1. Comparison of capecitabine and tegafur/gimeracil/oteracil (S-1) in the treatment of advanced breast carcinoma in the elderly
- Author
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Ji-Hai Jin, Yu-Juan Liu, and Dong-Xing Zheng
- Subjects
medicine.medical_specialty ,business.industry ,Nausea ,Pharmaceutical Science ,medicine.disease ,Gastroenterology ,Tegafur ,Metastatic breast cancer ,Breast carcinoma, Capecitabine, S-1, Adverse reactions, Myelosuppression, Leukopenia, Hand-foot syndrome ,Capecitabine ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Carcinoma ,Vomiting ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,medicine.symptom ,Breast carcinoma ,business ,Tegafur/gimeracil/oteracil ,medicine.drug - Abstract
Purpose: To analyse and compare the clinical effects and safety of capecitabine and tegafur/gimeracil/oteracil (S-1) in the treatment of advanced breast carcinoma.Methods: Eighty-four metastatic breast cancer elderly patients for whom first or second-line treatment had failed, were selected from among those admitted to the oncology ward of Binjiang People’s Hospital, China between January 2014 and June 2015. They were randomly divided into S-1 group (n =41) and capecitabine group (n = 41) and received varying doses of those drugs according to body surface area. Clinical effects, progression-free survival, and incidence of adverse reactions were compared for the two groups following treatment.Results: Disease control rate (CR) in S-1 group was 55.6 %, much higher than 35.1 % observed for capecitabine group (p < 0.05). The disease control rate for the S-1 group was 93.7 %, also much higher than the 70.6 % found in capecitabine group. Survival analysis showed that the median survival times of the two groups did not differ significantly (p > 0.05). Furthermore, some adverse reactions such as myelosuppression and lack of strength, did not differ significantly between the two groups (p > 0.05), whereas others, including leukopenia, nausea and vomiting and hand-foot syndrome were more serious and frequent in capecitabine group than in S-1 group (p < 0.05).Conclusion: Monotherapy with S-1 is more effective than that with capecitabine. Adverse reactions are minimal for both drugs.Keywords: Breast carcinoma, Capecitabine, S-1, Adverse reactions, Myelosuppression, Leukopenia, Hand-foot syndrome
- Published
- 2018