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5 results on '"Department of Health and Human Services (US)"'

1. Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins

Author

Luis Martinez-Sobrido, David J. Topham, Marta L. DeDiego, Aitor Nogales, National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), Department of Health and Human Services (US), Department of Defense (US), University of Rochester, and Comunidad de Madrid

Subjects
0301 basic medicine, viruses, NS1, lcsh:QR1-502, virus–host interactions, Review, Pathogenesis, Viral Nonstructural Proteins, medicine.disease_cause, Virus Replication, lcsh:Microbiology, Mice, Interferon, vaccine, Influenza A virus, Live attenuated influenza vaccine, innate immunity, Innate immunity, Virus–host interaction, Virulence, Virus–host interactions, pathogenesis, interferon, Influenza a virus, Infectious Diseases, Viral evolution, Host-Pathogen Interactions, Cytokines, host antiviral response, medicine.drug, PA, Biology, Virus, 03 medical and health sciences, Orthomyxoviridae Infections, Virology, Influenza, Human, medicine, Animals, Humans, Virus evolution|Vaccine, Immune Evasion, virus evolution, Innate immune system, Host antiviral response, Virus evolution, Immunity, Innate, cytokines, Repressor Proteins, influenza a virus, 030104 developmental biology, PA-X, Viral replication, Interferons, Vaccine
Abstract

Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a serious public health and economic problem, which is most effectively prevented through vaccination. The defense mechanisms that the host innate immune system provides restrict IAV replication and infection. Consequently, to successfully replicate in interferon (IFN)-competent systems, IAV has to counteract host antiviral activities, mainly the production of IFN and the activities of IFN-induced host proteins that inhibit virus replication. The IAV multifunctional proteins PA-X and NS1 are virulence factors that modulate the innate immune response and virus pathogenicity. Notably, these two viral proteins have synergistic effects in the inhibition of host protein synthesis in infected cells, although using different mechanisms of action. Moreover, the control of innate immune responses by the IAV NS1 and PA-X proteins is subject to a balance that can determine virus pathogenesis and fitness, and recent evidence shows co-evolution of these proteins in seasonal viruses, indicating that they should be monitored for enhanced virulence. Importantly, inhibition of host gene expression by the influenza NS1 and/or PA-X proteins could be explored to develop improved live-attenuated influenza vaccines (LAIV) by modulating the ability of the virus to counteract antiviral host responses. Likewise, both viral proteins represent a reasonable target for the development of new antivirals for the control of IAV infections. In this review, we summarize the role of IAV NS1 and PA-X in controlling the antiviral response during viral infection., Influenza virus research in the Luis Mart í nez-Sobrido and David J. Topham laboratories is partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institutes of Health (NIH), and the Department of Health and Human Services under the Centers of Excellence for Influenza Research and Surveillance (CEIRS) contract No. HHSN272201400005C (New York Influenza Center of Excellence, NYICE); by the Department of Defense (DoD) PR17046 (Luis Martinez-Sobrido); and with funds from a University of Rochester Research Award to Aitor Nogales and Marta Lopez de Diego. We also give thanks for the funds from Comunidad de Madrid, Spain, reference 2017-T1/BMD-5155 (Marta Lopez de Diego).

Published
2018

2. Proteomic analysis of methanonatronarchaeum thermophilum AMET1, a representative of a putative new class of euryarchaeota, 'methanonatronarchaeia'

Author

María Carmen Mena, Kira S. Makarova, Yuri I. Wolf, Dimitry Y. Sorokin, Rafael Bargiela, Sergio Ciordia, Eugene V. Koonin, Manuel Ferrer, Ministry of Education, Culture and Science (The Netherlands), Department of Health and Human Services (US), CSIC - Centro Nacional de Biotecnología (CNB), Ministerio de Economía, Industria y Competitividad (España), European Commission, and Instituto de Salud Carlos III

Subjects
0301 basic medicine, Proteomics, lcsh:QH426-470, Halophiles, Lineage (evolution), Genomics, Computational biology, Tandem mass spectrometry, Methanogenesis, Class Halobacteria, Article, 03 medical and health sciences, Genetics, proteomics, methanogenesis, halophiles, Methanonatronarchaeia, genomics, Genetics (clinical), biology, Chemistry, Thermophile, biology.organism_classification, Halophile, lcsh:Genetics, 030104 developmental biology, Euryarchaeota
Abstract

The recently discovered Methanonatronarchaeia are extremely halophilic and moderately thermophilic methyl-reducing methanogens representing a novel class-level lineage in the phylum Euryarchaeota related to the class Halobacteria. Here we present a detailed analysis of 1D-nano liquid chromatography–electrospray ionization tandem mass spectrometry data obtained for “Methanonatronarchaeum thermophilum” AMET1 grown in different physiological conditions, including variation of the growth temperature and substrates. Analysis of these data allows us to refine the current understanding of the key biosynthetic pathways of this triple extremophilic methanogenic euryarchaeon and identify proteins that are likely to be involved in its response to growth condition changes., D.Y.S. was supported by Gravitation-SIAM Program (grant 24002002, Dutch Ministry of Education and Science) and by RFBR (grant 16-04-00035). K.S.M., Y.I.W. and E.V.K. are supported by the intramural program of the U.S. Department of Health and Human Services (to the National Library of Medicine). The proteomic analysis was performed in the Proteomics Facility of The Spanish National Centre for Biotechnology (CNB-CSIC) that belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001. This project has received funding from the European Union’s Horizon 2020 research and innovation program [Blue Growth: Unlocking the potential of Seas and Oceans] under grant agreement No [634486]. This work was further funded by grants BIO2014-54494-R, BIO2017-85522-R, PCIN-2014-107 (within the ERA NET-IB2 program), PCIN-2017-078 (within the ERA-MarineBiotech program) from the Spanish Ministry of Economy, Industry and Competitiveness and grant AC17/00022 from the Instituto de Salud Carlos III (within the ERA TRANSCAN-2 program).

Published
2018

3. 50 years of the International Committee on Taxonomy of Viruses: progress and prospects

Author

Stuart G. Siddell, Robert L. Harrison, Max L. Nibert, Andrew M. Q. King, Andrew J. Davison, Hélène Sanfaçon, Mart Krupovic, Sead Sabanadzovic, Arvind Varsani, Balázs Harrach, Nick J. Knowles, Andrew M. Kropinski, Francisco Murilo Zerbini, Michael J. Adams, Elliot J. Lefkowitz, B. Douglas Smith, Jens H. Kuhn, Richard J. Orton, Alexander E. Gorbalenya, Arcady Mushegian, Peter Simmonds, University of Hertfordshire [Hatfield] (UH), University of Alabama at Birmingham [ Birmingham] (UAB), The Pirbright Institute, Biotechnology and Biological Sciences Research Council (BBSRC), Hungarian Academy of Sciences (MTA), United States Department of Agriculture (USDA), University of Guelph, Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris] (IP), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), National Science Foundation [Arlington] (NSF), Harvard Medical School [Boston] (HMS), Mississippi State University [Mississippi], Agriculture and Agri-Food (AAFC), University of Bristol [Bristol], University of Oxford, Arizona State University [Tempe] (ASU), Universidade Federal de Viçosa = Federal University of Viçosa (UFV), University of Glasgow, University of Edinburgh, Leiden University Medical Center (LUMC), Universiteit Leiden, Lomonosov Moscow State University (MSU), The ICTV is supported by Grants from IUMS, the American Society of Virology and the Microbiology Society, and by a Grant from the Wellcome Trust (WT108418AIA) to P.S., A.J.D. and S.G.S. The involvement of J.H.K. was supported in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. A subcontractor to Battelle Memorial Institute who performed this work is J.H.K., an employee of Tunnell Government Services, Inc. The involvement of A.R.M. was supported in part by the National Science Foundation Individual Research and Development program. The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the US Department of Health and Human Services, US National Science Foundation, or of the institutions and companies affiliated with the authors., The authors are the current ICTV EC Members together with two researchers (R.J.O., D.B.S.) supported by the Wellcome Trust grant detailed below. We gladly acknowledge the dedicated, voluntary efforts of hundreds of virologists based in various parts of the world over the entire period of the existence of the ICTV. The work of the organisation through its EC and Study Groups has always depended upon that contribution and will continue to do so., Institute for Animal Health, the Pirbright Institute, Institut Pasteur [Paris], Agriculture and Agri-Food [Ottawa] (AAFC), University of Oxford [Oxford], and Universidade Federal de Vicosa (UFV)

Subjects
0301 basic medicine, Societies, Scientific, Rabies, [SDV]Life Sciences [q-bio], 030106 microbiology, Library science, Biology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, History, 21st Century, Executive committee, MESH: Viruses, 03 medical and health sciences, Virology, Virus discovery, MESH: Phylogeny, Virus classification, Phylogeny, Virus species, Computational Biology, General Medicine, History, 20th Century, 3. Good health, MESH: Societies, Scientific, 030104 developmental biology, Viruses, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Online report, MESH: History, 20th Century, Metagenomics, MESH: Metagenomics, MESH: History, 21st Century, MESH: Computational Biology
Abstract

International audience; We mark the 50th anniversary of the International Committee on Taxonomy of Viruses (ICTV) by presenting a brief history of the organization since its foundation, showing how it has adapted to advancements in our knowledge of virus diversity and the methods used to characterize it. We also outline recent developments, supported by a grant from the Wellcome Trust (UK), that are facilitating substantial changes in the operations of the ICTV and promoting dialogue with the virology community. These developments will generate improved online resources, including a freely available and regularly updated ICTV Virus Taxonomy Report. They also include a series of meetings between the ICTV and the broader community focused on some of the major challenges facing virus taxonomy, with the outcomes helping to inform the future policy and practice of the ICTV.

Published
2017

4. Tick Genome Assembled: New Opportunities for Research on Tick-Host-Pathogen Interactions

Author

R. Michael Roe, Daniel E. Sonenshine, Robert M. Waterhouse, José M. C. Ribeiro, David B. Sattelle, José de la Fuente, Catherine A. Hill, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Waterhouse, Robert, National Institute of Allergy and Infectious Diseases (US), and Department of Health and Human Services (US)

Subjects
0301 basic medicine, Proteomics, Microbiology (medical), Anaplasma, Evolution, 030231 tropical medicine, Immunology, Genome, Insect, lcsh:QR1-502, Genomics, Computational biology, Tick, Genome, Microbiology, lcsh:Microbiology, 03 medical and health sciences, 0302 clinical medicine, proteomics, parasitic diseases, evolution, genomics, Animals, Humans, ddc:576.5, Ecosystem health, biology, Ixodes, Host (biology), Ecology, Borrelia, Sequence Analysis, DNA, biology.organism_classification, bacterial infections and mycoses, tick, 030104 developmental biology, Infectious Diseases, Ixodes scapularis, Perspective, Host-Pathogen Interactions, Arachnid Vectors
Abstract

As tick-borne diseases are on the rise, an international effort resulted in the sequence and assembly of the first genome of a tick vector. This result promotes research on comparative, functional and evolutionary genomics and the study of tick-host-pathogen interactions to improve human, animal and ecosystem health on a global scale., National Institutes of Health (U.S.), National Institute of Allergy and Infectious Diseases (U.S.), United States. Dept. of Health and Human Services

Published
2016

5. Nature Communications

Author

Adam R. Wespiser, Don Gilbert, Vincent Croset, Joseph J. Gillespie, Renfu Shao, Timothy J. Kurtti, Julio Rozas, Hugh M. Robertson, Stephen C. Barker, Karen E. Nelson, Ketaki Bhide, Yoonseong Park, Brooke W. Bissinger, Patricia V. Pietrantonio, Joao H. F. Pedra, Janice P. Van Zee, Peter Arensburger, Hyeogsun Kwon, Timothy P. Driscoll, Daniel Lawson, Ryan C. Kennedy, Emma G. Lang, David Jiang, Jessica B. Hostetler, Jesús Vázquez, Zhijian Jake Tu, José de la Fuente, Bruce W. Birren, Juraj Koči, David R. Nelson, Catherine A. Hill, Brian P. Walenz, Frank Hauser, Cornelis J. P. Grimmelikhuijzen, Mathangi Thiagarajan, Andrew B. Nuss, Richard Benton, Linda Hannick, Kristin Lees, Stephen K. Wikel, Daniel R. Caffrey, Evgeny M. Zdobnov, Jason R. Miller, Elisabet Caler, Melissa J. Caimano, José M. C. Ribeiro, Jeffrey M. Grabowski, Elena Bonzón-Kulichenko, Monika Gulia-Nuss, Marta Tojo, Daniel E. Sonenshine, Joyce M. Sakamoto, Rushika Perera, Sergey Koren, R. Michael Roe, Nieves Ayllón, Qiandong Zeng, Jyothi Thimmapuram, Katherine M. Kocan, Jenica L. Abrudan, Gloria I. Giraldo-Calderón, Margarita Villar, David B. Sattelle, Alejandro Sánchez-Gracia, Francisca C. Almeida, Donghun Kim, Granger G. Sutton, Richard J. Kuhn, Maiara S. Severo, Sayed M.S. Khalil, Jiwei Zhu, Cristian Tornador, Shelby L. Bidwell, Vinita Joardar, Jose M. C. Tubio, Robert M. Waterhouse, Justin D. Radolf, Martin Hammond, Sarah Young, Steven D. Buckingham, Frank H. Collins, Yumin Qi, Ladislav Šimo, Maria F. Unger, Jason M. Meyer, Karyn Megy, Neal S. Silverman, Filipe G. Vieira, Martin Shumway, Jennifer R. Wortman, Claire M. Fraser, Yunlong Yang, Vishvanath Nene, Waterhouse, Robert, Zdobnov, Evgeny, University of Nevada, Partenaires INRAE, Department of Entomology, Michigan State University [East Lansing], Michigan State University System-Michigan State University System, Department Biotechnology, University of São Paulo (USP), Department of Biological Sciences, The Open University [Milton Keynes] (OU), North Carolina State University, Center for High Performance Simulation and Department of Chemical and Biomolecular Engineering, Department of Genetic Medicine and Development, Université de Genève (UNIGE), Broad Institute of Harvard and MIT, Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL), Massachusetts Institute of Technology (MIT), University College of London [London] (UCL), SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University [Stillwater], National Institute of Allergy and Infectious Deseases (NIAID), University of Cambridge [UK] (CAM), VectorBase, Purdue University, J. Craig Venter Institute [La Jolla, USA] (JCVI), University of Notre Dame [Indiana] (UND), Universitat Autònoma de Barcelona (UAB), Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), University of Connecticut (UCONN), Virginia Polytechnic Institute and State University [Blacksburg], Department of Biology, Indiana University [Bloomington], Indiana University System-Indiana University System, Department of Biochemistry [Blacksburg], Virginia Tech [Blacksburg], Agricultural Research Center, Texas A&M University System, Minnesota State University, University of Manchester [Manchester], Department of Bioengineering and Therapeutic Sciences, University of California [San Francisco] (UCSF), University of California-University of California, Pennsylvania State University (Penn State), Penn State System-Penn State System, University of California [Riverside] (UCR), University of California, Universidade de Santiago de Compostela [Spain] (USC ), Department of Experimental and Health Sciences, Universitat Pompeu Fabra [Barcelona] (UPF), University of Barcelona, California State Polytechnic University [Pomona] (CAL POLY POMONA), University of Queensland [Brisbane], University of the Sunshine Coast (USC), University of Copenhagen = Københavns Universitet (KU), University of Tennessee, Universidade de Vigo, Cancer Genome Project, The Wellcome Trust Sanger Institute [Cambridge], University of Illinois, University of Illinois System, Quinnipiac University, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID, NIH, DHHS) [N01-AI30071, HHSN272200900007C, HHSN266200400001C, 5R01GM77117-5], NIH-NIAID [HHSN266200400039C, HHSN272200900039C], Australian Research Council [DP120100240], Ministerio de Ciencia e Innovacion of Spain [BFU2007-6292, BFU2010-15484, BIO2009-07990, BIO2012-37926], NIH [1R01AI090062, 1R21AI096268, HHSN272200900040C, R01AI017828, R01AI043006], NSF [IOS-0949194], Xunta de Galicia of Spain [10PXIB918057PR], EU FP7 ANTIGONE [278976], USDA-NRI/CREES [2008-35302-18820], Texas AgriLife Research Vector Biology grant, European Research Council Starting Independent, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Biochemistry, Fralin Life Sciences Institute, NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos), National Institutes of Health (Estados Unidos), Australian Research Council, Ministerio de Ciencia e Innovación (España), United States of Department of Health & Human Services, National Science Foundation (Estados Unidos), Xunta de Galicia (España), Unión Europea. Comisión Europea, United States Department of Agriculture. National Institute of Food and Agriculture, Texas AgriLife Research, European Research Council, Swiss National Science Foundation, Fundação para a Ciência e a Tecnologia (Portugal), Lundbeck Foundation, Broad Genomics Platform, National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), Department of Health and Human Services (US), National Science Foundation (US), Xunta de Galicia, European Commission, Department of Agriculture (US), Boehringer Ingelheim Fonds, Gulia-Nuss, Monika, and Fundação para a Ciência e Tecnologia (Portugal)

Subjects
0301 basic medicine, beetle tribolium-castaneum, Langat virus, [SDV]Life Sciences [q-bio], General Physics and Astronomy, PROTEIN, CATTLE TICK, Xenopus laevis, Lyme disease, anaplasma-phagocytophilum infection, Lyme Disease/transmission, ddc:576.5, BEETLE TRIBOLIUM-CASTANEUM, Genetics, Lyme Disease, Genome, Multidisciplinary, biology, Ecology, cattle tick, evolutionary analyses, CHEMOSENSORY RECEPTORS, Babesiosis, Genomics, drosophila, 3. Good health, Ixodes/genetics, DROSOPHILA, Ixodes scapularis, LIFE-STYLE, chemosensory receptors, Anaplasma phagocytophilum, life-style, Human granulocytic anaplasmosis, boophilus-microplus, united-states, protein, Science, Ligand-Gated Ion Channels/genetics, UNITED-STATES, Tick, ANAPLASMA-PHAGOCYTOPHILUM INFECTION, Article, General Biochemistry, Genetics and Molecular Biology, Arachnid Vectors/genetics, 03 medical and health sciences, BOOPHILUS-MICROPLUS, parasitic diseases, medicine, Animals, Ixodes, Gene Expression Profiling, General Chemistry, Ligand-Gated Ion Channels, Genome/genetics, Oocytes, biology.organism_classification, medicine.disease, bacterial infections and mycoses, EVOLUTIONARY ANALYSES, 030104 developmental biology, Arachnid Vectors
Abstract

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent., This project has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID, NIH, DHHS) under contract numbers N01-AI30071, HHSN272200900007C, HHSN266200400001C and 5R01GM77117-5. Its contents are solely the responsibility of the authors and do not represent the official views of the NIH. Additional grants and contracts supporting work described in this manuscript were from the NIH-NIAID (HHSN266200400039C and HHSN272200900039C) to F.H.C., and a subcontract under HHSN272200900039C to C.A.H. and J.M.M., the Australian Research Council Discovery Project (DP120100240) to S.C.B. and R.S., the Ministerio de Ciencia e Innovación of Spain (BFU2007–6292; BFU2010–15484) to J.R., BIO2009–07990 and BIO2012–37926 to J.V. NIH-1R01AI090062 to Y.P., L.S., and J.K., NIH 1R21AI096268 and NSF IOS-0949194 to R.M.R., the Xunta de Galicia of Spain (10PXIB918057PR) to J.M.C.T. and M.T., BFU2011–23896 and EU FP7 ANTIGONE (278976) to J.F., the USDA-NRI/CREES (2008-35302-18820) and Texas AgriLife Research Vector Biology grant to P.V.P. and European Research Council Starting Independent Researcher Grant (205202) to R.B., J.M.R was supported by the intramural program of the NIAID, R.M.W. by a Marie Curie International Outgoing Fellowship PIOF-GA-2011–303312, E.M.Z. by Swiss National Science Foundation awards 31003A-125350 and 31003A-143936, J.M.G. by an NIH-NCATS award TL1 TR000162 and NSF Graduate Research Fellowship (DGE 1333468), V.C. by a Boehringer Ingelheim Ph.D. Fellowship, F.G.V. by a Fundação para a Ciência e a Tecnologia, Portugal fellowship (SFRH/BD/22360/2005), C.J.P.G. and F.H. by The Lundbeck Foundation (Denmark), and J.J.G. by NIH awards HHSN272200900040C, R01AI017828 and R01AI043006. Support from the Broad Genomics Platform is gratefully acknowledged.

Published
2016

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