1. Serum biochemical parameters and cytokine profiles associated with natural African trypanosome infections in cattle
- Author
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Kwadwo A. Kusi, Soale Majeed Bakari, Mark Carrington, George Aning, Gordon A. Awandare, Theresa Manful Gwira, Jennifer Afua Ofori, and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Male ,Trypanosoma ,medicine.medical_treatment ,030106 microbiology ,Cattle Diseases ,Ghana ,lcsh:Infectious and parasitic diseases ,Proinflammatory cytokine ,Serum biochemical parameters ,03 medical and health sciences ,Immune system ,parasitic diseases ,medicine ,Prevalence ,Animals ,lcsh:RC109-216 ,Interferon gamma ,Longitudinal Studies ,Trypanosoma vivax ,Interleukin 4 ,Animal African trypanosomiasis ,biology ,Research ,Trypanosomiasis, Bovine ,Cytokine profiles ,Alanine Transaminase ,Bilirubin ,biology.organism_classification ,Alkaline Phosphatase ,Interleukin 10 ,030104 developmental biology ,Infectious Diseases ,Cytokine ,Cholesterol ,Trypanosomiasis, African ,Natural infections ,Creatinine ,Immunology ,Interleukin 12 ,Cytokines ,Parasitology ,Cattle ,Female ,Blood Chemical Analysis ,medicine.drug - Abstract
Background Animal African trypanosomiasis (AAT) greatly affects livestock production in sub-Saharan Africa. In Ghana prevalence of AAT is estimated to range between 5 and 50%. Studies have reported serum biochemical aberrations and variability in cytokine profiles in animals during infection. However, information regarding the biochemical parameters and cytokine profiles associated with natural infections are limited. This study was therefore aimed at investigating changes in the levels of serum biochemical parameters and inflammatory cytokines during a natural infection. Methods Nested internal transcribed spacer (ITS)-based PCR and sequencing were used to characterise trypanosome infection in cattle at two areas in Ghana (Adidome and Accra) of different endemicities. The cattle were sampled at four to five-week intervals over a period of six months. Levels of serum biochemical parameters, including creatinine, cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), total bilirubin and total protein and cytokines (interleukin 10, interleukin 4, interleukin 12, interferon gamma and tumor necrosis factor alpha) were measured in serum samples and then compared between infected cattle and uninfected controls. Results The predominant trypanosome species detected in Accra (non-endemic) and Adidome (endemic) were Trypanosoma theileri and Trypanosoma vivax, respectively. Serum biochemical parameters were similar between infected and uninfected cattle in Accra. Infected cattle at Adidome however, had significantly higher levels of ALP, creatinine, total protein and total bilirubin (P
- Published
- 2017