1. The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
- Author
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Hala Chaaban, Aarthi Gunasekaran, Jeffrey Eckert, Erynn Bergner, and Kathryn Burge
- Subjects
0301 basic medicine ,Male ,Breastfeeding ,lcsh:TX341-641 ,Inflammation ,Disease ,Review ,Infant, Premature, Diseases ,Protective Agents ,Pathogenesis ,neonatal ,03 medical and health sciences ,0302 clinical medicine ,Enterocolitis, Necrotizing ,Risk Factors ,030225 pediatrics ,medicine ,Humans ,Risk factor ,intestine ,Nutrition and Dietetics ,necrotizing enterocolitis ,Milk, Human ,business.industry ,Incidence (epidemiology) ,prematurity ,Infant, Newborn ,human milk ,medicine.disease ,Infant Formula ,3. Good health ,030104 developmental biology ,Breast Feeding ,glycosaminoglycans ,inflammation ,Necrotizing enterocolitis ,Immunology ,Etiology ,Female ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans.
- Published
- 2020