1. A new ferroptosis-related gene model for prognostic prediction of papillary thyroid carcinoma
- Author
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Ziqiang Chen, Liang Chen, Jian Tang, Xiaoyu Qian, Yongquan Chu, and Lin Li
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Adolescent ,overall survival ,Thyroid Gland ,Bioengineering ,gene model ,Biology ,Malignancy ,Applied Microbiology and Biotechnology ,Thyroid carcinoma ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Databases, Genetic ,Gene expression ,Biomarkers, Tumor ,medicine ,Humans ,Thyroid Neoplasms ,Gene ,Aged ,Aged, 80 and over ,Framingham Risk Score ,Models, Genetic ,Proportional hazards model ,Ferroptosis ,General Medicine ,Middle Aged ,Gene signature ,medicine.disease ,ferroptosis ,030104 developmental biology ,ROC Curve ,Thyroid Cancer, Papillary ,030220 oncology & carcinogenesis ,papillary thyroid carcinoma ,Female ,prognosis ,Transcriptome ,TP248.13-248.65 ,Research Article ,Research Paper ,Biotechnology - Abstract
Papillary thyroid carcinoma (PTC) is a highly heterogeneous malignancy with diverse prognoses. Ferroptosis is a new type of cell death dependent on iron. Nevertheless, the predictive ability of ferroptosis-related genes for PTC is unclear. Based on the mRNA expression information from The Cancer Genome Atlas, we compared tumor and normal tissues in terms of the gene expression, for identifying differentially expressed genes (DEGs). Then, the risk score of a 5-gene signature was calculated and a prognostic model was established to test the predictive value of this gene signature by virtue of the LASSO Cox regression. The 5 genes were validated in PTC tissues by RT-qPCR.At last, functional analysis was implemented to investigate the underlying mechanisms. We found a total of 45 ferroptosis-related genes expressed differentially between tumor and normal tissues. 6 DEGs exhibited a significant relevance to the overall survival (OS) (P
- Published
- 2021