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Your search keyword '"Stéphane Ramstein"' showing total 4 results
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4 results on '"Stéphane Ramstein"'

1. Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds

Author

Stéphane Mottin, Bruno Montcel, Hugues Guillet de Chatellus, Stéphane Ramstein, Clémentine Vignal, Nicolas Mathevon, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), OPTique et IMAgeries [Grenoble] ( OPTIMA-LIPhy), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Ecologie et Neuro-Ethologie Sensorielles (ENES), Université Jean Monnet - Saint-Étienne (UJM), Costrel De Corainville, Sylvie, Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), LIPhy-OPTIMA, Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Université Jean Monnet [Saint-Étienne] (UJM), Mottin, Stéphane, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), and SPIE

Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], bird, FOS: Physical sciences, Hemodynamics, chemistry.chemical_element, Stimulation, Vasodilation, Stimulus (physiology), 01 natural sciences, Oxygen, Optical imaging, 010309 optics, 03 medical and health sciences, 0302 clinical medicine, 0103 physical sciences, Mole, medicine, Tissues and Organs (q-bio.TO), Optical tomography, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Lasers, Brain, Quantitative Biology - Tissues and Organs, Blood, chemistry, Quantitative Biology - Neurons and Cognition, FOS: Biological sciences, Forebrain, Streak cameras, Biophysics, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurons and Cognition (q-bio.NC), medicine.symptom, 030217 neurology & neurosurgery, Vasoconstriction, Physics - Optics, Optics (physics.optics)
Abstract

International audience; Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography (POT) with a white laser and a streak camera can measure in vivo oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb) concentration changes following physiological stimulation (familiar calls and songs). POT demonstrated sufficient sub-micromolar sensitivity to resolve the fast changes in hippocampus and auditory forebrain areas with 250 μm resolution. The time-course is composed of (i) an early 2s-long event with a significant decrease in Hb and HbO2, respectively -0.7 μMoles/L and -0.9 μMoles/L (ii) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+0.3μMoles/L) and (iii) pronounced vasodilatation events immediately following the end of the stimulus. One of the findings of our work is the direct link between the blood oxygen level-dependent (BOLD) signals previously published in birds and our results. Furthermore, the early vasoconstriction event and post-stimulus ringing seem to be more pronounced in birds than in mammals. These results in bird, a tachymetabolic vertebrate with a long lifespan, can potentially yield new insights for example in brain aging.

Published
2011
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2. Functional white-laser imaging to study brain oxygen uncoupling/recoupling in songbirds

Author

Stéphane Ramstein, Nicolas Mathevon, Stéphane Mottin, Clémentine Vignal, Bruno Montcel, H. Chatelus, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), OPTIMA, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Ecologie et Neuro-Ethologie Sensorielles (ENES), Université Jean Monnet [Saint-Étienne] (UJM), Centre de Neurosciences Paris-Sud (CNPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Equipe 7 : Neuro-Ethologie Sensorielle, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), and Mottin, Stéphane

Subjects
Male, near-infrared spectroscopy, [SDV]Life Sciences [q-bio], Hemodynamics, Laser imaging, Stimulation, Vasodilation, white light generation, 01 natural sciences, Oxygen, Songbirds, [SPI]Engineering Sciences [physics], Hemoglobins, Nuclear magnetic resonance, 0302 clinical medicine, Neuronal Plasticity, Spectroscopy, Near-Infrared, Brain, Magnetic Resonance Imaging, Neurology, Cerebrovascular Circulation, brain energy metabolism, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Cardiology and Cardiovascular Medicine, Corrigendum, Feature Article Commentary, Materials science, neurovascular coupling, chemistry.chemical_element, Stimulus (physiology), bioacoustics, 010309 optics, optical imaging, 03 medical and health sciences, Oxygen Consumption, femtosecond laser, 0103 physical sciences, medicine, cerebral hemodynamics, Animals, Tomography, Optical, Brain Chemistry, Photons, business.industry, Lasers, Feature Article, Coupling (electronics), Functional imaging, chemistry, Vasoconstriction, Oxyhemoglobins, brain activation, Forebrain, Neurology (clinical), Finches, business, Energy Metabolism, Neuroscience, 030217 neurology & neurosurgery
Abstract

Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography with a white laser and a streak camera can measure in vivo oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) concentration changes following physiologic stimulation (familiar calls and songs). Picosecond optical tomography showed sufficient submicromolar sensitivity to resolve the fast changes in the hippocampus and auditory forebrain areas with 250 μm resolution. The time course is composed of (1) an early 2-second-long event with a significant decrease in Hb and HbO2 levels of −0.7 and −0.9 μmol/L, respectively, (2) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+ 0.3 μmol/L), and (3) pronounced vasodilatation events immediately after the end of the stimulus. One of the findings of our study is the direct link between blood oxygen level-dependent signals previously published in birds and our results. Furthermore, the early vasoconstriction event and poststimulus ringing seem to be more pronounced in birds than in mammals. These results in birds, tachymetabolic vertebrates with a long lifespan, can potentially yield new insights, e.g., into brain aging.

Published
2010
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3. In vivo and noninvasive measurement of a songbird head's optical properties

Author

Stéphane Ramstein, Stéphane Mottin, Nicolas Mathevon, Clémentine Vignal, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Ecologie et Neuro-Ethologie Sensorielles (ENES), and Université Jean Monnet [Saint-Étienne] (UJM)

Subjects
Materials science, Spectrophotometry, Infrared, Materials Science (miscellaneous), 01 natural sciences, Brain mapping, Industrial and Manufacturing Engineering, law.invention, 010309 optics, 03 medical and health sciences, Hemoglobins, 0302 clinical medicine, Optics, Nuclear magnetic resonance, In vivo, law, 0103 physical sciences, Image Interpretation, Computer-Assisted, Animals, Business and International Management, Zebra finch, Brain Mapping, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], biology, business.industry, Lasers, [SCCO.NEUR]Cognitive science/Neuroscience, technology, industry, and agriculture, Brain, Oxygenation, Laser, biology.organism_classification, Songbird, nervous system, Attenuation coefficient, Cerebrovascular Circulation, Nidopallium, Finches, business, Head, 030217 neurology & neurosurgery
Abstract

International audience; By assessing the cerebral blood volume and the hemoglobin oxygen saturation level, near-infrared spectroscopy (NIRS) probes brain oxygenation, which reflects cerebral activity. To develop a noninvasive method monitoring the brain of a songbird, we use an original NIRS device, i.e., a white laser coupled with an ultrafast spectrotemporal detector of optical signals without wavelength scanning. We perform in vivo measurements of the absorption coefficient and the reduced scattering coefficient of the caudal nidopallium area of the head of a songbird (the zebra finch).

Published
2005
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4. Detection of haemodynamic changes in zebra finch brain by optical and functional magnetic resonance imaging

Author

Nicolas Mathevon, Tiny Boumans, Stéphane Ramstein, Johan Van Audekerke, Stéphane Mottin, Marleen Verhoye, Clémentine Vignal, Annemie Van der Linden, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Universiteit Antwerpen [Antwerpen], and Mottin, Stéphane

Subjects
Pathology, medicine.medical_specialty, Near-InfraRed Spectroscopy, Brain activity and meditation, Haemodynamic response, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Hypercapnia, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, medicine, otorhinolaryngologic diseases, Normocapnia, Zebra finch, 030304 developmental biology, [PHYS]Physics [physics], 0303 health sciences, Songbird, medicine.diagnostic_test, Chemistry, Magnetic resonance imaging, Oxygenation, Magnetic Resonance Imaging, Diffuse optical imaging, Diffuse Optical Tomography, Neurology, nervous system, Brain Energy Metabolism, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.IB]Life Sciences [q-bio]/Bioengineering, Neurology (clinical), sense organs, Cardiology and Cardiovascular Medicine, Functional magnetic resonance imaging, 030217 neurology & neurosurgery
Abstract

Songbirds' vocal communication behaviour has been a favourite research domain for years. In order to study brain activation in response to acoustic stimuli, two different in-vivo methods that are able to assess neuronal activity based on detection of haemodynamic changes were compared within identical experimental settings. Optical imaging (non-invasive in-vivo broadband time-resolved spectroscopy) and functional magnetic resonance imaging (Blood Oxygenation Level Dependent MRI) were both performed in zebra finch brain upon a hypercapnic challenge known to induce a standard haemodynamic response. The use of these two methods offers the opportunity to compare their sensitivity and to correlate local variations in CBV and haemoglobin saturation level (obtained from optical data) with local BOLD signal variations (providing overall information on CBF, CBV and haemoglobin oxygenation). Both for optical imaging and fMRI, four adult female zebra finches (Taeniopygia guttata) were anaesthetized with 2% isoflurane while spontaneously breathing, and immobilized in a stereotactical device equipped with essential monitoring devices. Each bird underwent three runs of 5 minute hypercapnia (600 ml/min 7% CO2, 21% O2, 72% N2), interleaved by 20 minutes normocapnia (600 ml/min 21% O2, 79% N2). Optical imaging was performed with an ultrafast white laser and time-resolved spectrometer. With the 95% PL (i.e. mean path length of the light detected by the camera at 95% of the measured temporal profile) at 2 spectral windows centered at 748 nm and 793 nm, we quantify respectively the haemoglobin saturation level and CBV. MR imaging was performed at 300 MHz on a 7 Tesla in-vivo NMR microscope with horizontal bore and actively shielded gradient-insert (210 mT/m). The optical imaging data demonstrated that hypercapnia induced a significant increase of the hemoglobin saturation level in run1 (p=.01) and run2 (p=.01). No significant CBV changes were observed during run1 (p=.1), run2 (p=.75) and run3 (p=.5). The fMRI data demonstrated the existence of significant BOLD signal changes for run1 (p

Published
2005
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