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2 results on '"Steven V. Pham"'

1. A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience

Author

Ryan Chan, Joshua P Hedtke, Michael T Chang, Kristen M Omi, Namrata Kakade, William Y. Luo, Yurianna Hou, Gloria Chin Young, Sunjong Ji, Mai Abdusamad, Amy Ngo, Maggie M Yung, Carissa Chan, Sharon Lee, Mark R Murata, Ashwin Shinde, Jason P Xu, Angelica C Ayala, Emily Jin Kyung Kim, Elitzander Alegria‐Leal, Phuong Vo, Yuan Wan, Vivian K Chen, Raghav Goyal, Anabel Resendiz, Harin B Parikh, Jaime S Tan, Leah C Dorman, Annisa N Soeboer, Seethim Naicker, Pratyush Kandimalla, Petros S Dertsakyan, Faith A Hobby, Beatrice J Sun, Karen Hoi, Megha Pokhriyal, C Kimberly Tsui, Nguyen Khoi Le, Umar Chaudhary, Patrick Chin, Woo Kyeom Kim, Mengshi He, David A Sanville, Utpal Banerjee, Christine Sutanto, Tiffany Luu, Joshua Lin, Tony Yao, Josephine Liu, Janani Muthaiya, Ravinder Kaur, Steven V. Pham, Andrea Vega-Loza, Mia Lim, Nataliya S Balashova, Adam T Quaal, Hnin Hlaing, Patrick A. Truong, Bryan Stender, Harmanjit Bassi, Erwin Feng, Yuxuan Wang, Sarah Salarkia, Rina H Nguyen, Gloria Lam, Garuem Sin, Seong Ah Kim, Sindhuja Godavarthi, Jialing Li, Eileen Hu, Cindy La, Elaine Sang, Jun Ho Chung, Jinhua Shen, Celesti Hao, Josh Mytych, Elliott Wu, Jin Hee Kim, Duy Tran, Neel Chari, Andie O'Laughlin, Christopher J Smith, Mona Abutouk, Chak Lon Kuang, Pei-Hua Tsai, Alisa Sukhina, Li Li, Chongbin He, Daniel Wong, Jahzeel Paguntalan, Emily R Schoen, Edgar Corona, Vivian Yip, Trisha H Patel, Emily Kim, Ira E. Clark, Andrew Char, Guadalupe Ortega Almazan, Asmar Abdul Ghani, Nadiyah Priasti, Duy Q Ngo, Gabrielle Sibal, Sean P Bennion, Stephanie Pang, Vivien W. Ho, Rachel S Distler, Nateli Sama, Josef Madrigal, Maharshi Panchal, Zijie Cai, Ashley C. Hope, Miriam Beyder, Daphne Jin, Steven C Liu, John M. Olson, Janice Ly, Eric Wang, Irene Louie, Wilson Huang, Justin Rafael de la Fuente, Nathan Stutzman, Bilguudei Naranbaatar, Rose Graf, Jonelle Mungcal, Jason Capili, Ziqi Zhou, Kelly M Gu, Julie Ko, Jeffrey A Kho, Amber J Li, Daniel Tran, Cory J. Evans, Jocelyn Woo, Kristen Schnell, Praptee Chowdhury, Chi Ju Lee, Grace J. Lee, Tracy L. Johnson, Nadezhda Riabkova, David Lopatto, Amanda Phan, Mary C Onglatco, Stephanie Huang, Zhiqiao Dong, Sat Kartar Khalsa, Saurin Kadakia, Maique Vo, Jessica Ye, Eric Lin, Darron Miya, Julia A. Ainsworth, Nicholas James, Jonathan Chang, Chloe C Su, Jeffrey Lin, Leslie Jaworski, Jenna Kovsky, Alice Hsu, Michel Chen, Allysen B Ehresman, Ju-Yeon Lee, Talin Golnazarian, Dana Lee, Kai Y Alexander, Jill Zimmerman, Lauren Johnson, Bosco Q Giap, Jamlah Dalie, Jackson K Uriu, Amala John, Osvaldo Acosta, Tebogo Mokwena, Sanan Venkatesh, Brandon L. Tsai, Haris M Akram, Seo-Kyung Oh, Andrea T Fua, Mark A Douglass, Rebecca Yang, Jessica M. Lee, Derek Spitters, Carmen Javier, Alex W Chan, Richard Wong, Ivy H Fu, Connie Y Liu, Parich Tangmatitam, Sena Ji, Claire Park, Arash Ghaffari-Rafi, Vincent T Nguyen, Dorothy Yim, Kush V. Bhatt, Tonatiuh Montoya, Rayna Tian, Vivian Chiu, Malcolm Phung, Victoria Lee, Chinmay Bhoot, Purvi D Patel, Jensen Pak, Puja Yogi, Zhouyang Shen, Nhat-Thi Vo, Bama Charan Mondal, Davis W Popovich, Mane Williams, Oscar M A Del Rio, Alexander J Chassiakos, Ruth Ryu, Zijun Zhao, Renae L Cruz, Yishan Mai, Michael K Wang, Kenneth Chang Chien, Kayla Patel, Jun Wang, Courtney J Cruz, Nicholas J Gills, Alexis Baranoff, Dinali Wijiewarnasurya, Yancey Y Cashell, Iman Hamid, Ashley Hanson, Olivia L Lee, Jasmine Sjarif, Patrick W Chang, Jasmin Johal, Monica Ghaly, Momoko Ishii, Alexandra M Libro, Boyu Cao, Paras Shah, Jennifer Hsueh, Aaron W Bradshaw, Jagteshwar Singh Khatra, Tien M Phan-Everson, Jonathan Lai, David J. Lim, Na Eun Jeon, Caleb Kim, Hyun Wook Kim, Hannah Kim, Sean Full, Tierney G Brannigan, Inho Chang, Suhas P Dasari, Emily R Dennis, Ceejay Lee, Alexander Zai, Christine Zhang, Ayse Elif Kesaf, Ralph Albert, Rebecca M Barber, Shijia W Lu, Austin Ma, Spencer S Hu, Ipsita Dey, Hee Jong Kim, Nancy Ruano, Timothy C Voros, Sarah M. Kamel, Kimberly L Yan, Gah-Eun Jang, Dallas L Mould, Eduardo Hernandez, Sahra M Hosseinian, Iris Chen, Chon Ao, Cindy K Trac, Eric Y Du, Sam Law, Ysrael K Hernandez, Jeffrey S. Zhao, Angad Beniwal, Patricia Yeo, Vina Tran, James R. Lee, Manny Sosa, Zheying Chen, Alec Estrada, Cristian Sosa, Kevin Herrera, Mina Mohammadi, Rina Watanabe, Timothy Chai, Huy Nguyen, Dong Yeon Lee, Vishaal Yepuri, Melanie Huynh, Kyle Marik, Thao T T Nguyen, Xiao X Zhang, Jamie A Ngo, Anh Nguyen, Colton Bracken, Brandon Wei, Brian Aguirre, Sayonika Mohanta, Jeffrey C. Wang, Casey Shapiro, Sonia Gill, Fred Rong, Lauren Petersen, Pingdi Huang, Alexander Grunfeld, Sang Kuk Lee, An N Ha, Kevin Nishida, Shraddha Kumar, Terrence C Lee, Ariano Abbasi, Jenny Summapund, Karl Querubin, Siman Wei, Hanning Xing, Evan Yang, Liset Contreras, Sahar Yaftaly, Matthew Wilson, Ken Siangchin, Brian Kit, Mallory R Neebe, Irvin C Lien, Julia E Petersen, Jonathan Woo, Kaitlyn Honeychurch, Jesse Juarez, Stephen Chang, Raymond Zhou, Cristian Medina, Sean Louise G Laput, Jason T. Lee, Nguon L Tan, Sharon Choi, Natalia C Gutierrez, Zafar S Gill, Kenneth Kim, Jefferson M Dang, Tanveer Salim, Marc Levis-Fitzgerald, Dan Huynh, Joyce Wang, Marsha R Cheng, Lillian Xie, Hannah Markovic, Conny Tran, Mimi Chiang, Vivian Lam, Nick Waite, Ricardo Gray, and Jo M Huang

Subjects
AcademicSubjects/SCI01140, Candidate gene, Cell type, Universities, AcademicSubjects/SCI00010, Computational biology, Biology, AcademicSubjects/SCI01180, 03 medical and health sciences, 0302 clinical medicine, blood, RNA interference, Genetics, Animals, Humans, Students, Molecular Biology, Gene, Genetics (clinical), Loss function, CURE, 030304 developmental biology, Investigation, education, 0303 health sciences, Blood Cells, Genomics, hematopoiesis, Undergraduate research, RNAi, AcademicSubjects/SCI00960, Drosophila, Functional genomics, 030217 neurology & neurosurgery, Function (biology)
Abstract

Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes important for hematopoiesis in Drosophila. This screen disrupted the function of approximately 3500 genes and identified 137 candidate genes for which loss of function leads to observable changes in the hematopoietic development. Targeting RNAi to maturing, progenitor, and regulatory cell types identified key subsets that either limit or promote blood cell maturation. Bioinformatic analysis reveals gene enrichment in several previously uncharacterized areas, including RNA processing and export and vesicular trafficking. Lastly, the participation of students in this course-based undergraduate research experience (CURE) correlated with increased learning gains across several areas, as well as increased STEM retention, indicating that authentic, student-driven research in the form of a CURE represents an impactful and enriching pedagogical approach.

Published
2021
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2. Expression-Based Cell Lineage Analysis inDrosophilaThrough a Course-Based Research Experience for Early Undergraduates

Author

Daniel Chang, Earl Yoon, David Loppato, Justin N. Maghen, Silverio D. Alvarez, Kristy Ou, Katherine E. Peterson, Manjeet Bhamra, Helen H.-L. Chan, Lilit Gevorgyan, Clifton Lee, Peter Trinh, David M. Li, Elizabeth Kim, Garrick Iwamoto, Yue Zhao, Victor W. Yee, Kimberly Gon, Lisa M. Scully, Akram V. Uraizee, Sangita Datta, Sae Ho Song, Lisa Han, Andrew C. J. Huang, PhuongThao Tran, George K. Yeh, John M. Olson, Shawn J. Kim, Lili Sadri, Hannah G. Ahn, Grace E. Lee, Cindy L. Trang, Arezou Babaesfahani, Stephanie Wang, Saif Ansari, Hanwool Kim, Rakesh Bhatia, Brandon Lung, Victoria Ragland, Noemi E. Lee, Casey Shapiro, Van Thanh Mai, Sean H. K. Lee, Holly Dickinson, Joseph Park, Rona Law, Carrou Lee, Cameron M. Rice, Kirandeep Sumra, Alexandra L. Pourzia, Raj Dhaliwal, Vijay A. Patel, Michael Guillermo Daniel, Elaine L. Hsia, Hiu Wai Lam, Yujin Park, Jason H. Melehani, Annie Tigranyan, Xin Zheng, Nasser Heyrani, Jennifer Chang, Neda Asem, Joseph Duy Nguyen, Hanh H. Nguyen, Ted T. Uotani, Harnek Singh, Riley Guerin, Han-Ching H. Tseng, Kevin K. T. Vu, Max Mittelman, Gregory E. Tong, Cynthia Yeh, Jonathan Tran, Steven V. Pham, Bryan Lau, Kenny Lee, Tulika Ghosh, Roger K. Lau, An Huynh Pham, Christopher M. From, Elizabeth B. Johnson, Bobby Asem, Abhik Banerjee, Utpal Banerjee, Derek J. Cheung, Kambria Nguyen, Zainab Saifee, Carmel M. Moazez, Hung G. Trinh, Hannah Kim, Sonja Darwish, Lu Chen, Sondra L. Snyder, Pei-Yun Kao, Kevin Chen, Youngho Cho, Joseph Hargan Calvopina, Neil D. Poria, Vanessa Shih, Danica D. Wiredja, Shuo Wang, Zunera Ghaznavi, Jenny Dinh, Andrew J. Kim, Simran Kahlon, Awais M. Khan, Yuyu Chen, Julie Ko, Elise M. Calonico, Joseph N. Dickan, Huy D. Le, Leslie Jaworski, Xingfu Liang, Brooke Scruggs, Marc Levis-Fitzgerald, Susie Moon, Sara K. Taylor, An An Jiang, Nicholas Bumacod, Siddharth Sukumar, Matthew G. Keehn, Aleksandar Kitich, Cheng-An Tony Chien, Alexander N. Patananan, Jesse J. Cheung, Ragini Bhargava, Michael J. Jang, Alana M. Chin, Nikki Villarasa, Carman Chan, Ami Patel, Stacy Hu, Chiaen Chang, Solomon Rojhani, Michelle J. Kim, Shivani K. Thaker, Daisuke Furukawa, Arunit Singh Chugh, Volker Hartenstein, Hao Li, Akash Bhakta, Khoa T. Truong-N, Mark Sy, Daniel Rothberg, Melinda Feng, Kristine Kim, Nicole A. Azarian, David J. Groves, Sravya Mallam, Man Ting Chou, Katelyn F. Sobotka, Kathy T. Ngo, Justin Hsueh, Jasmine Y. Chen, Jessica Chew, Ira E. Clark, Zhong Ye, Mark R. Cubberly, Komal Wadhwani, Sumedha Singh, Jonathan J. Caine, Tamir Sholklapper, Jane Kuon, Nicholas G. Kouzelos, Emmylou Dowling, Francie Diep, Carolyn Chu, Kalkidan K. Gurara, Isabella Niu, Yaelim A. Park, Yong Jun Lee, Ali R. Haghighi, Nauman Charania, Nitish Mittal, Chee Jia Chin, Ben Sprung-Keyser, Naseem Moridzadeh, Donald N. Allen, Virginia Chu, Cory J. Evans, Luke Berry, Ahmad Bahrami, Justin J. Houman, Jesse M. Zaretsky, Kimberly A. Passmore, Chris Iwuchukwu, Rebecca S. Wang, Christina Lee, David Roh, Hee Jong Kim, Szuyao Lee, Rameen S. Moridzadeh, Randi K. Oyama, Amy A. Patel, Regina Lee, Serena S. Luong, Manpreet Kaur, Dhruv Patel, Xi Xue, Johnny He, Seo-Kyung Oh, Sabrena M. Ahmadi, Angela W. Nieh, Anke Ziegenbalg, Thien Nguyen, Jacinda N. Tran, John Y. Yu, Brian S. Kim, Eric Lin, Omair Khan, Ross G. Kelley, Sung Kyu Lee, Jessica S. Ma, Tanya Hioe, Nicole B. Chew, Kayla G. H. Gurley, Mark R Murata, Jiwon Lee, Hande Tan, Andrew L. Wong, Michael Koenig, Sung-Ling D. Lee, In Young Choi, Daniel Sitz, Paluk K. Walia, Maggie K. Chu, Ke-Huan K. Chow, Jessica R. Ong, Michelle J. Lee, Jenny Huynh, Rachael Le, Riki D. Ranat, Griselda Yanez, Yung-Hsuan Yang, Molly Howland, Ross A. Kornberg, Agafe Saguros, Peter Lin, Jessie C. Wu, Rahul Kumar Ghosh, Anand D. Gandhi, Jaskaran Gill, Edward Kuoy, Tulsi Thakore, Ritika Dutta, Himaja Gaddipati, Truc Ta, Melissa E. Phuphanich, Stacey Lu, Suji Kim, Letty Liang, Megan J. Leong, Derrick M. Chu, Michelle M. Lin, Alejandro LaRiviere, Alexandra L. Havard, Subir Bhatia, Minh-Tu Do, Sarah Kang, Jon Alkali, Kent K. T. Vu, Brian A. Shin, Samira J. Akhave, Kirim Hong, Thomas A. Caldwell, Jonathan Hofman, Vivi Tran, Katherine Chuang, Paul D. Picard, Jay Wang, Nicole A. Calica, Tiffany Y. Lin, Ryan C. Miller, Ida Azizkhanian, Manjot Sandhu, Dhaval Dixit, Kaley Ngo, Daniel Wu, Halley C. Sullivan, Jasmine C. Huynh, Tirth Patel, Vivian Yip, Manish M. Padhiar, Li Ma, Ryen Castillo, Shivtaj Mann, Tuan D. Tran, Albert J. Chang, and Kunal Thaker

Subjects
Lineage (genetic), QH426-470, Biology, 03 medical and health sciences, Gene expression, Genetics, stem, Molecular Biology, Drosophila, Genetics (clinical), 030304 developmental biology, education, 0303 health sciences, g-trace, 4. Education, 05 social sciences, 050301 education, biology.organism_classification, cure, Imaginal disc, Haematopoiesis, Undergraduate research, Expression (architecture), Evolutionary biology, gene expression, 0503 education, Functional genomics
Abstract

A variety of genetic techniques have been devised to determine cell lineage relationships during tissue development. Some of these systems monitor cell lineages spatially and/or temporally without regard to gene expression by the cells, whereas others correlate gene expression with the lineage under study. The GAL4 Technique for Real-time and Clonal Expression (G-TRACE) system allows for rapid, fluorescent protein-based visualization of both current and past GAL4 expression patterns and is therefore amenable to genome-wide expression-based lineage screens. Here we describe the results from such a screen, performed by undergraduate students of the University of California, Los Angeles (UCLA) Undergraduate Research Consortium for Functional Genomics (URCFG) and high school summer scholars as part of a discovery-based education program. The results of the screen, which reveal novel expression-based lineage patterns within the brain, the imaginal disc epithelia, and the hematopoietic lymph gland, have been compiled into the G-TRACE Expression Database (GED), an online resource for use by the Drosophila research community. The impact of this discovery-based research experience on student learning gains was assessed independently and shown to be greater than that of similar programs conducted elsewhere. Furthermore, students participating in the URCFG showed considerably higher STEM retention rates than UCLA STEM students that did not participate in the URCFG, as well as STEM students nationwide.

Published
2019
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