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3 results on '"Centre for Infectious Disease and Microbiology (CIDM)"'

1. Scedosporium and Lomentospora: an updated overview of underrated opportunists

Author

Adela Martin-Vicente, Javier Pemán, Sandrine Giraud, Aitor Rementeria, José F. Cano-Lira, Ana Alastruey-Izquierdo, Mariana Ingrid Dutra da Silva Xisto, Jean-Philippe Bouchara, Jardel Vieira de Meirelles, Carsten Schwarz, Laszlo Irinyi, María Teresa Martín-Gómez, Anne Bernhardt, Rodrigo Rollin-Pinheiro, Kathrin Tintelnot, Aize Pellon, Fernando L. Hernando, Idoia Buldain, Stéphane Ranque, Leyre M. López-Soria, Andoni Ramirez-Garcia, Yohann Le Govic, Markus Nagl, Sharon C.-A. Chen, Eliana Barreto-Bergter, Wieland Meyer, Vladimír Havlíček, Michaela Lackner, Patrick Vandeputte, Johannes Rainer, Javier Capilla, Sybren de Hoog, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Institute of Earth and Environmental Science [Potsdam], University of Potsdam, Robert Koch Institute [Berlin] (RKI), Universitat Rovira i Virgili, Innsbruck Medical University [Austria] (IMU), Centre for Infectious Disease and Microbiology (CIDM), The Westmead Institute for Medical Research, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), University of Potsdam = Universität Potsdam, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Westerdijk Fungal Biodiversity Institute, and Westerdijk Fungal Biodiversity Institute - Medical Mycology

Subjects
0301 basic medicine, medicine.medical_specialty, Antifungal Agents, Virulence Factors, 030106 microbiology, Drug resistance, Opportunistic Infections, Scedosporium, Immunocompromised Host, 03 medical and health sciences, Local infection, Ascomycota, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Drug Resistance, Multiple, Fungal, Epidemiology, medicine, Humans, Intensive care medicine, emergent, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Lomentospora, High rate, Ecology, business.industry, Mortality rate, Fungal genetics, General Medicine, Combined Modality Therapy, infection, 3. Good health, Molecular Typing, Infectious Diseases, Mycoses, Surgical Procedures, Operative, Host-Pathogen Interactions, fungi, business, pathogen
Abstract

International audience; Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.

Published
2018

2. Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis

Author

Gilles Nevez, Joerg Steinmann, Laurence Delhaes, Ludovic Duvaux, Jean-Philippe Bouchara, Wieland Meyer, Ludwig Sedlacek, Maxime Fleury, Nicolas Papon, Loïc Favennec, Patrick Vandeputte, Javier Pemán, Amandine Gastebois, Françoise Botterel, Jose A. Vazquez, Stéphane Ranque, Sharon C.-A. Chen, Ana Alastruey-Izquierdo, Solène Le Gal, Craig Williams, Marie-Elisabeth Bougnoux, Carsten Schwarz, Françoise Symoens, Estrella Martin Mazuelos, Guillermo Quindós, Thomas Dugé de Bernonville, Josep Cano, Amparo Solé, Amandine Rougeron, Sandrine Giraud, María Teresa Martín-Gómez, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), University of Sheffield [Sheffield], Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Anofel Cryptosporidium National Network, Laboratoire de Parasitologie-Mycologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Microbiologie, Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Parasitologie et de Mycologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Appareil Digestif Environnement Nutrition (ADEN ), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Augusta University, University System of Georgia (USG), The Westmead Institute for Medical Research, Centre for Infectious Disease and Microbiology (CIDM), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), APP1031943, National Health and Medical Research Council, 2010/IC1003, Vaincre la Mucoviscidose, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Groupe d'Etude des Interactions Hôte-Parasite (GEIHP), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte - Clermont Auvergne (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Groupe d’Etude des Interactions Hôte-Pathogène, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de la Recherche Agronomique (INRA)

Subjects
Microbiological Techniques, 0301 basic medicine, medicine.medical_specialty, Antifungal Agents, Cystic Fibrosis, biological diagnosis, 030106 microbiology, Medizin, Context (language use), Disease, Drug resistance, Cystic fibrosis, pathogenic mechanisms, cystic fibrosis, Scedosporium, 03 medical and health sciences, fungal respiratory infections, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Drug Resistance, Multiple, Fungal, medicine, Humans, Microbiome, Intensive care medicine, Respiratory Tract Infections, Genotyping, treatment, business.industry, Fungi, Genomics, General Medicine, medicine.disease, 3. Good health, Infectious Diseases, Mycoses, Scedosporium species, Identification (biology), business
Abstract

International audience; Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.

Published
2018

3. Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe

Author

Helena M. B. Seth-Smith, Bart Versteeg, Cécile Bébéar, Henry J. C. de Vries, Juan C. Galán, Ian Carter, David A. Lewis, Servaas A. Morré, Adrian Egli, Bertille de Barbeyrac, Sylvia M. Bruisten, Olivia Peuchant, Nicholas R. Thomson, Jen Kok, Daniel Goldenberger, Angèle Bénard, Clinical Microbiology, Hospital for Infectious Diseases, Applied Microbiology Research, Department of Biomedicine, University of Basel (Unibas), CIBER de Epidemiología y Salud Pública, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Western Sydney Sexual Health Centre, University of Sydney, USC 3671 Infections humaines à mycoplasmes et Chlamydiae, Institut National de la Recherche Agronomique (INRA), Université de Bordeaux (UB), The Wellcome Trust Sanger Institute [Cambridge], Centre for Infectious Disease and Microbiology (CIDM), The Westmead Institute for Medical Research, Department of Infectious Diseases, Public Health Service Amsterdam, STI Outpatient Clinic, Amsterdam Infection and Immunity Institute (AI&II), Academic Medical Centre, University of Amsterdam, Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Amsterdam Medical Center, Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, Maastricht University, London School of Hygiene and Tropical Medicine (LSHTM), Department of Dermatology, Academic Medical Center, AII - Infectious diseases, APH - Global Health, Medical Microbiology and Infection Prevention, APH - Methodology, Dermatology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Institute for Public Health Genomics, University of Amsterdam [Amsterdam] (UvA), and Maastricht University [Maastricht]

Subjects
0301 basic medicine, bacterial outer membrane proteins, Epidemiology, OUTBREAK, genotype, [SDV]Life Sciences [q-bio], 030106 microbiology, Chlamydia trachomatis, VARIANTS, urologic and male genital diseases, medicine.disease_cause, 03 medical and health sciences, male homosexuality, Virology, Genotype, Humans, Medicine, Homosexuality, Male, lymphogranuloma venereum, business.industry, Strain (biology), Lymphogranuloma venereum, Public Health, Environmental and Occupational Health, Outbreak, bacterial infections and mycoses, medicine.disease, female genital diseases and pregnancy complications, 3. Good health, Europe, 030104 developmental biology, Bacterial Outer Membrane Proteins, Lymphogranuloma Venereum, bacteria, business, Male Homosexuality
Abstract

A recent surveillance and outbreak report published in Eurosurveillance by Petrovay et al. on the ‘Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016’ [1] provides an observation of the first European cases of a genotype of Chlamydia trachomatis associated with severe haemorrhagic proctitis. The authors of this paper diagnosed the strains as lymphogranuloma venereum (LGV)- associated and performed partial sequencing of the ompA gene (ca 1,070 bp), which is a standard typing method for C. trachomatis. The ompA gene sequence obtained was compared with those from reference isolates, and reported to be 100% concordant with the ompA sequence belonging to an L2-D recombinant strain described in 2011 [2]. This strain was named ‘L2c’, as it was found to possess a chimeric genome, not because it has a novel ompA-genotype. We would like to point out that the ompA gene sequence of this L2-D recombinant strain, and by implication those of the Hungarian isolates, is identical to that of archetypal L2 strains, for example the reference strain L2/434 [3].

Published
2017

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