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3 results on '"Starace V"'

1. Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection

Author

Michele Cavalleri, Marco Battista, Luigi Capone, Alessio Grazioli Moretti, Vincenzo Starace, Francesca Gorgoni, Eleonora Corbelli, Francesco Bandello, Maria Brambati, Francesco Nadin, Domenico Grosso, Carlo Di Biase, Matteo Pederzolli, Cavalleri, M., Brambati, M., Starace, V., Capone, L., Nadin, F., Pederzolli, M., Gorgoni, F., Di Biase, C., Corbelli, E., Battista, M., Grazioli Moretti, A., Grosso, D., and Bandello, F.

Subjects
Male, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, RT-PCR, Betacoronavirus, Conjunctivitis, Viral, 03 medical and health sciences, 0302 clinical medicine, Pandemic, conjunctivitis, Humans, Immunology and Allergy, Medicine, Pandemics, 030203 arthritis & rheumatology, SARS-CoV-2, business.industry, COVID-19, Middle Aged, Virology, Respiratory support, Ophthalmology, Cross-Sectional Studies, 030221 ophthalmology & optometry, RNA, Viral, Female, Coronavirus Infections, business, Conjunctiva
Abstract

Purposes: To describe the prevalence of ocular features among COVID-19 patients and their relationship with clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients. Methods: 172 COVID-19 patients were evaluated for presence of ocular manifestations. Clinical and laboratory data were also reviewed. Conjunctival swabs were analyzed for SARS-CoV-2 by RT-PCR. Results: Forty-five patients (26.2%) reported ocular manifestations. Patients treated with CPAP were more likely to have ocular abnormalities (p

Published
2020

2. Longitudinal Evaluation of the Development of Wedge-Shaped Subretinal Hyporeflectivity in Geographic Atrophy

Author

Riccardo Sacconi, Enrico Borrelli, Vittorio Capuano, Giuseppe Querques, Francesco Bandello, Vincenzo Starace, Starace, V., Borrelli, E., Capuano, V., Sacconi, R., Bandello, F., and Querques, G.

Subjects
medicine.medical_specialty, genetic structures, media_common.quotation_subject, Visual Acuity, Retinal Drusen, Retinal Pigment Epithelium, Retina, 03 medical and health sciences, 0302 clinical medicine, Optical coherence tomography, Geographic Atrophy, Ophthalmology, Humans, Medicine, Contrast (vision), Aged, media_common, medicine.diagnostic_test, business.industry, eye diseases, Geographic atrophy, Left eye, medicine.anatomical_structure, 030221 ophthalmology & optometry, Female, sense organs, business, Tomography, Optical Coherence, Follow-Up Studies
Abstract

The authors present the case of a 73-year-old woman affected by geographic atrophy (GA) in her left eye. During her follow-up, she developed a subretinal hyporeflective space visible on optical coherence tomography (OCT) images. This peculiar OCT sign was recognized to represent a wedge-shaped subretinal hyporeflectivity (WSSH). In contrast to previous reports showing that WSSH develops during the flattening of drusenoid pigment epithelium detachment (PED), the authors found that the WSSH manifestation may be even consecutive to the regression of a large PED and consequent GA appearance. Therefore, the origin of this peculiar OCT finding could be more complex and variegated. [ Ophthalmic Surg Lasers Imaging Retina. 2020;51:116–118.]

Published
2020

3. Genotypic and phenotypic factors influencing the rate of progression in ABCA-4-related Stargardt disease

Author

Maria Vittoria Cicinelli, Vincenzo Starace, Alessandro Arrigo, Chiara Viganò, Francesco Bandello, Matteo Pederzolli, Maurizio Battaglia Parodi, Marco Battista, Maria Brambati, Starace, V., Battista, M., Brambati, M., Pederzolli, M., Vigano, C., Arrigo, A., Cicinelli, M. V., Bandello, F., and Battaglia Parodi, M.

Subjects
genetic structures, Biomedical Engineering, fundus flavimaculatus, retinal pigment epithelium, ABCA4, macromolecular substances, 03 medical and health sciences, 0302 clinical medicine, flecks, Genotype, medicine, stargardt disease, Genetic testing, abca4, Genetics, Retinal pigment epithelium, medicine.diagnostic_test, biology, business.industry, medicine.disease, Phenotype, eye diseases, Stargardt disease, Ophthalmology, Stargardt dystrophy, medicine.anatomical_structure, 030221 ophthalmology & optometry, biology.protein, Retinal imaging, business, 030217 neurology & neurosurgery, Optometry
Abstract

Introduction: Stargardt disease (STGD) is heterogeneous in terms of severity and rate of progression. New advancements in genetic testing and retinal imaging have improved prognostication in the disease. Areas covered: A PubMed-based search was carried out using the terms ‘Stargardt dystrophy’, ‘Stargardt disease’, ‘Fundus flavimaculatus’, and ‘ABCA4’. All studies published in English up to August 2020 were reviewed. Data from international multicenter trials were also considered in the discussion. Expert opinion: Genotype-phenotype correlations represent a challenge in STGD, as other epigenetic and environment modifiers participate in defining the clinical outcome and the long-term prognosis. Earlier age of onset and deleterious ABCA4 variants are the main determinants of severe progression. Quantitative imaging approaches are potentially useful for following-up STGD patients. Non-invasive biomarkers are needed to predict the natural history of the disease or drug effectiveness in future therapeutic trials.

Published
2021

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