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11 results on '"Néphrologie Dialyse Saint Guilhem (NDSG)"'

1. Les changements précoces de poids et de pression artérielle sont associés à la mortalité chez les patients en dialyse

Author

Philippe Brunet, Àngel Argilés, Flore Duranton, Catherine Rouanet, Yohan Duny, Sebastien Deleuze, François Maurice, Isabelle Selcer, Bernard Jover, Ilan Szwarc, Jean-Pierre Daurès, Jean-Pierre Rivory, Marie-Françoise Servel, Université de Montpellier (UM), Nephrologie - Dialyse St-guilhem, NephoCare, Biocommunication en Cardio-Métabolique (BC2M), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Agence de la Bio-Médecine, RD-Néphrologie, Néphrologie Dialyse Saint Guilhem ( NDSG ), Centre Hémodialyse Languedoc Méditerranée, CHLM, Centre hémodialyse Languedoc Méditerranée ( CHLM ), Centre hémodialyse Languedoc Méditerranée, Laboratoire de cristallographie et RMN biologiques ( LCRB - UMR 8015 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Physique et mécanique des milieux hétérogenes ( PMMH ), Centre National de la Recherche Scientifique ( CNRS ) -ESPCI ParisTech-Université Paris Diderot - Paris 7 ( UPD7 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 ( AIDMP ), Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Université de Liège, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Vascular research center of Marseille ( VRCM ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Recherche en Cancérologie de Montpellier ( IRCM - U1194 Inserm - UM ), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Jover, Bernard, RD-Néphrologie (R&D), Néphrologie Dialyse Saint Guilhem (NDSG), Centre hémodialyse Languedoc Méditerranée (CHLM), Laboratoire de cristallographie et RMN biologiques (LCRB - UMR 8015), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Physique et mécanique des milieux hétérogenes (UMR 7636) (PMMH), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
[ SDV.MHEP.UN ] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, 030204 cardiovascular system & hematology, Dialysis patients, Body weight, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 03 medical and health sciences, body weight, 0302 clinical medicine, Internal medicine, medicine, ComputingMilieux_MISCELLANEOUS, Transplantation, [ SDV ] Life Sciences [q-bio], business.industry, blood pressure, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Comorbidity, mortality, 3. Good health, haemodialysis, Blood pressure, Nephrology, Cardiology, Hemodialysis, incident, business, Dialysis
Abstract

Background While much research is devoted to identifying novel biomarkers, addressing the prognostic value of routinely measured clinical parameters is of great interest. We studied early blood pressure (BP) and body weight (BW) trajectories in incident haemodialysis patients and their association with all-cause mortality. Methods In a cohort of 357 incident patients, we obtained all records of BP and BW during the first 90 days on dialysis (over 12 800 observations) and analysed trajectories using penalized B-splines and mixed linear regression models. Baseline comorbidities and all-cause mortality (median follow-up: 2.2 years) were obtained from the French Renal Epidemiology and Information Network (REIN) registry, and the association with mortality was assessed by Cox models adjusting for baseline comorbidities. Results During the initial 90 days on dialysis, there were non-linear decreases in BP and BW, with milder slopes after 15 days [systolic BP (SBP)] or 30 days [diastolic BP (DBP) and BW]. SBP or DBP levels at dialysis initiation and changes in BW occurring in the first month or during the following 2 months were significantly associated with survival. In multivariate models adjusting for baseline comorbidities and prescriptions, higher SBP value and BW slopes were independently associated with a lower risk of mortality. Hazard ratios of mortality and 95% confidence intervals were 0.92 (0.85–0.99) for a 10 mmHg higher SBP and 0.76 (0.66–0.88) for a 1 kg/month higher BW change on Days 30–90. Conclusions BW loss in the first weeks on dialysis is a strong and independent predictor of mortality. Low BP is also associated with mortality and is probably the consequence of underlying cardiovascular diseases. These early markers appear to be valuable prognostic factors.

Published
2016
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2. Primary sclerosing cholangitis: a new cause of distal renal tubular acidosis

Author

I. Szwarc, Àngel Argilés, Jean Ribstein, Georges-Philippe Pageaux, Jean-Emmanuel Serre, Valentin Goutaudier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Néphrologie Dialyse Saint Guilhem (NDSG), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), and Néphrologie Dialyse Saint Guilhem ( NDSG )

Subjects
medicine.medical_specialty, Pathology, Urinary system, 030232 urology & nephrology, distal renal tubular acidosis, Gastroenterology, Primary sclerosing cholangitis, Nephropathy, Renal tubular acidosis, 03 medical and health sciences, Rare Diseases, 0302 clinical medicine, Distal renal tubular acidosis, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Internal medicine, medicine, 030212 general & internal medicine, Transplantation, liver transplantation, business.industry, primary sclerosing cholangitis, Metabolic acidosis, Jaundice, medicine.disease, Hypokalemia, 3. Good health, Nephrology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; We describe the first case of distal renal tubular acidosis (dRTA) associated with primary sclerosing cholangitis. A 26-year-old Lao-Thai male patient presented with severe jaundice, metabolic acidosis and hypokalaemia. He was diagnosed of dRTA. Liver transplantation resulted in correction of electrolyte disturbances and hyperbilirubinaemia. A fludrocortisone-furosemide test revealed normal urinary acidification, demonstrating no residual dRTA. This observation suggests that dRTA may be an early manifestation of bilirubin-associated nephropathy or the consequence of an immune mechanism.

Published
2016
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3. Successful treatment of a Streptococcus pneumoniae-associated haemolytic uraemic syndrome by eculizumab

Author

Georges Mourad, Guillaume Jeantet, Vincent Brunot, Vincent Pernin, Kada Klouche, Arnaud Roccabianca, Chantal Loirat, Véronique Frémeaux-Bacchi, Moglie Le Quintrec, Ilan Szwarc, Anouk Macombe, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Néphrologie Dialyse Saint Guilhem (NDSG), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Service de néphrologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Hôpital Robert Debré, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MORNET, Dominique, and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
medicine.medical_specialty, Thrombotic microangiopathy, 030232 urology & nephrology, urologic and male genital diseases, medicine.disease_cause, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, haemolytic uraemic syndrome, hemic and lymphatic diseases, Internal medicine, Streptococcus pneumoniae, medicine, complement, Transplantation, biology, Streptococcus, business.industry, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Eculizumab, medicine.disease, Haemolysis, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, female genital diseases and pregnancy complications, thrombotic microangiopathy, 3. Good health, Nephrology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, biology.protein, eculizumab, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, Antibody, Haemolytic-uraemic syndrome, Complication, business, medicine.drug
Abstract

International audience; Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.

Published
2018
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4. 'Neuro‐renal syndrome' related to anti‐contactin‐1 antibodies

Author

Pierre Labauge, Jérôme Devaux, Moglie Le Quintrec, Ilan Szwarc, Hélène Perrochia, Amandine Pialot, Guillaume Taieb, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Néphrologie Dialyse Saint Guilhem (NDSG), Service de Neurologie, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Physiology, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, 030105 genetics & heredity, Nephropathy, 03 medical and health sciences, Cellular and Molecular Neuroscience, nodopathy, 0302 clinical medicine, Focal segmental glomerulosclerosis, Antigen, Physiology (medical), [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine, paranodopathy, anti‐contactin‐1 IgG4 antibodies, chronic inflammatory demyelinating polyradiculoneuropathy, biology, business.industry, nephrotic syndrome, Autoantibody, Polyradiculoneuropathy, Glomerulonephritis, medicine.disease, 3. Good health, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, biology.protein, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Antibody, anti‐neurofascin‐186 IgG4 antibodies, business, Nephrotic syndrome, 030217 neurology & neurosurgery
Abstract

International audience; Since 1973, a few cases of concomitant inflammatory demyelinating polyradiculoneuropathy and nephrotic syndrome have been reported. The neuropathy was either an acute inflammatory demyelinating polyneuropathy (AIDP) or a chronic inflammatory demyelinating polyneuropathy (CIDP), and the nephrotic syndrome was related to either a focal segmental glomerulosclerosis (FSGS) or a membranous glomerulonephritis (MGN).Time course, severity, and response to treatment were heterogeneous, and evolution of neuropathy and nephropathy could be independent. This suggests that common epitopes are targeted by autoantibodies within the peripheral nerve and the glomerular filtration barrier. However, the antigenic targets are unknown. Here, we report a patient who developed CIDP associated with anti-contactin-1 immunoglobulin G4 (IgG4) antibodies and nephrotic syndrome.

Published
2019
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5. The CKD plasma lipidome varies with disease severity and outcome

Author

Jonas Laget, Jean-Sébastien Saulnier-Blache, Joost P. Schanstra, Klaus M. Weinberger, Ulrika Lundin, Harald Mischak, Flore Duranton, Nathalie Gayrard, Marie-Françoise Servel, Àngel Argilés, Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Equipe 7 Inserm U1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), BIOCRATES Life Sciences AG [Innsbruck, Austria], Mosaiques Diagnostics & Therapeutics (MOSAIQUES DIAGNOSTICS & THERAPEUTICS), Mosaiques Diagnostics & Therapeutics AG, Nephrologie - Dialyse St-guilhem [Sète], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Unité de recherche sur les obésités, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR 31 Louis Bugnard (IFR 31), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Mosaiques Diagnostics and Therapeutics AG, Néphrologie Dialyse Saint Guilhem (NDSG), Service de Néphrologie, Dialyse et Transplantation (Hôpital Lapeyronie [Montpellier] CHU), Hôpital Lapeyronie [Montpellier] (CHU), Mosaiques Diagnostics & Therapeutics AG [Hannover, Germany], Private University for Health Sciences, Medical Informatics and Technology [Tirol] (UMIT), sAnalytiCo Ltd [Belfast, UK], and Saulnier-Blache, Jean Sébastien

Subjects
Male, Sphingomyelin, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Gastroenterology, Renal disease, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Renal Dialysis, Internal medicine, Lipidomics, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Renal Insufficiency, Chronic, ComputingMilieux_MISCELLANEOUS, Aged, Lysophospholipid, chemistry.chemical_classification, Nutrition and Dietetics, business.industry, Fatty acid, Lipid metabolism, Lipidome, Middle Aged, medicine.disease, Lipid Metabolism, Elaidic acid, 3. Good health, [SDV] Life Sciences [q-bio], Primary Prevention, Phospholipid, chemistry, Phosphatidylcholines, Female, Hemodialysis, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract

International audience; Background: Various alterations in lipid metabolism have been observed in patients with chronic kidney disease (CKD).Objectives: To determine the levels of lipid species in plasma from CKD and hemodialysis (HD) patients and test their association with CKD severity and patient outcome.Methods: Seventy-seven patients with CKD stage 2 to HD were grouped into classes of CKD severity at baseline and followed-up for 3.5 years for the occurrence of transition to HD or death (combined outcome). Plasma levels of phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), sphingomyelins (SMs), and fatty acids were analyzed by flow-injection analysis coupled to tandem mass spectrometry or gas chromatography coupled with mass spectrometry. Kruskal Wallis rank tests and Cox regressions were used to analyze the association of lipids with CKD severity and the risk of combined outcome, respectively.Results: The plasma level of PCs, LPCs, and SMs was decreased in HD patients compared with nondialyzed CKD patients (all P < .05), whereas esterified and/or nonesterified fatty acids level did not change. Thirty-four lipids displayed significantly lower abundance in plasma of HD patients, whereas elaidic acid (C18:1ω9t) level was increased (P < .001). The total amount of LPCs and individual LPCs were associated with better outcome (P < .05). In particular, LPC 18:2 and LPC 20:3 were statistically associated with outcome in adjusted models (P < .05).Discussion: In HD patients, a reduction in plasma lipids is observed. Some of the alterations, namely reduced LPCs, were associated with the risk of adverse outcome. These changes could be related to metabolic dysfunctions.

Published
2019
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6. New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis

Author

Antonia Vlahou, Nathalie Neirynck, Szymon Filip, Raymond Vanholder, William Mullen, Griet Glorieux, Nathalie Gayrard, Eva Schepers, Harald Mischak, Joost P. Schanstra, Àngel Argilés, Joachim Jankowski, Holger Husi, Flore Duranton, Julie Klein, Pathologie, RS: CARIM - R3 - Vascular biology, Nephrology Section [Ghent], Ghent University Hospital, BHF Glasgow Cardiovascular Research Centre, University of Glasgow-Institute of Cardiovascular & Medical Sciences, RD-Néphrologie (R&D), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Cardiovascular and Medical Sciences [Glasgow], University of Glasgow, Néphrologie Dialyse Saint Guilhem (NDSG), and Biomedical Research Foundation of the Academy of Athens

Subjects
Male, medicine.medical_specialty, Proteome, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Renal function, Inflammation, 030204 cardiovascular system & hematology, urologic and male genital diseases, Bioinformatics, Proteomics, 03 medical and health sciences, 0302 clinical medicine, proteomics, Tandem Mass Spectrometry, Internal medicine, Medicine, Humans, Renal Insufficiency, Chronic, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Aged, 0303 health sciences, Transplantation, mechanisms, business.industry, biomarkers, uraemic solutes, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, 3. Good health, haemodialysis, Endocrinology, Nephrology, Heart failure, Biomarker (medicine), Female, Hemodialysis, medicine.symptom, business, chronic kidney disease, Kidney disease, Chromatography, Liquid
Abstract

BACKGROUND: \ud \ud The reduced glomerular filtration rate in the advanced stages of chronic kidney disease (CKD) leads to plasma accumulation of uraemic retention solutes including proteins. It has been hypothesized that these changes may, at least in part, be responsible for CKD-associated morbidity and mortality. However, most studies focused on the role of individual proteins, while a holistic, large-scale, integrative approach may generate significant additional insight.\ud \ud METHODS: \ud \ud In a discovery study, we analysed the plasma proteome of patients with stage 2-3 CKD (n = 14) and stage 5 CKD with haemodialysis (HD) (n = 15), using high-resolution LC-MS/MS analysis. Selected results were validated in a cohort of 40 patients with different CKD stages with or without HD, using ELISA.\ud \ud RESULTS: \ud \ud Of a total of 2054 detected proteins, 127 displayed lower, while 206 displayed higher abundance in the plasma of patients on HD. Molecular pathway analysis confirmed the modification of known processes involved in CKD complications, including decreased haemostasis and increased inflammation, complement activation and vascular damage. In addition, we identified the plasma increase during CKD progression of lysozyme C and leucine-rich alpha-2 glycoprotein, two proteins related to vascular damage and heart failure. High level of leucine-rich alpha-2 glycoprotein was associated with higher mortality in stage 5 CKD patients on HD.\ud \ud CONCLUSIONS: \ud \ud This study provides for the first time a comprehensive assessment of CKD plasma proteome, contributing to new knowledge and potential markers of CKD. These results will serve as a basis for future studies investigating the relevance of these molecules in CKD associated morbidity and mortality.

Published
2015
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7. Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides

Author

Schanstra, Joost, Zürbig, Petra, Alkhalaf, Alaa, Argilés, Angel, Bakker, Stephan, Beige, Joachim, Bilo, Henk, Chatzikyrkou, Christos, Dakna, Mohammed, Dawson, Jesse, Delles, Christian, Haller, Hermann, Haubitz, Marion, Husi, Holger, Jankowski, Jan, Jerums, George, Kleefstra, Nanne, Kuznetsova, Tatiana, Maahs, David, Menne, Jan, Mullen, William, Ortiz, Alberto, Persson, Frederik, Rossing, Peter, Ruggenenti, Piero, Rychlik, Ivan, Serra, Andreas, Siwy, Justyna, Snell-Bergeon, Jan, Spasovski, Goce, Staessen, Jan, Vlahou, Antonia, Mischak, Harald, Vanholder, Raymond, Zurbig, P., Bakker, J., Staessen, A., Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Institut National de la Santé et de la Recherche Médicale (INSERM), Mosaiques Diagnostics GmbH, Néphrologie Dialyse Saint Guilhem (NDSG), RD-Néphrologie (R&D), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Isala Clinics, Diabetes Centre, Mosaiques Diagnostics and Therapeutics, Mosaiques diagnostics and therapeutics, BHF Glasgow Cardiovascular Research Centre (BHF GCRC), University of Glasgow, Division of Nephrology and Hypertension, Department of Medicine, Hanover Medical School, Department of Nephrology (MHH), Hannover Medical School [Hannover] (MHH), Department of Poultry Science, University of Warmia and Mazury, BHF Glasgow Cardiovascular Research Centre, University of Glasgow-Institute of Cardiovascular & Medical Sciences, Département Réseaux et Services Multimédia Mobiles (RS2M), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Steno Diabetes Center of Copenhagen [Gentofte, Denmark], Charles University [Prague] (CU), Maastricht University [Maastricht], Biomedical Research Foundation of the Academy of Athens, Institute of Cardiovascular and Medical Sciences [Glasgow], Nephrology Section [Ghent], Ghent University Hospital, Department of Intensive Care, and Erasmus Medical Centre

Subjects
Male, CHRONIC KIDNEY-DISEASE, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, urologic and male genital diseases, Diabetic nephropathy, Cohort Studies, 0302 clinical medicine, Fibrosis, POSITION STATEMENT, 10. No inequality, ALBUMIN EXCRETION, RISK, 0303 health sciences, Area under the curve, renal progression, General Medicine, Middle Aged, female genital diseases and pregnancy complications, 3. Good health, Nephrology, IMPROVING GLOBAL OUTCOMES, Cohort, Disease Progression, Biomarker (medicine), biomarker, Female, PROTEOMIC ANALYSIS, medicine.symptom, Glomerular Filtration Rate, Adult, medicine.medical_specialty, Urinary system, extracellular matrix, BIOMARKERS, Urology, Renal function, albuminuria, DIABETIC-NEPHROPATHY, 03 medical and health sciences, Clinical Research, Internal medicine, Up Front Matters, medicine, CKD, INJURY, Humans, Renal Insufficiency, Chronic, 030304 developmental biology, Aged, business.industry, fibrosis, NEED, medicine.disease, Endocrinology, Albuminuria, business, Peptides
Abstract

Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or the presence of significant albuminuria. With the aim of early and improved risk stratification of patients with CKD, we studied urinary peptides in a large cross-sectional multicenter cohort of 1990 individuals, including 522 with follow-up data, using proteome analysis. We validated that a previously established multipeptide urinary biomarker classifier performed significantly better in detecting and predicting progression of CKD than the current clinical standard, urinary albumin. The classifier was also more sensitive for identifying patients with rapidly progressing CKD. Compared with the combination of baseline eGFR and albuminuria (area under the curve [AUC]=0.758), the addition of the multipeptide biomarker classifier significantly improved CKD risk prediction (AUC=0.831) as assessed by the net reclassification index (0.303±-0.065; P

Published
2015
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8. GEOGRAPHICAL VARIATIONS IN BLOOD PRESSURE LEVEL AND SEASONALITY IN HEMODIALYSIS PATIENTS

Author

Ziad A. Massy, Brian Bieber, Christian Combe, Flore Duranton, Anneke Kramer, Fernando Vetromile, Nathalie Gayrard, Bernard Jover, Ilan Szwarc, Marie-Françoise Servel, Àngel Argilés, Francesca Tentori, Kitty J. Jager, RD-Néphrologie (R&D), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Universiteit van Amsterdam (UvA), Néphrologie Dialyse Saint Guilhem (NDSG), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service Néphrologie/Dialyse [AP-HP Ambroise-Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Ambroise Paré [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), APH - Quality of Care, APH - Aging & Later Life, Medical Informatics, ACS - Amsterdam Cardiovascular Sciences, APH - Methodology, APH - Global Health, and ACS - Pulmonary hypertension & thrombosis

Subjects
Adult, Male, medicine.medical_treatment, Climate, Population, 030232 urology & nephrology, 030204 cardiovascular system & hematology, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, geography, 03 medical and health sciences, 0302 clinical medicine, Belgium, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Germany, Internal Medicine, medicine, Humans, longitudinal studies, Prospective Studies, education, ComputingMilieux_MISCELLANEOUS, Aged, Sweden, education.field_of_study, seasons, Blood pressure level, business.industry, blood pressure, Blood Pressure Determination, Seasonality, Middle Aged, medicine.disease, United Kingdom, Blood pressure, Italy, Spain, renal dialysis, weather, Female, Hemodialysis, France, business, Demography
Abstract

Seasons and climate influence the regulation of blood pressure (BP) in the general population and in hemodialysis patients. It is unknown whether this phenomenon varies across the world. Our objective was to estimate BP seasonality in hemodialysis patients from different geographical locations. Patients from 7 European countries (Spain, Italy, France, Belgium, Germany, United Kingdom, and Sweden) participating in the DOPPS (Dialysis Outcomes and Practice Patterns Study) on years 2005 to 2011 were studied. Factors influencing pre- and postdialysis systolic BP and diastolic BP levels were analyzed by mixed models. There were 9655 patients (median age, 68; 59% male) from 263 facilities, seen every 4 months during a median duration of 1.3 years. Pre- and postdialysis systolic BP increased by a mean estimate of 5.1 mm Hg (95% confidence interval [CI], 3.7–6.4 mm Hg) and 4.4 mm Hg (95% CI, 2.9–5.9 mm Hg) for each 10° increase in latitude (1111 km to the North). In the longitudinal analysis, predialysis systolic BP was lower in summer and higher in winter (difference, 1.7 mm Hg; 95% CI, 1.3–2.2 mm Hg), with greater differences in southern locations ( P interaction =0.04). Predialysis systolic BP was inversely associated with outdoor temperature (−0.8 mm Hg/7.2°C; 95% CI, −1.0 to −0.5 mm Hg/7.2°C), with steeper slopes in southern locations ( P interaction =0.005). Results were similar for predialysis diastolic BP. In conclusion, there is a geographical and seasonal gradient of BP in European hemodialysis patients. There is a need to consider these effects when evaluating and treating BP in this population and potentially in others.

Published
2018
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9. Consequences of increasing convection onto patient care and protein removal in hemodialysis

Author

Caroline Guzman, Chantal Cazevieille, Moglie Le Quintrec, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Alain Ficheux, Fernando Vetromile, Philippe Brunet, Ilan Szwarc, Marie-Françoise Servel, Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), RD-Néphrologie (R&D), Néphrologie Dialyse Saint Guilhem (NDSG), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier (INM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Herrada, Anthony

Subjects
Convection, Male, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, lcsh:Medicine, Hemodiafiltration, 030204 cardiovascular system & hematology, Dialysis patients, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Transmembrane pressure, Patient care, 03 medical and health sciences, 0302 clinical medicine, Osmotic Pressure, Renal Dialysis, Dialysis Solutions, medicine, Humans, lcsh:Science, Dialysis, Aged, Aged, 80 and over, Multidisciplinary, Mass removal, business.industry, lcsh:R, Correction, Membranes, Artificial, Blood Proteins, Middle Aged, Weight range, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, Surgery, Anesthesia, lcsh:Q, Female, Hemodialysis, Patient Care, business
Abstract

International audience; Introduction: Recent randomised controlled trials suggest that on-line hemodiafiltration (OL-HDF) improves survival, provided that it reaches high convective volumes. However, there is scant information on the feasibility and the consequences of modifying convection volumes in clinics.Methods: Twelve stable dialysis patients were treated with high-flux 1.8 m2 polysulphone dialyzers and 4 levels of convection flows (QUF) based on GKD-UF monitoring of the system, for 1 week each. The consequences on dialysis delivery (transmembrane pressure (TMP), number of alarms, % of achieved prescribed convection) and efficacy (mass removal of low and high molecular weight compounds) were analysed.Results: TMP increased exponentially with QUF (p56,000 monitoring values). Beyond 21 L/session, this resulted into frequent TMP alarms requiring nursing staff interventions (mean ± SEM: 10.3 ± 2.2 alarms per session, p 20L) is feasible by setting an HDF system at its optimal conditions based upon the GKD-UF monitoring. Prescribing higher convection volumes resulted in instability of the system, provoked alarms, was bothersome for the nursing staff and the patients, rarely achieved the prescribed convection volumes and increased removal of high molecular weight compounds, notably albumin.

Published
2016
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10. Assessment of Metabolomic and Proteomic Biomarkers in Detection and Prognosis of Progression of Renal Function in Chronic Kidney Disease

Author

Àngel Argilés, Petra Zürbig, Harald Mischak, Thomas Koeck, William Mullen, Holger Husi, Esther Nkuipou-Kenfack, Nathalie Gayrard, Flore Duranton, Julie Klein, Ulrika Lundin, Christian Delles, Klaus M. Weinberger, Mohammed Dakna, Hannover Medical School [Hannover] (MHH), RD-Néphrologie (R&D), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Néphrologie Dialyse Saint Guilhem (NDSG), Mosaiques Diagnostics and Therapeutics, Mosaiques diagnostics and therapeutics, University of Glasgow, and Institute of Cardiovascular and Medical Sciences [Glasgow]

Subjects
Proteomics, Male, Pathology, Metabolite, Urine, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Kidney, Biochemistry, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, chemistry.chemical_compound, 0302 clinical medicine, Chronic Kidney Disease, Medicine and Health Sciences, 0303 health sciences, Multidisciplinary, Prognosis, 3. Good health, medicine.anatomical_structure, Nephrology, Disease Progression, Medicine, Biomarker (medicine), Female, Research Article, Glomerular Filtration Rate, medicine.medical_specialty, Science, Urinary system, Urology, Renal function, Biology, 03 medical and health sciences, Metabolomics, Diagnostic Medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Humans, Renal Insufficiency, Chronic, Aged, 030304 developmental biology, Biology and Life Sciences, medicine.disease, chemistry, Biomarkers, Follow-Up Studies, Kidney disease
Abstract

International audience; Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may reach epidemic proportions over the next decade. Efforts have been made to improve diagnosis and management of CKD. We hypothesised that combining metabolomic and proteomic approaches could generate a more systemic and complete view of the disease mechanisms. To test this approach, we examined samples from a cohort of 49 patients representing different stages of CKD. Urine samples were analysed for proteomic changes using capillary electrophoresis-mass spectrometry and urine and plasma samples for metabolomic changes using different mass spectrometry-based techniques. The training set included 20 CKD patients selected according to their estimated glomerular filtration rate (eGFR) at mild (59.9616.5 mL/min/1.73 m 2 ; n = 10) or advanced (8.964.5 mL/min/1.73 m 2 ; n = 10) CKD and the remaining 29 patients left for the test set. We identified a panel of 76 statistically significant metabolites and peptides that correlated with CKD in the training set. We combined these biomarkers in different classifiers and then performed correlation analyses with eGFR at baseline and follow-up after 2.860.8 years in the test set. A solely plasma metabolite biomarker-based classifier significantly correlated with the loss of kidney function in the test set at baseline and follow-up (r = 20.8031; p,0.0001 and r = 20.6009; p = 0.0019, respectively). Similarly, a urinary metabolite biomarker-based classifier did reveal significant association to kidney function (r = 20.6557; p = 0.0001 and r = 20.6574; p = 0.0005). A classifier utilising 46 identified urinary peptide biomarkers performed statistically equivalent to the urinary and plasma metabolite classifier (r = 20.7752; p,0.0001 and r = 20.8400; p,0.0001). The combination of both urinary proteomic and urinary and plasma metabolic biomarkers did not improve the correlation with eGFR. In conclusion, we found excellent association of plasma and urinary metabolites and urinary peptides with kidney function, and disease progression, but no added value in combining the different biomarkers data.

Published
2014
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11. La toxoplasmose, une complication exceptionnelle mais grave chez le transplanté rénal : à propos de deux observations

Author

Georges Mourad, F. Vetromile, Yvon Sterkers, Sebastien Jugant, I. Szwarc, Vincent Pernin, Valérie Garrigue, Sylvie Delmas, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Néphrologie Dialyse Saint Guilhem (NDSG), Department of Nephrology, Transplantation and Peritoneal Dialysis, University Hospital, Service de néphrologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Biologie, Génétique et Pathologie des Pathogènes Eucaryotes (MIVEGEC-BioGEPPE), Pathogènes, Environnement, Santé Humaine (EPATH), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes]

Subjects
medicine.medical_specialty, Opportunistic infection, medicine.medical_treatment, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Infectious complication, Internal medicine, parasitic diseases, medicine, Biological fluids, 030212 general & internal medicine, Kidney transplantation, 0303 health sciences, biology, 030306 microbiology, business.industry, Toxoplasma gondii, Immunosuppression, medicine.disease, biology.organism_classification, Toxoplasmosis, 3. Good health, Transplantation, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Nephrology, MESH: Kidney transplantation, Postoperative Complicaions/diagnosis, Toxoplasmosis/diagnosis, Toxoplasmosis/drug therapy, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Toxoplasma infection is uncommon after renal transplantation. As a result, Toxoplasma gondii is often missed from the list of microbial agents which may be responsible of an infectious complication after renal transplantation. However, establishing this diagnosis is very important because toxoplasmosis can be life-threatening in an immunocompromised host, particularly when the diagnosis is too delayed. Here we report two cases of severe toxoplasmosis after renal transplantation. In the first case, primary infection transmitted by a cat developed in a seronegative recipient five years after renal transplantation. In the second case, reactivation of latent infection developed in a seropositive recipient 9 months after transplantation. In both cases, systematic screening for Toxoplasma gondii using polymerase chain reaction (PCR) in biological fluids was essential to suggest the diagnosis. Both recipients rapidly recovered after institution of antiparasitic therapy.

Published
2013
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