1. Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
- Author
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Zhenying Zuo, Kaipeng Jing, Hongluan Wu, Shujun Wang, Lin Ye, Zhihang Li, Chen Yang, Qingjun Pan, Wei Jing Liu, and Hua-feng Liu
- Subjects
0301 basic medicine ,Physiology ,Lupus nephritis ,Cellular homeostasis ,Disease ,Review ,Bioinformatics ,lcsh:Physiology ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Mitophagy ,mitochondrial dysfunction ,medicine ,lupus nephritis ,Kidney ,lcsh:QP1-981 ,business.industry ,Autophagy ,Acute kidney injury ,medicine.disease ,diabetic kidney disease ,Crosstalk (biology) ,030104 developmental biology ,medicine.anatomical_structure ,mitophagy ,acute kidney injury ,business ,030217 neurology & neurosurgery - Abstract
Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).
- Published
- 2020