1. Sensitisation of severe asthma in different occupations: A multicentre study in China
- Author
-
Mingshan Xue, Baoqing Sun, Huimin Huang, Haisheng Hu, Peiyan Zheng, Ge Wu, Nili Wei, and Nairui An
- Subjects
Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Medical staff ,Indoor air ,Severe asthma ,03 medical and health sciences ,0302 clinical medicine ,Weed pollen ,Internal medicine ,Hypersensitivity ,Humans ,Immunology and Allergy ,Medicine ,Asthmatic patient ,In patient ,030212 general & internal medicine ,Occupations ,Genetics (clinical) ,Skin Tests ,business.industry ,Allergens ,Immunoglobulin E ,Asthma ,030228 respiratory system ,Cohort ,business ,Tree pollen - Abstract
OBJECTIVE This was the first multicentre study assessing the sensitisation patterns in patients with severe asthma by different occupations as well as different regions of China, and aimed to provide evidence for the prevention of sensitised patients with severe asthma. METHODS A total of 676 adults were included and assigned to three cohorts. Cohort A was comprised of severe asthma patients without smoking (n = 454), cohort B comprised severe asthmatic patients who were ex-smokers (n = 149), and cohort C comprised non-asthma individuals (n = 73). All study subjects underwent testing of serum sIgE level of house dusts mix (hx2), foods mix (fx5), moulds mix (mx2), tree pollen mix (tx4) and weed pollen mix (wx5) simultaneously. RESULTS Overall, the positive rates of hx2, fx5, mx2, tx4 and wx5 were 37.6%, 11.9%, 16.6%, 9.0% and 9.5% in severe asthmatic patients, respectively. Comparing cohort A with cohort B, the hx2 positive rates in cohort A were higher in fulltime homemaker (30.0% vs. 0.0%) and medical staff (40.0% vs. 0.0%, P more...
- Published
- 2020
- Full Text
- View/download PDF