1. Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil)
- Author
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Bárbara Brasil Santana, Antonio Carlos Rosário Vallinoto, Samires Avelino de Souza França, Glenda Roberta Oliveira Naiff Ferreira, Samantha Assis de Aguiar, Izaura Maria Vieira Cayres-Vallinoto, M Santos, Marluísa de Oliveira Guimarães Ishak, Felipe Bonfim Freitas, and Ricardo Ishak
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Male ,0301 basic medicine ,Epidemiology ,viruses ,Human T-lymphotropic virus ,Antibodies, Viral ,law.invention ,HTLV-1aA ,0302 clinical medicine ,Medical microbiology ,Risk Factors ,law ,Marajó Island ,Prevalence ,Child ,Phylogeny ,Polymerase chain reaction ,Islands ,Human T-lymphotropic virus 1 ,education.field_of_study ,biology ,Amazon rainforest ,Human T-lymphotropic virus 2 ,Middle Aged ,Infectious Diseases ,Child, Preschool ,RNA, Viral ,Population study ,Female ,Brazil ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,030231 tropical medicine ,Population ,Sexually Transmitted Diseases ,Enzyme-Linked Immunosorbent Assay ,Real-Time Polymerase Chain Reaction ,Virus ,lcsh:Infectious and parasitic diseases ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,lcsh:RC109-216 ,education ,Base Sequence ,Sequence Analysis, RNA ,Infant, Newborn ,Infant ,biology.organism_classification ,HTLV-I Infections ,Virology ,Cross-Sectional Studies ,030104 developmental biology ,Social Class ,Parasitology - Abstract
Background This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data with the epidemiological characteristics of the study population. Methods A total of 1899 biological samples were evaluated. The samples were screened for the presence of anti-HTLV antibodies using an enzyme-linked immunosorbent assay (ELISA), and infection was confirmed using conventional polymerase chain reaction (PCR), real-time PCR and nucleotide sequencing. Results Eleven samples (0.58%) were seropositive for HTLV, but molecular analysis confirmed positivity in only two samples (0.11%). Nucleotide sequencing and phylogenetic analysis indicated that the two samples positive for HTLV-1 that were isolated in Chaves belonged to the Cosmopolitan subtype 1 (HTLV-1a) and Transcontinental subgroup (A). Conclusion Our results confirmed the presence of Cosmopolitan Transcontinental HTLV-1 in the Marajó Archipelago, Amazon region, and the majority of the population revealed a lack of knowledge about sexually transmitted infections, which increases the risk of dissemination of HTLV and other agents.
- Published
- 2017
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