1. Microtubular dysfunction and male infertility
- Author
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Ralf Henkel, Ahmad Joumah, Ashok Agarwal, Aabed Alguraigari, Malik Kayal, Sezgin Gunes, Mariana Marques Sinigaglia, and Pallav Sengupta
- Subjects
Axoneme ,Aging ,Microtubule-associated protein ,Urology ,030232 urology & nephrology ,lcsh:Medicine ,Review Article ,Microfilament ,lcsh:RC870-923 ,Male infertility ,03 medical and health sciences ,0302 clinical medicine ,male ,Microtubule ,medicine ,Pharmacology (medical) ,Cytoskeleton ,axoneme ,Sperm motility ,030219 obstetrics & reproductive medicine ,business.industry ,Health Policy ,microtubule-associated proteins ,lcsh:R ,Public Health, Environmental and Occupational Health ,Male Reproductive Health and Infertility ,medicine.disease ,Infertility, male ,lcsh:Diseases of the genitourinary system. Urology ,Sperm ,Cell biology ,Psychiatry and Mental health ,Reproductive Medicine ,kartagener syndrome ,business ,infertility - Abstract
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.
- Published
- 2018