109 results on '"Jae-Young Park"'
Search Results
2. Health-related quality of life after radical cystectomy
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Bum Sik Tae, Jae Hyun Bae, Jae Young Park, and Hoon Choi
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Health related quality of life ,medicine.medical_specialty ,Surgical approach ,Review Article on Muscle-Invasive Bladder Cancer ,business.industry ,Urology ,General surgery ,medicine.medical_treatment ,Urinary diversion ,030232 urology & nephrology ,Scopus ,humanities ,Review article ,Cystectomy ,03 medical and health sciences ,0302 clinical medicine ,Reproductive Medicine ,Quality of life ,030220 oncology & carcinogenesis ,medicine ,Robotic surgery ,business - Abstract
Herein, we review the assessment of quality-of-life (QoL) in radical cystectomy (RC) patients, summarize the result of studies for different surgical approaches, and provide an overview of patient management, as well as other considerations. In this review article, we reviewed the QoL research and research tools for patients undergoing RC, including urinary diversion methods, gender differences, and surgical methods (open surgery vs. robotic surgery). This narrative review focused primarily on articles indexed in PubMed, Embase, Scopus, and Google Scholar databases. We did not used formal search strategy and meta-analysis was not performed.
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- 2020
3. Comparable clinical and radiological outcomes between anatomical and high femoral tunnels in posterior cruciate ligament reconstruction
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Jung-Suk Kim, Sang-Gyun Kim, Kyoung Ho Yoon, Raymond Yeak Dieu Kiat, Jae-Young Park, and Soo Yeon Park
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Sports medicine ,Radiography ,Posterior Cruciate Ligament Reconstruction ,Osteoarthritis ,Arthroscopy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femur ,Treatment Failure ,Range of Motion, Articular ,Physical Examination ,Aged ,Retrospective Studies ,030222 orthopedics ,business.industry ,030229 sport sciences ,Lysholm Knee Score ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Posterior cruciate ligament ,Radiological weapon ,Orthopedic surgery ,Female ,Posterior Cruciate Ligament ,Surgery ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Range of motion ,Follow-Up Studies - Abstract
To compare clinical and radiological outcomes and failure rates between anatomical and high femoral tunnels in remnant-preserving single-bundle posterior cruciate ligament (PCL) reconstruction. 63 patients who underwent remnant-preserving single-bundle PCL reconstruction between 2011 and 2018 with a minimum 2-year follow-up were retrospectively reviewed. Patients were divided into two groups according to the femoral tunnel position: group A (33 patients with anatomical femoral tunnel) and group H (30 patients with high femoral tunnels). The femoral tunnel was positioned at the center (group A) or upper margin (group H) of the remnant anterolateral bundle. The position of the femoral tunnel was evaluated using the grid method on three-dimensional computed tomography. Clinical and radiological outcomes and failure rates were compared between the groups at the 2-year follow-up. The position of the femoral tunnel was significantly high in group H than in group A (87.4% ± 4.2% versus 76.1% ± 3.7%, p
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- 2020
4. Clinical Outcomes and the Failure Rate of Revision Anterior Cruciate Ligament Reconstruction Were Comparable Between Patients Younger Than 40 Years and Patients Older Than 40 Years: A Minimum 2-Year Follow-Up Study
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Sang-Gyun Kim, Kyoung Ho Yoon, Hyun Woo Lee, Jae-Young Park, and Sang Jun Kim
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Adult ,Male ,Reoperation ,medicine.medical_specialty ,Graft failure ,Adolescent ,Anterior cruciate ligament reconstruction ,medicine.medical_treatment ,Demographic data ,Group B ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Orthopedics and Sports Medicine ,In patient ,Postoperative Period ,Aged ,Retrospective Studies ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Anterior Cruciate Ligament Injuries ,Age Factors ,Follow up studies ,Stress radiography ,030229 sport sciences ,Middle Aged ,Surgery ,Treatment Outcome ,Female ,business ,Cartilage Diseases ,Meniscal lesions ,Follow-Up Studies - Abstract
To compare the clinical outcomes and failure rates of revision anterior cruciate ligament reconstruction (ACLR) between young and middle-aged surgery patients.Patients who underwent revision ACLRs between January 2008 and June 2017 with a minimum 2-year follow-up were retrospectively evaluated. Patients were divided into 2 groups according to age: ≥40 years (group A) and40 years (group B). Detailed patient demographic data, preoperative radiographic data, and concurrent meniscal and chondral lesion were reviewed. Clinical scores, laxity tests results, and graft failures were compared between groups at the final follow-up.Eighty-six patients (group A, n = 24, 46.6 ± 4.5 years; group B, n = 62, 26.2 ± 6.3 years) were included in this study. Demographic data showed that the time interval from primary to revision ACLR was longer in group A than in group B (96.2 ± 80.9 vs. 52.0 ± 42.1 months, P = .011). Group A had a higher prevalence of chondral defects of the trochlea (P = .016). No significant differences were identified in the prevalence and severity of meniscal lesions. At the final follow-up, all clinical scores were improved postoperatively but did not differ significantly between the groups. No significant differences were identified in side-to-side difference on Telos stress radiographs (group A, 6.3 ± 5.0 mm; group B, 5.6 ± 3.8 mm; P = .403) and graft failure rate (group A, 33.3%; group B, 30.6%; P = .358) at the final follow-up.The current study showed that the clinical outcomes of revision ACLRs in patients improved significantly in patients younger than 40 years and were comparable to those observed in patients older than 40 years at a minimum 2-year follow-up.III.
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- 2020
5. The platelet-to-lymphocyte ratio as a significant prognostic factor to predict survival outcomes in patients with synchronous metastatic renal cell carcinoma
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Jae Young Park, Sung-Hoo Hong, Eu Chang Hwang, Cheol Kwak, Hyeong Dong Yuk, Seong Il Seo, Minyong Kang, Cheryn Song, Seok-Soo Byun, Jinsoo Chung, Chang Wook Jeong, and Hakmin Lee
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Male ,lymphocytes ,medicine.medical_specialty ,Urological Oncology ,Urology ,blood platelets ,030232 urology & nephrology ,lcsh:RC870-923 ,Gastroenterology ,03 medical and health sciences ,neoplasm metastasis ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,Humans ,Medicine ,kidney neoplasms ,Lymphocyte Count ,Stage (cooking) ,Carcinoma, Renal Cell ,Lymph node ,Aged ,Retrospective Studies ,Platelet Count ,business.industry ,Hazard ratio ,biomarkers ,Middle Aged ,Prognosis ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Confidence interval ,Survival Rate ,body regions ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cohort ,Biomarker (medicine) ,Original Article ,Female ,business ,Kidney cancer - Abstract
Purpose: The clinical impact of the platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with metastatic renal cell carcinoma (mRCC) remains controversial. We investigated the associations between elevation of the PLR and disease prognosis in patients with synchronous mRCC. Materials and Methods: The data of 1,505 patients with synchronous mRCC were retrospectively analyzed. The entire cohort was stratified into two subgroups according to PLR. Kaplan–Meier and Cox proportional analyses were performed to investigate the possible associations between the PLR and disease prognosis. Results: There were 921 patients with a high PLR and 584 patients with a low PLR by use of the cutoff of 146. The patients with a high PLR had worse clinical characteristics in terms of advanced clinical stage (p
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- 2020
6. Optimal dose of topical tranexamic acid considering efficacy and safety in total knee arthroplasty: a randomized controlled study
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Myung Chul Lee, Hyuk Soo Han, Do Yoon Lee, Jae Young Park, Du Hyun Ro, and Jong Keun Kim
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medicine.medical_specialty ,Sports medicine ,Administration, Topical ,Deep vein ,Blood Loss, Surgical ,Postoperative Hemorrhage ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Orthopedics and Sports Medicine ,Prospective Studies ,Arthroplasty, Replacement, Knee ,030222 orthopedics ,business.industry ,030229 sport sciences ,medicine.disease ,Thrombosis ,Antifibrinolytic Agents ,Pulmonary embolism ,medicine.anatomical_structure ,Tranexamic Acid ,Anesthesia ,Orthopedic surgery ,Administration, Intravenous ,Surgery ,business ,Range of motion ,Tranexamic acid ,medicine.drug - Abstract
This study aimed to evaluate the optimal dosage of topical tranexamic acid (TXA) considering the efficacy and safety for controlling bleeding after total knee arthroplasty (TKA). This prospective randomized double-blinded placebo-controlled comparative study included 325 patients scheduled to undergo TKA, who were randomly assigned to five groups based on the topical TXA injection (n = 65 per group): control; group 1, 0.5 g TXA; group 2, 1.0 g TXA; group 3, 2.0 g TXA; and group 4, 3.0 g TXA. The primary outcome was decrease in postoperative hemoglobin levels. The secondary outcomes were blood loss calculated using Good’s method, drainage volume, frequency of transfusion, and range of motion (ROM). Plasma TXA levels and complications were also evaluated. Significant differences were noted in the decrease in hemoglobin levels between the control group and groups 2 (p = 0.0027), 3 (p = 0.005), and 4 (p = 0.001). No significant differences were shown among the experimental groups. Significant differences in total blood loss and frequency of transfusion were noted between the control group and groups 2 (p = 0.004, 0.002, respectively), 3 (p = 0.007, 0.001, respectively), and 4 (p = 0.001, 0.009, respectively) without showing significant differences among the experimental groups. With respect to drainage volume, no significant differences were observed among the groups. The serum TXA levels increased proportionally with the applied dose of topical TXA immediately and at 3 and 6 h postoperatively. Symptomatic deep vein thrombosis or pulmonary embolism was not observed in any group. Other complications related to TXA administration were not detected. Topical application of 1.0 g or more of TXA shows significant bleeding control without a dose–response relationship. Blood TXA levels increase with the TXA dose following topical TXA application. Therefore, to prevent overdosing and reduce potential complications with ensuring the effectiveness, 1.0 g of TXA is recommended as a topical application. I.
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- 2020
7. Indirect pathological indicators for cardiac sarcoidosis on endomyocardial biopsy
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Moon Young Kim, Jae Young Park, Eun Ah Park, Jeong-Wook Seo, Seil Oh, Myung Jin Cha, and SangHan Lee
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Histology ,Myocarditis ,Sarcoidosis ,Arrhythmogenic right ventricular dysplasia ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,medicine ,lcsh:Pathology ,Cardiac muscle ,Pathological ,Histiocyte ,business.industry ,medicine.disease ,Tachycardia, ventricular ,Transplantation ,030104 developmental biology ,030220 oncology & carcinogenesis ,Granuloma ,Original Article ,business ,lcsh:RB1-214 - Abstract
Background The definitive pathologic diagnosis of cardiac sarcoidosis requires observation of a granuloma in the myocardial tissue. It is common, however, to receive a "negative" report for a clinically probable case. We would like to advise pathologists and clinicians on how to interpret "negative" biopsies. Methods Our study samples were 27 endomyocardial biopsies from 25 patients, three cardiac transplantation and an autopsied heart with suspected cardiac sarcoidosis. Pathologic, radiologic, and clinical features were compared. Results The presence of micro-granulomas or increased histiocytic infiltration was always (6/6 or 100%) associated with fatty infiltration and confluent fibrosis, and they showed radiological features of sarcoidosis. Three of five cases (60%) with fatty change and confluent fibrosis were probable for cardiac sarcoidosis on radiology. When either confluent fibrosis or fatty change was present, one-third (3/9) were radiologically probable for cardiac sarcoidosis. We interpreted cases with micro-granuloma as positive for cardiac sarcoidosis (five of 25, 20%). Cases with both confluent fibrosis and fatty change were interpreted as probable for cardiac sarcoidosis (seven of 25, 28%). Another 13 cases, including eight cases with either confluent fibrosis or fatty change, were interpreted as low probability based on endomyocardial biopsy. Conclusions The presence of micro-granuloma could be an evidence for positive diagnosis of cardiac sarcoidosis. Presence of both confluent fibrosis and fatty change is necessary for probable cardiac sarcoidosis in the absence of granuloma. Either of confluent fibrosis or fatty change may be an indirect pathological evidence but they are interpreted as nonspecific findings.
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- 2020
8. Centralized anterior bone plug results in less graft extrusion in patients undergoing medial meniscus allograft transplantation following anterior cruciate ligament reconstruction
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Soo Yeon Park, Jung-Suk Kim, Jae-Young Park, Kyoung Ho Yoon, and Hyun Woo Lee
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Adult ,Male ,medicine.medical_specialty ,Allograft transplantation ,Knee Joint ,Anterior cruciate ligament reconstruction ,Radiography ,medicine.medical_treatment ,Osteoarthritis ,Meniscus (anatomy) ,Menisci, Tibial ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Retrospective Studies ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,030229 sport sciences ,Allografts ,medicine.disease ,Magnetic Resonance Imaging ,Tibial Meniscus Injuries ,Surgery ,medicine.anatomical_structure ,Female ,medicine.symptom ,business ,Medial meniscus ,Follow-Up Studies - Abstract
PURPOSE This study was performed to analyze the effect of anterior bone plug positioning on clinical and radiological outcomes in patients undergoing medial meniscus allograft transplantation (M-MAT) following anterior cruciate ligament reconstruction (ACLR). METHODS Data from 24 patients who underwent M-MAT following meniscectomy and ACLR from November 2008 to June 2017 were retrospectively investigated. Patients were divided into either the centrally positioned group (group C) or the medially positioned group (group M) based on the location of the anterior bone plug for M-MAT. Clinical and radiographic follow-up was performed at two years postoperatively. International Cartilage Repair Society (ICRS) grades of chondral lesion, graft extrusion, and meniscus signal intensity were evaluated by magnetic resonance imaging (MRI) at one year postoperatively. RESULTS There were no significant differences in demographics including follow-up time of two years between the two groups. There were no significant differences in postoperative subjective International Knee Documentation Committee (IKDC), Lysholm, and Tegner scores between groups. Furthermore, there were no significant differences in osteoarthritis progression or ICRS grade on MRI. However, group C showed significantly less absolute graft extrusion (P = .008) and relative graft extrusion (P
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- 2020
9. Costal Chondrocyte–Derived Pellet-Type Autologous Chondrocyte Implantation versus Microfracture for Repair of Articular Cartilage Defects: A Prospective Randomized Trial
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Jae Doo Yoo, Chong Hyuk Choi, Jae-Young Park, Jung Sun Lee, Jin Yeon Lee, Kyoung Ho Yoon, and Sang-Gyun Kim
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Cartilage, Articular ,medicine.medical_specialty ,Fractures, Stress ,education ,Biomedical Engineering ,Physical Therapy, Sports Therapy and Rehabilitation ,Articular cartilage ,Transplantation, Autologous ,Chondrocyte ,law.invention ,03 medical and health sciences ,Chondrocytes ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Autologous chondrocyte implantation ,Cartilage repair ,Clinical Research papers ,030222 orthopedics ,business.industry ,030229 sport sciences ,Costal cartilage ,Surgery ,medicine.anatomical_structure ,Quality of Life ,business - Abstract
Objective To compare the efficacy and safety of costal chondrocyte–derived pellet-type autologous chondrocyte implantation (CCP-ACI) with microfracture (MFx) for repair of articular cartilage defects of the knee. Design Thirty subjects with an International Cartilage Repair Society (ICRS) grade 3 to 4 chondral defect (2-10 cm2 in area; ≤4 cm3 in volume) were randomized at a ratio of 2:1 (CCP-ACI:MFx). Twenty patients were allocated in the CCP-ACI group and 10 patients in the MFx group. CCP-ACI was performed by harvesting costal cartilage at least 4 weeks before surgery. Implantation was performed without any marrow stimulation. Efficacy and safety were assessed at weeks 8, 24, and 48 after surgery according to the magnetic resonance observation of cartilage repair tissue (MOCART) score and clinical outcomes. Results MOCART scores improved from baseline to 24 and 48 weeks postoperatively in both treatment groups. The improvement in MOCART scores in the CCP-ACI group was significantly greater than that in the MFx group at 24 and 48 weeks (39.1 vs 21.8 and 43.0 vs 24.8, respectively). The proportions of complete defect repair and complete integration were significantly higher in the CCP-ACI group than the MFx group at 48 weeks. Improvement in Lysholm score and KOOS subscores, including Function (Sports and Recreational Activity) and knee-related quality of life was significantly greater in the CCP-ACI group than the MFx group at 48 weeks (35.4 vs 31.5, 35.7 vs 28.5, and 27.9 vs 11.6, respectively). Conclusion Treatment of cartilage defects with CCP-ACI yielded satisfactory cartilage tissue repair outcomes, with good structural integration with native cartilage tissue shown by magnetic resonance imaging at 24 and 48 weeks after surgery. Level of Evidence Level 1: Randomized controlled study.
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- 2020
10. The number of metabolic features as a significant prognostic factor in patients with metastatic renal cell carcinoma
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Cheol Kwak, Seok-Soo Byun, Jae Young Park, Minyong Kang, Sung-Hoo Hong, Hyeong Dong Yuk, Jinsoo Chung, Seong Il Seo, Cheryn Song, Chang Wook Jeong, Eu Chang Hwang, and Hakmin Lee
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Oncology ,medicine.medical_specialty ,Urology ,Cell ,030232 urology & nephrology ,lcsh:Medicine ,Subgroup analysis ,Kaplan-Meier Estimate ,Nephrectomy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,In patient ,lcsh:Science ,Carcinoma, Renal Cell ,Cancer ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Multidisciplinary ,business.industry ,lcsh:R ,Middle Aged ,Prognosis ,medicine.disease ,Kidney Neoplasms ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cohort ,lcsh:Q ,business ,METABOLIC FEATURES ,Clear cell - Abstract
The effect of metabolic characteristics on the prognosis of patients with metastatic renal cell carcinoma remains controversial. We investigated the associations between metabolic features of each individual and disease prognosis in patients with metastatic renal cell carcinoma. Data of 1,584 patients with metastatic renal cell carcinoma from a multi-institutional database were retrospectively analyzed. The entire cohort was stratified into three subgroups according to how many patients had abnormal metabolic features (hypertension, diabetes mellitus, and low body mass index). The Kaplan-Meier and Cox proportional analyses were performed to investigate the associations between abnormal metabolic features and disease prognosis. mThere were 465 subjects without any metabolic features, 995 with one or two, and 124 with three. When the survival outcomes were compared according to the number of metabolic features, patients with higher numbers of metabolic features had significantly shorter overall and cancer-specific survival than those with fewer metabolic features (all p values
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- 2020
11. Inside-Out Repair of the Meniscus in Concomitant Anterior Cruciate Ligament Reconstruction: Absorbable Versus Nonabsorbable Sutures
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Kyoung Ho Yoon, Yeon Jae Lee, Yoo Beom Kwon, Sang-Gyun Kim, Eung Ju Kim, and Jae-Young Park
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Adult ,Male ,medicine.medical_specialty ,Anterior cruciate ligament reconstruction ,medicine.medical_treatment ,medicine.disease_cause ,Weight-bearing ,Arthroscopy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Meniscus ,Orthopedics and Sports Medicine ,In patient ,Patient Reported Outcome Measures ,Autografts ,Retrospective Studies ,Lateral meniscus ,Fibrous joint ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,Sutures ,Tibia ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,030229 sport sciences ,Allografts ,Magnetic Resonance Imaging ,Tibial Meniscus Injuries ,Surgery ,medicine.anatomical_structure ,Concomitant ,Tears ,Female ,business ,Follow-Up Studies - Abstract
Purpose To compare the clinical and magnetic resonance imaging (MRI) outcomes of meniscal repair using absorbable versus nonabsorbable sutures in patients undergoing concomitant anterior cruciate ligament reconstruction. Methods Data of 142 patients who underwent meniscal repair with concomitant anterior cruciate ligament reconstruction using either absorbable or nonabsorbable sutures for longitudinal meniscal tear were retrospectively reviewed. Inside-out suture technique was used for all meniscal repairs. Weight bearing and flexion (>90°) were allowed after 6 weeks postoperatively. Clinical evaluations were assessed by the International Knee Documentation Committee subjective score, Lysholm score, and Tegner activity score preoperatively and at 2-year follow-up. MRI outcomes at 1-year follow-up were compared to identify the successful healing (complete or partial healing) rate and incidence of additional meniscal tears. Subgroup analysis was performed to evaluate the results of medial or lateral meniscus. Results Eighty patients underwent meniscal repair using absorbable sutures (mean age, 26.3 ± 11.9 years) and 62 patients with nonabsorbable sutures (mean age, 27.2 ± 10.0 years). There were no differences in zone and length of meniscal tears and stability tests between the groups. At a 2-year follow-up, all clinical scores had improved in both groups but did not differ significantly between the groups. Successful healing rate based on 1-year postoperative MRI was not significantly different between the absorbable and nonabsorbable sutures (93.7% vs 96.8%, P = .469). However, the absorbable sutures showed a lower additional tear incidence than the nonabsorbable sutures (2.5% vs 9.6%, P = .031). Subgroup analysis showed that the successful healing rate was not significantly different between the suture materials in both the medial and lateral menisci. Conclusions The use of absorbable sutures leads to comparable healing rates to and lower incidence of additional tears than nonabsorbable sutures in patients undergoing meniscal repair with anterior cruciate ligament reconstruction. Level of Evidence Level III, retrospective comparative therapeutic trial.
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- 2020
12. Costal Chondrocyte–Derived Pellet-Type Autologous Chondrocyte Implantation for Treatment of Articular Cartilage Defect
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Sang-Gyun Kim, Jin Yeon Lee, Jae-Young Park, Kyoung Ho Yoon, EunAh Lee, and Jung Sun Lee
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Cartilage, Articular ,Pathology ,medicine.medical_specialty ,Knee Joint ,Physical Therapy, Sports Therapy and Rehabilitation ,Articular cartilage ,Transplantation, Autologous ,Chondrocyte ,03 medical and health sciences ,Chondrocytes ,0302 clinical medicine ,Tissue engineering ,medicine ,Humans ,Orthopedic Procedures ,Orthopedics and Sports Medicine ,Autologous chondrocyte implantation ,030222 orthopedics ,Articular chondrocyte ,business.industry ,030229 sport sciences ,Magnetic Resonance Imaging ,Treatment Outcome ,medicine.anatomical_structure ,business ,Follow-Up Studies - Abstract
Background: Because articular chondrocyte-based autologous chondrocyte implantations (ACIs) have restrictively restored articular cartilage defects, alternative cell sources as a new therapeutic option for cartilage repair have been introduced. Purpose: To assess whether implantation of a costal chondrocyte–derived pellet-type (CCP) ACI allows safe, functional, and structural restoration of full-thickness cartilage defects in the knee. Study Design: Case series; Level of evidence, 4. Methods: In this first-in-human study, 7 patients with symptomatic, full-thickness cartilage lesions were enrolled. The chondrocytes isolated from the patients’ costal cartilage were expanded, followed by 3-dimensional pellet culture to prepare the CCP-ACI. Implantation of the pellets was performed via minimal arthrotomy and secured with a fibrin sealant. Clinical scores, including the International Knee Documentation Committee (IKDC) subjective, Lysholm, and Tegner activity scores, were estimated preoperatively and at 1, 2, and 5 years postoperatively. High-resolution magnetic resonance imaging was also performed to evaluate cartilage repair as well as to calculate the MOCART (magnetic resonance observation of cartilage repair tissue) score. Results: The costal chondrocytes of all patients formed homogeneous-sized pellets, which showed the characteristics of the hyaline cartilaginous tissue with lacunae-occupied chondrocytes surrounded by glycosaminoglycan and type II collagen-rich extracellular matrix. There were no treatment-related serious adverse events during the 5-year follow-up period. Significant improvements were seen in all clinical scores from preoperative baseline to the 5-year follow-up (IKDC subjective score, 34.67 to 75.86; Lysholm score, 34.00 to 85.33; Tegner activity score, 1.17 to 4.67; and MOCART score, 28.33 to 83.33). Two patients had complete defect filling on magnetic resonance imaging evaluation at 1 year. Moreover, at 5 years postoperatively, complete defect filling was observed in 4 patients, and hypertrophy or incomplete defect filling (50%-100%) was observed in 2 patients. Conclusion: The overall results of this clinical study suggest that CCP-ACI can emerge as a promising therapeutic option for articular cartilage repair with good clinical outcomes and structural regeneration and with stable results at midterm follow-up. Registration: NCT03517046 ( ClinicalTrials.gov identifier)
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- 2020
13. Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia
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Dong Young Lee, Jong Bin Bae, Hyeon Jang Jeong, Ki Woong Kim, Kyuhee Han, Kyung Phil Kwak, Seok Bum Lee, Jong Chul Youn, Tae Hui Kim, Dongyun Lee, Kyoung Hwan Lee, Dong Woo Lee, Jae Young Park, Jeong Lan Kim, Seung Wan Suh, Seonjeong Byun, Shin Gyeom Kim, Jin Hyeong Jhoo, Yoonseop So, Joon Hyuk Park, Jong Woo Hong, Jung Jae Lee, Hyun Ghang Jeong, Seungho Ryu, Ju Ri Lee, Kayoung Kim, Ji Won Han, Bong Jo Kim, Seok Woo Moon, Taehyun Kim, and Ji Young Seo
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Cognitive aging ,medicine.medical_specialty ,Longitudinal study ,business.industry ,Cognition ,medicine.disease ,Senility ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Blood pressure ,Diastolic blood pressure ,Internal medicine ,medicine ,Cardiology ,Dementia ,Elderly people ,Original Article ,Cognitive decline ,Low diastolic blood pressure ,business ,030217 neurology & neurosurgery ,Biological Psychiatry - Abstract
Objective Cardiovascular diseases are representative risk factors for the onset of cognitive decline. The purpose of this study was to confirm the relationship between diastolic blood pressure and cognitive function in elderly people in Korea. Methods Data from subjects who were enrolled in the prospective Korean Longitudinal Study on Cognitive Aging and Dementia were used in this study. Data from 701 subjects whose diastolic blood pressure range did not change (≤79 mm Hg or ≥80 mm Hg) over 2 years were analyzed. To analyze the differences in cognitive function between the groups at the 2-year follow-up, an analysis of covariance was performed with covariates, which were significantly different between the two groups, and the baseline cognitive function. Results Significant differences were observed between the two groups, and the mean scores on the constructional praxis (η2=0.010) and word list recall tests (η2=0.018) in the diastolic blood pressure ≥80 mm Hg group were higher than those in the diastolic blood pressure ≤79 mm Hg group at the 2-year follow-up. Conclusion These results indicate that maintaining a DBP below 79 mm Hg presents a greater risk of cognitive decline in Korean elderly people.
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- 2020
14. History of Investigative and Clinical Urology and an analysis of published articles
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Jae Young Park, Kwangsung Park, and Seong Jin Jeong
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Publishing ,medicine.medical_specialty ,History ,business.industry ,Acceptance rate ,Urology ,Publications ,030232 urology & nephrology ,Science Citation Index ,History, 20th Century ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,History, 21st Century ,Pediatric urology ,03 medical and health sciences ,Special Article ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Republic of Korea ,Medicine ,Periodicals as Topic ,business - Abstract
Investigative and Clinical Urology is the official journal of the Korean Urological Association (KUA). Taehan Pinyogikwa Hakhoe chi was the first version of the official journal of the KUA and was published in January 1960. The journal was renamed the Korean Journal of Urology in February 2009 and the Korean Journal of Urology changed its title to Investigative and Clinical Urology in January 2016. The official YouTube channel of Investigative and Clinical Urology has been in operation since January 2016. Investigative and Clinical Urology was registered in Science Citation Index Expanded (SCIE) on October 30, 2018. A total of 8,103 papers were published in Investigative and Clinical Urology from January 1960 to December 2018. The most common subjects in published articles were oncology (4,602), pediatric urology (1,540), endourology & urolithiasis (1,477), and sexual dysfunction & infertility (1,285). A total of 23 articles on randomized controlled trials were published from March 2010 to December 2018. The acceptance rate of original articles in Investigative and Clinical Urology has decreased continuously since 2014. Meanwhile, the submission rate by international authors has shown an increasing trend from 2014 to 2018. As the first urologic journal in South Korea, Investigative and Clinical Urology has faithfully played its academic role in the past and present for 60 years. Since joining the SCIE list in 2018, further progress of Investigative and Clinical Urology is highly expected.
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- 2020
15. Referencing the trochlear groove based on three-dimensional computed tomography imaging improves the reliability of the measurement of the tibial tuberosity–trochlear groove distance in patients with higher grades of trochlea dysplasia
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Young Jun Nam, Jae Young Park, Seung Deok Sun, Rajib Debnath, Byung Hoon Lee, Myung Jin Shin, and Kyung-Wook Nha
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Joint Instability ,Male ,Adolescent ,Knee Joint ,Anterior cruciate ligament ,Tibial tuberosity ,Computed tomography ,Femoral trochlear dysplasia ,Trochlear groove ,Young Adult ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Humans ,Medicine ,Orthopedics and Sports Medicine ,In patient ,Retrospective Studies ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Matched control ,Reproducibility of Results ,030229 sport sciences ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,Dysplasia ,Case-Control Studies ,Female ,Tomography, X-Ray Computed ,business ,Nuclear medicine - Abstract
To determine whether 3D-CT imaging technique is valid and reproducible compared to conventional CT measurement technique (CCT) for the detection of a femoropatellar instability.Patients who had undergone surgery for femoropatellar instability (patellar instability group) between 2010 and 2016 (n = 37 knees of 35 patients) were retrospectively enrolled. For the matched control group, patients who had acute anterior cruciate ligament injury (4 weeks previously; n = 30) were recruited. Preoperative CT data had been obtained in all patients. Inter-rater reliability was calculated for both measurement protocols, and inter-method reliability was calculated between the two imaging modalities. The results are reported using intraclass correlation coefficients (ICCs) and Bland-Altman 95% limits of agreement.All patients in the patellar instability group had femoral trochlear dysplasia (Dejour types A: four, B: 19, C: seven, and D: six), but no dysplasia was noted in the control group. In the patellar instability group, the CCT technique showed a poor inter-rater agreement (ICC = 0.74), and the 3D-CT technique still showed excellent inter-rater agreement (ICCs = 0.91). In the sub-analysis of the patellar instability group according to the trochlear dysplasia grade, ICCs were markedly decreased with severe trochlear dysplasia when using CCT technique; however, the 3D-CT technique could provide excellent reliability even with severe trochlear dysplasia.The 3D-CT imaging technique for the measurement of the TT-TG distance can be suggested as a better measurement technique for patellar instability patients with bone abnormality.
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- 2019
16. Proximal tibiofibular division in lateral closing wedge high tibial osteotomy does not increase varus instability of the knee
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Jong Keun Kim, Myung Chul Lee, Hyuk Soo Han, and Jae-Young Park
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Adult ,Joint Instability ,Male ,musculoskeletal diseases ,Knee Joint ,medicine.medical_treatment ,Osteoarthritis ,Osteotomy ,Instability ,03 medical and health sciences ,0302 clinical medicine ,High tibial osteotomy ,Genu Varum ,Contralateral knee ,medicine ,Humans ,Orthopedics and Sports Medicine ,Closing wedge ,Retrospective Studies ,Orthodontics ,030222 orthopedics ,Tibia ,business.industry ,Bone Malalignment ,030229 sport sciences ,Middle Aged ,Osteoarthritis, Knee ,musculoskeletal system ,medicine.disease ,Subchondral bone ,Fibula ,Fibular Shaft ,Female ,business ,Follow-Up Studies - Abstract
Purpose When performing lateral closing wedge high tibial osteotomy (LCWHTO), fibular untethering can be performed with either fibular shaft osteotomy (FSO) or proximal tibiofibular division (TFD). The aim of this study was to compare the degree of varus instability between the two methods after LCWHTO and to analyze the determinants of varus instability. Methods This study retrospectively analyzed 108 consecutive patients with medial compartment osteoarthritis who underwent LCWHTO and had > 2 years of follow-up. Patients who underwent unilateral LCWHTO without a previous history of ligament injury were included. Forty-five patients who received LCWHTO with TFD and 51 patients who received LCWHTO with FSO were finally analyzed. The mean follow-up duration was 5.3 years in LCWHTO with TFD and 4.1 years in LCWHTO with FSO. The shortest distance between the lateral tibial plateaus and the corresponding most distal subchondral bone surface of the lateral femoral condyle was measured on varus stress radiographs and compared with that on the unaffected contralateral knee. Multivariable logistic regression analyses were conducted to identify predictors of varus instability. Results Lateral joint space width showed no significant between-group difference. Multivariable logistic regression analysis revealed that the pre-operative hip-knee-ankle angle was positively correlated with the lateral joint space width. The type of fibular untethering procedure was not associated with postoperative varus instability. Conclusion The degree of pre-operative varus malalignment is associated with postoperative varus instability after LCWHTO. Proximal tibiofibular division is not a variable for postoperative varus instability after LCWHTO. Level of evidence Level III, Retrospective comparative study.
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- 2019
17. Preoperative sterile pyuria as a prognostic biomarker for intravesical recurrence in upper urinary tract urothelial carcinoma
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Jong Wook Kim, Byeong Jo Jeon, Bum Sik Tae, Jae Young Park, Jae Hyun Bae, Hoon Choi, and Hong Seok Park
- Subjects
Male ,medicine.medical_specialty ,Urologic Neoplasms ,Lymphovascular invasion ,Urological Oncology ,Urology ,030232 urology & nephrology ,lcsh:RC870-923 ,Risk Assessment ,03 medical and health sciences ,Leukocyte Count ,0302 clinical medicine ,Recurrence ,Predictive Value of Tests ,Outcome Assessment, Health Care ,medicine ,Humans ,Risk factor ,Pyuria ,Perioperative Period ,Upper urinary tract ,Aged ,Neoplasm Staging ,Carcinoma, Transitional Cell ,Urinary bladder ,business.industry ,Proportional hazards model ,Middle Aged ,lcsh:Diseases of the genitourinary system. Urology ,Prognosis ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,T-stage ,Urologic Surgical Procedures ,Original Article ,Female ,medicine.symptom ,Neoplasm Grading ,Neoplasm Recurrence, Local ,business - Abstract
Purpose To evaluate if preoperative sterile pyuria can be a prognostic factor for intravesical recurrence (IVR) and overall survival (OS)in patients with upper tract urothelial carcinoma (UTUC) undergoing surgery. Materials and methods We retrospectively reviewed the medical records of patients who were diagnosed with UTUC from October 2003 to December 2016 at Korea University Medical Center. Sterile pyuria was defined as urine containing five or more white blood cells per high-power field in the absence of bacteria in urine culture. We used a stepwise multivariable Cox proportional hazards model to assess the independent effects of the prognostic factors for IVR and OS. Results We investigated a total of 176 patients who were diagnosed with UTUC. Among them, 91 (51.7%) patients had preoperative sterile pyuria. There were no significant differences in the baseline characteristics between the pyuria and non-pyuria groups concerning tumor grade, T stage, tumor multiplicity, and recurrence history. However, there was a significant difference in the IVR between the two groups. In the multivariable analysis, preoperative sterile pyuria, diabetes mellitus, high-grade tumor, and lymphovascular invasion were revealed as independent risk factors for IVR, and only lymphovascular invasion was identified as an independent risk factor for OS. Conclusions Preoperative sterile pyuria is significantly associated with IVR in patients with UTUC undergoing surgery, but it is not associated with OS. Furthermore, diabetes mellitus, high-grade tumor, and lymphovascular invasion are also independent prognostic factors for these patients.
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- 2019
18. Development and validation of a prediction model for knee joint line orientation after high tibial osteotomy
- Author
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Myung Chul Lee, Sohee Oh, Chong Bum Chang, Seung Baik Kang, Dong Wan Kang, and Jae-Young Park
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Adult ,Male ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Correlation coefficient ,Knee Joint ,Knee joint line orientation ,Radiography ,Models, Biological ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,High tibial osteotomy ,Orientation (geometry) ,medicine ,Humans ,Orthopedics and Sports Medicine ,Tibia ,Postoperative Period ,Retrospective Studies ,030222 orthopedics ,Multivariable linear regression ,business.industry ,Patient Selection ,030229 sport sciences ,Bone Malalignment ,Middle Aged ,Osteoarthritis, Knee ,Osteotomy ,Orthopedic surgery ,Preoperative Period ,Female ,Knee joint line ,lcsh:RC925-935 ,business ,Nuclear medicine ,Research Article - Abstract
BackgroundMaintenance of optimal knee joint line orientation (KJLO) is important after high tibial osteotomy (HTO). No tools, however, are currently available that could predict the value of postoperative KJLO before surgery. First, this study sought to determine the effects of various preoperative anatomical alignment parameters to postoperative KJLO. Based upon these analyses, we aimed to devise an equation that predicts the value of postoperative KJLO.MethodsA total of 14 radiographic parameters were measured in preoperative and postoperative full-limb standing anteroposterior radiographs on 50 patients who underwent open-wedge HTO. The parameters were analysed using multivariable linear regression to predict KJLO after HTO. External validation of the equation was done with 20 patients who underwent HTO at another institution.ResultsAfter HTO, KJLO increased from − 0.8° to 2.9° (P ConclusionsThis study analysed the effects of preoperative anatomical alignment parameters on the postoperative KJLO. An equation which predicts postoperative KJLO with preoperative anatomical alignment factors was devised and validated. This equation would help in selecting optimal patients for HTO and in selecting the optimal target correction angle in HTO.
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- 2019
19. Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
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Byeong Jo Jeon, Jae Hyun Bae, Bum Sik Tae, Hoon Choi, and Jae Young Park
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0301 basic medicine ,Male ,Cancer Research ,medicine.medical_specialty ,Population ,nationwide population‐based study ,Antineoplastic Agents ,androgen deprivation therapy ,lcsh:RC254-282 ,Androgen deprivation therapy ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,education ,Propensity Score ,Original Research ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,education.field_of_study ,business.industry ,Proportional hazards model ,Cerebral infarction ,Incidence ,Hazard ratio ,Prostatic Neoplasms ,Androgen Antagonists ,Middle Aged ,medicine.disease ,cerebral infarction ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Survival Analysis ,030104 developmental biology ,Treatment Outcome ,Oncology ,prostate neoplasm ,030220 oncology & carcinogenesis ,Cohort ,Prostate neoplasm ,business ,Cancer Prevention - Abstract
Purpose Previous studies have suggested that androgen deprivation therapy (ADT) is associated with cerebral infarction. However, conflicting results have been reported by other researchers. The aim of this study was to evaluate the association between ADT and cerebral infarction in patients with prostate cancer (PC) using big data. Materials and Methods Using information from the National Health Insurance Service database representative of the entire Korean adult PC population (n = 206 735), data regarding ADT and cerebral infarction between 2009 and 2016 were analyzed. Adjusted hazard ratios for cerebral infarction associated with ADT were estimated using propensity score‐matched Cox proportional hazards models and Kaplan‐Meier survival analyses. Results The final cohort comprised 36 146 individuals with PC, including 24 069 men (66.6%) who underwent ADT. During the mean follow‐up of 4.1 years, 2792 patients were newly diagnosed with cerebral infarction. In the unmatched cohort, there was a significant difference in the annual incidence of cerebral infarction between the ADT and non‐ADT groups (22.8 vs 14.6 per 1000 person‐years, respectively). However, there was no significant difference between the ADT and non‐ADT groups in the matched cohort (14.9 vs 14.6 per 1000 person‐years). The adjusted hazard ratio for cerebral infarction for PC patients who underwent ADT was 1.045 (95% CI 0.943‐1.159; P = 0.401) compared with those who did not undergo ADT. In addition, the cumulative duration of ADT was also not associated with an increased risk for cerebral infarction. However, older age, hypertension, diabetes, myocardial infarction, congestive heart failure, peripheral vascular disease, renal disease, dementia, and atrial fibrillation were revealed to be factors contributing to cerebral infarction. Conclusion This nationwide population‐based study revealed that ADT was not associated with cerebral infarction after adjusting for potential confounders.
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- 2019
20. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment
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Kyuhee Han, Kyung Phil Kwak, Ji-Yeong Seo, Ju Ri Lee, Soomin Jang, Dong Woo Lee, Jeong Lan Kim, Dong Young Lee, Taehyun Kim, Jin Hyeong Jhoo, Jiyoon Shin, Jong Woo Hong, Ji Won Han, Hyun Ghang Jeong, Seok Bum Lee, Joon Hyuk Park, Seung Wan Suh, Seungho Ryu, Kayoung Kim, Hyeon Jang Jeong, Ki Woong Kim, Bong Jo Kim, Jung Jae Lee, Shin Gyeom Kim, Jae Young Park, Yoonseop So, Seok Woo Moon, Jong Chul Youn, Tae Hui Kim, Kyoung Hwan Lee, and Seonjeong Byun
- Subjects
Folate ,Longitudinal study ,medicine.medical_specialty ,Population ,03 medical and health sciences ,Elderly ,Cognition ,0302 clinical medicine ,Internal medicine ,medicine ,Dementia ,Prospective cohort study ,education ,Biological Psychiatry ,education.field_of_study ,business.industry ,Longitudinal studies ,Confounding ,Odds ratio ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Quartile ,Cohort studies ,Original Article ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia." The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). Conclusion Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status.
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- 2019
21. Survival and clinical prognostic factors in metastatic non‐clear cell renal cell carcinoma treated with targeted therapy: A multi‐institutional, retrospective study using the Korean metastatic renal cell carcinoma registry
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Cheol Kwak, Ill Young Seo, Jae Young Park, Sung-Han Kim, Chang Wook Jeong, Hakmin Lee, Eu Chang Hwang, Jung Kwon Kim, Sung Hoo Hong, Cheryn Song, Jungnam Joo, Mi Kyung Song, Jinsoo Chung, and Seong Il Seo
- Subjects
Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Cell ,Korean ,Kaplan-Meier Estimate ,metastatic renal cell carcinoma ,survival ,lcsh:RC254-282 ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Molecular Targeted Therapy ,Registries ,Carcinoma, Renal Cell ,Protein Kinase Inhibitors ,Original Research ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Curve analysis ,Clinical Cancer Research ,Retrospective cohort study ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Combined Modality Therapy ,Clear cell renal cell carcinoma ,Treatment Outcome ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cohort ,non‐clear cell ,Female ,prognosis ,Metastasectomy ,business - Abstract
Objectives The optimal treatment strategy for metastatic non‐clear cell renal cell carcinoma (mNCCRCC) is still elusive and mainly extrapolated from evidence available for metastatic clear cell renal cell carcinoma. The aim of the study was therefore to investigate the survival outcomes and prognostic factors affecting survival in patients with mNCCRCC treated with targeted therapy. Materials and methods We analyzed a total of 156 patients (8.1%) with mNCCRCC among the total cohort of 1922 patients in the Korean metastatic RCC registry. We used Kaplan‐Meier curve analysis to calculate the survival estimates for first‐line progression‐free survival (PFS), total PFS, and cancer‐specific survival (CSS). We also used the log‐rank test to compare the different groups and multivariate Cox‐proportional hazard regression analyses to evaluate the prognostic factors for survival. Results The mNCCRCC group had significantly inferior survival outcomes in terms of first‐line PFS, total PFS, and CSS (all P
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- 2019
22. Application of the International Metastatic Renal Cell Carcinoma Database Consortium and Memorial Sloan Kettering Cancer Center Risk Models in Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma: A Multi-Institutional Retrospective Study Using the Korean Metastatic Renal Cell Carcinoma Registry
- Author
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Jae Young Park, Chang Wook Jeong, Jinsoo Chung, Hakmin Lee, Ill Young Seo, Seong Il Seo, Cheryn Song, Sung-Han Kim, Eu Chang Hwang, Jung Kwon Kim, Mi Kyung Song, Sung Hoo Hong, Cheol Kwak, and Jungnam Joo
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Metastatic renal cell carcinoma ,Korean ,Kaplan-Meier Estimate ,computer.software_genre ,Risk Assessment ,03 medical and health sciences ,Risk model ,0302 clinical medicine ,Risk groups ,Risk Factors ,Renal cell carcinoma ,Republic of Korea ,medicine ,Humans ,In patient ,Registries ,Neoplasm Metastasis ,Carcinoma, Renal Cell ,neoplasms ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,validation ,Models, Statistical ,Database ,business.industry ,Cancer ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Criteria ,Kidney Neoplasms ,Non-clear cell ,Clear cell renal cell carcinoma ,Treatment Outcome ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cohort ,Female ,Original Article ,business ,computer - Abstract
Purpose The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) and the Memorial Sloan Kettering Cancer Center (MSKCC) risk models were developed predominantly with clear cell renal cell carcinoma (RCC). Accordingly, whether these two models could be applied to metastatic non-clear cell RCC (mNCCRCC) as well has not been well-known and was investigated herein. Materials and Methods From the Korean metastatic RCC registry, a total of 156 patients (8.1%) with mNCCRCC among the entire cohort of 1,922 patients were analyzed. Both models were applied to predict first-line progression-free survival (PFS), total PFS, and cancer-specific survival (CSS). Results The median first-line PFS, total PFS, and CSS were 5, 6, and 24 months, respectively. The IMDC risk model reliably discriminated three risk groups to predict survival: the median first-line PFS, total PFS, and CSS for the favorable, intermediate, and poor risk groups were 9, 5, and, 2 months (p=0.001); 14, 7, and 2 months (p < 0.001); and 41, 21, and 8 months (p < 0.001), all respectively. The MSKCC risk model also reliably differentiated three risk groups: 9, 5, and, 2 months (p=0.005); 10, 7, and 3 months (p=0.002); and 50, 21, and 8 months (p < 0.001), also all respectively. The concordance indices were 0.632 with the IMDC model and 0.643 with the MSKCC model for first-line PFS: 0.748 and 0.655 for CSS. Conclusion The current IMDC and MSKCC risk models reliably predict first-line PFS, total PFS, and CSS in mNCCRCC.
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- 2019
23. Effect of maternal age on emergency cesarean section
- Author
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In-Yang Park, Hyun Sun Ko, Yu-Ri Jang, Jae-Young Park, J. Wie, Jong-Chul Shin, Seong-Eun Bak, and Shin-Young Kim
- Subjects
medicine.medical_specialty ,Emergency Cesarean Section ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,medicine.medical_treatment ,Obstetrics and Gynecology ,03 medical and health sciences ,0302 clinical medicine ,Fetal heart rate ,Labor induction ,Pediatrics, Perinatology and Child Health ,Medicine ,030212 general & internal medicine ,business - Abstract
This study aims to investigate the independent influence of maternal age on the risk of emergency cesarean section (CS) due to nonreassuring fetal heart rate or arrest disorder.This was a cross-sectional study on women with nulliparous pregnancies, who are attempting vaginal delivery at term and have a cephalic presentation without the indication of elective CS at the onset of labor. The primary outcome was the rate of emergency CS. Independent risk factors were elucidated using multivariate logistic regression analysis.Of 3513 women, 541 (15.4%) delivered by emergency CS during a trial of vaginal delivery, with theses being due to nonreassuring fetal heart rate (N = 150) or arrest disorder (N = 391). In univariate analysis, both individual CS rate due to nonreassuring fetal heart rate or arrest disorder and total emergent CS rate increased with maternal age. The risk of emergency CS was also significantly higher when labor induction was performed (odds ratio (OR) 2.489, 95% confidence interval (CI) 2.043-3.033), while fetal weight was heavier (neonatal weight ≥3.5 kg; OR 2.396, 95% CI 1.956-2.934), and maternal BMI was higher (before pregnancy ≥25 kg/mAdvanced maternal age is an independent risk factor of emergency CS due to nonreassuring fetal heart rate or arrest disorder during the trial of vaginal delivery. The risk of emergency CS was also increased when labor induction was performed. Therefore, the risk of emergency CS needs to be considered, especially when the labor induction is planned, in women aged 40 or more.
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- 2019
24. A Novel Technique of Morcellation Using a Pneumovesicum After Holmium Laser Enucleation of the Prostate in Complicated Situations: Our Initial Experience and Tips
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Jae Young Park, Hoon Choi, Byung Jo Jeon, Bum Sik Tae, and Jae Hyun Bae
- Subjects
Novel technique ,medicine.medical_specialty ,Adenoma ,Urethral stricture ,Urology ,Enucleation ,030232 urology & nephrology ,Holmium laser ,Subgroup analysis ,Morcellation ,lcsh:RC870-923 ,03 medical and health sciences ,Holmium ,0302 clinical medicine ,Prostate ,medicine ,Clinical Investigation ,030219 obstetrics & reproductive medicine ,business.industry ,Pneumovesicum ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Surgery ,medicine.anatomical_structure ,Neurology ,Original Article ,Neurology (clinical) ,Morcellator ,business ,Prostatic hyperplasia - Abstract
Purpose To describe our initial experience with a novel method of adenoma retrieval using a pneumovesicum (PNV) after Holmium laser enucleation of the prostate (HoLEP). Methods From January 2016 to April 2018, a total of 93 consecutive patients treated with HoLEP were enrolled in this study. For tissue morcellation, we used the PNV morcellation technique for an initial series of 21 patients and the conventional technique (Lumenis VersaCut) for a consecutive series of 72 patients. We compared efficiency and safety between the novel technique and the traditional technique. Subgroup analysis was performed to assess the effectiveness of the current technique in the large prostate (>70 mL). Results There were significant differences in mean age and prostate volume between the 2 groups. However, there were no significant differences in the baseline characteristics and preoperative parameters in the subgroup analysis of large prostates (>70 mL). The mean morcellation efficiency was higher (8.50±1.94 minutes vs. 1.76±0.45 minutes, P
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- 2019
25. Sawing toward the fibular head during open-wedge high tibial osteotomy carries the risk of popliteal artery injury
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Do Weon Lee, Myung Chul Lee, Du Hyun Ro, Jae Young Park, Hyuk Soo Han, and Taehoon Kang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Computed Tomography Angiography ,Medial cortex ,medicine.medical_treatment ,Osteotomy ,03 medical and health sciences ,Imaging, Three-Dimensional ,Postoperative Complications ,0302 clinical medicine ,High tibial osteotomy ,Risk Factors ,medicine.artery ,Open wedge ,medicine ,Humans ,Popliteal Artery ,Orthopedics and Sports Medicine ,Aged ,Fibular Head ,Aged, 80 and over ,030222 orthopedics ,Tibia ,business.industry ,030229 sport sciences ,Middle Aged ,Osteoarthritis, Knee ,Popliteal artery ,Surgery ,medicine.anatomical_structure ,Fibula ,Orthopedic surgery ,Female ,business ,Artery - Abstract
Popliteal artery injury is a rare but devastating complication of open-wedge high tibial osteotomy (OWHTO). The objectives of this study were: to document the location of the artery in the virtual osteotomy plane (VOP), to measure the minimal distance between the popliteal artery and three virtual saw-progression lines (VSLs), and to present a safe sawing technique for OWHTO. In total, 45 computed tomography angiographies were reconstructed and virtual osteotomy was simulated using 3D image-processing software. The VOP was defined as an inclined plane commencing 3.5 cm below the articular plane towards the fibular head. VSLs were defined as saw-progression guidelines that lie on the VOP: “VSL-mid” runs from the midpoint of the tibial medial cortex towards the fibular head; “VSL-ant” starts from the same point as VSL-mid, but runs 10° anterior to the fibular head; and “VSL-post” runs 10° posterior to the fibular head. The distances between the popliteal artery and the three VSLs were measured, and the risk of injury was assessed. The popliteal artery was located 20.7° posterior to VSL-mid and 51 mm from the starting point. The minimum distance between the popliteal artery and VSL-mid was 18 mm (99% confidence interval 9–27 mm). When the saw was moved along VSL-mid, 42% of the arteries were susceptible to injury. However, when it followed VSL-ant, there was no risk of injury. Sawing toward the fibular head carries a risk of popliteal artery injury and should not be performed. When sawing in OWHTO, the recommended target should be 10° anterior to the fibular head. This technique eliminates the risk of popliteal artery injury.
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- 2019
26. The use of bisphosphonates after joint arthroplasty is associated with lower implant revision rate
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Hyuk Soo Han, Jae-Young Park, Du Hyun Ro, Myung Chul Lee, Heejin Jin, and Sungho Won
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,Knee Joint ,Arthroplasty, Replacement, Hip ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Orthopedics and Sports Medicine ,Revision rate ,Arthroplasty, Replacement, Knee ,Aged ,Proportional Hazards Models ,Retrospective Studies ,030222 orthopedics ,Diphosphonates ,Proportional hazards model ,business.industry ,Hazard ratio ,Retrospective cohort study ,030229 sport sciences ,Middle Aged ,Bisphosphonate ,Arthroplasty ,Prosthesis Failure ,Surgery ,Orthopedic surgery ,Female ,Implant ,business - Abstract
This study hypothesized that the use of bisphosphonates (BPs) after total joint arthroplasty (TJA) is associated with a lower implant revision rate. This study aimed (1) to investigate the association between BP use and the revision rate of TJA and (2) to determine the relationship between the medication period and the revision rate of TJA. National Health Insurance Service data on surgeries, medications, diagnoses, and screenings of 50 million Koreans were reviewed. People who underwent TJA in the period from 2002 to 2012 were identified and followed until 2016. During that period, 331,660 patients underwent total knee arthroplasty (TKA), and 56,043 patients underwent total hip arthroplasty (THA). Among them, 8447 knee patients (2.5%) and 2851 hip patients (5.0%) required revision surgery due to aseptic loosening. Demographic data, the duration of BP medication, and comorbidities were identified. The rate of revision surgery according to BP medication was investigated. The extended Cox proportional hazard model was used to evaluate the effect of the medication period. The rate of TKA revision was 1.4% for BP users and 2.9% for BP non-users (p
- Published
- 2018
27. TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13
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Jae Young Park, Myung Chul Lee, Hyuk Soo Han, Sung Hee Pyo, and Hyun Cheol Bae
- Subjects
Cartilage, Articular ,Anabolism ,0206 medical engineering ,Biomedical Engineering ,Medicine (miscellaneous) ,02 engineering and technology ,Osteoarthritis ,Matrix metalloproteinase ,Chondrocyte ,03 medical and health sciences ,Mice ,Chondrocytes ,GTP-Binding Proteins ,Transforming Growth Factor beta ,Matrix Metalloproteinase 13 ,medicine ,Animals ,Protein Glutamine gamma Glutamyltransferase 2 ,030304 developmental biology ,0303 health sciences ,Transglutaminases ,biology ,Chemistry ,Catabolism ,Cartilage homeostasis ,Cartilage ,Transforming growth factor beta ,medicine.disease ,020601 biomedical engineering ,Cell biology ,medicine.anatomical_structure ,biology.protein ,Original Article - Abstract
BACKGROUND: Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in chondrocyte catabolism remains unclear. Thus, we examined whether TGFβ1 increases catabolic processes in the osteoarthritic joint via transglutaminase 2 (TG2). In this study, we investigated whether interplay between TGFβ1 and TG2 mediates chondrocyte catabolism and cartilage degeneration in osteoarthritis. METHODS: To investigate the role of TGFβ1 and TG2 in osteoarthritis, we performed immunostaining to measure the levels of TGFβ1 and TG2 in 6 human non-osteoarthritic and 16 osteoarthritic joints. We conducted quantitative reverse transcription polymerase chain reaction and western blot analysis to investigate the relationship between TGFβ1 and TG2 in chondrocytes and determined whether TG2 regulates the expressions of matrix metalloproteinase (MMP)-13, type II, and type X collagen. We also examined the extent of cartilage degradation after performing anterior cruciate ligament transection (ACLT) and destabilization of the medial meniscus (DMM) surgery in TG2 knock-out mice. RESULTS: We confirmed the overexpression of TGFβ1 and TG2 in human osteoarthritic cartilage compared with non-osteoarthritic cartilage. TGFβ1 treatment significantly increased the expression of TG2 via p38 and ERK activation. TGFβ1-induced TG2 also elevated the level of MMP-13 and type X collagen via NF-κB activation in chondrocytes. Cartilage damage after ACLT and DMM surgery was less severe in TG2 knock-out mice compared with wild-type mice. CONCLUSION: TGFβ1 modulated catabolic processes in chondrocytes in a TG2-dependent manner. TGFβ1-induced TG2 might be the therapeutic target for treating cartilage degeneration and osteoarthritis.
- Published
- 2021
28. Influences of pregravid liver enzyme levels on the development of gestational diabetes mellitus
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Kyungdo Han, Woo Jeng Kim, Yoohyun Chung, Yong Gyu Park, Jae-Young Park, In Yang Park, Hyun Sun Ko, and Jihyun Park
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Diabetes mellitus ,medicine ,Humans ,Hepatology ,Obstetrics ,business.industry ,Insulin ,Type 2 Diabetes Mellitus ,Odds ratio ,medicine.disease ,Obesity ,Gestational diabetes ,Diabetes, Gestational ,Diabetes Mellitus, Type 2 ,Liver ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Metabolic syndrome ,business - Abstract
BACKGROUND & AIMS Elevated liver enzymes are associated with later development of type 2 diabetes mellitus. The objective of this study was to assess the association between prepregnancy liver enzyme levels and subsequent risk of gestational diabetes mellitus. METHODS Data from a total of 236,109 women who participated in the National Health Screening Examination between 2011 and 2015 was analysed. Multivariate logistic regression analyses were performed to estimate the risk of developing gestational diabetes mellitus in relation to pregravid liver enzyme levels. Subgroup analyses were performed according to pregravid obesity and metabolic syndrome (MetS). RESULTS Approximately 5.7% and 1.1% of women developed gestational diabetes mellitus with and without insulin treatment requirement respectively. Pregravid gamma-glutamyl transferase and alanine aminotransferase levels with greater than or equal to the 4th quartile were associated with significantly increased risks of gestational diabetes mellitus requiring insulin treatment in women with obesity and with MetS, (odds ratios [ORs] with 6.228 and 9.505, respectively, P
- Published
- 2020
29. Elastic pneumatic tourniquet cuff can reduce postoperative thigh pain after total knee arthroplasty: a prospective randomized trial
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Hyuk Soo Han, Sung Eun Kim, Myung Chul Lee, and Jae-Young Park
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Visual analogue scale ,Deep vein ,Blood Loss, Surgical ,Thigh ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Randomized controlled trial ,law ,medicine ,Humans ,Automatic pneumatic tourniquet ,Orthopedics and Sports Medicine ,Prospective Studies ,Arthroplasty, Replacement, Knee ,Prospective cohort study ,Elastic cuff ,030203 arthritis & rheumatology ,Pain, Postoperative ,030222 orthopedics ,Tourniquet ,business.industry ,Tourniquets ,musculoskeletal system ,Surgery ,body regions ,surgical procedures, operative ,medicine.anatomical_structure ,Total knee arthroplasty ,Orthopedic surgery ,Cuff ,lcsh:RC925-935 ,business ,Research Article - Abstract
Background Tourniquet use is associated with complications such as thigh pain, skin problems, and deep vein thrombosis (DVT). This prospective study aimed to evaluate the efficacy and safety of the pneumatic tourniquet system using an elastic cuff and limb occlusion pressure (LOP) in total knee arthroplasty (TKA). The hypothesis of this study was that an elastic cuff tourniquet would result in less postoperative thigh pain after TKA. Methods This prospective randomized controlled trial involved a total of 98 patients who underwent primary TKA. They were randomized into two groups: tourniquet system using an elastic cuff and LOP group (Group E) and tourniquet system using a conventional-cuff and LOP group (Group C). Outcomes including postoperative thigh pain assessed using a visual analog scale (VAS), serum muscle enzymes, recommended tourniquet pressure (RTP), bloodlessness of surgical field, surgical time, incidence of DVT, and the frequency of rescue analgesic use after surgery, were compared between groups. Results Patients in Group E experienced significantly less thigh pain compared to those in Group C on postoperative day 4 (P = 0.01) and day 7 (P = 0.04). The difference between RTP and systolic blood pressure was significantly lower in Group E (P = 0.045). One case of thigh DVT was found in Group E, while no such cases were found in Group C. One and two cases of poor bloodless surgical fields were observed in Group E and Group C, respectively. There was no significant difference in surgical time, levels of serum muscle enzymes, and the frequency of rescue analgesic use between the two groups. Conclusions The pneumatic tourniquet system using an elastic cuff and LOP reduced early postoperative thigh pain more effectively than did the tourniquet system using a conventional cuff and LOP. Trial registration #KCT0003149. Registered August 17, 2018 - Retrospectively registered.
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- 2020
30. Metastatic renal cell carcinoma to the pancreas: Clinical features and treatment outcome
- Author
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Jae Young Park, Cheryn Song, Teak Jun Shin, Minyong Kang, Jinsoo Chung, Sung-Hoo Hong, Chang Wook Jeong, Hakmin Lee, Eu Chang Hwang, Seongil Seo, and Cheol Kwak
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Treatment outcome ,urologic and male genital diseases ,Gastroenterology ,Metastasis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,medicine ,Humans ,Child ,Carcinoma, Renal Cell ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Hazard ratio ,Metastasectomy ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,Kidney Neoplasms ,Pancreatic Neoplasms ,Survival Rate ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Female ,business ,Pancreas ,Follow-Up Studies - Abstract
Background and objectives Metastatic renal cell carcinoma to the pancreas (PM-RCC) is infrequent; we sought to describe the characteristics of PM-RCC and analyze the outcome following treatment. Methods Data of 3107 mRCC patients treated between 1992 and 2007 from the Korean Renal Cancer Study Group database were obtained to identify 300 (9.7%) PM-RCC patients. Characteristics and survival were analyzed and compared to the rest of the mRCC, according to the timing of metastasis and surgical treatments received. Results PM-RCC was younger at initial diagnosis (55.0 vs. 58.2 years), more frequently in women (30.3% vs. 22.3%), and metachronous (65.3% vs. 41.9%) with a longer disease-free period (82.0 vs. 33.0 months). Overall survival (OS) was significantly better in PM-RCC but pancreas metastasectomy was associated with improved OS only among metachronous PM-RCC. In the 132 metachronous PM-RCC with pancreas metastasectomy, median recurrence-free survival was 17.2 months and we found Heng risk group (hazard ratio [HR] = 2.384, 95% confidence interval [CI] = 1.213-4.684), younger age (HR = 0.965, 95% CI = 0.945-0.987), shorter interval to pancreas metastasis (HR = 0.993, 95% CI = 0.986-0.999), and Eastern Cooperative Oncology Group performance status to be predictive of early progression following pancreas metastasectomy. Conclusion Compared to the other mRCC, PM-RCC demonstrated a favorable prognosis. Pancreas metastasectomy was associated with prolonged survival in the metachronous PM-RCC with a long progression-free period.
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- 2020
31. Influence of Posterior Tibial Slope on Clinical Outcomes and Survivorship After Anterior Cruciate Ligament Reconstruction Using Hamstring Autografts: A Minimum of 10-Year Follow-Up
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Kyoung Ho Yoon, Yoo Beom Kwon, Eung Ju Kim, Sang Jun Kim, Soo Yeon Park, Jae-Young Park, and Sang-Gyun Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Anterior cruciate ligament reconstruction ,Adolescent ,Knee Joint ,medicine.medical_treatment ,Anterior cruciate ligament ,Hamstring Muscles ,Kaplan-Meier Estimate ,Transplantation, Autologous ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Survivorship curve ,medicine ,Humans ,Orthopedics and Sports Medicine ,Treatment Failure ,Autografts ,Survival analysis ,Meniscectomy ,Retrospective Studies ,030222 orthopedics ,medicine.diagnostic_test ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Anterior Cruciate Ligament Injuries ,Magnetic resonance imaging ,030229 sport sciences ,Lysholm Knee Score ,Middle Aged ,Magnetic Resonance Imaging ,Confidence interval ,Surgery ,Radiography ,medicine.anatomical_structure ,Preoperative Period ,Ligament ,Female ,business ,Hamstring ,Follow-Up Studies - Abstract
Purpose To investigate the influence of medial and lateral posterior tibial slope (PTS) on long-term clinical outcomes and survivorship after anterior cruciate ligament (ACL) reconstruction using hamstring autografts. Methods A total of 232 patients (mean age, 28.2 ± 8.9 years) who underwent primary ACL reconstruction from October 2002 to July 2007 were retrospectively reviewed. Patients with multiple ligament reconstruction, total meniscectomy, contralateral knee surgery before ACL reconstruction, open growth plate, and less than 10-year follow-up were excluded in the study. The medial and lateral PTS were measured from preoperative magnetic resonance imaging. Based on Li et al.’s previous study, the patients were divided into 2 groups according to their medial PTS (≤5.6° vs >5.6°) and lateral PTS (≤3.8° vs >3.8°), respectively. Clinical outcomes (clinical scores, stability tests and failure rate) were compared between the groups at the last follow-up. Furthermore, survival analysis was performed using the Kaplan–Meier method. Results All clinical scores (International Knee Documentation Committee subjective, Lysholm, and Tegner activity scores) and stability tests (physical examinations and side-to-side difference in Telos stress radiographs) were insignificantly different between the 2 groups classified based on medial or lateral PTS. However, the failure rate was significantly higher in patients with medial PTS >5.6° (16.1% vs 5.1%, P = .01) or lateral PTS >3.8° (14.5% vs 4.7%; P = .01). The odds ratios of graft failure due to increased medial and lateral PTS were 3.18 (95% confidence interval, 1.22–8.28; P = .02) and 3.43 (95% confidence interval, 1.29–9.09; P = .01), respectively. In addition, the 10-year survivorship was significantly lower in patients with medial PTS >5.6° (83.9% vs 94.9%, P = .01) or lateral PTS >3.8° (85.5% vs 96.0%; P = .01). Conclusions Increased medial (>5.6°) and lateral (>3.8°) PTS were associated with higher failure rate and lower survivorship at a minimum of 10-year follow-up after primary ACL reconstruction using hamstring autografts. Level of Evidence Level III, retrospective comparative trial.
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- 2020
32. Repeat Stereotactic Radiosurgery for Recurred Metastatic Brain Tumors
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Woo-Youl Jang, Tae-Young Jung, Jae Young Park, Tae-Wook Song, Shin Jung, In-Young Kim, Sa-Hoe Lim, and Kyung-Sub Moon
- Subjects
Gamma knife radiosurgery ,medicine.medical_specialty ,medicine.medical_treatment ,Radiosurgery ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Recurrence ,parasitic diseases ,medicine ,Stereotactic radiosurgery ,Cause of death ,Clinical Article ,Functional ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Mortality rate ,Cancer ,Magnetic resonance imaging ,medicine.disease ,Radiation therapy ,030220 oncology & carcinogenesis ,Surgery ,Neurology (clinical) ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
Objective We investigated the outcomes of repeat stereotactic radiosurgery (SRS) for metastatic brain tumors that locally recurred despite previous SRS, focusing on the tumor control. Methods A total of 114 patients with 176 locally recurring metastatic brain tumors underwent repeat SRS after previous SRS. The mean age was 59.4 years (range, 33 to 85), and there were 68 male and 46 female patients. The primary cancer types were non-small cell lung cancer (n=67), small cell lung cancer (n=12), gastrointestinal tract cancer (n=15), breast cancer (n=10), and others (n=10). The number of patients with a single recurring metastasis was 95 (79.8%), and another 19 had multiple recurrences. At the time of the repeat SRS, the mean volume of the locally recurring tumors was 5.94 mL (range, 0.42 to 29.94). We prescribed a mean margin dose of 17.04 Gy (range, 12 to 24) to the isodose line at the tumor border primarily using a 50% isodose line. Results After the repeat SRS, we obtained clinical and magnetic resonance imaging follow-up data for 84 patients (73.7%) with a total of 108 tumors. The tumor control rate was 53.5% (58 of the 108), and the median and mean progression-free survival (PFS) periods were 246 and 383 days, respectively. The prognostic factors that were significantly related to better tumor control were prescription radiation dose of 16 Gy (p=0.000) and tumor volume less than both 4 mL (p=0.001) and 10 mL at the repeat SRS (p=0.008). The overall survival (OS) periods for all 114 patients after repeat SRS varied from 1 to 56 months, and median and mean OS periods were 229 and 404 days after the repeat SRS, respectively. The main cause of death was systemic problems including pulmonary dysfunction (n=58, 51%), and the identified direct or suspected brain-related death rate was around 20%. Conclusion The tumor control following repeat SRS for locally recurring metastatic brain tumors after a previous SRS is relatively lower than that for primary SRS. However, both low tumor volume and high prescription radiation dose were significantly related to the tumor control following repeat SRS for these tumors after previous SRS, which is a general understanding of primary SRS for metastatic brain tumors.
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- 2018
33. Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma
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Koeun Kim, Won-Jin Kim, Jae-Young Park, Jung Hwan Yoon, Jihye Kim, Yuri Cho, and Min Ji Park
- Subjects
Male ,Small interfering RNA ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Apoptosis ,Pancreatitis-Associated Proteins ,Catalysis ,Article ,crosstalk ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Downregulation and upregulation ,medicine ,Hepatic Stellate Cells ,Tumor Microenvironment ,stroma ,Animals ,Humans ,Physical and Theoretical Chemistry ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,hepatic stellate cell ,Platelet-Derived Growth Factor ,Microarray analysis techniques ,Chemistry ,Growth factor ,Organic Chemistry ,Liver Neoplasms ,General Medicine ,Hep G2 Cells ,hepatocellular carcinoma ,HCCS ,REG3A ,digestive system diseases ,Computer Science Applications ,Up-Regulation ,Crosstalk (biology) ,lcsh:Biology (General) ,lcsh:QD1-999 ,030220 oncology & carcinogenesis ,Hepatic stellate cell ,Cancer research ,030211 gastroenterology & hepatology ,Signal Transduction - Abstract
Background: Crosstalk between tumors and their microenvironment plays a crucial role in the progression of hepatocellular carcinoma (HCC). However, there is little existing information about the key signaling molecule that modulates tumor-stroma crosstalk. Methods: Complementary DNA (cDNA) microarray analysis was performed to identify the key molecule in tumor-stroma crosstalk. Subcutaneous xenograft in vivo murine model, immunoblotting, immunofluorescence, and real-time polymerase chain reaction using HCC cells and tissues were performed. Results: The key molecule, regenerating gene protein-3A (REG3A), was most significantly enhanced when coculturing HCC cells and activated human hepatic stellate cells (HSCs) (+8.2 log) compared with monoculturing HCC cells using cDNA microarray analysis. Downregulation of REG3A using small interfering RNA significantly decreased the proliferation of HSC-cocultured HCC cells in vitro and in vivo, and enhanced deoxycholic acid-induced HCC cell apoptosis. Crosstalk-induced REG3A upregulation was modulated by platelet-derived growth factor &beta, &beta, (PDGF-&beta, ) in p42/44-dependent manner. REG3A mRNA levels in human HCC tissues were upregulated 1.8-fold compared with non-tumor tissues and positively correlated with PDGF-&beta, levels. Conclusions: REG3A/p42/44 pathway/PDGF-&beta, signaling plays a significant role in hepatocarcinogenesis via tumor-stroma crosstalk. Targeting REG3A is a potential novel therapeutic target for the management of HCCs by inhibiting crosstalk between HCC cells and HSCs.
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- 2019
34. Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia
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Jin Hyeong Jhoo, Hyeon Jang Jeong, Seok Bum Lee, Ki Woong Kim, Ji Won Han, Jung Jae Lee, Seungho Ryu, Ju Ri Lee, Jae Young Park, Kayoung Kim, Dong Woo Lee, Seung Wan Suh, Taehyun Kim, Jeong Lan Kim, Bong Jo Kim, Jong Woo Hong, Shin Gyeom Kim, Yoonseop So, Jong Chul Youn, Tae Hui Kim, Kyoung Hwan Lee, Seok Woo Moon, Dong Young Lee, Seonjeong Byun, Joon Hyuk Park, Kyuhee Han, Kyung Phil Kwak, Hyun Ghang Jeong, and Ji Young Seo
- Subjects
Biopsychosocial model ,Gerontology ,Longitudinal study ,medicine.medical_specialty ,Activities of daily living ,Population ,Community ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Epidemiology ,medicine ,Dementia ,030212 general & internal medicine ,education ,Multicenter ,Biological Psychiatry ,education.field_of_study ,Korea ,business.industry ,Cognitive ageing ,Mild cognitive impairment ,medicine.disease ,Psychiatry and Mental health ,Prospective ,Longitudinal ,Original Article ,business ,Cohort study ,030217 neurology & neurosurgery - Abstract
Objective Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions. Methods The KLOSCAD is the first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled from residents aged 60 years or older who lived in 13 districts across South Korea. In the baseline assessment, which was conducted from November 2010 through October 2012, 6,818 (53.7%) individuals participated. Follow-up assessments have been conducted every two years, with the first follow-up assessment conducted between November 2012 and October 2014, and the second between November 2014 and October 2016. The third is now in progress, and will span from November 2016 to October 2018. Diagnosis of cognitive disorders, neuropsychological battery, behavioral and psychological symptoms of dementia, activities of daily living, physical and neurologic examination and laboratory tests, life styles, quality of life, and identification of death were evaluated in each assessment. Results The cumulative drop-out rate at the second follow-up assessment was 38.7%. Dementia and mild cognitive impairment were 5.0% and 27.0%, respectively. Conclusion The KLOSCAD may provide strong scientific evidence for advancing the fight against dementia both in Korea and globally.
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- 2018
35. The amount of displacement can determine non-operative treatment in posterior cruciate ligament avulsion fracture
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Sang-Gyun Kim, Jae-Young Park, and Kyoung Ho Yoon
- Subjects
Adult ,Male ,medicine.medical_specialty ,Conservative Treatment ,Avulsion ,03 medical and health sciences ,0302 clinical medicine ,Fracture Fixation ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Displacement (orthopedic surgery) ,Treatment Failure ,Retrospective Studies ,030222 orthopedics ,Receiver operating characteristic ,business.industry ,Avulsion fracture ,technology, industry, and agriculture ,Non operative treatment ,030229 sport sciences ,Lysholm Knee Score ,Middle Aged ,equipment and supplies ,musculoskeletal system ,medicine.disease ,Magnetic Resonance Imaging ,Fracture displacement ,Surgery ,Radiography ,Tibial Fractures ,medicine.anatomical_structure ,Fractures, Avulsion ,Posterior cruciate ligament ,Orthopedic surgery ,Female ,Posterior Cruciate Ligament ,business - Abstract
It is generally agreed that surgical treatment is warranted for acute posterior cruciate ligament (PCL) avulsion fracture with displacement. However, the amount of displacement that warrants surgical treatment has not been defined. The purpose of this study was to determine the optimal cut-off value for displacement of posterior cruciate ligament avulsion fracture in determining non-operative treatment and to compare the results of non-operative treatment in acute isolated PCL avulsion fractures with non-operative treatment of acute PCL injury. Between 2007 and 2017, 30 consecutive patients with acute isolated PCL avulsion fractures and 70 consecutive patients with acute isolated PCL injuries, all of whom underwent non-operative treatment (cast immobilization with > 2 years of follow-up) were retrospectively analyzed. Clinical scores including the International Knee Documentation Committee subjective score, Lysholm score, and Tegner activity score, as well as side-to-side differences on stress radiographs, were compared between the PCL avulsion fracture and PCL injury groups at the final follow-up. The failure rates of non-operative treatment were also compared. The predictive value of the amount of fracture displacement for successful non-operative treatment was calculated using area under the receiver operating characteristic curve (AUROC). The optimal cut-off of the amount of fracture displacement to determine non-operative treatment was based on the maximal sum of sensitivity and specificity. The two groups exhibited comparable clinical scores and mean side-to-side differences on stress radiographs. There were 5 (16.6%) failures of non-operative treatment in the PCL avulsion fracture group and 19 (27.1%) failures in the PCL injury group. (n.s) There was a significant positive correlation between the amount of initial avulsion fracture displacement and side-to-side difference in posterior stress radiographs at final follow up (P
- Published
- 2019
36. Does mirabegron relieve ureteric stent-related discomfort? A prospective, randomized, multicentre study
- Author
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Byung Jo Jeon, Keon-Cheol Lee, Bum Sik Tae, Sung Yong Cho, Jae Hyun Bae, Jae Young Park, Seok Cho, and Hoon Choi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Ureteral Calculi ,Urology ,Urinary system ,medicine.medical_treatment ,030232 urology & nephrology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Humans ,Medicine ,Prospective Studies ,Ureteric stent ,Aged ,Pain, Postoperative ,business.industry ,Stent ,Middle Aged ,Thiazoles ,Treatment Outcome ,030220 oncology & carcinogenesis ,Urological Agents ,Acetanilides ,Female ,Stents ,International Prostate Symptom Score ,General health ,Ureter ,business ,Mirabegron ,Symptom score ,medicine.drug - Abstract
Objectives To evaluate the effects of 50 mg mirabegron once daily for ureteric stent-related discomfort after ureteroscopic procedures by conducting a multicentre randomized study. Patients and methods A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either no treatment or mirabegron during the stenting period. At the time of stent removal, the validated Ureteral Stent Symptom Questionnaire (USSQ), International Prostate Symptom Score (IPSS), total amount of analgesics administered, and post-voiding residual urine volume were reported for each patient. Results Overall, 96 patients were enrolled for analysis. The postoperative USSQ body pain score (21.96 vs 13.96; P = 0.007) and overall pain score (5.58 vs 2.83; P = 0.002) were lower in the mirabegron group than in the control group. The USSQ urinary symptom scores (32.58 vs 27.92; P = 0.582) and USSQ general health score (17.71 vs 14.00; P = 0.281) were also lower in the mirabegron group, but the difference was not significant. Postoperative IPSS total scores and quality-of-life scores were lower in the mirabegron group, but the difference was not significant. The change in IPSS storage symptom score, however, was lower in the mirabegron group than in the control group (3.58 ± 3.58 vs 1.83 ± 4.39; P = 0.035). Post-void residual urine volume did not differ between the two groups (P > 0.05). Conclusion The use of 50 mg mirabegron once daily has the potential to reduce ureteric stent-related discomfort. Prospective larger-scale, placebo-controlled studies are warranted to further evaluate the beneficial effects of mirabegron on stent-related symptoms.
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- 2018
37. Prevalence and Risk Factors of Abusive Behaviors in the Caregivers of People with Dementia in Korea
- Author
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Dong Young Lee, Ki Woong Kim, Joon Hyuk Park, Hyeon Jeong, Ji Won Han, Jae Young Park, Jung Won Lee, Jin Hyeong Jhoo, Taehyun Kim, Seok Woo Moon, Shin Kyeom Kim, Jong Chul Youn, Tae Hui Kim, Jae Nam Bae, Kyung Phil Kwak, Dong Woo Lee, Jeong Lan Kim, Jung Jae Lee, Seungho Ryu, Bong Jo Kim, and Seok Bum Lee
- Subjects
Moderate to severe ,Conflict tactics scale ,Low income ,business.industry ,Family caregivers ,medicine.disease ,Abuse ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Risk factors ,Prevalence ,Asian country ,Medicine ,Dementia ,Original Article ,030212 general & internal medicine ,Past Three Months ,business ,030217 neurology & neurosurgery ,Biological Psychiatry ,dementia ,Clinical psychology - Abstract
Objective We investigated the prevalence and risk factors of physically abusive behaviors (PhAB) and psychologically abusive behaviors (PsAB) towards people with dementia (PWD) in family caregivers, and compared their prevalences between East Asian and Western countries. Methods We estimated the prevalence and risk factors of PhAB and PsAB in 467 Korean pairs of community-dwelling PWD and their primary family caregivers. We evaluated abusive behaviors using the Modified Conflict Tactics Scale. In addition, we compared the prevalence of abusive behaviors between Asian and Western countries through a meta-analysis on 12 studies including the current one. Results More than a half of the caregivers reported PsAB and about one out of seven caregivers admitted PhAB within past three months. PsAB and PhAB were slightly more prevalent in East Asian countries than in Western countries. Non-Alzheimer type and moderate to severe behavioral and psychological symptoms of dementia were associated with the risk of PhAB but not with the risk of PsAB. Severe care burden and low income were associated with the risk of PhAB and PsAB. Conclusion PhAB and PsAB were as prevalent in the family caregivers of PWD in Asian countries including Korea as in Western countries. Prevention strategies should be implemented according to the type of abusive behaviors.
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- 2018
38. Correlation of Androgen Deprivation Therapy with Cognitive Dysfunction in Patients with Prostate Cancer: A Nationwide Population-Based Study Using the National Health Insurance Service Database
- Author
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Bum Sik Tae, Seung Hun Shin, Byung Jo Jeon, Hoon Choi, Jae Young Park, and Jae Hyun Bae
- Subjects
0301 basic medicine ,Male ,Cancer Research ,Databases, Factual ,National Health Programs ,Population ,Prostate neoplasm ,Comorbidity ,Kaplan-Meier Estimate ,Androgen deprivation therapy ,computer.software_genre ,Risk Assessment ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Cognitive dysfunction ,Risk Factors ,Republic of Korea ,medicine ,Dementia ,Humans ,Public Health Surveillance ,Prospective cohort study ,education ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,education.field_of_study ,Database ,business.industry ,Hazard ratio ,Prostatic Neoplasms ,Androgen Antagonists ,Middle Aged ,medicine.disease ,Patient Outcome Assessment ,030104 developmental biology ,Oncology ,Nationwide population-based study ,030220 oncology & carcinogenesis ,Cohort ,Original Article ,business ,computer ,Follow-Up Studies - Abstract
Purpose The purpose of this study was to evaluate the association of androgen deprivation therapy (ADT) with cognitive dysfunction. Materials and methods Using the National Health Insurance Service database of the entire Korean adult prostate cancer population (n=236,391), data on ADT and cognitive dysfunction between 2008 and 2015 were analyzed. We excluded patients previously diagnosed with cognitive dysfunction, dementia, or a cerebral event history. We tested the effect of ADT on the risk of cognitive dysfunction using propensity score-matched Cox proportional hazards regression models and Kaplan-Meier survival analysis. Our final cohort comprised of 35,401 individuals with prostate cancer, including 24,567 men (70.6%) who underwent ADT. Results During a mean follow-up period of 4.1 years, 4,741 patients were newly diagnosed with cognitive dysfunction. A statistically significant association was found between ADT and the risk of cognitive dysfunction (hazard ratio, 1.169; p=0.002). Meanwhile, age (≥ 70 years), diabetes, hypertension, cardiovascular history, and peripheral vascular disease were identified as factors that contribute to the increased risk of cognitive dysfunction. In contrast, the use of statins and aspirin was associated with a lower risk of cognitive dysfunction. Kaplan-Meier analysis demonstrated that patients aged 70 years or older who underwent ADT had the lowest cumulative probability of remaining cognitive dysfunction-free (log-rank p Conclusion Our. Results revealed an association between the use of ADT for the treatment of prostate cancer and an increased risk of cognitive dysfunction in a nationwide population-based study. This finding should be further evaluated in prospective studies.
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- 2018
39. Comparative Antioxidant Activity and Structural Feature of Protocatechuic Acid and Phenolic Acid Derivatives by DPPH and Intracellular ROS
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Ho Joong Kim, Woong Kim, Jae Young Park, Hyeonsook Cheong, and Beomgi Lee
- Subjects
0301 basic medicine ,030109 nutrition & dietetics ,Antioxidant ,DPPH ,medicine.medical_treatment ,Pharmaceutical Science ,Phenolic acid ,Protocatechuic acid ,03 medical and health sciences ,chemistry.chemical_compound ,chemistry ,Biochemistry ,Feature (computer vision) ,Drug Discovery ,medicine ,Molecular Medicine ,Organic chemistry ,Intracellular - Published
- 2018
40. Successful anterior cruciate ligament reconstruction and meniscal repair in osteogenesis imperfecta
- Author
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Hyuk Soo Han, Myung Chul Lee, Jae-Young Park, and Tae Joon Cho
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Anterior cruciate ligament reconstruction ,medicine.medical_treatment ,Anterior cruciate ligament ,Knee Injuries ,Menisci, Tibial ,Bone-Patellar Tendon-Bone Grafting ,Arthroscopy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Dentinogenesis Imperfecta ,medicine ,Humans ,Transplantation, Homologous ,Orthopedics and Sports Medicine ,Anterior Cruciate Ligament ,Rupture ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,Sutures ,biology ,business.industry ,Anterior Cruciate Ligament Injuries ,030229 sport sciences ,Osteogenesis Imperfecta ,musculoskeletal system ,medicine.disease ,biology.organism_classification ,Tibial Meniscus Injuries ,Surgery ,Meniscal repair ,body regions ,Valgus ,surgical procedures, operative ,medicine.anatomical_structure ,Osteogenesis imperfecta ,Orthopedic surgery ,Female ,Absorbable sutures ,business ,human activities ,Medial meniscus - Abstract
A case of anterior cruciate ligament (ACL) reconstruction with meniscal repair in an osteogenesis imperfecta patient is reported. A 24-year-old female with osteogenesis imperfecta type 1a suffered from a valgus extension injury resulting in tear of ACL and medial meniscus. She underwent an arthroscopic-assisted ACL reconstruction and medial meniscus repair. Meniscal tear at the menisco-capsular junction of the posterior horn of medial meniscus was repaired with three absorbable sutures via inside-out technique. ACL reconstruction was then performed with a bone-patellar tendon-bone allograft. The patient was followed up for 1 year with intact ACL grafts and healed medial meniscus. This case report showed that successful ACL reconstruction and meniscal repair is possible in an osteogenesis imperfecta patient. Level of evidence V.
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- 2018
41. The effects of a heating pad on anxiety, pain, and distress during urodynamic study in the female patients with stress urinary incontinence
- Author
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Hyun Ju Kim, Seok Ho Kang, Jong Wook Kim, Mi Mi Oh, Jun Cheon, Jeong Gu Lee, Du Geon Moon, Sung G. Kang, Young Joo Park, Jae Young Park, Jae Hyun Bae, Je Jong Kim, and Hong Seok Park
- Subjects
Adult ,Hot Temperature ,Visual Analog Scale ,Visual analogue scale ,Urinary Incontinence, Stress ,Urology ,030232 urology & nephrology ,Diastole ,Pain ,Urinary incontinence ,Anxiety ,03 medical and health sciences ,0302 clinical medicine ,Heating pad ,Female patient ,Humans ,Pain Management ,Medicine ,Aged ,030219 obstetrics & reproductive medicine ,business.industry ,Diagnostic Techniques, Urological ,Middle Aged ,Urodynamics ,Distress ,Blood pressure ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Stress, Psychological - Abstract
AIMS Although generally well tolerated, a urodynamic study is an unpleasant and stressful procedure for some patients. This study evaluated the effects of a heating pad on anxiety, pain, and distress during urodynamic studies in female patients with stress urinary incontinence. METHODS A total of 74 female patients with stress urinary incontinence who underwent a urodynamic study between May 2015 and October 2015 were randomized to either the experimental group using a heating pad (n = 37) or control group (n = 37). In the experimental group, a heating pad was applied on the patient's sacrum during the urodynamic study. All patients completed the State-Trait Anxiety Inventory (20-80) before and after the procedure and assessed their degree of pain and distress after the procedure by the visual analog scale (0-10). Systolic and diastolic blood pressure and pulse rate were also checked before and after the procedure. RESULTS Demographic characteristics, mean age, procedure duration, pre and post-procedural systolic, and diastolic blood pressures, and pulse rate were statistically similar between the experimental and control groups. The mean State-Trait Anxiety Inventory was significantly lower in the experimental group than in the control group (30.9 ± 7.5 vs 42.5 ± 10.1, P
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- 2018
42. Gait Variability Can Predict the Risk of Cognitive Decline in Cognitively Normal Older People
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Ji Young Seo, Ki Woong Kim, Ji Won Han, Seung Wan Suh, Hyeon Jeong, Jong Woo Hong, Hyun Ghang Jeong, Kayoung Kim, Kyoung Hwan Lee, Taehyun Kim, Yoonseop So, Kyuhee Han, Ju Ri Lee, Tae Hui Kim, Jae Young Park, and Seonjeong Byun
- Subjects
Male ,Aging ,medicine.medical_specialty ,Multivariate analysis ,Cognitive Neuroscience ,Apolipoprotein E4 ,03 medical and health sciences ,0302 clinical medicine ,Gait (human) ,Physical medicine and rehabilitation ,Risk Factors ,Rating scale ,medicine ,Humans ,Cognitive Dysfunction ,Prospective Studies ,030212 general & internal medicine ,Cognitive decline ,Prospective cohort study ,Gait ,Alleles ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,business.industry ,Parkinsonism ,Hazard ratio ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Multivariate Analysis ,Female ,Geriatrics and Gerontology ,Older people ,business ,human activities ,030217 neurology & neurosurgery - Abstract
Background: The aim of this study was to investigate the association of gait speed and gait variability, an index of how much gait parameters, such as step time, fluctuate step-to-step, with risk of cognitive decline in cognitively normal elderly individuals. While high gait variability is emerging as an early indicator of dementing illnesses, there is little research on whether high gait variability predicts cognitive decline in cognitively normal elderly who have no evidence of cognitive impairment. Methods: In this 4-year prospective cohort study on 91 community-dwelling cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism, we evaluated gait speed and step time variability using a tri-axial accelerometer placed on the center of body mass, and diagnosed mild cognitive impairment (MCI) according to the International Working Group on MCI. We performed Kaplan-Meier analysis with consecutive log-rank testing for MCI-free survival by cohort-specific tertiles of gait speed; hazard ratios (HR) of incident MCI were estimated using Cox proportional hazards regression analysis adjusted for age, sex, education level, Cumulative Illness Rating Scale score, GDS score, and presence of the apolipoprotein E ε4 allele. Results: Out of the 91 participants in the baseline assessment, 87 completed one or more 2-year follow-up assessments, and the median duration of follow-up was 47.1 months. Kaplan-Meier curves of incident MCI show evident differences in risk by gait variability group (χ2 = 9.64, p = 0.002, log-rank test). Mean MCI-free survival in the high variability group was 12% shorter than in the mid-to-low tertile group (47.4 ± 1.74 [SD] vs. 54.04 ± 0.52 months), while it was comparable between gait speed groups (51.59 ± 0.70 vs. 50.64 ± 1.77 months; χ2 = 1.16, p = 0.281). In multivariate analysis, subjects with high gait variability showed about 12-fold higher risk of MCI (HR = 11.97, 95% CI = 1.29–111.37) than those with mid-to-low variability. However, those with slow gait speed showed comparable MCI risk to those with mid-to-high speed (HR = 5.04, 95% CI = 0.53–48.18). Conclusions: Gait variability may be a better predictor of cognitive decline than gait speed in cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism.
- Published
- 2018
43. Ten New Recorded Species of Macrofungi on Ulleung Island, Korea
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Changmu Kim, Hyun Lee, Ki Hyeong Park, Young Woon Lim, Hae Jin Cho, Min Ji Kim, Jae Young Park, Nam Kyu Kim, Jae Jin Kim, and Myung Soo Park
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0301 basic medicine ,Phylogenetic tree ,biology ,ved/biology ,Indigenous fungal species ,ved/biology.organism_classification_rank.species ,Zoology ,030108 mycology & parasitology ,biology.organism_classification ,Microbiology ,Phlebia radiata ,Biodiversity hotspot ,New record ,03 medical and health sciences ,Internal transcribed spacer ,Infectious Diseases ,Deconica ,Mycena zephirus ,Ulleung Island ,Pluteus ,Phaeomarasmius ,Research Article - Abstract
Ulleung Island is a biodiversity hotspot in South Korea. During a survey of indigenous fungal species from Ulleung Island conducted from 2015 to 2016, we discovered 10 unrecorded macrofungi in Korea. These macrofungi were identified to the species level using morphological features and phylogenetic analysis based on the internal transcribed spacer region: Deconica phyllogena, Mycena zephirus, Phaeomarasmius proximans, Phlebia radiata, Pluteus semibulbosus, Postia alni, Resinicium pinicola, Scytinostroma portentosum, Tricholomopsis flammula, and Tyromyces kmetii. We also provide detailed morphological descriptions for these 10 species.
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- 2017
44. Regulation of the Endoplasmic Reticulum Stress by BIP/GRP78 is involved in Meiotic Maturation of Porcine Oocytes In Vitro
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Jin-Woo Kim, Jae-Min Jung, Deog-Bon Koo, Seul-Gi Yang, Joung Jun Park, Hyo-Jin Park, Jae-Young Park, and Min-Ji Kim
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0301 basic medicine ,030103 biophysics ,Small interfering RNA ,biology ,Chemistry ,Endoplasmic reticulum ,Tauroursodeoxycholic acid ,UPR ,Oocyte ,Cell biology ,In vitro maturation ,Blot ,Original Research Paper ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,medicine.anatomical_structure ,BIP/GRP78 ,Unfolded protein response ,biology.protein ,medicine ,Porcine oocyte ,Binding immunoglobulin protein ,ER stress - Abstract
In the present study, we investigated the role of binding immunoglobulin protein/glucose-regulated protein, 78-kDa (BIP/GRP78)-regulated endoplasmic reticulum (ER)-stress on meiotic maturation and cumulus cells expansion in porcine cumulus-oocyte complexes (COCs). Previously, it has been demonstrated that unfolded protein response (UPR)-related genes, such as molecules involved in ER-stress defense mechanisms, were expressed in matured oocytes and cumulus cells during in vitro maturation (IVM) of porcine oocytes. However, BIP/GRP78-mediated regulation of ER stress in porcine oocytes has not been reported. Firstly, we observed the effects of knockdown of BIP/GRP78 (an UPR initiation marker) using porcine-specific siRNAs (#909, #693, and #1570) on oocyte maturation. Among all siRNAs, siRNA #693 significantly reduced the protein levels of UPR marker proteins (BIP/GRP78, ATF4, and P90ATF6) in porcine COCs observed by Western blotting and immunofluorescence analysis. We also observed that the reduction of BIP/GRP78 levels by siRNA#693 significantly inhibited the meiotic maturation of oocytes (siRNA #693: 32.5±10.1% vs control: 77.8±5.3%). In addition, we also checked the effect of ER-stress inhibitors, tauroursodeoxycholic acid (TUDCA, 200 μM) and melatonin (0.1 μM), in BIP/ GRP78-knockdown oocytes. TUDCA and melatonin treatment could restore the expression levels of ER-stress marker proteins (BIP/GRP78, p-eIF2α, eIF2α, ATF4, and P90ATF6) in siRNA #693-transfected matured COCs. In conclusion, these results demonstrated that BIP/GRP78-mediated regulation of UPR signaling and ER stress plays an important role in in vitro maturation of porcine oocytes.
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- 2017
45. Ruptured choroidal artery aneurysms in patients with moyamoya disease: Two case series and review of the literatures
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Sung-Pil Joo, You-Sub Kim, Sang-Deok Kim, Gwang-Jun Lee, Jae Young Park, and Tae-Sun Kim
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Hemodynamics ,Aneurysm, Ruptured ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Physiology (medical) ,medicine ,Humans ,In patient ,cardiovascular diseases ,030216 legal & forensic medicine ,Moyamoya disease ,Embolization ,Coil embolization ,business.industry ,Intracranial Aneurysm ,General Medicine ,Clipping (medicine) ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Neurology ,cardiovascular system ,Female ,Neurology (clinical) ,Radiology ,Choroidal artery ,Moyamoya Disease ,business ,030217 neurology & neurosurgery - Abstract
Distal peripheral artery aneurysms in moyamoya disease (MMD) remain difficult to treat given their deep location, small size, and fragility. Here, we report two cases of choroidal artery aneurysms associated with MMD who were treated through direct clipping and coil embolization. Timing of aneurysm formation remains unclear, however, annual follow-up DSA for surveillance of hemodynamic status is necessary and prompt treatment of aneurysm should be performed when diagnosed. Moreover, choroidal artery aneurysms may benefit from endovascular coil embolization due to their characteristics.
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- 2017
46. Clinicopathologic Characteristics and Prognosis of Xp11.2 Translocation Renal Cell Carcinoma: Multicenter, Propensity Score Matching Analysis
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Min Soo Choo, Chang Wook Jeong, Cheryn Song, Hwang Gyun Jeon, Seong Il Seo, Sung Kyu Hong, Seok-Soo Byun, Jin Soo Chung, Sung-Hoo Hong, Eu Chang Hwang, Hyeon Hoe Kim, Cheol Kwak, Jae Young Park, and Ill Young Seo
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Late onset ,Gastroenterology ,Translocation, Genetic ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,medicine ,Carcinoma ,Humans ,Age of Onset ,Propensity Score ,Carcinoma, Renal Cell ,Survival analysis ,Aged ,Chromosomes, Human, X ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Age Factors ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Kidney Neoplasms ,eye diseases ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,Age of onset ,business - Abstract
Background We evaluated the clinicopathologic characteristics and prognosis of Xp11.2 translocation (Xp11.2t) renal cell carcinoma (RCC) from a multicenter study and compare them with clear-cell RCC using a propensity score matching analysis. Patients and Methods Between 2004 and 2013, 8384 consecutive patients from 7 institutions who were diagnosed with RCC were reviewed, and the pathologically confirmed Xp11.2t cases were enrolled. The oncological outcomes of Xp11.2t were compared with those of clear-cell RCC by selecting matched cases using 1:3 propensity score matching methods in a precollected clear-cell RCC data set from our hospital. The patients were divided into 2 subgroups on the basis of age of onset, either before (early) or after (late) 45 years old. Results Xp11.2t was found in 61 cases, corresponding to 0.72% of RCC cases for the 10 years. The mean age was 38.2 ± 19.4 years, and the mean tumor size was 6.2 ± 3.9 cm. The Xp11.2t cases were at more advanced stages and showed tendencies to involve lymph nodes at diagnosis. After the matching, there were no significant differences in recurrence-free and overall survival compared with clear-cell RCC. The age of incidence for Xp11.2t had a bimodal distribution, which was most common in the 30s and smaller peak in the 60s. Xp11.2t corresponded to a significantly worse prognosis for overall survival in late onset (after 45 years) subgroup ( P = .038; hazard ratio, 3.199; 95% confidence interval, 1.065-9.609). Conclusion This neoplasm has more aggressive clinicopathologic features at diagnosis. In older patients with onset age > 45 years, Xp11.2t showed a significantly worse prognosis than clear-cell RCC.
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- 2017
47. Efficacy and safety of silodosin in the treatment of lower urinary tract symptoms in elderly men taking antihypertensive medications
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Woo Suk Choi, Jeong Woo Lee, Min Chul Cho, Sang Wook Lee, Jae Young Park, Sung Yong Cho, Sang Hoon Song, and Jin Kyu Oh
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medicine.medical_specialty ,Urology ,Population ,Orthostatic ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Adrenergic Alpha Antagonists ,lcsh:RC870-923 ,03 medical and health sciences ,Orthostatic vital signs ,0302 clinical medicine ,Quality of life ,Lower urinary tract symptoms ,Internal medicine ,Medicine ,Ejaculation ,education ,education.field_of_study ,Hyperplasia ,business.industry ,Silodosin ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Discontinuation ,Prostatic ,Blood pressure ,Anesthesia ,Hypertension ,International Prostate Symptom Score ,Original Article ,Hypotension ,business ,medicine.drug - Abstract
Background Both hypertension and lower urinary tract symptoms (LUTS) are common conditions in the elderly population. This study investigated the efficacy and safety of silodosin in the treatment of LUTS in elderly men who were taking antihypertensive medications. Methods This is an observational study which collected the medical records of patients who started silodosin medication for their LUTS between April 2015 and December 2015. Inclusion criteria were age ≥ 65 years, currently taking antihypertensive medication, and International Prostate Symptom Score (IPSS) ≥ 8. Pretreatment evaluation included IPSS, Male Sexual Health Questionnaire, systemic symptoms, blood pressure, and uroflowmetry. Post-treatment evaluation was performed 3 months after the initial administration of silodosin medication. Results Mean age of the total 48 patients was 70.7 ± 5.2 years. Thirty-two (66.7%) patients who continued silodosin single treatment showed a significant decrease in IPSS Quality of life scores (4.2 ± 1.1 vs. 3.0 ± 1.6, P = 0.001) and an increase in the maximum flow rate (10.7 ± 6.0 mL/s vs. 14.0 ± 4.5 mL/s, P = 0.001). Blood pressures did not change, and none of the patients needed to adjust their antihypertensive medication. New development of orthostatic hypotension was observed in one (2.5%) patient. Among the six patients who had orthostatic hypotension before silodosin treatment, none of the patients showed symptom aggravation. Ejaculatory dysfunction that required discontinuation of silodosin medication developed in only one (2.5%) patient. Conclusion Silodosin is an effective and safe agent in elderly men who are taking antihypertensive medications. Silodosin has an advantage in the treatment of LUTS in this population, even if the patients have orthostatic hypotension before treatment.
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- 2017
48. Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission
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Kyu-Tae Chang, Seung-Bin Yoon, Sun-Uk Kim, Seul-Gi Yang, Deog-Bon Koo, Jae-Hyun Ahn, Jin-Woo Kim, Chang-Hyun Kim, Hyo-Jin Park, Soo-Yong Park, and Jae-Young Park
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Dynamins ,0301 basic medicine ,animal structures ,Swine ,Biology ,Mitochondrial Dynamics ,03 medical and health sciences ,DNM1L ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Animals ,Blastocyst ,Molecular Biology ,Superoxide ,Embryogenesis ,Embryo ,Cell Biology ,Tyrphostins ,Molecular biology ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Apoptosis ,030220 oncology & carcinogenesis ,embryonic structures ,Molecular Medicine ,Female ,Mitochondrial fission ,Tyrphostin A9 - Abstract
Mitochondrial dynamics are associated with the development of porcine embryos. However, little is known about the effects of mitochondrial dynamics-related genes (Drp1 and pDrp1-Ser616) on early porcine embryo development. Here, we investigated the effect of Drp1-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, tyrphostin A9 (TA9). We determined that TA9 (1μM) treated embryos were increased the mitochondrial functions, blastocyst development rate and quality, as well as decreased mitochondria-specific superoxide and mitochondrial apoptosis. Thus, TA9-induced appropriate mitochondrial fission improved the developmental competence via maintenance of a balance in mitochondrial dynamics in porcine embryo.
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- 2017
49. Contralateral Hemispheric Brain Atrophy After Primary Intracerebral Hemorrhage
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Sang-Deok Kim, Tae-Sun Kim, Sung-Pil Joo, Sung-Hyun Kim, Jae Young Park, You-Sub Kim, and Ju-Hwi Kim
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Adult ,Male ,0301 basic medicine ,Functional Laterality ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Cerebrospinal fluid ,Hematoma ,medicine ,Foramen ,Humans ,Glasgow Coma Scale ,Septum pellucidum ,Aged ,Cerebral Hemorrhage ,Retrospective Studies ,Intracerebral hemorrhage ,business.industry ,Age Factors ,Brain ,Middle Aged ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Ventricle ,Anesthesia ,Female ,Surgery ,Neurology (clinical) ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,030217 neurology & neurosurgery - Abstract
In patients with intracerebral hematoma (ICH), it is well known that brain atrophy occurs in the hemisphere ipsilateral to the hematoma. The present study aimed to investigate contralateral hemispheric volume changes in patients with ICH as well as related factors.Of 112 patients with ICH who were surgically treated at our hospital between January 2011 and December 2015, 44 were included in the present study. We measured contralateral hemispheric brain areas in 3 planes of axial brain computed tomography images. We obtained the proportion of contralateral hemispheric parenchyma to the hemispheric intracranial area to adjust for individual differences in head size. We analyzed the relationship between various factors and volume changes in the contralateral hemisphere.The average volume percentages of preoperative and follow-up contralateral hemispheric parenchyma were 92.3% versus 88.8%, 90.3% versus 85.3%, and 86.9% versus 82.5% in the level of foramen of Monro, septum pellucidum, and lateral ventricle, respectively. These decreases were all statistically significant (paired t-test; P 0.001). As far as the causes of these decreases, the presence of intraventricular hematoma was the most significant factor for a decrease (P = 0.006). Glasgow coma scale score on arrival, as well as, smoking were independent factors in a multivariate analysis (P = 0.016, 0.039).Contralateral parenchymal volumes were significantly decreased at the 3-month follow-up brain computed tomography scan. These findings may offer important clinical information on the remote brain injury of ICH.
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- 2017
50. Does uneven geographic distribution of urologists effect bladder and prostate cancers mortality? National health insurance data in Korea from 2007-2011
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Jae Young Park, Young Myoung Ko, Jae Heon Kim, Hyun Jung Kim, Dong Il Chun, and Hwa Yeon Sun
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medicine.medical_specialty ,urologic and male genital diseases ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,urologist density ,medicine ,030212 general & internal medicine ,Preventive healthcare ,Gynecology ,Univariate analysis ,Bladder cancer ,business.industry ,Mortality rate ,Incidence (epidemiology) ,Cancer ,Ecological study ,prostate cancer ,medicine.disease ,mortality ,female genital diseases and pregnancy complications ,Oncology ,030220 oncology & carcinogenesis ,bladder cancer ,business ,Research Paper ,Demography - Abstract
// Jae Heon Kim 1 , Hwa Yeon Sun 1 , Hyun Jung Kim 2 , Young Myoung Ko 3 , Dong-Il Chun 4 and Jae Young Park 5 1 Department of Urology, Soonchunhyang University Hospital, Soonchuhyang University Medical College, Seoul, Korea 2 Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea 3 Department of Industrial and Management Engineering, Pohang University of Science and Technology, Pohang, Korea 4 Department of Orthopaedics, Soonchunhyang University Hospital, Soonchuhyang University Medical College, Seoul, Korea 5 Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea Correspondence to: Jae Heon Kim, email: piacekjh@hanmail.net Jae Young Park, email: jaeyoungpark@korea.ac.kr Keywords: urologist density, bladder cancer, prostate cancer, mortality Received: March 08, 2017 Accepted: May 08, 2017 Published: May 20, 2017 ABSTRACT The relationship between distribution of urologists and mortality of bladder and prostate cancers has not been clearly established. The aim of this study was to investigate the relationship between uneven distribution of urologists and urologic cancer specific mortality at country level. Data from the National Health Insurance Service and National Statistical Office in Korea from 2007 to 2011 were analyzed in this ecological study. Univariate and multivariable regression analyses were performed to determine risk factors for age standardized mortality rates (ASMR) of bladder and prostate cancers. Linear regression analysis showed a markedly ( p < 0.001) uneven distribution of urologists between metropolitan and non-metropolitan areas. There was no significant difference in cancer specific ASMRs for either bladder cancer or prostate cancer. Univariate analysis after adjusting for time showed that country area, urologist density, and income were significant factors affecting bladder cancer incidence ( p < 0.001, p = 0.013, and p < 0.001, respectively). It also showed that the number of training hospitals was a significant factor for prostate cancer incidence ( p = 0.002). Although country area showed borderline significance ( p = 0.056) for ASMR of bladder cancer, urologist density was not related to ASMR of bladder cancer or prostate cancer. Although there was a marked difference in urologist density between metropolitan and non-metropolitan areas for these years analyzed, mortality rates of bladder and prostate cancers were not significantly affected by country area or urologist density.
- Published
- 2017
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