1. In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues
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Sabina Yasmin, Ganesh Chandra Sahoo, Praveen Kumar, Yousuf Ansari, Mohamed Jawed Ahsan, Monika Soni, and Surender Singh Jadav
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0301 basic medicine ,lcsh:R5-920 ,biology ,Stereochemistry ,Acetohydrazide analogues ,Aryl ,030106 microbiology ,Leishmania donovani ,Pharmaceutical Science ,Medicine (miscellaneous) ,Antileishmanial activity ,biology.organism_classification ,Agricultural and Biological Sciences (miscellaneous) ,In vitro ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,Standard protocol ,lcsh:Q ,Cytotoxicity ,lcsh:Medicine (General) ,lcsh:Science - Abstract
A series of new 2-(substitutedphenoxy)- N -[(aryl)methylidene]acetohydrazide analogues ( 8a-n ) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)- N ′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide ( 8k ) showed the most promising antileishmanial activity with IC 50 of 48.10 µM, free from cytotoxicity (>153.08 µM).
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