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34 results on '"Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)"'

1. Investigating three types of continuous auditory feedback in visuo-manual tracking

Author: Patrick Susini, Frédéric Bevilacqua, Eric O. Boyer, Sylvain Hanneton, Laboratoire Psychologie de la Perception (LPP - UMR 8242), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), IRCAM, Sciences et Technologies de la Musique et du Son (STMS), IRCAM-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Perception et design sonores, Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Perception et design sonores, Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Interactions Son Musique Mouvement, ANR-11-BS02-0012,LEGOS,Evaluation de l'apprentissage sesnorimoteur dans des systèmes intéractifs geste-son(2011), ircam, ircam, BLANC - Evaluation de l'apprentissage sesnorimoteur dans des systèmes intéractifs geste-son - - LEGOS2011 - ANR-11-BS02-0012 - BLANC - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Psychologie de la Perception ( LPP - UMR 8242 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), and ANR-11-BS02-0012,LEGOS,Evaluation de l'apprentissage sesnorimoteur dans des systèmes intéractifs geste-son ( 2011 )
Subjects: Male, Computer science, Speech recognition, [SDV]Life Sciences [q-bio], [ SCCO.PSYC ] Cognitive science/Psychology, Motion (physics), Learning effect, Task (project management), Tracking error, [SCCO]Cognitive science, 0302 clinical medicine, Feedback, Sensory, ComputingMilieux_MISCELLANEOUS, Auditory feedback, learning, General Neuroscience, 05 social sciences, Middle Aged, [SDV] Life Sciences [q-bio], [ SCCO.NEUR ] Cognitive science/Neuroscience, [SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology, Auditory Perception, Female, [ SCCO ] Cognitive science, sensori-motor, Adult, Adolescent, Movement, Sound design, 050105 experimental psychology, sound design, Young Adult, 03 medical and health sciences, Reaction Time, Humans, 0501 psychology and cognitive sciences, sonification, auditory, Aged, Analysis of Variance, Communication, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, [ SDV ] Life Sciences [q-bio], business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Motor control, [SCCO] Cognitive science, [SHS.MUSIQ] Humanities and Social Sciences/Musicology and performing arts, Acoustic Stimulation, Sonification, business, Photic Stimulation, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract: International audience; The use of continuous auditory feedback for motor control and learning is still understudied and deserves more attention regarding fundamental mechanisms and applications. This paper presents the results of three experiments studying the contribution of task-, error-, and user-related sonification to visuo-manual tracking and assessing its benefits on sensorimotor learning. First results show that sonification can help decreasing the tracking error, as well as increasing the energy in participant’s movement. In the second experiment, when alternating feedback presence, the user-related sonification did not show feedback dependency effects, contrary to the error and task-related feedback. In the third experiment, a reduced exposure of 50% diminished the positive effect of sonification on performance, whereas the increase of the average energy with sound was still significant. In a retention test performed on the next day without auditory feedback, movement energy was still superior for the groups previously trained with the feedback. Although performance was not affected by sound, a learning effect was measurable in both sessions and the user-related group improved its performance also in the retention test. These results confirm that a continuous auditory feedback can be beneficial for movement training and also show an interesting effect of sonification on movement energy. User-related sonification can prevent feedback dependency and increase retention. Consequently, sonification of the user’s own motion appears as a promising solution to support movement learning with interactive feedback.
Published: 2017

2. Design and evaluation of tinnitus synthesis methods: From spectral to spatial matching

Author: Alexis Baskind, Isabelle Viaud-Delmon, Stephanie Bertet, Alain Londero, Laure Bonfils, Olivier Warusfel, Espaces acoustiques et cognitifs (EAC), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sonic Arts Research Laboratory, Queen's University [Belfast] (QUB), SRH Hochschule der populären Künste (hdpk), Centre d'étude de la SensoriMotricité (CESEM - UMR 8194), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Equipe Espaces acoustiques et cognitifs, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Queen's University [Belfast] ( QUB ), SRH Hochschule der populären Künste ( hdpk ), Centre d'étude de la SensoriMotricité ( CESEM - UMR 8194 ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, medicine.medical_specialty, Synthesis methods, Audiology, Pitch Discrimination, Tinnitus, 03 medical and health sciences, 0302 clinical medicine, spectral matching, otorhinolaryngologic diseases, Humans, Medicine, Computer Simulation, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, Auditory threshold, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, MESH : Auditory Threshold, Pitch discrimination, tinnitus/therapy, 030223 otorhinolaryngology, business.industry, Pure tone, [SCCO.NEUR]Cognitive science/Neuroscience, spatial matching, MESH: Auditory Threshold, Pitch discrimination, tinnitus/therapy, Middle Aged, Otorhinolaryngology, [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, [ SCCO.NEUR ] Cognitive science/Neuroscience, Spectral matching, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Contralateral ear, medicine.symptom, Percept, business, Merge (version control), 030217 neurology & neurosurgery
Abstract: International audience; PURPOSE: This study was designed to investigate methods to help patients suffering from unilateral tinnitus synthesizing an auditory replica of their tinnitus.MATERIALS AND METHODS: Two semi-automatic methods (A and B) derived from the auditory threshold of the patient and a method (C) combining a pure tone and a narrow band-pass noise centred on an adjustable frequency were devised and rated on their likeness over two test sessions. A third test evaluated the stability over time of the synthesized tinnitus replica built with method C, and its proneness to merge with the patient's tinnitus. Patients were then asked to try and control the lateralisation of this single percept through the adjustment of the tinnitus replica level.RESULTS: The first two tests showed that seven out of ten patients chose the tinnitus replica built with method C as their preferred one. The third test, performed on twelve patients, revealed pitch tuning was rather stable over a week interval. It showed that eight patients were able to consistently match the central frequency of the synthesized tinnitus (presented to the contralateral ear) to their own tinnitus, which leaded to a unique tinnitus percept. The lateralisation displacement was consistent across patients and revealed an average range of 29dB to obtain a full lateral shift from the ipsilateral to the contralateral side.CONCLUSIONS: Although spectrally simpler than the semi-automatic methods, method C could replicate patients' tinnitus, to some extent. When a unique percept between synthesized tinnitus and patients' tinnitus arose, lateralisation of this percept was achieved.
Published: 2013

3. Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: Results of a randomized controlled trial

Author: Olivier Warusfel, Pierre Bonfils, G Chatellier, R Niarra, D. Malinvaud, Alain Londero, Isabelle Viaud-Delmon, Ph Peignard, Centre de neurophysique, physiologie, pathologie ( UMR 8119 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Service ORL et Chirurgie Cervico-Faciale [Hôpital Européen], Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Service d’Épidémiologie et de Recherche Clinique [Hôpital Européen Georges Pompidou], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Equipe Espaces acoustiques et cognitifs, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Cognition and Action Group ( COGNAC-G - UMR 8257 ), École normale supérieure - Cachan ( ENS Cachan ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de neurophysique, physiologie, pathologie (UMR 8119), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d’Épidémiologie et de Recherche Clinique [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Espaces acoustiques et cognitifs (EAC), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Cognition and Action Group (COGNAC-G - UMR 8257), École normale supérieure - Cachan (ENS Cachan)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, Time Factors, Multivariate analysis, Severity of Illness Index, tinnitus/psychology, law.invention, Disability Evaluation, Tinnitus, 0302 clinical medicine, Randomized controlled trial, law, Informed consent, Surveys and Questionnaires, 030223 otorhinolaryngology, 10. No inequality, [ INFO.INFO-GR ] Computer Science [cs]/Graphics [cs.GR], Middle Aged, Sensory Systems, Virtual reality therapy, [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR], 3. Good health, auditory perception, Treatment Outcome, [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Visual Perception, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Psychology, Clinical psychology, Tinnitus/therapy, Adult, Paris, medicine.medical_specialty, Visual analogue scale, Virtual reality, 03 medical and health sciences, Imaging, Three-Dimensional, Computer Graphics, medicine, Humans, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Aged, Cognitive Behavioral Therapy, Virtual Reality Exposure Therapy, virtual reality exposure therpay, Therapeutic effect, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Chronic Disease, Physical therapy, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Subjective tinnitus (ST) is a frequent audiologic condition that still requires effective treatment. This study aimed at evaluating two therapeutic approaches: Virtual Reality (VR) immersion in auditory and visual 3D environments and Cognitive Behaviour Therapy (CBT).METHODS: This open, randomized and therapeutic equivalence trial used bilateral testing of VR versus CBT. Adult patients displaying unilateral or predominantly unilateral ST, and fulfilling inclusion criteria were included after giving their written informed consent. We measured the different therapeutic effect by comparing the mean scores of validated questionnaires and visual analog scales, pre and post protocol. Equivalence was established if both strategies did not differ for more than a predetermined limit. We used univariate and multivariate analysis adjusted on baseline values to assess treatment efficacy. In addition of this trial, purely exploratory comparison to a waiting list group (WL) was provided.RESULTS: Between August, 2009 and November, 2011, 148 of 162 screened patients were enrolled (VR n = 61, CBT n = 58, WL n = 29). These groups did not differ at baseline for demographic data. Three month after the end of the treatment, we didn't find any difference between VR and CBT groups either for tinnitus severity (p = 0.99) or tinnitus handicap (p = 0.36).CONCLUSION: VR appears to be at least as effective as CBT in unilateral ST patients.
Published: 2016

4. A high-throughput sequencing ecotoxicology study of freshwater bacterial communities and their responses to tebuconazole

Author: Simon Roux, Julie Leloup, Joan Artigas, Didier Debroas, Rémy D. Tadonléké, Noémie Pascault, Stéphane Pesce, Jean-François Humbert, Agnès Bouchez, Microbiologie du Sol et de l'Environnement ( MSE ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ), Equipe Espaces acoustiques et cognitifs, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Milieux aquatiques, écologie et pollutions ( UR MALY ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ), Laboratoire Microorganismes : Génome et Environnement ( LMGE ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Chimie Moléculaire ( SCM ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques ( CARRTEL ), Institut National de la Recherche Agronomique ( INRA ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Laboratoire Image, Ville, Environnement [Strasbourg] ( LIVE ), Université de Strasbourg ( UNISTRA ), Microbiologie du Sol et de l'Environnement (MSE), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Chimie Moléculaire (SCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de la Recherche Agronomique (INRA), Laboratoire Image, Ville, Environnement [Strasbourg] (LIVE), Université de Strasbourg (UNISTRA), Espaces acoustiques et cognitifs (EAC), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Sendefo project in the Contaminants Ecosystems Health programme of the French ANR (Agence Nationale de la Recherche) [CES-2009], Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV]Life Sciences [q-bio], Microbial Consortia, Context (language use), 010501 environmental sciences, Biology, Ecotoxicology, 01 natural sciences, Applied Microbiology and Biotechnology, Microbiology, Freshwater ecosystem, 03 medical and health sciences, Rivers, RNA, Ribosomal, 16S, Gammaproteobacteria, Water Pollutants, Ecosystem, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Base Sequence, Ecology, [ SDV ] Life Sciences [q-bio], Microbiota, TEBUCONAZOLE, Community structure, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA, Triazoles, biology.organism_classification, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], 6. Clean water, Fungicides, Industrial, Actinobacteria, POLLUTANT, Lakes, 13. Climate action, NGS, Pyrosequencing, BACTERIAL COMMUNITIES, FRESHWATER ECOSYSTEMS, Microcosm
Abstract: [Departement_IRSTEA]Eaux [TR1_IRSTEA]BELCA; International audience; The pollution of lakes and rivers by pesticides is a growing problem worldwide. However, the impacts of these substances on microbial communities are still poorly understood, partly because next-generation sequencing (NGS) has rarely been used in an ecotoxicology context to study bacterial communities despite its interest for accessing rare taxa. Microcosm experiments were carried out to evaluate the effects of tebuconazole (TBZ) on the structure and composition of bacterial communities from two types of freshwater ecosystem (lakes and rivers) with differing histories of pollutant contamination (pristine vs. previously exposed sites). Pyrosequencing revealed that bacterial diversity was higher in the river than in the lakes and in previously exposed sites than in pristine sites. Lakes and river stations shared very few OTUs, and differences at the phylum level were identified between these ecosystems (i.e. the relative importance of Actinobacteria and Gammaproteobacteria). Despite differences between these ecosystems and their contamination history, no significant effect of TBZ on bacterial community structure or composition was observed. Compared to functional parameters that displayed variable responses, we demonstrated that a combination of classical methods and NGS is necessary to investigate the ecotoxicological responses of microbial communities to pollutants.
Published: 2014

5. Learning Movement Kinematics with a Targeted Sound

Author: Eric O. Boyer, Quentin Pyanet, Frédéric Bevilacqua, Sylvain Hanneton, Equipe Interactions musicales temps-réel, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Psychologie de la Perception (LPP - UMR 8242), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Spinger, Interactions Son Musique Mouvement, Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Laboratoire Psychologie de la Perception ( LPP - UMR 8242 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), and Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Descartes - Paris 5 ( UPD5 )
Subjects: [ INFO.INFO-IA ] Computer Science [cs]/Computer Aided Engineering, Computer science, [INFO.INFO-OH]Computer Science [cs]/Other [cs.OH], [ SCCO.PSYC ] Cognitive science/Psychology, Kinematics, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, adaptation, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Motion (physics), law.invention, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], sound, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, law, interactive sys-tems, Sound (geography), [ INFO.INFO-MM ] Computer Science [cs]/Multimedia [cs.MM], sensorimotor, geography.geographical_feature_category, learning, 05 social sciences, [INFO.INFO-MM]Computer Science [cs]/Multimedia [cs.MM], Gyroscope, TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS, [SCCO.PSYC]Cognitive science/Psychology, [INFO.INFO-SD]Computer Science [cs]/Sound [cs.SD], gesture, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Gesture, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ SHS.MUSIQ ] Humanities and Social Sciences/Musicology and performing arts, Acoustics, interactive sys- tems, Angular velocity, Adaptation (eye), Harmonic (mathematics), 050105 experimental psychology, [ INFO.INFO-LG ] Computer Science [cs]/Machine Learning [cs.LG], Informatique musicale, 03 medical and health sciences, [ INFO.INFO-HC ] Computer Science [cs]/Human-Computer Interaction [cs.HC], [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], sound-oriented task, 0501 psychology and cognitive sciences, auditory feedback, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], [ INFO.INFO-AI ] Computer Science [cs]/Artificial Intelligence [cs.AI], geography, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], [INFO.INFO-IA]Computer Science [cs]/Computer Aided Engineering, Computer Science::Sound, [ INFO.INFO-OH ] Computer Science [cs]/Other [cs.OH], [ INFO.INFO-SD ] Computer Science [cs]/Sound [cs.SD], 030217 neurology & neurosurgery
Abstract: cote interne IRCAM: Boyer14a; National audience; This study introduces an experiment designed to analyze the sensorimotor adaptation to a motion-based sound synthesis system. We investigated a sound-oriented learning task, namely to reproduce a tar- geted sound. The motion of a small handheld object was used to control a sound synthesizer. The object angular velocity was measured by a gy- roscope and transmitted in real time wirelessly to the sound system. The targeted sound was reached when the motion matched a given refer- ence angular velocity profile with a given accuracy. An incorrect velocity profile produced either a noisier sound or a sound with a louder high har- monic, depending on the sign of the velocity error. The results showed that the participants were generally able to learn to reproduce sounds very close to the targeted sound. A corresponding motor adaptation was also found to occur, at various degrees, in most of the participants when the profile is altered.
Published: 2013

6. Glottic Bamboo Nodules From Systemic Lupus Erythematosus

Author: Subramanian Mukundan, Lise Crevier-Buchman, Ollivier Laccourreye, David Malinvaud, Pierre Bonfils, Laboratoire de Neurobiologie des Réseaux Sensorimoteurs ( LNRS ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 ), Department of oto-rhino-laryngology - head & neck surgery and Department of thoracic surgery, Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 ( LPP ), Université Sorbonne Nouvelle - Paris 3-Centre National de la Recherche Scientifique ( CNRS ), Equipe Espaces acoustiques et cognitifs, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Neurobiologie des Réseaux Sensorimoteurs (LNRS), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 (LPP), Université Sorbonne Nouvelle - Paris 3-Centre National de la Recherche Scientifique (CNRS), Espaces acoustiques et cognitifs (EAC), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Lo Bue, Gwénaëlle
Subjects: Adult, Glottis, Pathology, medicine.medical_specialty, Glottic Bamboo Nodules, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Systemic lupus erythematosus, medicine, Humans, Lupus Erythematosus, Systemic, In patient, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, 030223 otorhinolaryngology, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, Autoimmune disease, business.industry, General Medicine, medicine.disease, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, 3. Good health, medicine.anatomical_structure, Otorhinolaryngology, [ SHS.LANGUE ] Humanities and Social Sciences/Linguistics, Female, business, Medical literature
Abstract: Bamboo nodules of the glottis are of late being described as a distinct entity seen in patients with autoimmune diseases. We report the symptoms, clinical features, and management of a case of bamboo nodules of the glottis in a patient with systemic lupus erythematosus. We discuss the pathogenesis and management of this condition on the basis of a review of the medical literature.
Published: 2013

7. Social cognition and the superior temporal sulcus: implications in autism

Author: M. Zilbovicius, Yves Samson, Francis Brunelle, A Bargiacchi, Ana Saitovitch, N. Chabane, Nathalie Boddaert, Service de Psychiatrie de l'Enfant et de l'Adolescent, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré, Service de psychopathologie de l'enfant et de l'adolescent, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 ), Service de radiologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement ( Inserm U781 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement (Inserm U781), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: genetic structures, Eye Movements, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, MESH: Social Perception, MESH : Social Behavior, MESH: Cognition, MESH : Autistic Disorder, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Magnetic Resonance Imaging, 0302 clinical medicine, Cognition, MESH: Eye Movements, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, media_common, 0303 health sciences, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Social perception, Superior temporal sulcus, Magnetic Resonance Imaging, MESH: Positron-Emission Tomography, Temporal Lobe, MESH : Social Perception, Neurology, Social Perception, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], MESH : Cognition, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Psychology, MESH: Social Behavior, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Cognitive psychology, media_common.quotation_subject, MESH: Autistic Disorder, behavioral disciplines and activities, 03 medical and health sciences, Social cognition, Perception, MESH : Magnetic Resonance Imaging, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, MESH: Temporal Lobe, Humans, Autistic Disorder, Social Behavior, MESH : Temporal Lobe, 030304 developmental biology, MESH : Eye Movements, MESH: Humans, MESH : Humans, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH : Positron-Emission Tomography, medicine.disease, Gaze, Social relation, Radiography, Positron-Emission Tomography, Autism, Eye tracking, Neurology (clinical), sense organs, 030217 neurology & neurosurgery
Abstract: International audience; The most common clinical sign of autism spectrum disorders (ASD) is social interaction impairment, which is associated with communication deficits and stereotyped behaviors. Based on brain-imaging results, our hypothesis is that abnormalities in the superior temporal sulcus (STS) are highly implicated in ASD. These abnormalities are characterized by decreased grey matter concentration, rest hypoperfusion and abnormal activation during social tasks. STS anatomofunctional anomalies occurring early across brain development could constitute the first step in the cascade of neural dysfunctions underlying autism. It is known that STS is highly implicated on social perception processing, from perception of biological movements, such as body movements or eye gaze, to more complex social cognition processes. Among the impairments that can be described in social perception processing, eye gaze perception is particularly relevant in autism. Gaze abnormalities can now be objectively measured using eye-tracking methodology. In the present work, we will review recent data on STS contributions to normal social cognition and its implication in autism, with particular focus on eye gaze perception.
Published: 2012

8. Immersing Patients in a Virtual Reality Environment for Brain Mapping During Awake Surgery: Safety Study

Author: Matthieu Delion, Ghislaine Aubin, Philippe Menei, Florian Bernard, Evelyne Klinger, Aram Ter Minassian, Département de neurochirurgie [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Equipe Espaces acoustiques et cognitifs, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Politecnico di Torino [Torino] (Polito), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Service de neurochirurgie, Espaces acoustiques et cognitifs (EAC), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Politecnico di Torino = Polytechnic of Turin (Polito), Design and Application of Innovative Local Treatments in Glioblastoma (CRCINA-ÉQUIPE 17), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), CCSD, Accord Elsevier, Handicap et système nerveux :Action, communication, interaction: rétablissement de la fonction et de la participation [Bordeaux] (EA4136), UFR Sciences médicales 3 [Bordeaux]-Université de Bordeaux Ségalen [Bordeaux 2], Département de Neurologie [CHU Angers], and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Subjects: Male, HACS, Intraoperative Neurophysiological Monitoring, [SDV]Life Sciences [q-bio], computer.software_genre, Brain mapping, Neurosurgical Procedures, Virtual reality, 0302 clinical medicine, Parietal Lobe, Prospective Studies, Virtual reality sickness, Intraoperative Complications, Language, Cerebral Cortex, Brain Neoplasms, Neuropsychology, Brain, Cognition, Glioma, Middle Aged, Temporal Lobe, Social cognition, 3. Good health, Frontal Lobe, [SDV] Life Sciences [q-bio], Awake surgery, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Headset, Oligodendroglioma, Neurosurgery, Astrocytoma, 03 medical and health sciences, Young Adult, Physical medicine and rehabilitation, Seizures, medicine, Humans, Wakefulness, Aged, business.industry, Electric Stimulation, Virtual machine, Surgery, Neurology (clinical), business, Glioblastoma, computer, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Brain mapping by direct electrical stimulation during awake craniotomy is now a standard procedure that reduces the risk of permanent neurologic deficits. Virtual reality technology immerses the patient in a virtually controlled, interactive world, offering a unique opportunity to develop innovative tasks for perioperative mapping of complex cognitive functions. The objective of this prospective single-center study was to evaluate the tolerance and safety of a virtual reality headset (VRH) and immersive virtual experiences in patients undergoing awake craniotomy and brain mapping by direct electrical stimulation.METHODS: The study included 30 patients with a brain tumor near the language area. Language mapping was performed with a naming task, DO 80, presented on a digital tablet and then in two-dimensional and three-dimensional formats through a VRH. During wound closure, different virtual reality experiences were proposed to the patient, offering different types of virtual motion or interaction with an avatar piloted by a neuropsychologist.RESULTS: Two patients could not use the VRH owing to technical issues. No procedure was aborted, no patient experienced virtual reality sickness and all patients reported they would repeat the procedure. Despite a high rate of intraoperative focal seizures, there was no argument to attribute the seizures to VRH use.CONCLUSIONS: This study shows that it is possible during awake brain surgery to immerse the patient in a virtual environment and to interact with the patient, opening the field of new brain mapping procedures for complex cognitive functions.Copyright © 2019 Elsevier Inc. All rights reserved.
Published: 2020

9. Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

Author: Emma Partiot, Nilda Vanesa Ayala-Nunez, Jacky G. Goetz, Gautier Follain, Judith R.E. Roels, Anita Eckly, Béatrice Uring-Lambert, Maxime Chazal, Raphael Gaudin, Gillian Hale, Frank M. J. Jacobs, Sandrine Bourdoulous, Orestis Faklaris, Sherif R. Zaki, Aurélie Hirschler, Nolwenn Jouvenet, Margot Carocci, Florian Bakoa, Sarah Cianférani, Christine Carapito, Frédéric Doussau, Brigid C. Bollweg, François Delalande, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA), Institut National de la Santé et de la Recherche Médicale (INSERM), Immuno-Rhumatologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Swammerdam Institute for Life Sciences, University of Amsterdam [Amsterdam] (UvA)-Center for Neurosciences, Génomique virale et vaccination, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Université Paris Descartes - Paris 5 (UPD5), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), BioCampus Montpellier (BCM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion, Université de Strasbourg (UNISTRA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Les Hôpitaux Universitaires de Strasbourg (HUS), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), This work has received funding from the French State via the French National Research Agency (ANR) as part of the program Investissements d’avenir (IdEx Université de Strasbourg) to RG. This work was supported by an ATIP-AVENIR starting grant to RG. The research leading to these results has received funding from the People Program (Marie Curie Actions) of the European Union’s Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCOFUND-GA-2013-609102, through the PRESTIGE program coordinated by Campus France, and from the French Agency for Research on AIDS and Viral Hepatitis (ANRS), both attributed to NVAN. Experiments conducted by G.F. and J.G.G. were funded by Plan Cancer (OptoMetaTrap), Ligue contre le Cancer, Idex Attractivités (University of Strasbourg), and by institutional funds from INSERM and University of Strasbourg. G.F. was supported by a doctoral fellowship from Ligue Contre le Cancer. Mass spectrometry experiments were supported by the French Proteomic Infrastructure (ProFI, ANR-10-INBS-08-03). F.B. is a recipient of a PhD grant provided by ANRT (Association Nationale de la Recherche et de la Technologie). N.J. is funded by Agence Nationale pour la Recherche (ANR-16-CE15-0025-01), Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur. CDC contributions to this paper written and edited by G.L.H. and B.C.B. in their private capacity. No official support or endorsement by the Centers for Disease Control and Prevention, Department of Health and Human Services is intended, nor should be inferred. All authors read, provided feedback, and approved the paper. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-1 NL4-3 AD8 Infectious Molecular Clone (pNL(AD8)) from Dr. Eric O. Freed (cat# 11346)., ANR-16-CE15-0025,Viro-Storm,Mécanismes de production incontrôlée de cytokines au cours de l'infection virale(2016), European Project: 609102,EC:FP7:PEOPLE,FP7-PEOPLE-2013-COFUND,PRESTIGE(2014), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), BioCampus (BCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), EFS-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), jouvenet, nolwenn, Mécanismes de production incontrôlée de cytokines au cours de l'infection virale - - Viro-Storm2016 - ANR-16-CE15-0025 - AAPG2016 - VALID, PRES Towards International Gain of Excellence - PRESTIGE - - EC:FP7:PEOPLE2014-09-01 - 2019-08-31 - 609102 - VALID, Equipe Direction scientifique, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Neuro-Immunologie Virale, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire de Photonique Quantique et Moléculaire (LPQM), Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-École normale supérieure - Cachan (ENS Cachan), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion (http://www.u949.inserm.fr/), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse BioOrganique, Département des Sciences Analytiques, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France (LSMBO-DSA-IPHC), Centre National de la Recherche Scientifique (CNRS), Immunorhumathologie moléculaire, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Molecular Neuroscience (SILS, FNWI)
Subjects: Central Nervous System, 0301 basic medicine, MESH: Neurons, General Physics and Astronomy, MESH: Organoids, MESH: Monocytes, Monocytes, Zika virus, 0302 clinical medicine, MESH: Transendothelial and Transepithelial Migration, Cerebellum, MESH: Animals, lcsh:Science, MESH: Embryonic Stem Cells, ComputingMilieux_MISCELLANEOUS, Zebrafish, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Neurons, Multidisciplinary, Zika Virus Infection, Cell adhesion molecule, food and beverages, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, Phenotype, 3. Good health, Cell biology, Organoids, Mechanisms of disease, medicine.anatomical_structure, MESH: Cell Survival, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Endothelium, Cell Survival, Science, MESH: Zika Virus, Biology, MESH: Endothelium, Article, General Biochemistry, Genetics and Molecular Biology, Virus, MESH: Cell Adhesion, 03 medical and health sciences, Virology, medicine, Animals, Humans, MESH: Central Nervous System, Cellular microbiology, Cell adhesion, MESH: Zebrafish, Embryonic Stem Cells, MESH: Humans, Monocyte, fungi, Transendothelial and Transepithelial Migration, Zika Virus, General Chemistry, biology.organism_classification, Embryonic stem cell, MESH: Cerebellum, Disease Models, Animal, 030104 developmental biology, lcsh:Q, MESH: Disease Models, Animal, Cell Adhesion Molecules, MESH: Female, 030217 neurology & neurosurgery
Abstract: Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the bloodstream to tissues through a mature endothelium, remains unclear. Here, we show that ZIKV-infected monocytes represent suitable carriers for viral dissemination to the CNS using human primary monocytes, cerebral organoids derived from embryonic stem cells, organotypic mouse cerebellar slices, a xenotypic human-zebrafish model, and human fetus brain samples. We find that ZIKV-exposed monocytes exhibit higher expression of adhesion molecules, and higher abilities to attach onto the vessel wall and transmigrate across endothelia. This phenotype is associated to enhanced monocyte-mediated ZIKV dissemination to neural cells. Together, our data show that ZIKV manipulates the monocyte adhesive properties and enhances monocyte transmigration and viral dissemination to neural cells. Monocyte transmigration may represent an important mechanism required for viral tissue invasion and persistence that could be specifically targeted for therapeutic intervention., Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.
Published: 2019

10. Context-dependent signaling of coincident auditory and visual events in primary visual cortex

Author: Alexandre Kempf, Anton Filipchuk, Brice Bathellier, Thomas Deneux, Evan R. Harrell, Sebastian Ceballo, Equipe Autre (hors R&D), Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Paris-Saclay (Neuro-PSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Institut des Neurosciences Paris-Saclay (NeuroPSI)
Subjects: 0301 basic medicine, genetic structures, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, neuroscience, Mice, 0302 clinical medicine, auditory cortex, Biology (General), visual cortex, education.field_of_study, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, General Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, General Medicine, Chemogenetics, calcium imaging, medicine.anatomical_structure, Visual Perception, Medicine, cell types, Research Article, multisensory processing, QH301-705.5, Science, Population, Biology, Stimulus (physiology), Auditory cortex, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Calcium imaging, Stimulus modality, Coincident, Interneurons, medicine, otorhinolaryngologic diseases, Animals, education, mouse, General Immunology and Microbiology, 030104 developmental biology, Visual cortex, Acoustic Stimulation, Evoked Potentials, Visual, chemogenetics, Neuroscience, 030217 neurology & neurosurgery, Photic Stimulation
Abstract: International audience; Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.
Published: 2019

11. Emotional prosody in congenital amusia: Impaired and spared processes

Author: Bedoin, N., Besombes, A.-M., Escande, E., Dumont, A., Lalitte, P., Pralus, A., Fornoni, L., Bouet, R., Gomot, M., Bhatara, A., Tillmann, Barbara, Caclin, A., Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Psychologie de la Perception (LPP - UMR 8242), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Etude des Mécanismes Cognitifs (EMC), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, medicine.medical_specialty, Cognitive Neuroscience, media_common.quotation_subject, Emotions, Experimental and Cognitive Psychology, Amusia, Audiology, 050105 experimental psychology, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, Neurodevelopmental disorder, 0302 clinical medicine, Perception, Vowel, medicine, Humans, 0501 psychology and cognitive sciences, Pitch Perception, ComputingMilieux_MISCELLANEOUS, media_common, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Auditory Perceptual Disorders, 05 social sciences, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Recognition, Psychology, Middle Aged, medicine.disease, Reading, Social Perception, Emotional prosody, Tone deafness, Categorization, Speech Perception, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Timbre, Music, 030217 neurology & neurosurgery, Sentence
Abstract: Congenital amusia is a lifelong deficit of music processing, in particular of pitch processing. Most research investigating this neurodevelopmental disorder has focused on music perception, but pitch also has a critical role for intentional and emotional prosody in speech. Two previous studies investigating amusics’ emotional prosody recognition have shown either some deficit or no deficit (compared to controls). However, these previous studies have used only long sentence stimuli, which allow for limited control over acoustic content. Here, we tested amusic individuals for emotional prosody perception in sentences and vowels. For each type of material, participants performed an emotion categorization task, followed by intensity ratings of the recognized emotion. Compared to controls, amusic individuals had similar recognition of emotion in sentences, but poorer performance in vowels, especially when distinguishing sad and neutral stimuli. These lower performances in amusics were linked with difficulties in processing pitch and spectro-temporal parameters of the vowel stimuli. For emotion intensity, neither sentence nor vowel ratings differed between participant groups, suggesting preserved implicit processing of emotional prosody in amusia. These findings can be integrated into previous data showing preserved implicit processing of pitch and emotion in amusia alongside deficits in explicit recognition tasks. They are thus further supporting the hypothesis of impaired conscious analysis of pitch and timbre in this neurodevelopmental disorder.HighlightsAmusics showed preserved emotional prosody recognition in sentencesAmusics showed a deficit for emotional prosody recognition in short voice samplesPreserved intensity ratings of emotions in amusia suggest spared implicit processes
Published: 2019

12. Auteur(s) et acteurs de la genèse

Author: Nicolas Donin, Daniel Ferrer, Equipe Analyse des pratiques musicales, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Équipe génétique et histoire des arts (ITEM – GénéArts), Institut des textes et manuscrits modernes (ITEM), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Département Littératures et langage - ENS Paris (LILA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Département Littératures et langage - ENS Paris (LILA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Équipe James Joyce et le Modernisme anglophone (ITEM – Joyce), Joyce et le Modernisme anglophone, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Département Littératures et langage (LILA), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Département Littératures et langage (LILA)
Subjects: 0303 health sciences, architecture, Jack Stillinger, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, [SHS.LITT]Humanities and Social Sciences/Literature, General Medicine, processus de création, [SHS.ART]Humanities and Social Sciences/Art and art history, 03 medical and health sciences, 0302 clinical medicine, processus créateur, cinéma, littérature, musique, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: Nous avons écrit l’Anti-Œdipe à deux. Comme chacun denous était plusieurs, ça faisait déjà beaucoup de monde.Gilles Deleuze et Felix Guattari, Rhizome Quiconque se figure la fabrication d’un chef-d’œuvre de la littérature comme résultant nécessairement de l’exercice solitaire d’une souveraineté sans partage devrait jeter un coup d’œil au manuscrit de The Waste Land (fig. 1). Il se présente pour la plus grande partie comme un dactylogramme corrigé au crayon de la main de T. S. Eliot, mais on y...
Published: 2015

13. Alterations of EEG rhythms during motor preparation following awake brain surgery

Author: Bénédicte Poulin-Charronnat, Anthony Boyer, Sofiane Ramdani, David Guiraud, Hugues Duffau, François Bonnetblanc, Control of Artificial Movement and Intuitive Neuroprosthesis ( CAMIN ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Efficience Déficience Motrice [Montpellier] ( EDM ), Université Montpellier 1 ( UM1 ), Hôpital Gui de Chauliac, Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), ANR-10-LABX-0020/10-LABX-0020,NUMEV,Digital and Hardware Solutions and Modeling for the Environement and Life Sciences ( 2010 ), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Interactive Digital Humans (IDH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), LabEx NUMEV project by the French government's 'Investissements d'Avenir' program ANR-10-LABX-20 Institut Universitaire de France INSERM laboratory U1093, ANR-10-LABX-0020,NUMEV,Digital and Hardware Solutions and Modeling for the Environement and Life Sciences(2010), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)
Subjects: Adult, Male, medicine.medical_specialty, Cognitive Neuroscience, [SDV.CAN]Life Sciences [q-bio]/Cancer, Experimental and Cognitive Psychology, Spectral analysis, 050105 experimental psychology, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Lesion, 03 medical and health sciences, Cognition, 0302 clinical medicine, Arts and Humanities (miscellaneous), Awake brain surgery, Reaction Time, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, Brainwaves, Wakefulness, Balance (ability), Brain Neoplasms, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Healthy subjects, Brain, Electroencephalography, Middle Aged, Surgery, Electrophysiology, Neuropsychology and Physiological Psychology, Behavioral data, Diffuse low-grade glioma, [ SCCO.NEUR ] Cognitive science/Neuroscience, Eeg rhythms, Female, medicine.symptom, Psychology, Eeg monitoring, 030217 neurology & neurosurgery
Abstract: International audience; Slow-growing, infiltrative brain tumours may modify the electrophysiological balance between the two hemispheres. To determine whether and how asymmetry of EEG rhythms during motor preparation might occur following " awake brain surgery " for this type of tumour, we recorded electroencephalograms during a simple visuo-manual reaction time paradigm performed by the patients between 3 and 12 months after surgery and compared them to a control group of 8 healthy subjects. Frequency analyses revealed imbalances between the injured and healthy hemispheres. More particularly, we observed a power increase in the δ frequency band near the lesion site and a power increase in the α and β frequency bands. Interestingly, these alterations seem to decrease for the two patients whose surgery were anterior to 9 months, independently of the size of the lesion. Reaction times did not reflect this pattern as they were clearly not inversely related to the anteriority of the surgery. Electrophysiology suggests here different processes of recovery compared to behavioral data and brings further insights for the understanding of EEG rhythms that should not be systematically confounded or assimilated with cognitive performances. EEG monitoring is rare for these patients, especially after awake brain surgery, however it is important.
Published: 2018

14. Exploring Trandisciplinarity in Art and Science

Author: Moreno Andreatta, Emmanuelle Volle, Julien Renoult, Zoï Kapoula, Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Représentations musicales (Repmus), Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Mathématique Avancée (IRMA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Groupe de recherches expérimentales sur l'acte musical - [LabEx] (GREAM), Université de Strasbourg (UNISTRA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Groupe de recherches expérimentales sur l'acte musical (GREAM), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, Computer science, 05 social sciences, 050105 experimental psychology, Epistemology, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Transdisciplinarity, 0501 psychology and cognitive sciences, [INFO]Computer Science [cs], [MATH]Mathematics [math], 030217 neurology & neurosurgery, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

15. Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods

Author: Yves Vandenbrouck, Charlotte Macron, Thomas Fréour, Lydie Lane, Karine Rondel, Charles Pineau, Paula D. Duek, François Delalande, Christine Carapito, Marine Seffals, Cecilia Lindskog, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Swiss Institute of Bioinformatics [Genève] (SIB), H2P2 - Histo Pathologie Hight Precision (H2P2), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Uppsala University, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), French National Agency for Research (ANR) [ANR-10-INBS-08], Biogenouest, Infrastructures en Biologie Sante et Agronomie (IBiSA), Conseil Regional de Bretagne, ANR-10-INBS-0008,ProFI,Infrastructure Française de Protéomique(2010), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université de Lausanne (UNIL), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Equipe Direction scientifique, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Etude de la dynamique des protéomes (EDyP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Département de science des protéines humaines [Genève], Université de Genève (UNIGE)-Faculté de médecine [Genève], Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent, and Infrastructure Française de Protéomique - - ProFI2010 - ANR-10-INBS-0008 - INBS - VALID
Subjects: 0301 basic medicine, Male, Proteome, [SDV]Life Sciences [q-bio], Tandem mass spectrometry, Biochemistry, immunocytochemistry, Tandem Mass Spectrometry, Testis, Human proteome project, ComputingMilieux_MISCELLANEOUS, ddc:616, biology, Histocytochemistry, bioinformatics, Immunohistochemistry, Spermatozoa, [SDV] Life Sciences [q-bio], spermatozoon, Chromosomes, Human, Pair 2, immunohistochemistry, Antibody, missing proteins, Human, human proteome project, targeted proteomics, Octoxynol, Human Protein Atlas, Context (language use), Computational biology, Chromosomes, Antibodies, 03 medical and health sciences, Spermatozoa/chemistry, Proteome/analysis, Humans, Chromosomes, Human, Pair 14, 030102 biochemistry & molecular biology, Testis/chemistry, General Chemistry, data mining, Sperm, Molecular biology, parallel reaction monitoring, 030104 developmental biology, Targeted mass spectrometry, biology.protein, Pair 14/genetics, Pair 2/genetics
Abstract: The present study is a contribution to the "neXt50 challenge", a coordinated effort across C-HPP teams to identify the 50 most tractable missing proteins (MPs) on each chromosome. We report the targeted search of 38 theoretically detectable MPs from chromosomes 2 and 14 in Triton X-100 soluble and insoluble sperm fractions from a total of 15 healthy donors. A targeted mass-spectrometry-based strategy consisting of the development of LC-PRM assays (with heavy labeled synthetic peptides) targeting 92 proteotypic peptides of the 38 selected MPs was used. Out of the 38 selected MPs, 12 were identified with two or more peptides and 3 with one peptide after extensive SDS-PAGE fractionation of the two samples and with overall low-intensity signals. The PRM data are available via ProteomeXchange in PASSEL (PASS01013). Further validation by immunohistochemistry on human testes sections and cytochemistry on sperm smears was performed for eight MPs with antibodies available from the Human Protein Atlas. Deep analysis of human sperm still allows the validation of MPs and therefore contributes to the C-HPP worldwide effort. We anticipate that our results will be of interest to the reproductive biology community because an in-depth analysis of these MPs may identify potential new candidates in the context of human idiopathic infertilities.
Published: 2017

16. Brain voice processing with bilateral cochlear implants: a positron emission tomography study

Author: Evelyne Ferrary, Yves Samson, Isabelle Mosnier, Emmanuèle Ambert-Dahan, Jean-Luc Martinot, Didier Bouccara, Arnaud Coez, Olivier Sterkers, Eric Bizaguet, Monica Zilbovicius, Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'oto-rhino-laryngologie, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut Claude Bernard - Physiologie et Pathologie ((IFR_2)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie en psychiatrie (U1000), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Service ORL, CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Hôpital Beaujon, Institut Claude Bernard - Physiologie et Pathologie, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 ( SCALab ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Neuroimagerie en psychiatrie ( U1000 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Male, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.medical_treatment, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Sound perception, Audiology, Monaural, MESH : Voice, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Cochlear Implants, MESH: Auditory Perceptual Disorders, 0302 clinical medicine, Hearing, Cochlear implant, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, MESH : Female, 030223 otorhinolaryngology, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, MESH: Cerebrovascular Circulation, General Medicine, MESH : Adult, Cochlear Implantation, Temporal Lobe, MESH: Positron-Emission Tomography, MESH : Auditory Perceptual Disorders, MESH: Voice, MESH : Hearing Loss, Bilateral, Cerebrovascular Circulation, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Speech Perception, Female, MESH : Speech Perception, MESH : Cochlear Implantation, MESH : Hearing, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Adult, Sound localization, Auditory perception, medicine.medical_specialty, MESH : Male, MESH: Acoustic Stimulation, Sensory system, Hearing Loss, Bilateral, 03 medical and health sciences, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, otorhinolaryngologic diseases, medicine, Humans, MESH: Temporal Lobe, MESH: Hearing, MESH : Temporal Lobe, MESH: Humans, business.industry, Auditory Perceptual Disorders, MESH : Humans, MESH : Positron-Emission Tomography, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], MESH: Adult, MESH : Acoustic Stimulation, MESH: Speech Perception, MESH: Hearing Loss, Bilateral, MESH: Male, Cochlear Implants, Acoustic Stimulation, MESH: Cochlear Implantation, Otorhinolaryngology, Positron-Emission Tomography, Voice, MESH : Cochlear Implants, MESH : Cerebrovascular Circulation, sense organs, Implant, business, MESH: Female, Binaural recording, 030217 neurology & neurosurgery
Abstract: International audience; Most cochlear implantations are unilateral. To explore the benefits of a binaural cochlear implant, we used water-labelled oxygen-15 positron emission tomography. Relative cerebral blood flow was measured in a binaural implant group (n = 11), while the subjects were passively listening to human voice sounds, environmental sounds non-voice or silence. Binaural auditory stimulation in the cochlear implant group bilaterally activated the temporal voice areas, whereas monaural cochlear implant stimulation only activated the left temporal voice area. Direct comparison of the binaural and the monaural cochlear implant stimulation condition revealed an additional right temporal activation during voice processing in the binaural condition and the activation of a right fronto-parietal cortical network during sound processing that has been implicated in attention. These findings provide evidence that a bilateral cochlear implant stimulation enhanced the spectral cues associated with sound perception and improved brain processing of voice stimuli in the right temporal region when compared to a monaural cochlear implant stimulation. Moreover, the recruitment of sensory attention resources in a right fronto-parietal network allowed patients with bilateral cochlear implant stimulation to enhance their sound discrimination, whereas the same patients with only one cochlear implant stimulation had more auditory perception difficulties.
Published: 2013

17. Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities

Author: Brice Bathellier, Thomas Deneux, Alexandre Kempf, Emmanuel Ponsot, Aurélie Daret, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Unité de Neurosciences Information et Complexité [Gif sur Yvette] (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences de la Timone ( INT ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Unité de Neurosciences Information et Complexité [Gif sur Yvette] ( UNIC ), Centre National de la Recherche Scientifique ( CNRS ), Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), and Aucouturier, Jean-Julien
Subjects: Male, 0301 basic medicine, genetic structures, Computer science, General Physics and Astronomy, Mice, 0302 clinical medicine, Hearing, media_common, Neurons, education.field_of_study, Microscopy, Confocal, Multidisciplinary, musculoskeletal, neural, and ocular physiology, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Sound, Auditory Perception, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Auditory perception, Acoustics, media_common.quotation_subject, Science, Population, Auditory cortex, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Calcium imaging, Perception, otorhinolaryngologic diseases, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], education, Cochlear Nerve, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Auditory Cortex, Condensed Matter::Quantum Gases, Quantitative Biology::Neurons and Cognition, Cochlear nerve, General Chemistry, Mice, Inbred C57BL, 030104 developmental biology, Acoustic Stimulation, Receptive field, Computer Science::Sound, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Physics::Accelerator Physics, Neuroscience, human activities, 030217 neurology & neurosurgery, Coding (social sciences)
Abstract: Sound recognition relies not only on spectral cues, but also on temporal cues, as demonstrated by the profound impact of time reversals on perception of common sounds. To address the coding principles underlying such auditory asymmetries, we recorded a large sample of auditory cortex neurons using two-photon calcium imaging in awake mice, while playing sounds ramping up or down in intensity. We observed clear asymmetries in cortical population responses, including stronger cortical activity for up-ramping sounds, which matches perceptual saliency assessments in mice and previous measures in humans. Analysis of cortical activity patterns revealed that auditory cortex implements a map of spatially clustered neuronal ensembles, detecting specific combinations of spectral and intensity modulation features. Comparing different models, we show that cortical responses result from multi-layered nonlinearities, which, contrary to standard receptive field models of auditory cortex function, build divergent representations of sounds with similar spectral content, but different temporal structure., In humans, sounds that increase in intensity over time (up-ramp) are perceived as louder than down-ramping sounds. Here the authors show that in mice this bias also exists and is reflected in the complex nonlinearities of auditory cortex activity.
Published: 2016

18. Emergency medical triage decisions are swayed by computer-manipulated cues of physical dominance in caller’s voice

Author: Jean-Julien Aucouturier, Laurent Boidron, Christophe Avena, Karim Boudenia, Jean-Michel Boucheix, Département de médecine d'urgence / SAMU - SMUR - CESU 21 (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Sciences et Technologies de la Musique et du Son (STMS), and Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Attractiveness, Adult, Male, Persuasion, Emergency Medical Services, media_common.quotation_subject, Applied psychology, Decision Making, 050109 social psychology, [ SCCO.PSYC ] Cognitive science/Psychology, Complementarity, Article, [ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, 03 medical and health sciences, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0302 clinical medicine, Phone, Emergency medical services, Pressure, Humans, 0501 psychology and cognitive sciences, 030212 general & internal medicine, Simulation, media_common, Multidisciplinary, Mens voices, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, Emergency Medical Service Communication Systems, 05 social sciences, S Voice, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Patient satisfaction, Triage, Telephone consultation, Formant, Masculinity, Behaviors, [SCCO.PSYC]Cognitive science/Psychology, Formant frequencies influence, Voice, Female, business, Psychology
Abstract: In humans as well as other animals, displays of body strength such as power postures or deep masculine voices are associated with prevalence in conflicts of interest and facilitated access to resources. We conduct here an ecological and highly critical test of this hypothesis in a domain that, on first thought, would appear to be shielded from such influences: access to emergency medical care. Using acoustic manipulations of vocal masculinity, we systematically varied the perceived level of physical dominance of mock patients calling a medical call center simulator. Callers whose voice were perceived as indicative of physical dominance (i.e. those with low fundamental and formant frequency voices) obtained a higher grade of response, a higher evaluation of medical emergency and longer attention from physicians than callers with strictly identical medical needs whose voice signaled lower physical dominance. Strikingly, while the effect was important for physician participants, it was virtually non-existent when calls were processed by non-medically-trained phone operators. This finding demonstrates an unprecedented degree of vulnerability of telephone-based medical decisions to extra-medical factors carried by vocal cues and shows that it may not simply be assumed that more medical training will shield decisions from such influences.
Published: 2016

19. Covert digital manipulation of vocal emotion alter speakers' emotional states in a congruent direction

Author: Petter Johansson, Katsumi Watanabe, Lars Hall, Rodrigo Segnini, Jean-Julien Aucouturier, Lolita Mercadié, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Swedish Collegium for Advanced Study [Uppsala], Lund University Cognitive Science, Lund University [Lund], Siemens Healthcare [Tokyo], NTT Communication Science Laboratories, NTT Corporation, Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Science and Engineering [University of Waseda], Waseda University [Tokyo, Japan], Research Center for Advanced Science and Technology [Tokyo] (RCAST), The University of Tokyo (UTokyo), Waseda University, Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Research Center for Advanced Science and Technology [Tokyo] ( RCAST ), The University of Tokyo, and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)
Subjects: Adolescent, media_common.quotation_subject, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Emotions, Social Sciences, emotion, [ SCCO.PSYC ] Cognitive science/Psychology, 050105 experimental psychology, Emotional competence, [ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, 03 medical and health sciences, 0302 clinical medicine, [ SHS.INFO ] Humanities and Social Sciences/Library and information sciences, Humans, 0501 psychology and cognitive sciences, Active listening, Emotional expression, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), peripheral feedback, Aged, media_common, Multidisciplinary, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, 05 social sciences, voice, Cognition, 16. Peace & justice, Self Concept, Sadness, monitoring, Feeling, Covert, [SCCO.PSYC]Cognitive science/Psychology, Happiness, Female, Psychology, Social psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: International audience; Research has shown that people often exert control over their emotions. By modulating expressions, reappraising feelings, and redirecting attention, they can regulate their emotional experience. These findings have contributed to a blurring of the traditional boundaries between cognitive and emotional processes, and it has been suggested that emotional signals are produced in a goal-directed way and monitored for errors like other intentional actions. However, this interesting possibility has never been experimentally tested. To this end, we created a digital audio platform to covertly modify the emotional tone of participants' voices while they talked in the direction of happiness, sadness, or fear. The result showed that the audio transformations were being perceived as natural examples of the intended emotions, but the great majority of the participants, nevertheless, remained unaware that their own voices were being manipulated. This finding indicates that people are not continuously monitoring their own voice to make sure that it meets a predetermined emotional target. Instead, as a consequence of listening to their altered voices, the emotional state of the participants changed in congruence with the emotion portrayed, which was measured by both self-report and skin conductance level. This change is the first evidence, to our knowledge, of peripheral feedback effects on emotional experience in the auditory domain. As such, our result reinforces the wider framework of self-perception theory: that we often use the same inferential strategies to understand ourselves as those that we use to understand others. emotion monitoring | vocal feedback | self-perception | digital audio effects | voice emotion
Published: 2016

20. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery

Author: Engsig, F. N., Zangerle, R., Katsarou, O., Dabis, F., Reiss, P., Gill, J., Porter, K., Sabin, C., Riordan, A., Fatkenheuer, G., Gutierrez, F., Raffi, F., Kirk, O., Mary-Krause, M., Stephan, C., de Olalla, P. G., Guest, J., Samji, H., Castagna, A., d'Arminio Monforte, A., Skaletz-Rorowski, A., Ramos, J., Lapadula, G., Mussini, C., Force, L., Meyer, L., Lampe, F., Boufassa, F., Bucher, H. C., De Wit, S., Burkholder, G. A., Teira, R., Justice, A. C., Sterling, T. R., M. Crane, H., Gerstoft, J., Grarup, J., May, M., Chene, G., Ingle, S. M., Sterne, J., Obel, N., Burkholder, G., Justice, A., R Sterling, T., Crane, H. M., Boulle, A., Brodt, H.-R., Casabona, J., Cavassini, M., Costagliola, D., D'Arminio Monforte, A., del Amo, J., Van Sighem, A., Hans-Ulrich Haerry, D., Hogg, R., Mocroft, A., Kitahata, M., Saag, M., Williams, M., Ingle, S., Touloumi, G., Warszawski, J., Krause, M. M., Ghosn, J., Leport, C., Wit, F., Prins, M., Gibb, D., Del Amo, J., Thorne, C., Perez-Hoyos, S., Hamouda, O., Gussenheimer-Bartmeyer, B., Noguera-Julian, A., Antinori, A., Brockmeyer, N., Battegay, M., Rauch, A., Tookey, P., Miro, J. M., de Wit, S., Goetghebuer, T., Torti, C., Garrido, M., Judd, A., Conejo, P. R., Haerry, D., Weller, I., d'Arminio-Monforte, A., Colin, C., Schwimmer, C., Termote, M., Kjaer, J., Campbell, M., Raben, D., Bohlius, J., Bouteloup, V., Bucher, H., Cozzi-Lepri, A., Dorrucci, M., Egger, M., Engsig, F., Furrer, H., Lambotte, O., Lewden, C., Lodi, S., Lodwick, R., Matheron, S., Miro, J., Monge, S., Nakagawa, F., Paredes, R., Phillips, A., Puoti, M., Reekie, J., Scherrer, A., Smit, C., Thiebaut, R., Wittkop, L., 2nd Blood Transfusion Center and Hemophilia Center, 'Laiko' General Hospital, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Structures et propriétés d'architectures moléculaire (SPRAM - UMR 5819), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Micro et Nano Technologies (OMNT - UMS 2920), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Southern Alberta Clinic, Research Department of Infection and Population Health [London], University College of London [London] (UCL), Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Equipe Interactions musicales temps-réel, Maladies infectieuses et tropicales, Université Pierre et Marie Curie - Paris 6 (UPMC), Institute of Biology, Neuchatel, Université de Neuchâtel (UNINE), School of Psychology, St Andrews, University of St Andrews [Scotland], Infectious Diseases, San Raffaele Scientific Institute, EA 4100, Histoire culturelle et sociale de l'art (HiCSA), Université Panthéon-Sorbonne (UP1)-Université Panthéon-Sorbonne (UP1), Laboratory of Inorganic Chemistry, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Princeton University, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Population Sciences, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Paläontologisches Institut und Museum, Universität Zürich [Zürich] (UZH), Laboratory, GD Deventer, Rigshospitalet [Copenhagen], Department of Social Medicine, University of Bristol [Bristol], Department of Infectious Diseases, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), School of Psychology and Neuroscience [University of St. Andrews], Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 1 Panthéon-Sorbonne (UP1), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Zürich [Zürich] = University of Zurich (UZH), Royal GD [Deventer], Copenhagen University Hospital, Copenhagen University Hospital-Copenhagen University Hospital, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Engsig, F. N., Zangerle, R., Katsarou, O., Dabis, F., Reiss, P., Gill, J., Porter, K., Sabin, C., Riordan, A., Fatkenheuer, G., Gutierrez, F., Raffi, F., Kirk, O., Mary-Krause, M., Stephan, C., De Olalla, P. G., Guest, J., Samji, H., Castagna, A., D'arminio Monforte, A., Skaletz-Rorowski, A., Ramos, J., Lapadula, G., Mussini, C., Force, L., Meyer, L., Lampe, F., Boufassa, F., Bucher, H. C., De Wit, S., Burkholder, G. A., Teira, R., Justice, A. C., Sterling, T. R., M. Crane, H., Gerstoft, J., Grarup, J., May, M., Chene, G., Ingle, S. M., Sterne, J., Obel, N., Engsig, F, Zangerle, R, Katsarou, O, Dabis, F, Reiss, P, Gill, J, Porter, K, Sabin, C, Riordan, A, Fatkenheuer, G, Gutierrez, F, Raffi, F, Kirk, O, Mary-Krause, M, Stephan, C, De Olalla, P, Guest, J, Samji, H, Castagna, A, D'arminio Monforte, A, Skaletz-Rorowski, A, Ramos, J, Lapadula, G, Mussini, C, Force, L, Meyer, L, Lampe, F, Boufassa, F, Bucher, H, De Wit, S, Burkholder, G, Teira, R, Justice, A, Sterling, T, M. Crane, H, Gerstoft, J, Grarup, J, May, M, Chene, G, Ingle, S, Sterne, J, Obel, N, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, and Infectious diseases
Subjects: Male, Oncology, MESH: CD4 Lymphocyte Count, [SDV]Life Sciences [q-bio], HIV Infections, MESH: Logistic Models, Cohort Studies, MESH: Cause of Death, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Cause of Death, Medicine, HIV Infection, 030212 general & internal medicine, MESH: Anti-HIV Agents, MESH: Cohort Studies, Immunodeficiency, Cause of death, 0303 health sciences, MESH: Middle Aged, Hazard ratio, MESH: HIV Infections, Middle Aged, Viral Load, 3. Good health, Infectious Diseases, MESH: Substance-Related Disorders, HIV/AIDS, Female, MESH: Viral Load, Viral load, MESH: Heterosexuality, Human, Adult, Microbiology (medical), Cart, medicine.medical_specialty, Logistic Model, Anti-HIV Agents, Substance-Related Disorders, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Internal medicine, Humans, sustained viral suppression, Heterosexuality, 030304 developmental biology, MESH: Humans, business.industry, Proportional hazards model, Risk Factor, Anti-HIV Agent, HIV, MESH: Adult, Substance-Related Disorder, medicine.disease, mortality, CD4 cell recovery, Confidence interval, MESH: Male, CD4 Lymphocyte Count, Logistic Models, Immunology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort Studie, business, MESH: Female
Abstract: Background. Some human immunodeficiency virus (HIV)-infected individuals initiating combination antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but not CD4 cell recovery. We aimed to identify (1) risk factors for failure to achieve CD4 count >200 cells/μL after 3 years of sustained viral suppression and (2) the association of the achieved CD4 count with subsequent mortality.Methods. We included treated HIV-infected adults from 2 large international HIV cohorts, who had viral suppression (≤500 HIV type 1 RNA copies/mL) for >3 years with CD4 count ≤200 cells/μL at start of the suppressed period. Logistic regression was used to identify risk factors for incomplete CD4 recovery (≤200 cells/μL) and Cox regression to identify associations with mortality.Results. Of 5550 eligible individuals, 835 (15%) did not reach a CD4 count >200 cells/μL after 3 years of suppression. Increasing age, lower initial CD4 count, male heterosexual and injection drug use transmission, cART initiation after 1998, and longer time from initiation of cART to start of the virally suppressed period were risk factors for not achieving a CD4 count >200 cells/μL. Individuals with CD4 ≤200 cells/μL after 3 years of viral suppression had substantially increased mortality (adjusted hazard ratio, 2.60; 95% confidence interval, 1.86-3.61) compared with those who achieved CD4 count >200 cells/μL. The increased mortality was seen across different patient groups and for all causes of death.Conclusions. Virally suppressed HIV-positive individuals on cART who do not achieve a CD4 count >200 cells/μL have substantially increased long-term mortality. © The Author 2014.
Published: 2014

21. On the effectiveness of vocal imitations and verbal descriptions of sounds

Author: Davide Rocchesso, Guillaume Lemaitre, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), IUAV University Venice, Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Università Iuav di Venezia = Iuav University of Venice (IUAV), Lemaitre G., and Rocchesso D.
Subjects: Sound (medical instrument), Settore INF/01 - Informatica, Acoustics and Ultrasonics, Speech recognition, Acoustics, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Referent, 050105 experimental psychology, Task (project management), 03 medical and health sciences, [SPI]Engineering Sciences [physics], vocal imitations, 0302 clinical medicine, Arts and Humanities (miscellaneous), Selection (linguistics), Identifiability, 0501 psychology and cognitive sciences, NA, [INFO]Computer Science [cs], Psychology, 030217 neurology & neurosurgery
Abstract: cote interne IRCAM: Lemaitre14b; None / None; International audience; Describing unidentified sounds with words is a frustrating task and vocally imitating them is often a convenient way to address the issue. This article reports on a study that compared the effectiveness of vocal imitations and verbalizations to communicate different referent sounds. The stimuli included mechanical and synthesized sounds and were selected on the basis of participants' confidence in identifying the cause of the sounds, ranging from easy-to-identify to unidentifiable sounds. The study used a selection of vocal imitations and verbalizations deemed adequate descriptions of the referent sounds. These descriptions were used in a nine-alternative forced-choice experiment: Participants listened to a description and picked one sound from a list of nine possible referent sounds. Results showed that recognition based on verbalizations was maximally effective when the referent sounds were identifiable. Recognition accuracy with verbalizations dropped when identifiability of the sounds decreased. Conversely, recognition accuracy with vocal imitations did not depend on the identifiability of the referent sounds and was as high as with the best verbalizations. This shows that vocal imitations are an effective means of representing and communicating sounds and suggests that they could be used in a number of applications.
Published: 2014

22. Implicit Sequence Learning in a Continuous Pursuit-Tracking Task

Author: Carole Ferrel-Chapus, Olivier Gapenne, Alexandre Lang, Dominique Aubert, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche sur le Sport et le Mouvement (CeRSM), Université Paris Nanterre (UPN), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Biomécanique et Bioingéniérie, Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche sur le Sport et le Mouvement ( CeRSM ), Université Paris Nanterre ( UPN ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), and Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, Time Factors, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Transfer, Psychology, Speech recognition, media_common.quotation_subject, Motion Perception, Multi-task learning, Experimental and Cognitive Psychology, Analyse du Mouvement en Biomécanique Physiologie et Imagerie, 050105 experimental psychology, Task (project management), 03 medical and health sciences, Random Allocation, Young Adult, 0302 clinical medicine, Arts and Humanities (miscellaneous), Perception, Developmental and Educational Psychology, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Learning, 0501 psychology and cognitive sciences, Motion perception, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Block (data storage), media_common, [ PHYS.MECA.BIOM ] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Sequence, Communication, business.industry, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], 05 social sciences, General Medicine, Implicit learning, Space Perception, Female, Sequence learning, business, Psychology, 030217 neurology & neurosurgery, Transfer Psychology
Abstract: Epub 2012 Oct 30; Assessing implicit learning in the continuous pursuit-tracking task usually concerns a repeated segment of target displacements masked by two random segments, as referred to as Pew's paradigm. Evidence for segment learning in this paradigm is scanty and contrasts with robust sequence learning in discrete tracking tasks. The present study investigates this issue with two experiments in which participants (N = 56) performed a continuous tracking task. Contrary to Pew's paradigm, participants were presented with a training sequence that was continuously cycled during 14 blocks of practice, but Block 12 in which a transfer sequence was introduced. Results demonstrate sequence learning in several conditions except in the condition that was obviously the most similar to previous studies failing to induce segment learning. Specifically, it is shown here that a target moving too slowly combined with variable time at which target reversal occurs prevents sequence learning. In addition, data from a post-experimental recognition test indicate that sequence learning was associated with explicit perceptual knowledge about the repetitive structure. We propose that learning repetition in a continuous tracking task is conditional on its capacity to (1) allow participants to detect the repeated regularities and (2) restrict feedback-based tracking strategies.
Published: 2013

23. Seven problems that keep MIR from attracting the interest of cognition and neuroscience

Author: Emmanuel Bigand, Jean-Julien Aucouturier, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Sciences et Technologies de la Musique et du Son ( STMS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IRCAM-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), and Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS )
Subjects: Computer Networks and Communications, Computer science, Aside, Process (engineering), Music psychology, 05 social sciences, Cognition, Musical, 050105 experimental psychology, Body of knowledge, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, PACS: 43.75.Xz, 43.66.Ba, Artificial Intelligence, Hardware and Architecture, [INFO.INFO-SD]Computer Science [cs]/Sound [cs.SD], Music information retrieval, 0501 psychology and cognitive sciences, [ SCCO ] Cognitive science, [ INFO.INFO-SD ] Computer Science [cs]/Sound [cs.SD], Neuroscience, 030217 neurology & neurosurgery, Software, Information Systems
Abstract: International audience; Despite one and a half decade of research and an impressive body of knowledge on how to represent and process musical audio signals, the discipline of Music Information Retrieval still does not enjoy broad recognition outside of computer science. In music cognition and neuroscience in particular, where MIR's contribution could be most needed, MIR technologies are scarcely ever utilized-when they're not simply brushed aside as irrelevant. This, we contend here, is the result of a series of misunderstandings between the two fields, about deeply different methodologies and assumptions that are not often made explicit. A collaboration between a MIR researcher and a music psychologist, this article attempts to clarify some of these assumptions, and offers some suggestions on how to adapt some of MIR's most emblematic signal processing paradigms, evaluation procedures and application scenarios to the new challenges brought forth by the natural sciences of music.
Published: 2013

24. Localization of endogenous morphine-like compounds in the mouse spinal cord

Author: François Delalande, Pierrick Poisbeau, Erwan Bezard, Alain Van Dorsselaer, Denise Stuber, Yannick Goumon, Enrica Bianchi, Alexis Laux, Jinane Mouheiche, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Siena = University of Siena (UNISI), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Goumon, Yannick, Physiopathologie du système nerveux., Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM), Département Neurotransmission et sécrétion neuroendocrine, Centre National de la Recherche Scientifique (CNRS), Equipe Direction scientifique, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse BioOrganique [Strasbourg] (LSMBO), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Perimeter Institute for Theoretical Physics [Waterloo], Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Laboratoire de Spectrométrie de Masse BioOrganique, Département des Sciences Analytiques, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France (LSMBO-DSA-IPHC)
Subjects: Male, Mouse, [SDV]Life Sciences [q-bio], Endogeny, Morphine-6-glucuronide, Pharmacology, MESH: Spinal Cord, chemistry.chemical_compound, GABA, Mice, [SCCO]Cognitive science, 0302 clinical medicine, MESH: Microscopy, Confocal, MESH: Animals, GABAergic Neurons, Morphine-3-glucuronide, 0303 health sciences, Astrocytes, Codeine, Morphine, Spinal cord, Microscopy, Confocal, General Neuroscience, Immunohistochemistry, 3. Good health, medicine.anatomical_structure, Spinal Cord, MESH: Morphine Derivatives, MESH: GABAergic Neurons, MESH: Microscopy, Electron, Transmission, GABAergic, medicine.drug, Central nervous system, Biology, MESH: Codeine, White matter, 03 medical and health sciences, Microscopy, Electron, Transmission, MESH: Mice, Inbred C57BL, medicine, Animals, MESH: Mice, 030304 developmental biology, Morphine Derivatives, MESH: Immunohistochemistry, [SCCO] Cognitive science, MESH: Male, Mice, Inbred C57BL, MESH: Astrocytes, MESH: Morphine, chemistry, 030217 neurology & neurosurgery
Abstract: Morphine, codeine, morphine-6-glucuronide, and morphine-3-glucuronide are synthesized de novo in mammalian cells and in the central nervous system. Knowledge on endogenous morphine-like compound distribution in the adult mouse brain has been recently improved, and new hypotheses have been suggested about the potential implications in brain physiology. Endogenous morphine-like compounds have been shown to be synthesized in the spinal cord, but their localization is unknown. Here we describe the distribution of endogenous morphine-like compounds (morphine and/or its glucuronides and/or codeine) in the adult mouse spinal cord using a well-validated antibody. By using different microscopy approaches, we found the presence of morphine, codeine, or morphine glucuronides in γ-aminobutyric acid (GABA)-ergic neurons and astrocytes of the spinal cord. Whereas GABAergic neurons containing endogenous morphine-like compounds were located primarily in the ventral horn, astrocytes that were labeled for morphine-like compounds were found throughout the gray matter and the white matter. Our study demonstrates the possibility that endogenous morphine-like compounds in the central nervous system have other functions beyond their analgesic functions. J. Comp. Neurol. 520:1547–1561, 2012. © 2011 Wiley Periodicals, Inc.
Published: 2012

25. A Lexical Analysis of Environmental Sound Categories

Author: Guillaume Lemaitre, Olivier Houix, Nicolas Misdariis, Isabel Urdapilleta, Patrick Susini, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Parisien de Psychologie Sociale (LAPPS), Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Université Paris Nanterre (UPN)-Université Paris 8 Vincennes-Saint-Denis (UP8)
Subjects: Adult, Male, Computer science, environmental sounds, Experimental and Cognitive Psychology, Environment, computer.software_genre, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Humans, 0501 psychology and cognitive sciences, lexical analysi, Practical implications, similarity, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], business.industry, 05 social sciences, Environmental sounds, Lexical analysis, classification task, Cognition, Middle Aged, categorization, Hierarchical clustering, Sound, Acoustic Stimulation, Categorization, [SCCO.PSYC]Cognitive science/Psychology, Auditory Perception, Auditory stimuli, Female, Artificial intelligence, business, computer, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, 030217 neurology & neurosurgery, Natural language processing
Abstract: International audience; In this article we report on listener categorization of meaningful environmental sounds. A starting point for this study was the phenomenological taxonomy proposed by Gaver (1993b). In the first experimental study, 15 participants classified 60 environmental sounds and indicated the properties shared by the sounds in each class. In a second experimental study, 30 participants classified and described 56 sounds exclusively made by solid objects. The participants were required to concentrate on the actions causing the sounds independent of the sound source. The classifications were analyzed with a specific hierarchical cluster technique that accounted for possible cross-classifications, and the verbalizations were submitted to statistical lexical analyses. The results of the first study highlighted 4 main categories of sounds: solids, liquids, gases, and machines. The results of the second study indicated a distinction between discrete interactions (e.g., impacts) and continuous interactions (e.g., tearing) and suggested that actions and objects were not independent organizational principles. We propose a general structure of environmental sound categorization based on the sounds' temporal patterning, which has practical implications for the automatic classification of environmental sounds
Published: 2012

26. A processing work-flow for measuring erythrocytes velocity in extended vascular networks from wide field high-resolution optical imaging data

Author: Ivo Vanzetta, Guillaume S. Masson, Thomas Deneux, Amiram Grinvald, Sylvain Takerkart, Equipe Autre (hors R&D), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Department of Neurobiology, Weizmann Institute of Science [Rehovot, Israël], Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), InVibe, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Subjects: Erythrocytes, Light, Computer science, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Hemodynamics, [SCCO]Cognitive science, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Extrastriate cortex, Image Processing, Computer-Assisted, Scattering, Radiation, Computer vision, Oximetry, ComputingMilieux_MISCELLANEOUS, Visual Cortex, 0303 health sciences, Blood Volume, Microscopy, Video, Cortical Spreading Depression, medicine.anatomical_structure, Neurology, Hematocrit, Cerebrovascular Circulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Blood Flow Velocity, Diagnostic Imaging, Cognitive Neuroscience, Image processing, 03 medical and health sciences, Optical imaging, medicine, Animals, Computer Simulation, 030304 developmental biology, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Image segmentation, Filter (signal processing), Somatosensory Cortex, Macaca mulatta, Visualization, Rats, Functional imaging, Oxygen, Light intensity, Visual cortex, Cats, Blood Vessels, Artificial intelligence, business, 030217 neurology & neurosurgery, Software
Abstract: Comprehensive information on the spatio-temporal dynamics of the vascular response is needed to underpin the signals used in hemodynamics-based functional imaging. It has recently been shown that red blood cells (RBCs) velocity and its changes can be extracted from wide-field optical imaging recordings of intrinsic absorption changes in cortex. Here, we describe a complete processing work-flow for reliable RBC velocity estimation in cortical networks. Several pre-processing steps are implemented: image co-registration, necessary to correct for small movements of the vasculature, semi-automatic image segmentation for fast and reproducible vessel selection, reconstruction of RBC trajectories patterns for each micro-vessel, and spatio-temporal filtering to enhance the desired data characteristics. The main analysis step is composed of two robust algorithms for estimating the RBCs' velocity field. Vessel diameter and its changes are also estimated, as well as local changes in backscattered light intensity. This full processing chain is implemented with a software suite that is freely distributed. The software uses efficient data management for handling the very large data sets obtained with in vivo optical imaging. It offers a complete and user-friendly graphical user interface with visualization tools for displaying and exploring data and results. A full data simulation framework is also provided in order to optimize the performances of the algorithm with respect to several characteristics of the data. We illustrate the performance of our method in three different cases of in vivo data. We first document the massive RBC speed response evoked by a spreading depression in anesthetized rat somato-sensory cortex. Second, we show the velocity response elicited by a visual stimulation in anesthetized cat visual cortex. Finally, we report, for the first time, visually-evoked RBC speed responses in an extended vascular network in awake monkey extrastriate cortex.
Published: 2012

27. Prestress effects on the eigenfrequencies of the soundboards: Experimental results on a simplified string instrument

Author: François Ollivier, Adrien Mamou-Mani, Sylvie Le Moyne, Charles Besnainou, Joël Frelat, Equipe Acoustique instrumentale, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Modélisation, Propagation et Imagerie Acoustique (IJLRDA-MPIA), Institut Jean le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Groupe Aleph et Géode (GAGE), École polytechnique (X), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Mécanique et Ingénierie des Solides Et des Structures (IJLRDA-MISES), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Institut Jean Le Rond d'Alembert (DALEMBERT)
Subjects: Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Test bench, Acoustics and Ultrasonics, Acoustics, [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Acoustic holography, 01 natural sciences, law.invention, Acoustical holography, Vibration, Musical acoustics, 03 medical and health sciences, Transverse plane, 0302 clinical medicine, Arts and Humanities (miscellaneous), law, [SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], 0103 physical sciences, C++ string handling, Bridge (instrument), 030223 otorhinolaryngology, 010301 acoustics
Abstract: International audience; This paper presents an experimental study of the effects of prestresses on the vibration behavior of string instruments. These prestresses are created by gluing ribs (crowning) and tensioning string (downbearing). The effects of these prestresses were previously studied numerically for a piano soundboard by Mamou-Mani et al. [J. Acoust. Soc. Am. 123, 2401–2406 (2008)] and analytically for simplified models by Mamou-Mani et al. [Acta Acust. Unit. Acust. 95, 915–926 (2009)]. In the present study, a specified test bench is designed, including a simplified soundboard (a rectangular plate), a bridge, and a single string. The plate is subjected to in-plane and transverse loads. Vibrational eigenmodes are identified using nearfield acoustical holography (NAH) measurement. The evolution of eigenfrequencies with these specific prestresses is studied. The results show the effectiveness of NAH for this purpose and a very good qualitative concordance with previous numerical and analytical calculus.
Published: 2012

28. Simultaneous beat and downbeat-tracking using a probabilistic framework : theory and large-scale evaluation

Author: Hélène Papadopoulos, Geoffroy Peeters, Analyse et synthèse sonores [Paris], Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Acoustics and Ultrasonics, Computer science, reverse Viterbi decoding, 02 engineering and technology, Viterbi algorithm, computer.software_genre, Linear Discriminant Analysis, 030507 speech-language pathology & audiology, 03 medical and health sciences, symbols.namesake, Discriminative model, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Hidden Markov model, Audio signal processing, hidden Markov model, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Downbeat, Beat-templates, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Probabilistic logic, Beat-tracking, Pattern recognition, Linear discriminant analysis, symbols, 020201 artificial intelligence & image processing, Algorithm design, NA, Artificial intelligence, 0305 other medical science, business, Beat (music), computer, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: None / None; International audience; This paper deals with the simultaneous estimation beat and downbeat location in an audio-ﬁle. We propose a probabilistic framework in which the time of the beats and their associated beat-positions-inside-a-measure role, hence the downbeats, are considered as hidden states and are estimated simultaneously using signal observations. For this, we propose a "reverse" Viterbi algorithm which decodes hidden states over beat-numbers. A beat-template is used to derive the beat observation probabilities. For this task, we propose the use of a machine-learning method, the Linear Discriminant Analysis, to estimate the most discriminative beat-templates. We propose two observations to derive the beat-position-inside-a-measure observation probability: the variation over time of chroma vectors and the spectral balance. We then perform a large-scale evaluation of beat and downbeat-tracking using six test-sets. In this, we study the inﬂuence of the various parameters of our method, compare this method to our previous beat and downbeat- tracking algorithms, and compare our results to state-of-the-art results on two test-sets for which results have been published. We ﬁnally discuss the results obtained by our system in the MIREX- 09 contest for which our system ranked ﬁrst for the "McKinney Collection" test-set.
Published: 2011

29. Quasistatic nonlinear characteristics of double-reed instruments

Author: André Almeida, Christophe Vergez, René Causse, Equipe Acoustique instrumentale, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Analyse et synthèse sonores [Paris], Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Interaction Son Musique Mouvement [Paris], and Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 43.75.Ef, Acoustics and Ultrasonics, quasi-static, hautbois, FOS: Physical sciences, double reed, Diaphragm (mechanical device), Physics - Classical Physics, caractéristique non-linéaire, [PHYS.MECA.SOLID]Physics [physics]/Mechanics [physics]/Mechanics of the solides [physics.class-ph], 01 natural sciences, Double reed, Diffuser (thermodynamics), 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), 0103 physical sciences, Humans, 030223 otorhinolaryngology, 010301 acoustics, Physics, Pressure drop, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], régime quasi-statique, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, non-linear characteristics, [SCCO.NEUR]Cognitive science/Neuroscience, Classical Physics (physics.class-ph), [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Mechanics, Conical surface, Acoustics, Models, Theoretical, woodwind, Volumetric flow rate, pacs 43.75.Pq, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Nonlinear system, Nonlinear Dynamics, anche-double, Calibration, [PHYS.MECA.STRU]Physics [physics]/Mechanics [physics]/Mechanics of the structures [physics.class-ph], [INFO.INFO-SD]Computer Science [cs]/Sound [cs.SD], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Quasistatic process, Music
Abstract: cote interne IRCAM: Almeida07a; None / None; National audience; This article proposes a characterization of the double reed in quasistatic regimes. The nonlinear relation between the pressure drop, delta p, in the double reed and the volume flow crossing it, q, is measured for slow variations of these variables. The volume flow is determined from the pressure drop in a diaphragm replacing the instrument's bore. Measurements are compared to other experimental results on reed instrument exciters and to physical models, revealing that clarinet, oboe, and bassoon quasistatic behavior relies on similar working principles. Differences in the experimental results are interpreted in terms of pressure recovery due to the conical diffuser role of the downstream part of double-reed mouthpieces (the staple).
Published: 2007

30. Cortical correlates of illusory hand movement perception in humans: A MEG study

Author: Patricia Romaiguère, Antoine Ducorps, Laurence Casini, Jean-Pierre Roll, Denis Schwartz, Jean-Luc Anton, Neurobiologie intégrative et adaptative (NIA), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), CEREG, Université Marc Bloch - Strasbourg II, Image et ville (IV), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Radiologie et imagerie médicale, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Sciences du cerveau et de la cognition (SCC), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'IRM Fonctionnelle Cérébrale, Hôpital de la Timone [CHU - APHM] (TIMONE), Tir, Nadia, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Études et de Recherches Éco-Géographiques (CEREG), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, Wrist Joint, media_common.quotation_subject, Movement, Illusion, human perception, Superior parietal lobule, Vibration, 050105 experimental psychology, Functional Laterality, Angular gyrus, Tendons, 03 medical and health sciences, 0302 clinical medicine, tendon vibration, Supramarginal gyrus, Perception, medicine, Humans, 0501 psychology and cognitive sciences, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Molecular Biology, media_common, Cerebral Cortex, Supplementary motor area, medicine.diagnostic_test, General Neuroscience, 05 social sciences, Magnetoencephalography, Hand, Illusions, medicine.anatomical_structure, cortex, Cerebral cortex, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), MEG movement illusion, Psychology, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology
Abstract: International audience; The present study aimed to investigate cortical activity associated with perception of illusory hand movements elicited by tendon vibration using magnetoencephalography (MEG) in humans. We compared MEG responses in two conditions of stimulation, ``illusion'' and ``no illusion''. In the ``illusion'' condition, covibration at different frequencies applied on the tendons of the right wrist flexor and extensor muscle groups evoked illusory movements of the hand. In the ``no illusion'' condition, covibration was delivered at the same frequency on both tendon groups and no movement was perceived. In both experimental conditions, equivalent current dipoles (ECD) were identified in each of four time windows: 0-200 ms, 200400 ms, 400-600 ms and 600-800 ms. Our data showed similar activation in S1, superior parietal gyrus and supramarginal gyrus in both conditions, whereas the supplementary motor area, M1 and the left angular gyrus were found active in the ``illusion'' condition only. Our results confirmed the role of posterior parietal areas as well as motor areas in the arising of kinesthetic sensations. The hypothesis of an interaction between the angular gyrus and the primary motor area occurring about 400 ins after the beginning of the stimulation is discussed. (c) 2006 Elsevier B.V. All rights reserved.
Published: 2006

31. Productions in bilinguism, early foreign language learning and monolinguism: A prosodic comparison

Author: Claire Gerard, Sabine Metta, Christelle Dodane, Ranka Bijeljac-Babic, Université de Poitiers - UFR Sciences Humaines et Arts (Poitiers UFR SHA), Université de Poitiers, Praxiling (Praxiling), Centre National de la Recherche Scientifique (CNRS)-Université Paul-Valéry - Montpellier 3 (UPVM), Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Dodane, Christelle
Subjects: Foreign language learning, Computer science, 4. Education, 020206 networking & telecommunications, Interaction hypothesis, 02 engineering and technology, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, Linguistics, 030507 speech-language pathology & audiology, 03 medical and health sciences, Stress (linguistics), 0202 electrical engineering, electronic engineering, information engineering, Language education, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, 0305 other medical science, ComputingMilieux_MISCELLANEOUS
Abstract: The degree of L2 foreign accent is likely to vary, according to the age of the acquisition, the length of contact with L2 and the possible interaction between L1 and L2. This study examined how children who master French and English at different levels pronounce disyllabic words in both languages. Acoustic analysis (F0, duration and amplitude) of syllables in disyllabic words were compared between 8 bilingual children (French-English, aged between 3;6 and 6;1 years) and 16 monolingual children (8 French children and 8 English children of the same age) and confronted to the analysis of 20 (7 years aged) early French Learners of English (FLE) children. Results showed that the bilingual children acquired prosodic patterns in both languages. However, the accent of their disyllabic words differed from those of the monolingual children. French 7 years old-aged learners of English, after only two years of acquisition, produced the native-like accent. Our findings modulate the “critical age” hypothesis and bring some new elements in favour of the L1 and L2 obligatory interaction hypothesis.
Published: 2006

32. The role of auditory beats induced by frequency modulation and polyperiodicity in the perception of spectrally embedded complex target sounds

Author: Stephen McAdams, Cécile M. H. Marin, Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, Periodicity, Acoustics and Ultrasonics, Acoustics, behavioral disciplines and activities, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), 0103 physical sciences, Modulation (music), Humans, Computer Simulation, [INFO]Computer Science [cs], Center frequency, 030223 otorhinolaryngology, 010301 acoustics, Mathematics, Auditory Threshold, Fundamental frequency, Interval (music), Noise, Formant, Harmonic, Auditory Perception, Female, NA, Frequency modulation, Perceptual Masking, psychological phenomena and processes
Abstract: The contribution of auditory beats to the perception of target sounds differing from an interfering background by their frequency modulation (FM) pattern or by a difference in fundamental frequency (F0) was investigated. On each trial, test sounds composed of a single, second-order formant were embedded in harmonic backgrounds and presented in successive intervals. The center frequencies of these "normal" formants differed across intervals. Subjects were to decide which interval contained the test formant with a center frequency matching that of an isolated target formant presented before each test stimulus. Matching thresholds were measured in terms of the width of modulation for FM stimuli or the mistuning of the F0's of unmodulated test formants relative to that of the background. Beats may have allowed the identification of the spectral region of the target in both experiments. To reduce interactions between test and background components, matching thresholds were measured for "flat" formants composed of two or three equal-amplitude components embedded in a harmonic background in which components corresponding to those of test formants were absent. These measures were repeated with the addition of a pink noise floor. Matching was still possible in all cases, though at higher thresholds than for normal formants. Computer simulations suggested that the modulation depth of envelope fluctuations within auditory channels played a significant role in the matching of target sounds when their components were mixed in the same frequency region with those of an interfering sound, but not when the target and background components were separated by as much as 250 Hz, the F0 of the stimulus.
Published: 1996

33. The perceptual reality of tone chroma in early infancy

Author: Françoise Armand, Laurent Demany, Equipe Perception et cognition musicales, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie expérimentale (LPE - UMR8581), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-École pratique des hautes études (EPHE)
Subjects: Melody, medicine.medical_specialty, Acoustics and Ultrasonics, Acoustics, [SHS.PSY]Humanities and Social Sciences/Psychology, Psychology, Child, Audiology, 01 natural sciences, 050105 experimental psychology, Pitch Discrimination, 03 medical and health sciences, Tone (musical instrument), Sequence (music), 0302 clinical medicine, Arts and Humanities (miscellaneous), 0103 physical sciences, medicine, Octave, Humans, 0501 psychology and cognitive sciences, Psychoacoustics, Habituation, Psychophysiologic, 030223 otorhinolaryngology, 010301 acoustics, ComputingMilieux_MISCELLANEOUS, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts, 05 social sciences, Novelty, Infant, Interval (music), [SCCO.PSYC]Cognitive science/Psychology, Psychology, Music, 030217 neurology & neurosurgery
Abstract: It has often been advanced that pitch is a two-dimensional perceptual attribute, its two dimensions being: (1) tone height, a perceptual quality monotonically related to frequency; and (2) tone chroma, a quality shared by tones forming an octave interval. However, given that many musically uneducated adults do not seem to perceive tone chroma, this model is controversial. We investigated the sensitivity of three-month-old infants to tone chroma by means of a behavioral habituation-dishabituation procedure. Infants were presented with two successive melodic sequences of pure tones, the second sequence being a distorted version of the first one. The distortion consisted in shifting the frequency of some of the original tones, through a seventh or a ninth for some infants, through an octave for others. In the former case, infants displayed significant novelty reactions. In the latter case, significant novelty reactions were observed when the two sequences differed in melodic contour, but not when they had the same contour. These results suggest that young infants are sensitive to both tone height and tone chroma, and thus that tone chroma perception does not necessitate some form of musical experience.
Published: 1984

34. A perceptive categorization of sounds produced the interaction of solid objects

Author: Isabel Urdapilleta, Nicolas Misdariis, Patrick Susini, Olivier Houix, Guillaume Lemaitre, ircam, ircam, Equipe Perception et design sonores, Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)
Subjects: Acoustics and Ultrasonics, Computer science, media_common.quotation_subject, Object (grammar), [INFO] Computer Science [cs], computer.software_genre, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Perception, 0103 physical sciences, Similarity (psychology), [INFO]Computer Science [cs], 030223 otorhinolaryngology, Set (psychology), 010301 acoustics, media_common, Complement (set theory), business.industry, Hierarchical clustering, Categorization, NA, Artificial intelligence, business, computer, Natural language processing
Abstract: cote interne IRCAM: Houix10c; None / None; National audience; The literature on the perception of environmental sounds often postulates that these sounds are perceptually organized according to their cause. In a previous study, we found experimental results consistent with this assumption by showing that, in the case of identifiable sounds and non‐expert listeners, main categories of liquids, gases, electrical devices, and solids appear. We report here a study specifically exploring this latter category. Participants were required to categorize a set of sounds according to the actions causing the sound and to describe the resulting categories. We analyze the classifications with a specific hierarchal cluster analysis producing two dendrograms. The second dendrogram is used to highlight a possible secondary categorization that may add to the primary categorization. Therefore, this technique allows taking into account the multiple types of similarity that might occur in a categorization task. This statistical analysis of the classifications was complemented by a linguistic analysis of the descriptions of the categories (ALCESTE and LEXICO). This analysis shows two main categories of descriptions: those describing several objects in interaction and those describing modifications of an object. Eventually, we discuss how hierarchical cluster and linguistic analyses complement to provide a portrait of the perceptive categorization of sounds of solids.

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34 results on '"Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)"'

1. Investigating three types of continuous auditory feedback in visuo-manual tracking

2. Design and evaluation of tinnitus synthesis methods: From spectral to spatial matching

3. Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: Results of a randomized controlled trial

4. A high-throughput sequencing ecotoxicology study of freshwater bacterial communities and their responses to tebuconazole

5. Learning Movement Kinematics with a Targeted Sound

6. Glottic Bamboo Nodules From Systemic Lupus Erythematosus

7. Social cognition and the superior temporal sulcus: implications in autism

8. Immersing Patients in a Virtual Reality Environment for Brain Mapping During Awake Surgery: Safety Study

9. Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

10. Context-dependent signaling of coincident auditory and visual events in primary visual cortex

11. Emotional prosody in congenital amusia: Impaired and spared processes

12. Auteur(s) et acteurs de la genèse

13. Alterations of EEG rhythms during motor preparation following awake brain surgery

14. Exploring Trandisciplinarity in Art and Science

15. Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods

16. Brain voice processing with bilateral cochlear implants: a positron emission tomography study

17. Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities

18. Emergency medical triage decisions are swayed by computer-manipulated cues of physical dominance in caller’s voice

19. Covert digital manipulation of vocal emotion alter speakers' emotional states in a congruent direction

20. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery

21. On the effectiveness of vocal imitations and verbal descriptions of sounds

22. Implicit Sequence Learning in a Continuous Pursuit-Tracking Task

23. Seven problems that keep MIR from attracting the interest of cognition and neuroscience

24. Localization of endogenous morphine-like compounds in the mouse spinal cord

25. A Lexical Analysis of Environmental Sound Categories

26. A processing work-flow for measuring erythrocytes velocity in extended vascular networks from wide field high-resolution optical imaging data

27. Prestress effects on the eigenfrequencies of the soundboards: Experimental results on a simplified string instrument

28. Simultaneous beat and downbeat-tracking using a probabilistic framework : theory and large-scale evaluation

29. Quasistatic nonlinear characteristics of double-reed instruments

30. Cortical correlates of illusory hand movement perception in humans: A MEG study

31. Productions in bilinguism, early foreign language learning and monolinguism: A prosodic comparison

32. The role of auditory beats induced by frequency modulation and polyperiodicity in the perception of spectrally embedded complex target sounds

33. The perceptual reality of tone chroma in early infancy

34. A perceptive categorization of sounds produced the interaction of solid objects

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34 results on '"Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)"'

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