1. B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis
- Author
-
Je Young Shin, Yoon-Ho Hong, Jung-Joon Sung, Young Gi Min, Canaria Park, and Young Nam Kwon
- Subjects
0301 basic medicine ,CD19 ,Flow cytometry ,Transcriptome ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Immunophenotyping ,B-lymphocytes ,Medicine ,Distribution (pharmacology) ,Myasthenia gravis ,B cell ,biology ,medicine.diagnostic_test ,business.industry ,Autoantibody ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Immunology ,biology.protein ,Original Article ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.
- Published
- 2019