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Sedentary behaviour research is rapidly growing. Scoping reviews are important to inform policy and practice.The aim of this scoping a review was to map the available evidence from systematic reviews and meta-analyses of sedentary behaviour research on adults (≥18 years), within the phases of the behavioural epidemiology framework, and to identify bibliometric parameters of studies included in this review. Nine bibliographic databases were searched. Studies were screened and relevant information (e.g., general information, inclusion criteria, findings and reporting quality) was extracted independently by two authors. In total, 108 systematic reviews and/or meta-analyses of sedentary behaviour research in adults (≥18 years) were included. Most papers (91.7%) were published between 2010 and 2020. Studies on the relationship of sedentary behaviour with health (53.7%) and interventions to reduce sedentary behaviour (25.9%) were most common. Forty-five (41.7%) studies reported quality assessment with categorization, and 887 out of 1268 (70%) included primary studies were categorized having moderate-to-high quality. Sedentary behaviour research on adults (≥18 years) has grown exponentially in the last decade and demonstrates strength in several stages of the behavioural epidemiology framework. However, more research should focus on the measurement, prevalence/epidemiology and determinants of sedentary behaviour, to better inform policy development.

Purpose: To investigate the associations between sleep and competitive performance in basketball. Methods: A total of 7 semiprofessional, male players were monitored across the in-season. On nights prior to competition, sleep duration and quality were assessed using actigraphs and sleep diaries. The data were accumulated over 1 (night 1), 2 (nights 1–2 combined), 3 (nights 1–3 combined), and 4 (nights 1–4 combined) nights prior to competition. Performance was reported as player statistics (field goal and free-throw accuracy, rebounds, assists, steals, blocks, and turnovers) and composite performance statistics (offensive rating, defensive rating, and player efficiency). Linear regression analyses with cluster-robust standard errors using bootstrapping (1000 replications) were performed to quantify the association between sleep and performance. Results: The night before competition, subjective sleep quality was positively associated with offensive rating and player efficiency (P Conclusions: Strategies to increase subjective sleep quality the night before competition should be considered to increase the likelihood of successful in-game performance, given its association with composite performance metrics.

In Australia, exercise practitioners (i.e., clinical professionals specializing in exercise assessment and delivery) are increasingly recognized as core mental health team members. In response to the COVID-19 pandemic, exercise practitioners, like other mental health professions, have had to adapt methods of clinical service delivery to ensure social distancing and reduce risk of community transmission. As such, telehealth interventions have rapidly replaced most face-to-face services. To date, evidence surrounding the application of telehealth exercise interventions for people living with mental illness is scarce, and currently there is no consensus or recommendations on how exercise practitioners can provide telehealth services for this population. As such, the aim of this article is to draw on existing research and expert opinion to provide practical and service-based guidance for exercise practitioners delivering telehealth services to people with mental illnesses. Specifically, we explore the potential benefits of telehealth exercise interventions, the various challenges and considerations of telehealth exercise among those with mental illness, and some practical solutions to guide exercise practitioners in delivering telehealth services.

Neck of femur (NOF) fractures present a significant challenge for healthcare systems and are associated with major complications and high mortality. Hospital clinical pathways aim to improve care and optimise outcomes for individuals sustaining NOF fractures; however, these pathways exclude the pre-hospital management of suspected NOF fractures. Therefore, there remains a lack of evidenced-based standardisation for pre-hospital management. To date, research into pre-hospital management of NOF fractures has mostly focussed on pain relief, with very little research examining immobilisation techniques. This is despite immobilisation offering great clinical benefit for other long bone fractures. Unlike hospital clinical pathways that undergo annual reports and reviews, pre-hospital guidelines for NOF fracture immobilisation have received little attention in the past decade. Given advances in research-informed practice for pre-hospital management of other fractures, it seems timely and pertinent to examine current clinical practice guidelines for NOF fractures, focusing on the appropriateness of current immobilisation techniques.

Older adults' participation in resistance training is low. Recent research suggests social aspects are important determinants of exercise engagement. In this study, 13 older women (50 years and older) were interviewed to examine their experiences of powerlifting training. Data were thematically analyzed revealing two main themes: Challenging Beliefs and Positive Social Influences. Peer advocates were essential for uptake, with social interactions in group resistance training, and having a skilled trainer, identified as important adherence factors. Strategies to improve resistance training uptake in older women could leverage off the experience of others and powerlifting training culture and practices.

Purpose: To quantify and compare external and internal game workloads according to contextual factors (game outcome, game location, and score-line). Methods: Starting semiprofessional, male basketball players were monitored during 19 games. External (PlayerLoad™ and inertial movement analysis variables) and internal (summated-heart-rate-zones and rating of perceived exertion [RPE]) workload variables were collected for all games. Linear mixed-effect models and effect sizes were used to compare workload variables based on each of the contextual variables assessed. Results: The number of jumps, absolute and relative (in min−1) high-intensity accelerations and decelerations, and relative changes-of-direction were higher during losses, whereas session RPE was higher during wins. PlayerLoad™ the number of absolute and relative jumps, high-intensity accelerations, absolute and relative total decelerations, total changes-of-direction, summated-heart-rate-zones, session RPE, and RPE were higher during away games, whereas the number of relative high-intensity jumps was higher during home games. PlayerLoad™, the number of high-intensity accelerations, total accelerations, absolute and relative decelerations, absolute and relative changes-of-direction, summated-heart-rate-zones, sRPE, and RPE were higher during balanced games, whereas the relative number of total and high-intensity jumps were higher during unbalanced games. Conclusions: Due to increased intensity, starting players may need additional recovery following losses. Given the increased external and internal workload volumes encountered during away games and balanced games, practitioners should closely monitor playing times during games. Monitoring playing times may help identify when players require additional recovery or reduced training volumes to avoid maladaptive responses across the in-season.

Over the past 40 years there has been a steady rise in the number of people with chronic kidney disease due mainly to a significant increase in the number of people with diabetic kidney disease (DKD). Current treatments (blood pressure control, blood sugar control, and renin-angiotensin-aldosterone system inhibitors) have had a significant impact on slowing progression of DKD. But the continued rise illustrates that there is a great need for new medications. Recently, a number of potentially reno-protective medicines have been studied. In this review, these new medications are discussed with respect to both their reported benefits and possible risks.

Sleep is essential in the preparation for, and the recovery from, training and competition. Despite being important for all individuals, young athletes are considered an at-risk group for reduced sleep duration and quality. The purpose of this review is to synthesise current literature relating to sleep duration and quality in young (14-25 years) athletes. Specifically, typical sleep and wake patterns, factors affecting sleep and wake patterns, and the consequences of altered sleep and wake patterns in young athletes are discussed. Scheduling training and competition in the afternoon or evening appears to result in reduced sleep duration due to less time in bed. Evidence suggests that young athletes who obtain less than 8 h of sleep per night are at a higher risk of musculoskeletal injury. An increase in sleep duration above habitual nightly sleep may be associated with favourable performance in young athletes; however, the associations between sleep quality and performance- and health-related outcomes remain unclear.

Objective To systematically identify, appraise, and examine evidence regarding the effects of therapeutic tape on pain and function in individuals with lateral epicondylalgia (LE). Methods Five electronic databases were systematically searched up to March 2018. Full-text, peer-reviewed, English-language studies were included if they had an LE population, a standalone tape condition, and an outcome related to pain or function. Results Eight out of 2022 screened studies were included. Three studies demonstrated immediate (i.e. within 1 h) improvements in pain and pain-free grip strength following diamond deloading rigid tape. One study reported immediate improvements in proprioception following transverse rigid tape. The immediate effects of longitudinal kinesiotape were inconsistent. One study reported improvements in pain and pain-free grip strength, while another study reported no effect on pain, strength, or muscle activity. Two studies examined short-term (i.e. within six weeks) kinesiotape application. One study reported two weeks of longitudinal kinesiotape improved pain and maximum grip strength. The other study reported one week of diamond kinesiotape improved patient-reported pain and function, but not maximum grip strength. Conclusions In individuals with LE, diamond deloading rigid tape may immediately improve pain and strength. There is conflicting evidence regarding kinesiotape effects in both immediate and short-term timeframes.

Purpose: To quantify and compare internal and external workloads in regular and overtime games and examine changes in relative workloads during overtime compared with other periods in overtime games in male basketball players. Methods: Starting players for a semiprofessional male basketball team were monitored during 2 overtime games and 2 regular games (nonovertime) with similar contextual factors. Internal (rating of perceived exertion and heart-rate variables) and external (PlayerLoad and inertial movement analysis variables) workloads were quantified across games. Separate linear mixed-models and effect-size analyses were used to quantify differences in variables between regular and overtime games and between game periods in overtime games. Results: Session rating-of-perceived-exertion workload (P = .002, effect size 2.36, very large), heart-rate workload (P = .12, 1.13, moderate), low-intensity change-of-direction events to the left (P = .19, 0.95, moderate), medium-intensity accelerations (P = .12, 1.01, moderate), and medium-intensity change-of-direction events to the left (P = .10, 1.06, moderate) were higher during overtime games than during regular games. Overtime periods also exhibited reductions in relative PlayerLoad (first quarter P = .03, −1.46, large), low-intensity accelerations (first quarter P = .01, −1.45, large; second quarter P = .15, −1.22, large), and medium-intensity accelerations (first quarter P = .09, −1.32, large) compared with earlier periods. Conclusions: Overtime games disproportionately elevate perceptual, physiological, and acceleration workloads compared with regular games in starting basketball players. Players also perform at lower external intensities during overtime periods than earlier quarters during basketball games.

Objectives To assess the validity of the Polar Team Pro Sensor for measuring speed and distance indoors during continuous locomotive and change-of-direction tasks at low, medium, and high intensities. Design Descriptive validation study. Methods 26 recreationally-active participants (age: 32.2 ± 11.0 yr; stature: 173.3 ± 9.9 cm; body mass: 74.2 ± 16.2 kg) completed three trials of low- (walking speed), medium- (jogging speed), and high-intensity (maximal sprinting speed) continuous locomotive and change-of-direction tasks. Participants wore back- and chest-mounted sensors to determine mean speed and total distance covered. One-way analysis of variance, t-tests, Pearson’s Product moment correlation, and Bland–Altman plots were utilised to compare the speed and distance measured with the back- and chest-mounted sensors to reference measures (measured distance of the court via a trundle wheel and speed derived from measured distance and electronic timing lights). Results Speed and distance measured using the back- and chest-mounted sensors showed wide limits of agreement, which increased at high intensities for speed. The sensors typically underestimated speed and distance by as much as 2.76 km h−1 and 32.6 m, and overestimated speed and distance by as much as 4.52 km h−1 and 59.6 m across tasks and intensities compared to reference measures (168.45 and 40.00 m). Conclusions There was low agreement between both back- and chest-mounted sensors and the reference devices for measuring speed and distance indoors. Practitioners should understand the limitations and potential for error when using the Polar Team Pro Sensors indoors to measure speed and distance during continuous locomotive and change-of-direction tasks.

Match activity demands of basketball players have been well reported but little exists in terms of quantifying the demands encountered by referees during match-play. Potential differences between referees and players may identify different fitness capacities and subsequent need for different training regimes.

The substantial physical health disadvantage experienced by people diagnosed with mental illness is now identified in a growing body of research evidence. The recent promulgation of improved physical health care as a goal of contemporary Australian Mental Health Policy should provide impetus for initiatives and strategies to address this inequity. To date increased knowledge of the problem has not resulted in obvious and sustained changes. The aim of this article is to introduce the role of the Physical Health Nurse Consultant as a potential strategy. The potential contribution and value of this role is considered by reviewing the evidence from the perspective of multiple stakeholders and considering the suitability of nursing to meet the complex needs involved in improving physical health. The requirement for a multi-faceted and comprehensive evaluation is also articulated. A robust, prospective and long-term evaluation plan includes physical health measures, changes in health behaviours, cost-benefit analysis and consumer acceptability to ensure the intervention is effective in the long term. This thorough approach is essential to provide the level of evidence required to facilitate changes at the practice and policy levels. The specialist nursing role presented in this article, subject to the comprehensive evaluation proposed, could become an integral component of a comprehensive approach to addressing physical health inequities in people with mental illness.

Background: Twitter is increasingly used as a medium to communicate scholarly content and facilitate expedited knowledge translation. Academic conferences typically use event-specific hashtags to promote conferences and move conference-related conversations to the public domain. Like other health disciplines, exercise physiology and exercise science attract global interest, and Twitter used during conferences can promote conference content to a broader audience than attendees. However, despite conferences in these disciplines having previously used hashtags, no published studies have examined their use. This study examined the use of the #RTP18 during the 2018 Exercise & Sports Science Australia Research to Practice Conference. Methods: Freely accessible Twitter data were mined using twdocs. Descriptive statistics were used to report the number of original tweets and retweets. Content analysis was used to differentiate original tweets related to specific conference sessions from tweets related to the conference in general. Data are presented for each day of the conference and overall for the three days of the conference. Results: A total of 262 original tweets were identified using the hashtag #RTP18. Seventy-one percent (n = 187) of the original tweets were related to specific conference content, while n = 75 (29%) of original tweets were related to the conference in general. More than 11,500 retweets were identified across the duration of the conference. The mean retweet rate was 12.7 times and ranged from 0–73. Conclusion: Twitter appears to be a powerful tool to extend the reach of conference activities. The use of social media may enhance organizational and personal networking opportunities for conference delegates.

Low rates of physical activity, in addition to other poor physical health behaviors, contribute to lower quality of life and increased rates of premature mortality for people living with mental illness. Physical activity reduces this mortality gap while simultaneously improving mood, cognitive function, and symptomology for a variety of psychiatric disorders. While physical activity programs are feasible and acceptable in this population, significant barriers exist that limit long-term adherence. Accredited exercise physiologists (AEPs) are best-placed in Australia to lead physical activity interventions for people living with mental illness. Additionally, AEPs provide an important role in improving culture change within mental health settings by influencing clinicians' attitudes to physical activity interventions. Leading international mental health organizations should collaborate and promote the role of physical activity to increase the provision of such services to people living with mental illness.

BACKGROUND: Exercise is nowadays considered as an evidence-based treatment modality in people with mental illness. Nurses and occupational therapists working in low-resourced mental health settings are well-placed to provide exercise advice for people with mental illness. OBJECTIVES: We examined the current exercise prescription practices employed by Ugandan health care professionals when working with people with mental illness, and identified perceived barriers to exercise prescription and exercise participation for people with mental illness. METHODS: In this study, 31 Ugandan health care professionals 20 men; 31.2 ± 7.1 years completed the Exercise in Mental Illness Questionnaire- Health Professionals Version EMIQ-HP. RESULTS: The vast majority of the respondents 29/31, 94% reported they prescribed exercise at least "occasionally" to people with mental illness. Exercise-prescription parameters used were consistent with those recommended for people with mental illness. Regarding barriers to exercise participation, coping with side effects of psychotropic medication at the individual level and reducing stigma at community level should be prioritized. CONCLUSION: A health care reform to enable collaboration with exercise professionals, such as exercise physiologists or physiotherapists, might increase exercise uptake for people with mental illness, thereby improving health outcomes for this vulnerable population. ispartof: AFRICAN HEALTH SCIENCES vol:19 issue:2 pages:2172-2182 ispartof: location:Uganda status: published

This study investigates changes in willingness to vaccinate against COVID-19 and the effect of the extended restrictions in metropolitan Victoria on this change. Longitudinal and repeated cross-sectional data were collected from online surveys distributed in April, between July and August, and December 2020. Australian adults who were ≥18 years old were recruited through email lists, social media networks, and paid Facebook advertisement. Willingness to vaccinate against COVID-19 was self-reported. The results showed that participants were more willing to vaccinate if the vaccine was safe at survey 1 (longitudinal: adjusted OR (aOR) = 1.88, 95%CI = 1.38, 2.56, cross-sectional: aOR = 3.73, 95%CI = 2.55, 5.45) and survey 2 (longitudinal: aOR = 1.54, 95%CI = 1.19, 2.00, cross-sectional: aOR = 2.48, 1.67, 3.67), compared to survey 3. The change in willingness to vaccinate if the vaccine was safe and effective was not significant for those in Metropolitan Victoria, but was for those living in other Australian locations at survey 1 (OR = 2.13, 95%CI = 1.64, 2.76) and survey 2 (OR = 1.62, 95%CI = 1.30, 2.01), compared to survey 3. Willingness to vaccinate even if a vaccine had not been proven safe decreased at survey 3 (OR = 2.02, 95%CI = 1.14, 3.57) for those living in Metropolitan Victoria. In conclusion willingness to vaccinate against COVID-19 decreased over time among Australians, except for those living in metropolitan Victoria, where an additional strict and prolonged lockdown was implemented around the time of survey 2. Either the experience of the lockdown, or the presence of the COVID-19 virus itself had a positive influence on participants’ willingness to vaccinate, even if such a vaccine was not yet proven to be safe and effective.

Controversy around the safety and efficacy of COVID-19 vaccines may lead to low vaccination rates. Survey data were collected in April and August 2020 from a total of 2343 Australian adults. A quarter (n = 575, 24%) completed both surveys. A generalized linear mixed model analysis was conducted to determine whether willingness to vaccinate changed in the repeated sample, and a multinominal logistic regression was conducted in all participants to determine whether willingness to vaccinate was associated with demographics, chronic disease, or media use. Willingness to vaccinate slightly decreased between April (87%) and August (85%) but this was not significant. Willingness to vaccinate was lower in people with a certificate or diploma (79%) compared to those with a Bachelor degree (87%), p &lt, 0.01 and lower in infrequent users of traditional media (78%) compared to frequent users of traditional media (89%), p &lt, 0.001. Women were more likely to be unsure if they would be willing to vaccinate (10%) compared to men (7%), p &lt, 0.01. There were no associations between willingness to vaccinate and age, chronic disease, or social media use. Promotion of a COVID-19 vaccine should consider targeting women, and people with a certificate or diploma, via non-traditional media channels.

Diabetic kidney disease (DKD) continues to be the primary cause of chronic kidney disease in the USA and around the world. The numbers of people with DKD also continue to rise despite current treatments. Certain newer hypoglycemic drugs offer a promise of slowing progression, but it remains to be seen how effective these will be over time. Thus, continued exploration of the mechanisms underlying the development and progression of DKD is essential in order to discover new treatments. Hyperglycemia is the main cause of the cellular damage seen in DKD. But, exactly how hyperglycemia leads to the activation of processes that are ultimately deleterious is incompletely understood. Studies primarily over the past 10 years have provided novel insights into the interplay of hyperglycemia, glucose metabolic pathways, mitochondrial function, and the potential importance of what has been called the Warburg effect on the development and progression of DKD. This review will provide a brief overview of glucose metabolism and the hypotheses concerning the pathogenesis of DKD and then discuss in more detail the supporting data that indicate a role for the interplay of glucose metabolic pathways and mitochondrial function.

Background Burnout and compassion fatigue (CF) are common among mental health practitioners. Accredited Exercise Physiologists (AEPs) provide clinical services to individuals experiencing mental illness, increasing their likelihood of experiencing burnout and CF. Aims To examine the prevalence of burnout and CF among AEPs working with people experiencing mental illness. Methods An anonymous online cross-sectional survey of AEPs working with people experiencing mental illness was distributed via the Exercise and Sports Science Australia Mental Health Special Interest Group Facebook page between July and November 2019. In addition to demographics and caseload data, respondents completed the Professional Quality of Life scale and Oldenburg Burnout Inventory (OLBI). Results are reported using descriptive statistics. Results Sixty-two AEPs (68%, n = 42 female) completed the survey. Most (n = 53, 86%) reported delivering services to consumers with severe mental health conditions. Less than half (n = 27, 44%) reported working in a dedicated mental health facility. Moderate levels of burnout and CF were experienced by 60% and 30% of respondents, respectively. Conclusions The prevalence of moderate burnout and CF symptoms in AEPs is comparable with other mental health professionals. Strategies to preserve psychological well-being such as enhancing mental health training for undergraduates and formalized supervision structures discussed.

Objective: The aim of this study was to understand the knowledge, beliefs, barriers, and behaviors of mental health professionals about physical activity and exercise for people with mental illness. Methods: The Portuguese version of The Exercise in Mental Illness Questionnaire was used to assess knowledge, beliefs, barriers, and behaviors about exercise prescription for people with mental illness in a sample of 73 mental health professionals (68.5% women, mean age = 37.0 years) from 10 Psychosocial Care Units (Centros de Atenção Psicossocial) in Porto Alegre and Canoas, state of Rio Grande do Sul, Brazil. Results: Most of respondents had received no formal training in exercise prescription. Exercise ranked fifth as the most important treatment, and most of the sample never or occasionally prescribed exercise. The most frequently reported barriers were lack of training in physical activity and exercise prescription and social stigma related to mental illness. Professionals who themselves met recommended physical activity levels found fewer barriers to prescribing physical activity and did so with greater frequency. Conclusion: Exercise is underrated and underused as a treatment. It is necessary to include physical activity and exercise training in mental health curricula. Physically active professionals are more likely to prescribe exercise and are less likely to encounter barriers to doing so. Interventions to increase physical activity levels among mental health professionals are necessary to decrease barriers to and increase the prescription of physical activity and exercise for mental health patients.

People with mental illness are twice as likely to develop cardiovascular, respiratory, infectious and metabolic diseases compared with the general population.1This disparity in health occurs from the earliest presentation of mental ill health and affects people across the life span,1 reducing life expectancy by 15–30 years compared with the general population.2 This poor physical health, as well as the associated widening mortality gap,3 has been described as a ‘human rights scandal’.2 This problem led to a Lancet Psychiatry Commission1 on protecting the physical health of people living with mental illness, with a focus on prevention and early intervention across all levels of treatment. The Lancet Psychiatry Commission outlines advances in our understanding of the link between physical and mental health, summarising findings from over 100 systematic reviews and meta-analyses, providing a practical blueprint towards protecting the physical health of this vulnerable population.1 Importantly, the blueprint recommends that all people living with mental illness have access to exercise and dietary interventions as part of routine mental healthcare. For people living with mental illness, higher rates of smoking, sleep disturbance, physical inactivity and …

Circumcisions are among the most commonly performed procedures in the pediatric population, but the value of the preputial skin often goes unrecognized as a potential graft (Ehrlichman et al., 2018). We highlight three patients who underwent coordinated circumcision and use of the excised preputial skin as a graft for syndactyly repair. Syndactyly, a condition where fingers are fused together, is often repaired utilizing skin from the groin region, which can result in unwanted hair growth and subcutaneous fat growth. The utilization of the prepuce is a convenient alternative that may have fewer undesirable qualities.

Bromilow, L, Stanton, R, and Humphries, B. A structured e-investigation into the prevalence and acceptance of smartphone applications by exercise professionals. J Strength Cond Res 34(5): 1330-1339, 2020-The primary purpose of this study was to examine the prevalence and acceptance of smartphone applications by exercise professionals when interacting with clients and patients. A 29-item anonymous online survey was designed, containing separate sections on demographics, smartphone proficiency, benefits and barriers to using smartphones, and use of smartphones in a professional setting. Accredited members of the Australian Strength and Conditioning Association, and Exercise and Sports Science Australia received an information sheet through organizational communication channels, inviting them to participate. Two hundred forty-nine exercise professionals completed the survey, with men (71%; n = 176) accounting for most of the respondents. Proficiency using smartphone applications is predominantly-advanced (37%; n = 92), intermediate (33%; n = 82), or expert (14%; n = 35). Identified strategies to find smartphone applications included personal searches (67%; n = 167) and colleague recommendations (55%; n = 137). Reported benefits include fast access to information (67%; n = 167), saves time for record keeping (56%; n = 141), and allows performance tracking (55%; n = 138). Almost all respondents (92%; n = 229) identified barriers, such as inexperience with using particular applications (42%; n = 105). Almost all respondents (96%; n = 239) reported they would recommend smartphone applications to clients and patients, primarily for self-tracking (53%; n = 132). Smartphone use among exercise professionals is prevalent; however, application and sensor technology are reluctantly underused. Increasing acceptance requires embedding within educational curricula, recognition from professional organizations, and collaboration with, to maximize the potential capabilities of smartphone technology within working environments.

Background: Physical activity (PA) significantly improves physical health and clinical symptoms across mental disorders. Accredited Exercise Physiologists (AEPs) are trained to lead PA interventions for people with mental illness, but referrals to AEPs are low. Aims: To determine the knowledge and attitudes of delegates attending the 2017 Royal Australian and New Zealand College of Psychiatrists (RANZCP) conference toward physical health monitoring and exercise interventions for people with mental illness. Methods: A cross-sectional survey of RANZCP delegates investigated knowledge and attitudes toward PA for people with mental illness, self-reported PA, and their understanding of AEP’s role within mental health settings. A subgroup of delegates underwent fitness assessments. Results: Seventy-three delegates completed surveys and 24 underwent fitness assessments. Delegates demonstrated good knowledge regarding associations between PA and cardiovascular disease risk. Delegates were less knowledgeable of AEP’s role within mental health settings. Forty-six participants (63%) did not meet the Australian recommended guidelines for PA. No association between referrals to AEPs and self-reported PA or fitness measures were evident. Conclusions: Promoting PA participation for mental health professionals, coupled with education on the important role AEPs play in the multidisciplinary treatment of mental health consumers is vital to improve health outcomes for this vulnerable group.

Background: Exercise is a well-established treatment for depression, and its use in clinical care is supported by consumers and clinicians. However, whether public health messages regarding the benefits of exercise for depression have translated to public knowledge remains unknown. This study aims to examine the community's mental health literacy, and views regarding exercise delivery for people with depression. Methods: A vignette was presented as part of the telephone-based 2017 National Social Survey (n = 1,265). Interviewees identified what (if anything) was wrong with the person described, who they should seek help from, whether exercise might be beneficial, and how exercise should be delivered for the person described in the vignette. Results are reported using descriptive statistics. Results: From 1,265 respondents (response rate = 24%, n = 598 males, mean age 54.7 years [range 18–101]), almost two-thirds correctly identified the condition described in the vignette as depression. There was widespread support for seeking help from a general practitioner. Exercise was well supported in the treatment of the person described in the vignette, with general practitioners and accredited exercise physiologists highlighted as persons to consult regarding exercise. Views regarding the type of program were consistent with current best practice recommendations. Conclusions: Australian adults demonstrate a high level of exercise and mental health literacy. The high level of support for accredited exercise physiologists is evidence of the effectiveness of health promotion campaigns from peak exercise professional agencies.

Background Over 690,000 Australians experience psychosis annually, significantly impacting cardiometabolic illness and healthcare costs. Current models of care are fragmented and a critical implementation gap exists regarding the delivery of coordinated physical healthcare for Australians with psychosis. Objectives To describe a trial implementing a Physical Health Nurse Consultant (PHNC) role to coordinate physical health care in a community mental health setting. Design/Methods In this 24-month, 2-group randomised controlled trial, 160 adults with psychosis will be randomised to usual care, or to the PHNC in addition to usual care. Using the Positive Cardiometabolic Health treatment framework and working in collaborative partnerships with consumers (consumer-led co-design), the PHNC will provide care coordination including referral to appropriate programmes or services based on the treatment framework, with the consumer. Burden of Disease risk factors will be collected according to Australian Bureau of Statistics' National Health Survey guidelines. Consumer experience will be assessed using the ‘Access’, ‘Acceptability’ and ‘Shared Decision Making’ dimensions of the Patient Experiences in Primary Healthcare Survey. Cost-effectiveness will be modelled from Burden of Disease data using the Assessing Cost Effectiveness Prevention methodology. Results Data collection of two years duration will commence in late 2018. Preliminary findings are expected in December 2019. Primary outcomes will be the effect of the PHNC role on physical healthcare in community-based adults with psychosis. Conclusions The PHNC is an innovative approach to physical health care for adults with psychosis which aims to meet the physical health needs of consumers by addressing barriers to physical health care.

Adequate training loads promote favorable physical and physiological adaptations, reduce the likelihood of illness and injury, and, therefore, increase the possibility of success during competition. Our objective was to systematically examine the association between training load and performance outcomes in team sports. We systematically searched the PubMed, SPORTDiscus, and PsycINFO databases for original research published before July 2018. The search included terms relevant to training load, performance, and team sports. Articles were screened using pre-defined selection criteria, and methodological quality was assessed independently by two authors before data were extracted by the lead author. The electronic search yielded 5848 articles, 2373 of which were duplicates. A further 17 articles were retrieved from additional sources. In total, 26 articles met the inclusion criteria for this review, with quality scores ranging from 6 to 10 out of 11. Training exposure was more strongly associated with aerobic performance than other external training load measures. High-intensity activity (≥ 90% of maximum heart rate) was strongly associated with aerobic performance. The individualized training impulse model was strongly associated with aerobic performance, whereas various other training impulse models and perceptual training load measures showed weak associations with aerobic performance. There were no clear associations between training load and neuromuscular variables or game-related statistics. We found no consistent associations between external training load measures and performance. High-intensity internal training load appears to be the most prominent indicator of aerobic performance.

Countermovement jump (CMJ) height is an important parameter in physical performance. This study compared CMJ height measured using ChronoJump contact mat (CJ) and Myotest accelerometer (MT) systems with a force platform (FP). Thirty recreationally active adults (32.1 ± 10.4 years, 75.9 ± 12.0 kg, 173.2 ± 6.3 cm) completed a CMJ protocol where height was simultaneously recorded using the three systems. CJ and MT measures were strongly and significant correlated (r = 0.65, 0.66, respectively; p 0.05), yet MT-derived measures were significantly different from those obtained using the FP (p

Scoliosis is a complication of fibrous dysplasia/McCune-Albright syndrome (FD/MAS); however, risk factors and long-term outcomes are unknown. Bisphosphonates are commonly used; however, it is unknown whether their use decrease the risk of progressive scoliosis. Clinical data from the National Institutes of Health (NIH) cohort study was reviewed. Cobb angles were measured, and variables associated with scoliosis progression were identified. Of 138 subjects with available radiographs, 84 (61%) had scoliosis, including 55 (65%) classified as mild (Cobb angle >10 to ≤30 degrees), 11 (13%) as moderate (>30 to ≤45 degrees), and 18 (22%) as severe (>45 degrees). Total skeletal disease burden was highly associated with scoliosis severity (p < 0.0001). Endocrinopathies associated with scoliosis included fibroblast growth factor 23 (FGF23)-mediated hypophosphatemia (p < 0.001) and hyperthyroidism (p < 0.001). Bone turnover markers, including osteocalcin and NTX-telopeptides, were associated with severe scoliosis (p < 0.01). Associations were identified between Cobb angle and functional metrics, including leg length discrepancy (p < 0.01), hip range of motion (p < 0.05), and strength of the gluteus medius and maximus (p < 0.01). Longitudinal analyses were conducted in 69 subjects who had serial radiographs over a median 4.9-year period (range, 0.9 to 14.7 years). Twenty-two subjects were treated with bisphosphonates; there was no difference in Cobb angle progression compared to untreated subjects (0.10 versus 0.53 degrees/year, p = 0.36). Longitudinal data was available for 10 of 12 subjects treated with spinal fusion; one had instrumentation failure, but in nine subjects Cobb angles were stable with 6.1 years of follow-up (range, 0.9 to 14.7 years). Two fatalities from scoliosis-associated restrictive lung disease occurred in subjects managed non-operatively. Scoliosis occurs frequently in patients with polyostotic FD, and may be potentially fatal. The primary risk factor for progressive scoliosis is total skeletal disease burden. Treatable features that contribute to scoliosis progression include leg length discrepancy, FGF23-mediated hypophosphatemia, and hyperthyroidism. Current data do not support routine use of bisphosphonates to prevent progression of spinal curvature. Spinal fusion is frequently effective in providing long-term stability, and may be lifesaving. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

Objective Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregulation puts patients at increased risk for depression and Alzheimer's disease. In the present study, we aimed to determine how glucose is metabolized in different regions of the brain using imaging mass spectrometry (IMS). Methods To examine the relative abundance of glucose and other metabolites in the brain, mouse brain sections were subjected to imaging mass spectrometry at a resolution of 100 μm. This was correlated with immunohistochemistry, qPCR, western blotting and enzyme assays of dissected brain regions to determine the relative contributions of the glycolytic and pentose phosphate pathways to regional glucose metabolism. Results In brain, there are significant regional differences in glucose metabolism, with low levels of hexose bisphosphate (a glycolytic intermediate) and high levels of the pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase (G6PD) and PPP metabolite hexose phosphate in thalamus compared to cortex. The ratio of ATP to ADP is significantly higher in white matter tracts, such as corpus callosum, compared to less myelinated areas. While the brain is able to maintain normal ratios of hexose phosphate, hexose bisphosphate, ATP, and ADP during fasting, fasting causes a large increase in cortical and hippocampal lactate. Conclusion These data demonstrate the importance of direct measurement of metabolic intermediates to determine regional differences in brain glucose metabolism and illustrate the strength of imaging mass spectrometry for investigating the impact of changing metabolic states on brain function at a regional level with high resolution., Highlights • Utilization of glucose for glycolysis or the pentose phosphate pathway (PPP) is region-specific. • IMS allows simultaneous measurement of glucose metabolites across brain regions. • PPP is high in thalamus, while glycolysis predominates in cortex and amygdala. • Fasting induces changes in lactate distribution but not glucose metabolites or ATP.

This study aimed to establish the reliability of a novel netball task using a single-leg horizontal jump (SLHJ). Twenty-five females 18–39 years performed SLHJs for maximal displacement and ground-reaction forces. Participants completed two trials for each leg on two occasions separated by 6 weeks of pre-season netball training. Paired sample t tests highlighted no significant differences within trials for either limb. Significant (p ≤ .05) changes are reported for displacement, and dominant and nondominant X and Y forces, after 6-week netball training. SLHJ displacement showed excellent within-session reliability at baseline for dominant (intraclass correlation coefficient (ICC(2,1)) = 0.922, 95% confidence interval (CI) 0.826–0.966) and nondominant (ICC(2,1) = 0.925; 95% CI 0.832–0.967) landings. At 6 weeks, within-session reliability remained excellent for dominant (ICC(2,1) = 0.967, 95% CI 0.926–0.985) and nondominant ICC 0.968 (95% CI 0.929–0.986) landings. The reliability of the single-leg h...

The purpose of this study was to quantify and compare training and competition demands in basketball.Fifteen semiprofessional male basketball players wore microsensors during physical conditioning training (PCT), games-based training (GBT), and competition to measure absolute and relative (·minPlayerLoad (arbitrary units [AU]) and EED (m) were statistically significantly (p .05) higher during PCT (632 ± 139 AU, d = 1.36; 5,964 ± 1,312 m, d = 1.36; 6.50 ± 0.81 AU·minTraining demands exceeded competition demands.

Community awareness of mental illness is crucial for helping people access mental health support. The association between ability to recognise mental health disorders and lived experience is not well examined in Australian populations. Australian adults (n = 1265) provided responses to a vignette depicting a person with depression and self-reported a previous diagnosis of depression and/or anxiety. People who had lived experience with depression and/or anxiety had significantly higher levels of this aspect of mental health literacy than people without lived experience. Public mental health literacy promotion efforts should consider incorporating insights from people with lived experience of mental illness.

In fibrous dysplasia/McCune-Albright syndrome (FD/MAS), bone and bone marrow are, to varying degrees, replaced by fibro-osseous tissue typically devoid of hematopoietic marrow. Despite the extensive marrow replacement in severely affected patients, bone marrow failure is not commonly associated with FD/MAS. We present a 14-year-old girl with FD/MAS, who developed pancytopenia and extramedullary hematopoiesis (EMH) with no identified cause, in the setting of iatrogenic thyrotoxicosis and hyperparathyroidism. Pancytopenia, requiring monthly blood transfusions, persisted despite multiple strategies to correct these endocrinopathies. Due to worsening painful splenomegaly, likely as a result of sequestration, splenectomy was performed. Following splenectomy, pancytopenia resolved and patient has since been transfusion-independent. We report the first detailed case of bone marrow failure and EMH in FD/MAS. The etiology of marrow failure is likely multifactorial and related to the loss of marrow reserve due to extensive polyostotic FD, exacerbated by iatrogenic thyrotoxicosis and hyperparathyroidism. Mini Abstract: A patient with fibrous dysplasia developed bone marrow failure and extramedullary hematopoiesis. The etiology likely involved loss of hematopoetic marrow space and uncontrolled endocrinopathies. Splenectomy was therapeutic.

People diagnosed with mental illness (hereinafter "consumers") have higher rates of chronic disease and significantly shorter lives than the wider population. Peer workers have become increasingly involved in facilitating access to physical health care, yet the consumer perspective regarding peer involvement is unknown. This absent voice is needed to inform strategic planning and generate solutions to address the current inequity in health status.To articulate the views of consumers in regards to the potential use of peer workers to further the physical health of people with mental illness.A qualitative exploratory study was conducted involving four focus groups with 31 consumer participants. Focus group responses were analysed thematically.Three themes pertaining to enhancing physical health care emerged: (1) the potential of peer workers in mitigating existing barriers, (2) consumer advocacy organisations expanding their agenda and (3) benefits of segregated activities as a segue to mainstream options.The envisaged forms of peer contribution have far greater scope and depth than is currently considered in policy, the research literature and health practice. Innovative solutions are required for this neglected population. Individual and systemic advocacy led by peer workers can enhance access to physical health care and have the potential to reduce physical health inequalities.

Diabetic kidney disease (DKD) is one of the most common complications in diabetes mellitus and accounts for a large proportion of clinical nephrology practice. Studies have shown that the kallikrein-kinin system (KKS) may be involved in several pathogenic mechanisms that contribute to DKD, including oxidative stress, inflammatory cytokines, and profibrotic autacoids. This review focuses on recent research advance on the potential role of the KKS in the development of DKD and its clinical relevance.A number of recent studies support the idea that there is a protective role of the KKS in diabetes. For example, agents that activate the KKS have shown strong renal protective effects that might highlight its potential to change the clinical practice. In addition, diabetic mice lacking both bradykinin B2 and B1 receptors have worse kidney lesions as compared with wild-type diabetic mice.Current basic research has demonstrated that pharmacological activation of the KKS improves renal outcomes in diabetes. These findings suggest that this system may be a therapeutic target in preventing and treating DKD.

Central obesity is a risk factor for metabolic syndrome, but taking waist circumference measurements can be uncomfortable for psychiatric inpatient clinicians and consumers, and if often avoided. The objective of this study was to assess whether metabolic syndrome in people with mental illness can be diagnosed without using waist circumference measurements. This study involved a retrospective file audit of metabolic monitoring forms stored in consumers’ electronic health records of community-based and inpatient mental health consumers at a mental health service located in regional Queensland, Australia. Of the 721 consumer files audited, 261 included a metabolic monitoring form. Of these 261 forms, 74 contained data on all five criteria for metabolic syndrome and the population-specific criteria for waist circumference was met in 54 (73%) of cases. Metabolic syndrome was detected in 39 consumers and waist circumference was necessary for this diagnosis in 12 (31%) cases. Measurement of waist circumference is, therefore, necessary for the detection of metabolic syndrome for a substantial proportion of consumers. The common practice of avoiding waist circumference measurements clearly needs to change if the physical health needs of consumers are to be adequately addressed.

Fox, JL, Scanlan, AT, and Stanton, R. A review of player monitoring approaches in basketball: current trends and future directions. J Strength Cond Res 31(7): 2021-2029, 2017-Effective monitoring of players in team sports such as basketball requires an understanding of the external demands and internal responses, as they relate to training phases and competition. Monitoring of external demands and internal responses allows coaching staff to determine the dose-response associated with the imposed training load (TL), and subsequently, if players are adequately prepared for competition. This review discusses measures reported in the literature for monitoring the external demands and internal responses of basketball players during training and competition. The external demands of training and competition were primarily monitored using time-motion analysis, with limited use of microtechnology being reported. Internal responses during training were typically measured using hematological markers, heart rate, various TL models, and perceptual responses such as rating of perceived exertion (RPE). Heart rate was the most commonly reported indicator of internal responses during competition with limited reporting of hematological markers or RPE. These findings show a large discrepancy between the reporting of external and internal measures and training and competition demands. Microsensors, however, may be a practical and convenient method of player monitoring in basketball to overcome the limitations associated with current approaches while allowing for external demands and internal responses to be recorded simultaneously. The triaxial accelerometers of microsensors seem well suited for basketball and warrant validation to definitively determine their place in the monitoring of basketball players. Coaching staff should make use of this technology by tracking individual player responses across the annual plan and using real-time monitoring to minimize factors such as fatigue and injury risk.

Accredited Exercise Physiologists (AEPs) are trained to deliver exercise and physical activity interventions for people with chronic and complex health conditions including those with mental illness. However, their views on exercise for mental illness, their exercise prescription practices, and need for further training are unknown.To examine the way in which Australian AEPs prescribe exercise for people with mental illness.Eighty-one AEPs (33.3 ± 10.4 years) completed an online version of the Exercise in Mental Illness Questionnaire. Findings are reported using descriptive statistics.AEPs report a high level of knowledge and confidence in prescribing exercise for people with mental illness. AEPs rate exercise to be at least of equal value to many established treatments for mental illness, and frequently prescribe exercise based on current best-practice principles. A need for additional training was identified. The response rate was low (2.4%) making generalisations from the findings difficult.Exercise prescription practices utilised by AEPs are consistent with current best-practice guidelines and there is frequent consultation with consumers to individualise exercise based on their preferences and available resources. Further training is deemed important.

Objectives: Evaluation of physical activity (PA) programs among populations with severe mental illness (SMI) has predominately focused on efficacy and therapeutic benefits. There is now strong evidence to support the benefits of PA in people with SMI. What remains is a gap in the implementation of pragmatic and sustainable PA interventions in mental-health settings. The current paper provides examples of interventions that have been successfully implemented in Australian settings, identifies key components of successful PA interventions and outlines practical strategies that can assist with widespread implementation of PA interventions in mental-health settings. Conclusions: There is an emergence of PA interventions being imbedded within a variety of mental-health settings. These interventions vary in terms of mode and intensity of service delivery. Yet, all aim to increase PA and reduce sedentary behaviour. Adopting the identified strategies may help facilitate successful implementation and increase access to PA interventions for mental-health service users.

Objectives Smartphone applications are increasingly used by researchers, coaches, athletes and clinicians. The aim of this study was to examine the concurrent validity and intra-rater reliability of the smartphone-based application, MyJump , against laboratory-based force plate measurements. Design Cross sectional study. Methods Participants completed counter-movement jumps (CMJ) (n=29) and 30cm drop jumps (DJ) (n=27) on a force plate which were simultaneously recorded using MyJump . To assess concurrent validity, jump height, derived from flight time acquired from each device, was compared for each jump type. Intra-rater reliability was determined by replicating data analysis of MyJump recordings on two occasions separated by seven days. Results CMJ and DJ heights derived from MyJump showed excellent agreement with the force plate (ICC values range from 0.991 for CMJ to 0.993) However mean DJ height from the force plate was significantly higher than MyJump (mean difference: 0.87cm, 95% CI: 0.69–1.04cm). Intra-rater reliability of MyJump for both CMJ and DJ was almost perfect (ICC values range from 0.997 for CMJ to 0.998 for DJ); however, mean CMJ and DJ jump height for Day 1 was significantly higher than Day 2 (CMJ: 0.43cm, 95% CI: 0.23–0.62cm); (DJ: 0.38cm, 95% CI: 0.23–0.53cm). Conclusion The present study finds MyJump to be a valid and highly reliable tool for researchers, coaches, athletes and clinicians; however, systematic bias should be considered when comparing MyJump outputs to other testing devices.

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from individuals with extreme duration of diabetes (ł50 years) without DN and those with histologic signs of DN. Enzymes in the glycolytic, sorbitol, methylglyoxal and mitochondrial pathways were elevated in individuals without DN. In particular, pyruvate kinase M2 (PKM2) expression and activity were upregulated. Mechanistically, we showed that hyperglycemia and diabetes decreased PKM2 tetramer formation and activity by sulfenylation in mouse glomeruli and cultured podocytes. Pkm-knockdown immortalized mouse podocytes had higher levels of toxic glucose metabolites, mitochondrial dysfunction and apoptosis. Podocyte-specific Pkm2-knockout (KO) mice with diabetes developed worse albuminuria and glomerular pathology. Conversely, we found that pharmacological activation of PKM2 by a small-molecule PKM2 activator, TEPP-46, reversed hyperglycemia-induced elevation in toxic glucose metabolites and mitochondrial dysfunction, partially by increasing glycolytic flux and PGC-1α mRNA in cultured podocytes. In intervention studies using DBA2/J and Nos3 (eNos) KO mouse models of diabetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and kidney pathology. Thus, PKM2 activation may protect against DN by increasing glucose metabolic flux, inhibiting the production of toxic glucose metabolites and inducing mitochondrial biogenesis to restore mitochondrial function.

Aims and Objectives: To elicit the perspectives of carers of people with mental illness regarding access to, and experience with, physical healthcare services for mental health consumers. Background: People diagnosed with mental illness have increased risks of physical illness and earlier death, problems able to be addressed through better physical health services. Carers of people with mental illness play a significant role in the mental healthcare system yet research examining their views is lacking. Design: Qualitative exploratory. Methods: In-depth interviews were conducted with 13 mental health carers. They were asked to describe their views and experiences pertaining to the physical health and availability of physical health care for the people they care for. Data were analysed using the framework of Braun and Clarke. Results: Analysis of carer responses identified two important themes: responsiveness and access, and a shortage of care coordination. Carers felt alienated from physical healthcare providers and were compelled to fill gaps in available care through persistence in ensuring access to physical healthcare services. Conclusions: The findings identify carers as key stakeholders in the physical health care for the people they care for. Their involvement in accessing and coordinating care provides vital perspective on health service capacity, which requires further consideration in the practice and research domains. Relevance to clinical practice: Carers of people diagnosed with mental illness are crucial to the effective delivery of mental health services. Their perspectives must be central to their research agenda and contribute to the development of initiatives to improve clinical practice and promote improved physical health care.

Background: People diagnosed with mental illness have shorter lives and poorer physical health, compared to the general population. These health inequities are usually viewed at an individual and clinical level, yet there is little research on the views of mental health consumers on clinical factors in broader contexts. Objective: To elicit the views of consumers of mental health services regarding their physical health and experiences of accessing physical health-care services. Design: Qualitative exploratory design involving focus groups. Setting and participants: The research was conducted in the Australian Capital Territory. Participants were consumers of mental health services. Main outcome measures: The Commission on Social Determinants of Health Framework was drawn on to lead deductive analysis of focus group interview transcripts. Results: Issues impacting consumers included poverty, the neglect of public services and being treated as second-class citizens because of diagnosis of mental illness and/or experiencing a psychosocial disability. These factors were connected with significant barriers in accessing physical health care, including the quality and relevance of health provider communication, especially when the broader contexts of mental health consumer's lives are not well understood. Discussion and conclusions: These findings suggest the Commission on Social Determinants of Health Framework could be utilized in research and policy, and may provide an effective platform for exploring better health communication with mental health consumers regarding this neglected health inequity.

Purpose of review Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. G6PD is the main source of the essential cellular reductant, NADPH. The purpose of this review is to describe the biochemistry of G6PD and NADPH, cellular factors that regulate G6PD, normal physiologic roles of G6PD, and the pathogenic role altered G6PD/NADPH plays in kidney disease. Recent findings NADPH is required for many essential cellular processes such as the antioxidant system, nitric oxide synthase, cytochrome p450 enzymes, and NADPH oxidase. Decreased G6PD activity and, as a result, decreased NADPH level have been associated with diabetic kidney disease, altered nitric oxide production, aldosterone-mediated endothelial dysfunction, and dialysis-associated anemia. Increased G6PD activity is associated with all cancers including kidney cancer. Inherited G6PD deficiency is the most common mutation in the world that is thought to be a relatively mild disorder primarily associated with anemia. Yet, intriguing studies have shown an increased prevalence of diabetes mellitus in G6PD-deficient people. It is not known if G6PD-deficient people are at more risk for other diseases. Summary Much more research needs to be done to determine the role of altered G6PD activity (inherited or acquired) in the pathogenesis of kidney disease.

The prevalence of diabetes around the world has reached epidemic proportions and is projected to increase to 642 million people by 2040. Diabetes is already the leading cause of end-stage kidney disease (ESKD) in most developed countries, and the growth in the number of people with ESKD around the world parallels the increase in diabetes. The presence of kidney disease is associated with a markedly elevated risk of cardiovascular disease and death in people with diabetes. Several new therapies and novel investigational agents targeting chronic kidney disease patients with diabetes are now under development. This conference was convened to assess our current state of knowledge regarding optimal glycemic control, current antidiabetic agents and their safety, and new therapies being developed to improve kidney function and cardiovascular outcomes for this vulnerable population.

Purpose: To examine the impact of workload volume during training sessions and games on subsequent sleep duration and sleep quality in basketball players. Methods: Seven semiprofessional male basketball players were monitored across preseason and in-season phases to determine training session and game workloads, sleep duration, and sleep quality. Training and game data were collected via accelerometers, heart-rate monitors, and rating of perceived exertion (RPE) and reported as PlayerLoad™ (PL), summated heart-rate zones, and session RPE (sRPE). Sleep duration and sleep quality were measured using wrist-worn activity monitors in conjunction with self-report sleep diaries. For daily training sessions and games, all workload data were independently sorted into tertiles representing low, medium, and high workload volumes. Sleep measures following low, medium, and high workloads and control nights (no training/games) were compared using linear mixed models. Results: Sleep onset time was significantly later following medium and high PL and sRPE game workloads compared with control nights (P P P P > .05). Conclusions: Following high PL and sRPE game workloads, basketball practitioners should consider strategies that facilitate longer time in bed, such as napping and/or adjusting travel or training schedules the following day.

Nearly 100 years ago, Otto Warburg undertook a study of tumor metabolism, and discovered increased lactate caused by increased glycolysis in cancer cells. His experiments were conducted in the presence of excess oxygen, but today tumor tissue is known to be a hypoxic environment. However, an increase of glycolysis and lactate production is still a valid observation. Numerous abnormalities and mutations of metabolic enzymes have been found in many cancers. For example, pyruvate kinase M2 has been associated with many cancers and is a major contributor to directing glycolysis into fermentation, forming lactate. Increases in several enzymes, including glucose 6-phosphate dehydrogenase, pyruvate kinase M2, Rad6, or deficiency of other enzymes such as succinate dehydrogenase, all may contribute directly or indirectly to increases in lactate associated with the Warburg effect. In addition, the increased lactate and acid-base changes are modified further by monocarboxylate transporters and carbonic anhydrase, which contribute to alkalinizing tumor cells while acidifying the tumor extracellular environment. This acidification leads to cancer spread. Fully understanding the mechanisms underlying the Warburg effect should provide new approaches to cancer treatment.

The association between psychotic illness and poor physical health is now clearly articulated in the literature. By contrast the impact of depression and/or anxiety on physical health is considerably less understood, despite depression being the leading cause of disability worldwide and is associated with significantly higher prevalence of physical comorbidities than found in the general population. An Australia national cross-sectional population-based survey was conducted to ascertain the prevalence of chronic physical health conditions in persons with, and without depression and/or anxiety, allowing for demographic characteristics and lifestyle factors. The telephone-based survey was conducted using trained interviewers. Survey questions included those eliciting information about demographics, health status, and health behaviours. Independent t-tests and chi square tests showed demographic, health behaviours, and physical illness differed between those with and without depression and/or anxiety. Heart disease, high blood pressure, stroke, cancer, arthritis, chronic neck and/or back pain, and asthma were significantly higher in participants diagnosed with depression and/or anxiety. Binary logistic regression showed the strongest predictor of chronic illness was having a diagnosis of depression and/or anxiety. Depression and anxiety present major health problems impacting a considerable proportion of the population. A greater understanding of the associated physical health issues should provide impetus to broaden the physical health and mental illness research agenda to include these diagnoses.