Endocrinology, Diabetes and Metabolism, CHROMOGRANIN-A, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Endocrinology, PROGNOSTIC-FACTORS, PROLIFERATIVE INDEX, Prognosis, Neuroendocrine Tumors, Neuroendocrine Tumors/classification, CUSHINGS-SYNDROME, Tumour classification, ENETS 2016 Munich Advisory Board Participants, Life Sciences & Biomedicine, medicine.medical_specialty, Carcinoid Tumor/classification, 030209 endocrinology & metabolism, Carcinoid Tumor, ENETS CONSENSUS GUIDELINES, 03 medical and health sciences, Cellular and Molecular Neuroscience, Endocrinology & Metabolism, Biomedical Research/trends, Internal medicine, Pulmonary carcinoids, medicine, Humans, EUROPEAN ASSOCIATION, Science & Technology, Endocrine and Autonomic Systems, CLINICAL-FEATURES, Bronchial carcinoid tumour, Neurosciences, 1103 Clinical Sciences, ECTOPIC ACTH SYNDROME, Lung Neoplasms/classification, Clinical trial, NET, Neuroendocrine neoplasm, Bronchial carcinoid tumours, Ectopic ACTH syndrome, Neuroendocrine neoplasms, Neurosciences & Neurology, RECEPTOR RADIONUCLIDE THERAPY, Human medicine, Management principles, Atypical carcinoid, 1109 Neurosciences
Abstract

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

Published
2019

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