1. The contribution of acute infarcts to cerebral small vessel disease progression
- Author
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Miguel Ángel Araque Caballero, Martin Dichgans, Annemieke ter Telgte, Frank-Erik de Leeuw, Floris H.B.M. Schreuder, Catharina J.M. Klijn, Jabke J. de Klerk, Anil M. Tuladhar, Mathias Huebner, Benno Gesierich, José P. Marques, David G. Norris, Marco Duering, Kim Wiegertjes, Hugo J. Kuijf, and Magnetic Detection and Imaging
- Subjects
Male ,0301 basic medicine ,Neurology ,UT-Hybrid-D ,blood supply [White Matter] ,0302 clinical medicine ,Interquartile range ,pathology [White Matter] ,pathology [Intracranial Hemorrhages] ,Stroke ,Research Articles ,Aged, 80 and over ,complications [Intracranial Hemorrhages] ,medicine.diagnostic_test ,Incidence ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,pathology [Stroke, Lacunar] ,complications [Cerebral Small Vessel Diseases] ,Disease Progression ,Female ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Clinical Neurology ,Neuroimaging ,Acute infarcts ,behavioral disciplines and activities ,150 000 MR Techniques in Brain Function ,Lesion ,03 medical and health sciences ,mental disorders ,medicine ,Journal Article ,Humans ,ddc:610 ,cardiovascular diseases ,Aged ,complications [Stroke, Lacunar] ,business.industry ,pathology [Brain Infarction] ,Magnetic resonance imaging ,medicine.disease ,Hyperintensity ,Diffusion Magnetic Resonance Imaging ,030104 developmental biology ,complications [Brain Infarction] ,pathology [Cerebral Small Vessel Diseases] ,Neurology (clinical) ,Nuclear medicine ,business ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 208985.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression of white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers. METHODS: We performed monthly 3T magnetic resonance imaging (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, and 3-dimensional fluid-attenuated inversion recovery, T1, and susceptibility-weighted imaging. We determined DWI+ lesion evolution, WMH progression rate (ml/mo), and number of incident lacunes and microbleeds, and calculated for each marker the proportion of progression explained by DWI+ lesions. RESULTS: We identified 39 DWI+ lesions on 21 of 472 DWI scans in 9 of 54 subjects. Of the 36 DWI+ lesions with follow-up MRI, 2 evolved into WMH, 4 evolved into a lacune (3 with cavity
- Published
- 2019
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