1. Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study
- Author
-
Tilak Das, Martin J. Graves, Zhongzhao Teng, Sarah Hilborne, Ammara Usman, Andrew J. Patterson, Jonathan H. Gillard, Andrew N. Priest, Dario Prudencio, Jianmin Yuan, Gregory Makris, Teng, Zhongzhao [0000-0003-3973-6157], Gillard, Jonathan [0000-0003-4787-8091], Graves, Martin [0000-0003-4327-3052], and Apollo - University of Cambridge Repository
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Morphology (linguistics) ,Plaque ulceration ,Biophysics ,Contrast Media ,Lumen (anatomy) ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,Neovascularization ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Adventitia ,medicine ,Humans ,Contrast enhanced MR angiography (CE-MRA) ,Carotid Stenosis ,Radiology, Nuclear Medicine and imaging ,Aged ,Aged, 80 and over ,Neovascularization, Pathologic ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Models, Cardiovascular ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Carotid atherosclerotic plaque ,Cardiac Imaging Techniques ,Stenosis ,medicine.anatomical_structure ,Dynamic contrast enhanced MRI (DCE-MRI) ,Feasibility Studies ,Female ,medicine.symptom ,business ,Perfusion ,Algorithms ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery ,Research Article - Abstract
This study aims to explore the relationship between plaque surface morphology and neovascularization using a high temporal and spatial resolution 4D contrast-enhanced MRI/MRA sequence. Twenty one patients with either recent symptoms or a carotid artery stenosis ≥40% were recruited in this study. Plaque surface morphology and luminal stenosis were determined from the arterial phase MRA images. Carotid neovascularization was evaluated by a previously validated pharmacokinetic (PK) modeling approach. K trans (transfer constant) and v p (partial plasma volume) were calculated in both the adventitia and plaque. Image acquisition and analysis was successfully performed in 28 arteries. Mean luminal stenosis was 44% (range 11–82%). Both adventitial and plaque K trans in ulcerated/irregular plaques were significantly higher than smooth plaques (0.079 ± 0.018 vs. 0.064 ± 0.011 min−1, p = 0.02; 0.065 ± 0.013 vs. 0.055 ± 0.010 min−1, p = 0.03, respectively). Positive correlations between adventitial K trans and v p against stenosis were observed (r = 0.44, p = 0.02; r = 0.55, p = 0.01, respectively). This study demonstrates the feasibility of using a single sequence to acquire both high resolution 4D CE-MRA and DCE-MRI to evaluate both plaque surface morphology and function. The results demonstrate significant relationships between lumen surface morphology and neovascularization.
- Published
- 2017
- Full Text
- View/download PDF