1. Expression of CD1a by Langerhan’s Cells in Oral Lichen Planus - A Retrospective Analysis
- Author
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Yennavaram Vijay Kumar, Kalepu Venkata Karthik, Sadananda Kolimi, Esther Priyadarshini Sakki, Venumbaka Siva Kalyan, Ravi Perika, Kandukuri Mahesh Kumar, and Ganesh Kulkarni
- Subjects
Pathology ,medicine.medical_specialty ,Clinical Biochemistry ,Antigen presentation ,lcsh:Medicine ,medicine.disease_cause ,03 medical and health sciences ,Gingivitis ,0302 clinical medicine ,Allergen ,Antigen ,stomatognathic system ,antigens ,medicine ,Retrospective analysis ,dendritic cells ,skin and connective tissue diseases ,integumentary system ,business.industry ,lcsh:R ,Cancer ,030206 dentistry ,General Medicine ,medicine.disease ,Dentistry Section ,stomatognathic diseases ,antigen presentation ,030220 oncology & carcinogenesis ,Oral epithelium ,mouth mucosa ,Oral lichen planus ,medicine.symptom ,business - Abstract
Introduction: Langerhan’s Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. Aim: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. Materials and Methods: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test . Results: LC population in OLP was significantly higher when compared to the normal epithelium (p
- Published
- 2016