1. The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
- Author
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František Novák, Hana Bastova, Jana Hajslova, Monika Cahova, Jaroslav Zelenka, Hana Malinska, Eva Meisnerova, Miriam Bratova, Nikola Vrzacova, Helena Dankova, Vit Kosek, Kamila Bechynska, Petr Wohl, Olga Novakova, Alzbeta Hlavackova, Nikola Daskova, Jiri Suttnar, Marie Heczkova, and Olena Oliyarnyk
- Subjects
0301 basic medicine ,Male ,Parenteral Nutrition ,Erythrocytes ,hydroxy-fatty acids ,medicine.disease_cause ,fish oil ,Antioxidants ,home parenteral nutrition ,Lipid peroxidation ,chemistry.chemical_compound ,0302 clinical medicine ,oxidative stress ,Physics::Chemical Physics ,chemistry.chemical_classification ,Aged, 80 and over ,Quantitative Biology::Biomolecules ,Nutrition and Dietetics ,Chemistry ,Lipidome ,Middle Aged ,Fish oil ,Malondialdehyde ,olive oil ,Lipids ,Quantitative Biology::Genomics ,030211 gastroenterology & hepatology ,Female ,lcsh:Nutrition. Foods and food supply ,plasmalogens ,Polyunsaturated fatty acid ,Adult ,medicine.medical_specialty ,Fat Emulsions, Intravenous ,Quantitative Biology::Tissues and Organs ,lcsh:TX341-641 ,Article ,03 medical and health sciences ,Fish Oils ,intestinal failure ,Internal medicine ,Lipidomics ,Fatty Acids, Omega-3 ,medicine ,Humans ,Aged ,Glutathione ,Intestinal Diseases ,030104 developmental biology ,Endocrinology ,Cross-Sectional Studies ,Case-Control Studies ,lipidomics ,Oxidative stress ,Food Science - Abstract
Omega-3 polyunsaturated fatty acids (&omega, 3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered &omega, 3 PUFAs without (FO/&ndash, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/&ndash, and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/&ndash, subcohort. The lipidome of all subjects receiving &omega, 3 PUFAs was enriched with lipid species containing &omega, 3 PUFAs (FO/&ndash, ˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/&ndash, We confirmed the protective effect of OO in PN mixtures containing &omega, 3 PUFAs.
- Published
- 2020
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