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9 results on '"MESH: Housing"'

1. Ability of the Premise Condition Index to Identify Premises with Adult and Immature Aedes Mosquitoes in Kampong Cham, Cambodia

Author

John S. Bradley, Sébastien Boyer, Vibol Chan, Rithea Leang, Dyna Doum, BunLeng Sam, Neal Alexander, John Hustedt, Sergio Lopes, Vanney Keo, Marco Liverani, Didot Budi Prasetyo, Jeffrey Hii, Agus Rachmat, Sokha Ly, Malaria Consortium [Phnom Penh, Cambodge], London School of Hygiene and Tropical Medicine (LSHTM), Cambodian National Dengue Control Program [Phnom Penh, Cambodia], World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), and US Naval Medical Research Unit n°2

Subjects
Mosquito Control, [SDV]Life Sciences [q-bio], 030231 tropical medicine, MESH: Dengue, Mosquito Vectors, Rate ratio, Disease cluster, Premises, Models, Biological, Dengue, 03 medical and health sciences, 0302 clinical medicine, Aedes, Virology, Animals, MESH: Animals, MESH: Mosquito Control, biology, MESH: Cambodia, MESH: Models, Biological, Regression analysis, MESH: Aedes, Articles, biology.organism_classification, MESH: Housing, Mosquito control, Infectious Diseases, Quartile, Conventional PCI, Housing, MESH: Mosquito Vectors, Female, Parasitology, Seasons, Cambodia, MESH: Female, MESH: Seasons, Demography
Abstract

International audience; Aedes-transmitted diseases, especially dengue, are increasing throughout the world and the main preventive methods include vector control and the avoidance of mosquito bites. A simple Premise Condition Index (PCI) categorizing shade, house, and yard conditions was previously developed to help prioritize households or geographical areas where resources are limited. However, evidence about the accuracy of the PCI is mixed. The current study aimed to contribute to a better understanding of the relevance by collecting data from 2,400 premises at four time points over 1 year in Kampong Cham, Cambodia. Regression models were then used to identify associations between PCI and Aedes adult female mosquitoes and pupae. In addition, receiver operating characteristic curves were used to measure the ability of PCI to identify premises in the top quartile of mosquito abundance. The density of adult Aedes females was positively associated with PCI at the household (ratio of means = 1.16 per point on the PCI scale) and cluster level (ratio of means = 1.54). However, the number of Aedes pupae was negatively associated with PCI at the household level (rate ratio = 0.74) and did not have a statistically significant association at the cluster level. Receiver operating characteristic curves suggest the PCI score had "rather low accuracy" (area under the ROC curve = 0.52 and 0.54) at identifying top-quartile premises in terms of adult female Aedes and pupae, respectively. These results suggest that caution is warranted in the programmatic use of PCI in areas of similar geography and mosquito abundance.

Published
2020

2. Efficacy of Bendiocarb Used for Indoor Residual Spraying for Malaria Control in Madagascar: Results With Local Anopheles Species (Diptera: Culicidae) From Experimental Hut Trials

Author

Sébastien Boyer, Jade Assoukpa, Yoann Madec, Thiery Nirina Jean Jose Nepomichene, Sanjiarizaha Randriamaherijaona, Unité d'Entomologie Médicale [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université d'Antananarivo, Unité d'Epidémiologie [Antananarivo, Madagascar] (IPM), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), This study was supported by the Institut Pasteur de Madagascar (IPM), Institut Pasteur de Madagascar - Réseau International des Instituts Pasteur (RIIP), Ecole doctorale Science de la vie et de l'Environnement, Epidémiologie des Maladies Emergentes, Conservatoire National des Arts et Métiers [CNAM] (CNAM) - Institut Pasteur [Paris] - Pasteur-Cnam risques infectieux et émergents (PACRI), Institut Pasteur [Paris] - Conservatoire National des Arts et Métiers [CNAM] : EA4628 - Conservatoire National des Arts et Métiers [CNAM] : EA4628, Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)

Subjects
Insecticides, Veterinary medicine, Mosquito Control, Indoor residual spraying, MESH: Pesticide Residues, MESH: Madagascar, chemistry.chemical_compound, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, experimental hut, MESH: Animals, 030212 general & internal medicine, MESH: Mosquito Control, biology, Ecology, Anopheles, MESH: Housing, 3. Good health, Mosquito control, Infectious Diseases, bendiocarb, MESH: Feeding Behavior, Malaria control, 030231 tropical medicine, Phenylcarbamates, Bendiocarb, MESH: Anopheles, 03 medical and health sciences, MESH: Phenylcarbamates, parasitic diseases, Madagascar, medicine, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Central Highlands, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, General Veterinary, residual activity, Significant difference, Pesticide Residues, Feeding Behavior, biology.organism_classification, medicine.disease, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, MESH: Insecticides, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, chemistry, Insect Science, Housing, Parasitology, Malaria
Abstract

International audience; To control malaria in Madagascar, two primary vector control interventions are being scaled up: insecticide-treated nets and indoor residual spraying of bendiocarb, which was implemented in the Malagasy Central Highlands in 2009. The current efficacy of bendiocarb against Anopheles species was evaluated in a small-scale field trial. An experimental hut trial comparing the effectiveness of bendiocarb sprayed on five substrates (cement, wood, tin, mud, and vegetative materials) was carried out against Anopheles species in two study sites located in the eastern foothills of Madagascar. No significant difference was detected in either exophily or blood-feeding rates between treated and untreated huts. The mortality rate was significantly greater in treated huts compared to untreated huts. Efficacy up to 80% was found for 5 mo posttreatment. Although effective, bendiocarb has been used for 7 yr, and therefore an alternative insecticide may be needed to avoid the emergence of resistance.

Published
2017

3. Storage mite concentrations are underestimated compared to house dust mite concentrations

Author

Gabriel Reboux, Sandrine Roussel, Steffi Rocchi, Laurence Millon, Emeline Scherer, Benoît Valot, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de parasitologie et mycologie [CHRU de Besançon], and Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)

Subjects
0106 biological sciences, Allergy, Veterinary medicine, MESH: Dermatophagoides pteronyssinus, Dermatophagoides pteronyssinus, 01 natural sciences, MESH: Dust, Lepidoglyphus destructor, 030308 mycology & parasitology, immune system diseases, MESH: Animals, MESH: Dermatophagoides farinae, Mites, 0303 health sciences, Dermatophagoides farinae, Ecology, integumentary system, House dust mites, MESH: Real-Time Polymerase Chain Reaction, Dust, MESH: Acaridae, General Medicine, 3. Good health, MESH: Housing, qPCR, Storage mites, France, MESH: Population Density, MESH: Hypersensitivity, MESH: Mites, Biology, Real-Time Polymerase Chain Reaction, complex mixtures, 03 medical and health sciences, parasitic diseases, Hypersensitivity, medicine, Mite, Animals, Humans, In patient, Acaridae, Population Density, House dust mite, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, MESH: Humans, MESH: Animal Distribution, Electrostatic dust collector, Dwellings, medicine.disease, Acarus, biology.organism_classification, respiratory tract diseases, MESH: France, 010602 entomology, Animal ecology, Insect Science, Housing, Animal Distribution
Abstract

International audience; Dwellings are increasingly well insulated to save energy and this leads to higher humidity and temperature, which improves conditions for mites. Dermatophagoides antigens are the main allergens involved and tested in atopic asthma. We developed three new species-specific quantitative PCR (qPCR) methods for house dust mites (Dermatophagoides pteronyssinus and D. farinae) and storages mites (Acarus siro, Glycyphagus domesticus, Lepidoglyphus destructor). We sampled dust with electrostatic dust collectors, in the bedrooms, under beds and in the kitchens of patients with allergies (n = 24) and healthy controls (n = 18). Mite quantification was carried out with the three new qPCRs and the qPCR previously described for the Dermatophagoides genus. The qPCRs were highly specific and efficient for house dust mite species and the storage mites. Storage mite concentrations were higher than house dust mite concentrations and were higher in dwellings of patients with allergies. Consequently, allergists should test more often patients against the storage mite antigens by prick tests or IgE serology. Dampness is a major factor in storage mite development and the presence of effective mechanical ventilation can reduce storage mite concentrations four-fold. In addition, to limit exposure to dust mites, treatments should be used throughout dwellings and not only in patients' bedrooms.

Published
2019

4. Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes

Author

Eric Viscogliosi, Maiken Cavling Arendrup, O. Le Rouzic, Boualem Sendid, Saad Nseir, P. Le Pape, Philippe Gosset, N. Bautin, Gabriel Reboux, C. Dauchy, S. Fry, René Wintjens, Emilie Fréalle, Service de Parasitologie-Mycologie [CHRU LIlle], Institut de Microbiologie [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Clinique de pneumologie [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Service de parasitologie et mycologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université libre de Bruxelles (ULB), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cibles et médicaments de l'infection, de l'immunité et du cancer (IICiMed), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Statens Serum Institut [Copenhagen], Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Copenhagen = Københavns Universitet (KU), Acting for a healthier population, the Région Hauts- de- France funded this work (Environment Health program, grant no. 2010- 12266 & 2010- 12268), which was also supported by GILEAD Sciences, MSD, and Pfizer grants., This work is dedicated to the memory of Eduardo Dei‐Cas, who actively contributed to the initial design and practical achievement of the FungiCOPD project. We also would like to thank Stéphanie Delvart, Sandrine Bonaventure, Dorothée Monvillers, Michèle Wauquier, Filoména Naji, and Nausicaa Gantois for technical assistance, Dr Isabelle Durand‐Joly, Pr El Moukhtar Aliouat, and Dr Annie Standaert‐Vitse for their steady interest in the work and for fruitful discussions, and all the physicians who participated to the recruitment of patients. This work was partially presented as an oral communication at the 'European Congress of Clinical Microbiology and Infectious Diseases' in 2014, at the congress of the 'French Medical Mycology Society' in 2016, and as a poster at the TIMM‐7 in 2015. RW is a Research Associate at the National Fund for Scientific Research FNRS‐FRS (Belgium)., Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Cibles et Médicaments des Infections et de l'Immunité (IICiMed), and University of Copenhagen = Københavns Universitet (UCPH)

Subjects
Drug Resistance, Fungal -- genetics, 0301 basic medicine, Azoles, Male, Antifungal Agents, Exacerbation, MESH: Fungal Proteins/isolation & purification, [SDV]Life Sciences [q-bio], Colony Count, Microbial, Aspergillus fumigatus, MESH: Aspergillus fumigatus/drug effects, MESH: Cytochrome P-450 Enzyme System/drug effects, MESH: Genotype, Pulmonary Disease, Chronic Obstructive, dwelling, Cytochrome P-450 Enzyme System, Genotype, Pulmonary Disease, Chronic Obstructive -- microbiology, Prevalence, Prospective Studies, chemistry.chemical_classification, MESH: Aged, COPD, Azole-resistance, MESH: Middle Aged, biology, MESH: Drug Resistance, Fungal/genetics, Mold environmental exposure, Sciences bio-médicales et agricoles, Middle Aged, 3. Good health, MESH: Pulmonary Disease, Chronic Obstructive/microbiology, MESH: Housing, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Air Pollution, Indoor, Acute Disease, Disease Progression, MESH: Acute Disease, MESH: Cytochrome P-450 Enzyme System/isolation & purification, MESH: Disease Progression, Female, medicine.drug, medicine.medical_specialty, Environmental Engineering, Itraconazole, MESH: Fungal Proteins/drug effects, 030106 microbiology, Aspergillus fumigatus -- drug effects -- genetics -- isolation & purification, MESH: Azoles/pharmacology, Fungal Proteins -- drug effects -- isolation & purification, chronic obstructive pulmonary disease, Microbiology, Fungal Proteins, 03 medical and health sciences, azole resistance, MESH: Air Pollution, Indoor/analysis, Drug Resistance, Fungal, Internal medicine, medicine, Humans, MESH: Aspergillus fumigatus/genetics, Dwelling, MESH: Colony Count, Microbial, MESH: Prevalence, Aged, Aspergillus, MESH: Humans, Azoles -- pharmacology, electrostatic dust collector, Public Health, Environmental and Occupational Health, mold environmental exposure, Electrostatic dust collector, Building and Construction, medicine.disease, biology.organism_classification, MESH: Male, MESH: Prospective Studies, chemistry, Cytochrome P-450 Enzyme System -- drug effects -- isolation & purification, Housing, Azole, ARAF, MESH: Aspergillus fumigatus/isolation & purification, Antifungal Agents -- pharmacology, MESH: Antifungal Agents/pharmacology, MESH: Female, Air Pollution, Indoor -- analysis
Abstract

Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and environmental (n = 48) isolates yielded ARAF detection in 1 of 11 A. fumigatus colonized patients with COPD (9%) and 2 of 15 A. fumigatus-positive patient's homes (13%). The clinical isolate had no CYP51A mutation. Two environmental isolates from two patients harbored TR34/L98H mutation, and one had an H285Y mutation. Coexistence of different cyp51A genotypes and/or azole resistance profiles was detected in 3 of 8 respiratory and 2 of 10 environmental samples with more than one isolate, confirming the need for a systematic screening of all clinically relevant isolates. The high prevalence of ARAF in patients with COPD and their homes supports the need for further studies to assess the prevalence of azole resistance in patients with Aspergillus diseases in Northern France., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

5. Effect of Genome and Environment on Metabolic and Inflammatory Profiles

Author

Marina Sirota, Eco J. C. de Geus, David R. Cox, Dorret I. Boomsma, Sean Kennedy, Purnima Sundar, Steven J. Pitts, Karen E. Malone, Cornelis Kluft, S. Dusko Ehrlich, Edi Prifti, Shobha Potluri, Gonneke Willemsen, Jacoline Neuteboom, Pfizer/Rinat Laboratories [South San Francisco], Vrije Universiteit Amsterdam [Amsterdam] (VU), MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Good Biomarker Sciences [Leiden, Netherlands] (GBS), Funding was obtained from INRA-Pfizer, the Netherlands Organisation for Scientific Research (NWO 911 –09–032, NWO 480-04-004), EMGO+ Institute for Health and Care Research, Neuroscience Campus Amsterdam, BBMRI –NL (Biobanking and Biomolecular Resources Research Infrastructure), and the European Research Council (Genetics of Mental Illness 230374)., We would like to dedicate this manuscript to the memory of David R. Cox, our dear friend and colleague, a visionary and passionate scientist who has had a profound influence on the fields of genetics and biomedicine. We will always be inspired by David’s lifelong dedication to biomedical research and the use of human genetics to improve human health. We would like to thank all twins and family members for their participation in the Netherlands Twin Register Biobank project. We thank Gareth Davies, Erik Ehli and Patrizia Huizenga from Avera Institute for Human Genetics, Sioux Falls, USA for their assistance with the zygosity determination., Sambhara, Suryaprakash, Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, and EMGO+ - Lifestyle, Overweight and Diabetes

Subjects
Male, Netherlands Twin Register (NTR), Multivariate statistics, Twins, lcsh:Medicine, 030204 cardiovascular system & hematology, MESH: Inflammation/genetics, Blood counts, Genome, 0302 clinical medicine, 2.1 Biological and endogenous factors, Cluster Analysis, Aetiology, lcsh:Science, Genetics, 0303 health sciences, Hematologic Tests, Multidisciplinary, MESH: Environment, MESH: Inflammation/metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Cell enumeration techniques, Phenotype, MESH: Housing, Phenotypes, Cholesterol, Cohort, Cytokines, Female, Human, Research Article, Adult, General Science & Technology, Environment, Biology, MESH: Phenotype, Monozygotic, MESH: Hematologic Tests, 03 medical and health sciences, Family studies, MESH: Genome, Human, Similarity (network science), SDG 3 - Good Health and Well-being, Clinical Research, Liver enzyme, Humans, 030304 developmental biology, Inflammation, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, Genome, Human, Human Genome, lcsh:R, Fibrinogen, MESH: Adult, Twins, Monozygotic, MESH: Inflammation/blood, MESH: Cluster Analysis, MESH: Male, MESH: Twins, Monozygotic/genetics, Housing, lcsh:Q, Human genome, MESH: Female
Abstract

Twin and family studies have established the contribution of genetic factors to variation in metabolic, hematologic and immunological parameters. The majority of these studies analyzed single or combined traits into pre-defined syndromes. In the present study, we explore an alternative multivariate approach in which a broad range of metabolic, hematologic, and immunological traits are analyzed simultaneously to determine the resemblance of monozygotic (MZ) twin pairs, twin-spouse pairs and unrelated, non-cohabiting individuals. A total of 517 participants from the Netherlands Twin Register, including 210 MZ twin pairs and 64 twin-spouse pairs, took part in the study. Data were collected on body composition, blood pressure, heart rate, and multiple biomarkers assessed in fasting blood samples, including lipid levels, glucose, insulin, liver enzymes, hematological measurements and cytokine levels. For all 51 measured traits, pair-wise Pearson correlations, correcting for family relatedness, were calculated across all the individuals in the cohort. Hierarchical clustering techniques were applied to group the measured traits into sub-clusters based on similarity. Sub-clusters were observed among metabolic traits and among inflammatory markers. We defined a phenotypic profile as the collection of all the traits measured for a given individual. Average within-pair similarity of phenotypic profiles was determined for the groups of MZ twin pairs, spouse pairs and pairs of unrelated individuals. The average similarity across the full phenotypic profile was higher for MZ twin pairs than for spouse pairs, and lowest for pairs of unrelated individuals. Cohabiting MZ twins were more similar in their phenotypic profile compared to MZ twins who no longer lived together. The correspondence in the phenotypic profile is therefore determined to a large degree by familial, mostly genetic, factors, while household factors contribute to a lesser degree to profile similarity.

Published
2015

6. The process of domestication in triatominae

Author

Christopher J. Schofield, Jean-Pierre Dujardin, Liléia Diotaiuti, London School of Hygiene and Tropical Medicine (LSHTM), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Institut de Recherche pour le Développement (IRD), This work has benefited from international collaboration through the ECLAT network., and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Male, Microbiology (medical), Chagas disease, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Process (engineering), 030231 tropical medicine, lcsh:QR1-502, AMAZONIE, DOMESTICATION ANIMALE, MESH: Triatominae, lcsh:Microbiology, domestication, 03 medical and health sciences, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, 0302 clinical medicine, DISPERSION, Animals, MESH: Animals, dispersal, HABITAT, VARIABILITE GENETIQUE, Domestication, Triatominae, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, MESH: Housing, biology, VECTEUR, ETUDE REGIONALE, population genetics, biology.organism_classification, MESH: Insect Vectors, EVOLUTION, MESH: Male, Insect Vectors, GENOTYPE, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, INSECTE, BOLIVIE, Evolutionary biology, MALADIE DE CHAGAS, Housing, Female, MESH: Female
Abstract

International audience

Published
1999

7. Correlation between Environmental Relative Moldiness Index (ERMI) values in French dwellings and other measures of fungal contamination

Author

Pierre Le Cann, Stephen Vesper, Larry Wymer, Delphine Méheust, Tiina Reponen, Jean-Pierre Gangneux, Laboratoire d'étude et de recherche en environnement et santé (LERES), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Environmental Health, University of Cincinnati (UC), US Environmental Protection Agency [Cincinnati], US Environmental Protection Agency (EPA), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
MESH: Fungi, Veterinary medicine, Dust sample, Fungal growth, Environmental Engineering, Fungal contamination, 010501 environmental sciences, Culture technique, Polymerase Chain Reaction, 01 natural sciences, MESH: Dust, 03 medical and health sciences, Culture Techniques, Environmental Chemistry, Waste Management and Disposal, Dwelling, 0105 earth and related environmental sciences, ERMI, 0303 health sciences, 030306 microbiology, Environmental engineering, Fungi, Dust, MESH: Polymerase Chain Reaction, Pollution, QPCR, MESH: Housing, MESH: France, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Culture Techniques, 13. Climate action, Air Pollution, Indoor, Housing, Environmental science, France, MESH: Air Pollution, Indoor, human activities, MESH: Environmental Monitoring, Environmental Monitoring
Abstract

International audience; The Environmental Relative Moldiness Index (ERMI) is a DNA-based metric developed to describe the fungal contamination in US dwellings. Our goal was to determine if the ERMI values in dwellings in north western France were correlated with other measures of fungal contamination. Dust and air samples were obtained from 40 dwellings and analyzed by quantitative PCR and/or by culturing. These dwellings were also inspected and the amount of visible fungal growth estimated in m(2). The ERMI values in these dwellings ranged from -2.7 to 28.8 and the fungal contamination estimates ranged from 0 to 20 m(2). The 40 dwellings were divided into those with a low (8) ERMI values (n=20 in each). The average ERMI value was 15.70 for the high ERMI compared to 2.68 for the low ERMI dwellings. ERMI values were correlated (significant Kendall's tau values) with concentrations of fungi in air samples analyzed by QPCR or culturing. ERMI values were also correlated (significant Kendall's tau values) with the visible estimates of fungal contamination. Older dwellings were more likely to have higher ERMI values. These results suggest that the ERMI dust sample, which is quick and easy to collect, may be useful in making decisions about reducing fungal exposures in homes.

Published
2012

8. Indoor fungal contamination of moisture-damaged and allergic patient housing analysed using real-time PCR

Author

Laurence Millon, E. Didier-Scherer, Jean-Charles Dalphin, Sandrine Roussel, Gabriel Reboux, Frédéric Grenouillet, Anne-Pauline Bellanger, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
MESH: Fungi, Moho, MESH : Colony Count, Microbial, MESH : Housing, Stachybotrys chartarum, Colony Count, Microbial, 010501 environmental sciences, Polymerase Chain Reaction, 01 natural sciences, Applied Microbiology and Biotechnology, Alternaria alternata, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Environmental Microbiology, Humans, Food science, Mycotoxin, MESH: Colony Count, Microbial, MESH : Polymerase Chain Reaction, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, MESH : Fungi, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, 0105 earth and related environmental sciences, 0303 health sciences, MESH: Humans, biology, 030306 microbiology, MESH : Humans, Fungi, MESH: Environmental Microbiology, MESH: Polymerase Chain Reaction, Fungi imperfecti, biology.organism_classification, Penicillium chrysogenum, Spore, MESH: Housing, MESH : Environmental Microbiology, chemistry, 13. Climate action, Housing, Aspergillus versicolor
Abstract

International audience; AIMS: The aim of our study was to compare, using real-time (Rt) PCR, quantitative levels of five fungal species in three kinds of dwellings. METHODS AND RESULTS: Three groups of homes were recruited: moisture-damaged homes (MDH, n = 30), allergic patient homes (APH, n = 25) and paired control homes (CH, n = 55). Five moulds with allergenic compounds or mycotoxin production characteristics (Cladosporium sphaerospermum, Penicillium chrysogenum, Aspergillus versicolor, Alternaria alternata and Stachybotrys chartarum) were quantified using Rt-PCR. Cycle threshold results were expressed in spore equivalent per volume or surface unit using a direct calculation based on a spore standard curve. MDH presented significantly higher amounts of DNA from C. sphaerospermum in both air and surface samples than CH (P < 0.001). APH presented slightly elevated amounts of DNA from A. versicolor in both air and surface samples, compared to CH (P < 0.05). CONCLUSION: Rt-PCR quantification of targeted fungal species is a rapid, reliable tool that could be included in a global indoor mould evaluation. SIGNIFICANCE AND IMPACT OF THE STUDY: Quantification of C. sphaerospermum using Rt-PCR can help to better target social service intervention in MDH. Quantification of A. versicolor DNA could be informative for characterization of APH.

Published
2009

9. Exploiting triatomine behaviour: alternative perspectives for their control

Author

Claudio R. Lazzari, Marcelo G. Lorenzo, Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), and Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Microbiology (medical), Chagas disease, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, MESH: Insect Vectors/physiology, lcsh:QR1-502, MESH: Insect Control/methods, vector control, Biology, Insect Control, lcsh:Microbiology, 03 medical and health sciences, 0302 clinical medicine, Feeding behavior, Animals, Humans, MESH: Triatominae/physiology, Animal communication, MESH: Animals, Control (linguistics), Triatominae, Ecosystem, 030304 developmental biology, 0303 health sciences, MESH: Humans, Host (biology), Ecology, MESH: Feeding Behavior/physiology, Feeding Behavior, biology.organism_classification, MESH: Ecosystem, Insect Vectors, MESH: Housing, Animal Communication, MESH: Animal Communication, Habitat, MESH: Chagas Disease/transmission, Housing, behavioural traits, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Living in close association with a vertebrate host and feeding on its blood requires different types of adaptations, including behavioural adjustements. Triatomines exhibit particular traits associated with the exploitation of their habitat and food sources and these traits have been the subject of intense analysis. Many aspects of triatomine behaviour have been relatively well characterised and some attempts to exploit the behaviours have been undertaken. Baited traps based on host-associated cues, artificial refuges and light-traps are some of the tools used. Here we discuss how our knowledge of the biology of Chagas disease vectors may help us sample and detect these insects and even increase the efficiency of control measures.

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