1. The association of weight change and all-cause mortality in older adults
- Author
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Tagrid Abdullah G Alharbi, Rosanne Freak-Poli, Susan Paudel, Alice J. Owen, Danijela Gasevic, Joanne Ryan, and Epidemiology
- Subjects
Aging ,030204 cardiovascular system & hematology ,Weight Gain ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,Weight Loss ,Medicine ,Humans ,030212 general & internal medicine ,Aged ,Proportional Hazards Models ,business.industry ,Weight change ,Hazard ratio ,Weight Fluctuation ,General Medicine ,Confidence interval ,Meta-analysis ,Observational study ,Independent Living ,Geriatrics and Gerontology ,medicine.symptom ,business ,Weight gain ,Demography - Abstract
Objective there may be age-related differences in the impact of weight change on health. This study systematically reviewed the evidence on the relationship between weight change and all-cause mortality in adults aged 65 years and older. Methods MEDLINE, EMBASE and CINAHL were searched from inception to 11 June 2020, PROSPERO CRD 42019142268. We included observational studies reporting on the association between weight change and all-cause mortality in older community-dwelling adults. A random-effects meta-analysis was performed to calculate pooled hazard ratios and scored based on the Agency for Healthcare Research and Quality guidelines. Results a total of 30 studies, including 1,219,279 participants with 69,255 deaths, demonstrated that weight loss was associated with a 59% increase in mortality risk (hazard ratio (HR): 1.59; 95% confidence interval (CI): 1.45–1.74; P 0.05). Conclusion for community-dwelling older adults, weight changes (weight loss, gain or weight fluctuation) are associated with an increased risk of all-cause mortality risk relative to stable weight. Further research is needed to determine whether these associations vary depending upon initial weight, and whether or not the weight loss/gain was intentional.
- Published
- 2021
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