1. Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma
- Author
-
Daiju Hu
- Subjects
0301 basic medicine ,Immunology ,Inflammation ,Disease ,Pathogenesis ,03 medical and health sciences ,Immune system ,medicine ,Immunology and Allergy ,Animals ,Humans ,Asthma ,business.industry ,Interleukins ,Interleukin ,respiratory system ,Eosinophil ,medicine.disease ,Mucus ,respiratory tract diseases ,030104 developmental biology ,medicine.anatomical_structure ,medicine.symptom ,Inflammation Mediators ,business ,Interleukin-1 - Abstract
Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma. Hopefully, the information obtained may lead to a better understanding of the pathogenesis of the disease.
- Published
- 2016