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Start Over Author "Minzeng Sun" Topic 0301 basic medicine
2 results on '"Minzeng Sun"'

1. Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China

Author

Yueli Liu, Lin Chen, Mingqin Lin, Hui Liu, Lihui Ma, Tiansong Wang, Penghuan Chang, Peiqiong Li, Haifeng Lin, and Minzeng Sun

Subjects
0301 basic medicine, Blood Glucose, Male, Apolipoprotein B, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Myocardial Infarction, 030204 cardiovascular system & hematology, Gastroenterology, Coronary artery disease, 0302 clinical medicine, Endocrinology, Ethnicity, lcsh:RC620-627, biology, Middle Aged, lcsh:Nutritional diseases. Deficiency diseases, C-Reactive Protein, Female, ApoCIII, Lipidology, medicine.medical_specialty, China, Clinical chemistry, Clinical nutrition, Association, 03 medical and health sciences, Internal medicine, medicine, Humans, Angina, Stable, Angina, Unstable, Triglycerides, Aged, Apolipoproteins B, Apolipoprotein C-III, Unstable angina, business.industry, Tumor Necrosis Factor-alpha, Research, Biochemistry (medical), C-reactive protein, Cholesterol, HDL, Cholesterol, LDL, medicine.disease, Atherosclerosis, 030104 developmental biology, Blood pressure, Logistic Models, Case-Control Studies, TNF-α, Hs-CRP, biology.protein, business
Abstract

Background Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. Methods A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal–Wallis or Wilcoxon–Mann–Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software. Results Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P

Published
2018
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2. Association of the S2 allele of the SstI polymorphism in the apoC3 gene with plasma apoCIII interacts with unfavorable lipid profiles to contribute to atherosclerosis in the Li ethnic group in China

Author

Lin Chen, Lihui Ma, Hui Liu, Yueli Liu, Minzeng Sun, and Tiansong Wang

Subjects
Male, 0301 basic medicine, China, medicine.medical_specialty, Apolipoprotein B, Clinical chemistry, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Population, 030204 cardiovascular system & hematology, Biology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Asian People, Internal medicine, Genotype, medicine, Humans, Genetic Predisposition to Disease, Allele, education, lcsh:RC620-627, Allele frequency, Triglycerides, Aged, Genetics, Apolipoprotein C-III, education.field_of_study, Polymorphism, Genetic, Apolipoprotein A-I, Research, S2 allele, Biochemistry (medical), Lipid metabolism, Middle Aged, Atherosclerosis, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, Apolipoprotein B-100, biology.protein, Female, ApoCIII, Lipidology
Abstract

Background The SstI polymorphism in the apolipoprotein 3 gene (apoC3) has been identified in many ethnic groups. In addition, the S2 allele of the SstI polymorphism is shown to be associated with increased plasma triglyceride (TG) levels. Plasma apoCIII is an important atherogenic factor, which interrupts lipid metabolism and is positively associated with plasma TG levels. However, the existence of the SstI polymorphism in the Li ethnic group in China remains to be confirmed. The relationship between the S2 allele of the SstI polymorphism and plasma apoCIII or TG and their roles in atherosclerosis are also unknown. Methods A cohort of 628 participants was recruited (316 atherosclerotic patients and 312 healthy controls) from both the Li and Han ethnic groups. Blood samples were obtained to evaluate the SstI polymorphism in the apoC3 and lipid profiles. Chi-squared and t-tests and multiple unconditional logistic regression were employed to analyze the genotypic and allelic frequencies and lipid profiles using SPSS version 20.0 software. Results The SstI polymorphism in the apoC3 was identified in the Li ethnic group. The S2 allele and plasma apoCIII and TG levels were associated with the development of atherosclerosis (P

Published
2017
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