1. Ancient genomes reveal structural shifts after the arrival of Steppe-related ancestry in the Italian Peninsula
- Author
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Stefano Benazzi, Andrea Dolfini, Ophélie Lebrasseur, Eugenia D’Atanasio, Mait Metspalu, Cinzia Scaggion, Monica Miari, Mario Federico Rolfo, Greger Larson, Jessica Beckett, Tina Saupe, Francesco Montinaro, Cristian Capelli, Flavio De Angelis, Luca Pagani, Luca Alessandri, Ruoyun Hui, Letizia Silvestri, Robin Skeates, Anu Solnik, Christiana L. Scheib, Sahra Talamo, Toomas Kivisild, Ilenia Arienzo, Nicola Carrara, Classical and Mediterranean Archaeology, Saupe T., Montinaro F., Scaggion C., Carrara N., Kivisild T., D'Atanasio E., Hui R., Solnik A., Lebrasseur O., Larson G., Alessandri L., Arienzo I., De Angelis F., Rolfo M.F., Skeates R., Silvestri L., Beckett J., Talamo S., Dolfini A., Miari M., Metspalu M., Benazzi S., Capelli C., Pagani L., and Scheib C.L.
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0301 basic medicine ,Human Migration ,Settore L-ANT/01 ,Datasets as Topic ,genome-wide shotgun data ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Cave ,Peninsula ,Bronze Age ,Leprosy ,Human population genetics ,Kinship ,Humans ,DNA, Ancient ,isotope ,ancient DNA ,History, Ancient ,isotopes ,kinship ,geography ,geography.geographical_feature_category ,human population genetic ,Genome, Human ,Genomics ,Chalcolithic ,immunity ,Archaeology ,Genetics, Population ,Phenotype ,030104 developmental biology ,Ancient DNA ,Italy ,human population genetics ,Genetic structure ,later prehistory ,gene flow ,General Agricultural and Biological Sciences ,030217 neurology & neurosurgery - Abstract
Across Europe, the genetics of the Chalcolithic/Bronze Age transition is increasingly characterized in terms of an influx of Steppe-related ancestry. The effect of this major shift on the genetic structure of populations in the Italian Peninsula remains underexplored. Here, genome-wide shotgun data for 22 individuals from commingled cave and single burials in Northeastern and Central Italy dated between 3200 and 1500 BCE provide the first genomic characterization of Bronze Age individuals (n = 8; 0.001-1.2× coverage) from the central Italian Peninsula, filling a gap in the literature between 1950 and 1500 BCE. Our study confirms a diversity of ancestry components during the Chalcolithic and the arrival of Steppe-related ancestry in the central Italian Peninsula as early as 1600 BCE, with this ancestry component increasing through time. We detect close patrilineal kinship in the burial patterns of Chalcolithic commingled cave burials and a shift away from this in the Bronze Age (2200-900 BCE) along with lowered runs of homozygosity, which may reflect larger changes in population structure. Finally, we find no evidence that the arrival of Steppe-related ancestry in Central Italy directly led to changes in frequency of 115 phenotypes present in the dataset, rather that the post-Roman Imperial period had a stronger influence, particularly on the frequency of variants associated with protection against Hansen's disease (leprosy). Our study provides a closer look at local dynamics of demography and phenotypic shifts as they occurred as part of a broader phenomenon of widespread admixture during the Chalcolithic/Bronze Age transition. ispartof: CURRENT BIOLOGY vol:31 issue:12 pages:2576-+ ispartof: location:England status: published
- Published
- 2021
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